Rat α-synuclein interacts with Tat binding protein 1, a component of the 26S proteasomal complex

Journal of Neurochemistry

Volumn 75, Issue 5, 2000, Pages 2221-2224

  Ghee, M ^a   Fournier, A ^a   Mallet, J ^a  

^a CNRS   (France)

Author keywords

Parkinson's disease; Tat binding protein 1; Synuclein

Indexed keywords

ALPHA SYNUCLEIN; BINDING PROTEIN; ENZYME ACTIVATOR; PROTEASOME; PROTEIN SUBUNIT; TRANSACTIVATOR PROTEIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; COMPLEX FORMATION; DEGENERATIVE DISEASE; EMBRYO; GENETIC SCREENING; HUMAN; HUMAN CELL; LEWY BODY; NERVE ENDING; NONHUMAN; ONSET AGE; PARKINSON DISEASE; POINT MUTATION; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN PROTEIN INTERACTION; RAT;

ANIMAL; BRAIN; CELL LINE; CLONE CELLS; DNA-BINDING PROTEINS; DOPAMINE; HUMAN; KIDNEY; LEWY BODIES; MACROMOLECULAR SYSTEMS; NERVE TISSUE PROTEINS; NEURONS; PARKINSONIAN DISORDERS; PEPTIDE HYDROLASES; PRECIPITIN TESTS; PRESYNAPTIC TERMINALS; PROTEINS; RATS; SACCHAROMYCES; SUPPORT, NON-U.S. GOV'T; TRANSFECTION; TWO-HYBRID SYSTEM TECHNIQUES; TYROSINE 3-MONOOXYGENASE;

EID: 0033788434     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2000.0752221.x     Document Type: Article

References (30)

1. Structural and functional effects of PA700 and modulator protein on proteasomes
2. Using the two-hybrid system to detect protein-protein interactions
3. Degradation of α-synuclein by proteasome
4. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein - Dye binding
5. Intrastriatal injection of an adenoviral vector expressing glial-cell-line-derived neurotrophic factor prevents dopaminergic neuron degeneration and behavioral impairment in a rat model of Parkinson disease
6. Accelerated in vitro fibril formation by a mutant α-synuclein linked to early-onset Parkinson disease
7. PA700, an ATP-dependent activator of the 20S proteasome, is an ATPase containing multiple members of a nucleotide-binding protein family
8. Identification, purification, and characterization of a PA700-dependent activator of the proteasome
9. A 26 S protease subunit that binds ubiquitin conjugates
10. Subunit 4 of the 26 S protease is a member of a novel eukaryotic ATPase family
11. Peptide sequencing identifies MSS1, a modulator of HIV Tat-mediated transactivation, as subunit 7 of the 26 S protease
12. Tat-binding protein 7 is a subunit of the 26S protease
13. Synphilin-1 associates with α-synuclein and promotes the formation of cytosolic inclusions
14. Neuropathology of Parkinson's disease
15. Mutant and wild type human α-synucleins assemble into elongated filaments with distinct morphologies in vitro
16. A subcomplex of the proteasome regulatory particle required for ubiquitin-conjugate degradation and related to the COP9-signalosome and eIF3
17. Identification of a new family of tissue-specific basic helix-loop-helix proteins with a two-hybrid system
18. New developments in the pathology of Parkinson's disease
19. 30Pro mutation in the gene encoding α-synuclein in Parkinson's disease
20. The rat brain synucleins; family of proteins transiently associated with neuronal membrane
21. α-Synuclein in neurodegenerative disorders: Murderer or accomplice?
22. Both familial Parkinson's disease mutations accelerate α-synuclein aggregation
23. Proteasome-dependent degradation of the human estrogen receptor
24. A cDNA for a protein that interacts with the human immunodeficiency virus Tat transactivator
25. Pathology and biology of the Lewy body
26. Mutation in the α-synuclein gene identified in families with Parkinson's disease
27. α-Synuclein in Lewy bodies
28. α-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with Lewy bodies
29. Recognition of misfolding proteins by PA700, the regulatory subcomplex of the 26 S proteasome
30. NACP, a protein implicated in Alzheimer's disease and learning, is natively unfolded