Fibrils formed in vitro from α-synuclein and two mutant forms linked to Parkinson's disease are typical amyloid

Biochemistry

Volumn 39, Issue 10, 2000, Pages 2552-2563

  Conway, Kelly A ^a   Harper, James D ^a   Lansbury Jr , Peter T ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA SYNUCLEIN; AMYLOID BETA PROTEIN; COMPLEMENTARY DNA; MUTANT PROTEIN; RECOMBINANT PROTEIN;

ALZHEIMER DISEASE; ARTICLE; DEGENERATIVE DISEASE; ELECTRON MICROSCOPY; GENE EXPRESSION; GENE MUTATION; HUMAN; LEWY BODY; MISSENSE MUTATION; NEUROLOGIC DISEASE; NONHUMAN; PARKINSON DISEASE; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN PURIFICATION;

ALANINE; ALPHA-SYNUCLEIN; AMINO ACID SEQUENCE; AMYLOID; BINDING SITES; BRAIN; CIRCULAR DICHROISM; CONGO RED; ENDOPEPTIDASES; HUMANS; HYDROLYSIS; IMMUNOHISTOCHEMISTRY; LEWY BODIES; MICROSCOPY, ATOMIC FORCE; MICROSCOPY, POLARIZATION; MOLECULAR SEQUENCE DATA; MUTATION, MISSENSE; NERVE TISSUE PROTEINS; PARKINSON DISEASE; POSTMORTEM CHANGES; PROLINE; PROTEIN STRUCTURE, SECONDARY; RECOMBINANT PROTEINS; SPECTROMETRY, FLUORESCENCE; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; SYNUCLEINS; THIAZOLES; THREONINE;

EID: 0034646391     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi991447r     Document Type: Article

References (82)

1. Kosaka, K., and Iseki, E. (1996) Curr. Opin. Neurol. 9, 271-5.
2. Pollanen, M. S., Dickson, D. W., and Bergeron, C. (1993) J. Neuropath. Exp. Neurol. 52, 183-191.
3. Forno, L. S. (1996) J. Neuropathol. Exp. Neurol. 55, 259-72.
4. Tompkins, M. M., Basgall, E. J., Zamrini, E., and Hill, W. D. (1997) Am. J. Pathol. 150, 119-31.
5. Tompkins, M. M., and Hill, W. D. (1997) Brain Res. 775, 24-9.
6. Fomo, L. S., and Langston, J. W. (1993) Neurodegen. 2, 19-24.
7. Polymeropoulos, M. H., Lavedan, C., Leroy, E., Ide, S. E., Dehejia, A., Dutra, A., Pike, B., Root, H., Rubenstein, J., Boyer, R., Stenroos, E. S., Chandradekharappa, S., Athanassiadou, A., Papapetropoulos, T., Johnson, W. G., Lazzarini, A. M., Duvoisin, R. C., Di Iorio, G., Golbe, L. I., and Nussbaum, R. L. (1997) Science 276, 2045-2047.
8. Kruger, R., Kuhn, W., Muller, T., Woitalla, D., Graeber, M., Kosel, S., Przuntek, H., Epplen, J. T., Schols, L., and Riess, O. (1998) Nat. Genet. 18, 106-108.
9. Spillantini, M. G., Schmidt, M. L., Lee, V. M.-Y., Trojanowski, J. Q., Jakes, R., and Goedert, M. (1997) Nature 388, 839-840.
10. Baba, M., Nakajo, S., Pang-Hsien, T., Tomita, T., Nakaya, K., Lee, V. M.-Y., Trojanowski, J. Q., and Iwatsubo, T. (1998) Am. J. Pathol 152, 879-884.
11. Arima, K., Ueda, K., Sunohara, N., Arakawa, K., Hirai, S., Nakamura, M., Tonozuka-Uehara, H., and Kawai, M. (1998) Acta Neuropathol. (Berl) 96, 439-44.
12. Tu, P.-H., Galvin, J. E., Baba, M., Giasson, B., Tomita, T., Leight, S., Nakajo, S., Iwatsubo, T., Trojanowski, J. Q., and Lee, V. M.-Y. (1998) Ann. Neurol. 44, 415-422.
13. Wakabayashi, K., Yoshimoto, M., Tsuji, S., and Takahashi, H. (1998) Neurosci. Lett. 249, 180-2.
14. Spillantini, M. G., Crowther, R. A., Jakes, R., Cairns, N. J., Lantos, P. L., and Goedert, M. (1998) Neurosci. Lett. 251, 205-8.
15. Ueda, K., Fukushima, H., Masliah, E., Xia, Y., Iwai, A., Yoshimoto, M., Otero, D. A. C., Kondo, J., Ihara, Y., and Saitoh, T. (1993) Proc. Natl. Acad. Sci. U.S.A 90, 11282-11286.
16. Lansbury, P. T. (1997) Neuron 19, 1151-1154.
17. Maroteaux, L., Campanelli, J. T., and Scheller, R.H. (1988) J. Neurosci. 8, 2804-2815.
18. Maroteaux, L., and Scheller, R.H. (1991) Mol. Brain Res. 11, 335-343.
19. Jakes, R., Spillantini, M. G., and Goedert, M. (1994) FEBS Lett. 345, 27-32.
20. George, J. M., Jin, H., Woods, W. S., and Clayton. D. F. (1995) Neuron 15, 361-72.
21. Iwai, A., Masliah, E., Yoshimoto, M., Ge, N., Flanagan, L., de Silva, H. A., Kittel, A., and Saitoh, T. (1995) Neuron 14, 467-75.
22. Shibayama-Imazu, T., Okahashi, I., Omata, K., Nakajo, S., Ochiai, H., Nakai, Y., Hama, T., Nakamura, Y., and Nakaya, K. (1993) Brain Res. 622, 17-25.
23. Withers, G. S., George, J. M., Banker, G. A., and Clayton, D. F. (1997) Dev. Brain Res. 99, 87-94.
24. Jenco, J. M., Rawlingson, A., Daniels, B., and Morris, A. J. (1998) Biochemistry 37, 4901-4909.
25. Han, H., Weinreb, P. H., and Lansbury, P. T. (1995) Chem. Biol. 2, 163-9.
26. Crowther, R. A., Jakes, R., Spillantini, M. G., and Goedert, M. (1998) FEBS Lett. 436, 309-12.
27. Weinreb, P. H., Zhen, W., Poon, A. W., Conway, K. A., and Lansbury, P. T., Jr. (1996) Biochemistry 35, 13709-13715.
28. Davidson, W. S., Jonas, A., Clayton, D. F., and George, J. M. (1998) J. Biol. Chem. 273, 9443-9449.
29. Jensen, P. H., Nielsen, M. S., Jakes, R., Dotti, C. G., and Goedert, M. (1998) J. Biol. Chem. 273, 26292-4.
30. Conway, K. A., Harper, J. D., and Lansbury, P. T. (1998) Nat. Med. 4, 1318-1320.
31. Hashimoto, M., Hsu, L. J., Sisk, A., Xia, Y., Takeda, A., Sundsmo, M., and Masliah, E. (1998) Brain Res. 799, 301-6.
32. El-Agnaf, O. M., Jakes, R., Curran, M. D., and Wallace, A. (1998) FEBS Lett. 440, 67-70.
33. Giasson, B. I., Uryu, K., Trojanowski, J. Q., and Lee, V. M. Y. (1999) J. Biol. Chem. 274, 7619-22.
34. Narhi, L., Wood, S. J., Steavenson, S., Jiang, Y., Wu, G. M., Anafi, D., Kaufman, S. A., Martin, F., Sitney, K., Denis, P., Louis, J. C., Wypych, J., Biere, A. L., and Citron, M. (1999) J. Biol. Chem. 274, 9843-6.
35. Harper, J. D., Lieber, C. M., and Lansbury, P. T. (1997) Chem. Biol. 4, 951-959.
36. Harper, J. D., Wong, S. S., Lieber, C. M., and Lansbury, P. T., Jr. (1997) Chem. Biol. 4, 119-125.
37. Harper, J. D., Wong, S. S., Lieber, C. M., and Lansbury, P. T., Jr. (1999) Biochemistry 38, 8972-80.
38. Walsh, D. M., Lomakin, A., Benedek, G. B., Condron, M. M., and Teplow, D. B. (1997) J. Biol. Chem. 272, 22364-72.
39. Kelly, J. W., and Lansbury, P. T., Jr. (1994) Amyloid: Int. J. Exp. Clin. Invest. 1, 186-205.
40. Lansbury, P. T., Jr. (1992) Biochem. 31, 6865-6870.
41. Kocisko, D. A., Raymond, G., Lansbury. P. T., and Caughey, B. (1996) Biochem. 35, 13434-13442.
42. Nordstedt, C., Naslund, J., Tjernberg, L. O., Karlstrom, A. R., Thyberg, J., and Terenius, L. (1994) J. Biol. Chem. 269, 30773-30776.
43. Langston, J. W., Sastry, S., Chan, P., Forno, L. S., Bolin, L. M., and Di Monte, D. A. (1998) Exp. Neurol. 154, 684-90.
44. Iwai, A., Yoshimoto, M., Masliah, E., and Saitoh, T. (1995) Biochemistry 34, 10139-45.
45. Hasegawa, K., Yamashita, I., and Namba, K. (1998) Biophys. J. 74, 569-575.
46. Iwatsubo, T., Yamaguchi, H., Fujimuro, M., Yokosawa, H., Ihara, Y., Trojanowski, J. Q., and Lee, V. M. (1996) Am. J. Pathol. 148, 1517-29.
47. Spillantini, M. G., Crowther, R. A., Jakes, R., Hasegawa, M., and Goedert, M. (1998) Proc. Natl. Acad. Sci. U.S.A. 95, 6469-6473.
48. Woody, R. W. (1995) Methods Enzymol. 246, 34-71.
49. Walsh, D. M., Hartley, D. M., Kusumoto, Y., Fezoui, Y., Condron, M. M., Lomakin, A., Benedek, G. B., Selkoe, D. J., and Teplow, D. B. (1999) J. Biol. Chem. 274, 25945-25952.
50. Adler, A. J., Greenfield, N. J., and Fasman, G. D. (1973) Methods Enzymol. 27, 675-735.
51. Conway, K. A., Lee, S.-J., Rochet, J.-C., Ding, T. T., Williamson, R. E., and Lansbury, P. T., Jr. (2000) Proc. Natl. Acad. Sci. U.S.A., 97, 571-576.
52. Bandekar, J., and Krimm, S. (1985) Int. J. Peptide Protein Res. 26, 407-415.
53. Krimm, S., and Bandekar, J. (1986) in Advances in Protein Chemistry (Anfinsen, C., Ed.) pp 183-364.
54. Ladewig, P. (1945) Nature 156, 81.
55. Cooper, J. H. (1974) Lab. Invest. 31, 232-238.
56. Puchtler, H., Sweat Waldrop, F., and Meloan, S. N. (1983) Histochem. 77, 431-45.
57. Elghetany, M. T., and Saleem, A. (1988) Stain Technol. 63, 201-12.
58. Klunk, W. E., Jacob, R. F., and Mason, R. P. (1999) Anal. Biochem. 266, 66-76.
59. Klunk, W. E., Pettegrew, J. W., and Abraham, D. J. (1989) J. Histochem. Cytochem. 37, 1293-1297.
60. Bonifacio, M. J., Sakaki, Y., and Saraiva, M. J. (1996) Biochim Biophys Acta 1316, 35-42.
61. Klunk, W. E., Pettegrew, J. W., and Abraham, D. J. (1989) J. Histochem. Cytochem. 37, 1273-1281.
62. LeVine, H., III. (1993) Protein Sci. 2, 404-410.
63. Naiki, H., Higuchi, K., Hosokawa, M., and Takeda, T. (1989) Anal. Biochem. 177, 244-249.
64. Kudva, Y. C., Mueske, C., Butler, P. C., and Eberhardt, N. L. (1998) Biochem. J. 331, 809-13.
65. Nandi, P. K. (1998) Arch. Virol. 143, 1251-63.
66. Naiki, H., and Nakakuki, K. (1996) Lab Invest. 74, 374-83.
67. Friedhoff, P., Schneider, A., Mandelkow, E. M., and Mandelkow, E. (1998) Biochemistry 37, 10223-30.
68. Caughey, B., Raymond, G. J., Kocisko, G. J., and Lansbury, P. T., Jr. (1997) J. Virol. 71, 4107-4110.
69. Soto, C., and Castano, E. M. (1996) Biochem. J. 314, 701-1.
70. Bolton, D. C., McKinley, M. P., and Prusiner, S. B. (1982) Science 218, 1309-1311.
71. Prusiner, S. B., McKinley, M. P., Bowman, K. A., Bolton, D. C., Bendheim, P. E., Groth, D. F., and Glenner, G. G. (1983) Cell 35, 349-58.
72. Sipe, J. D. (1992) Annu. Rev. Biochem. 61, 947-975.
73. Glenner, G. G., Eanes, E. D., and Page, D. L. (1972) J. Histochem, Cytochem, 20, 821-6.
74. Burke, M. J., and Rougvie, M. A. (1972) Biochemistry 11, 2435-9.
75. Harper, J. D., and Lansbury, P. T. (1997) Annu. Rev. Biochem. 66, 385-407.
76. Goedert, M., Crowther, R. A., and Spillantini, M. G. (1998) Neuron 21, 955-8.
77. Friedhoff, P., von Bergen, M., Mandelkow, E. M., Davies, P., and Mandelkow, E. (1998) Proc. Natl. Acad. Sci. U.S.A. 95, 15712-15717.
78. Herzfeld, J. (1996) Ace. Chem. Res. 29, 31-37.
79. Scherzinger, E., Sittler, A., Schweiger, K., Heiser, V., Lurz, R., Hasenbank, R., Bates, G. P., Lehrach, H., and Wanker, E. E. (1999) Proc. Natl. Acad. Sci. U.S.A. 96, 4604-9.
80. Saudou, F., Finkbeiner, S., Devys, D., and Greenberg, M. E. (1998) Cell 95, 55-66.
81. Klement, I. A., Skinner, P. J., Kaytor, M. D., Yi, H., Hersch, S. M., Clark, H. B., Zoghbi, H. Y., and Orr, H. T. (1998) Cell 95, 41-53.
82. Lansbury, P. T. (1999) Proc. Natl. Acad Sci. U.S.A. 96, 3342-2244.