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Volumn 179, Issue 1, 2003, Pages 9-16

Subcutaneous rotenone exposure causes highly selective dopaminergic degeneration and α-synuclein aggregation

Author keywords

Complex I; Mitochondria; Oxidative stress; Parkinson's disease; Pesticides

Indexed keywords

ALPHA SYNUCLEIN; PESTICIDE; PHOSPHOPROTEIN DARPP 32; ROTENONE;

EID: 0037229425     PISSN: 00144886     EISSN: None     Source Type: Journal    
DOI: 10.1006/exnr.2002.8072     Document Type: Article
Times cited : (615)

References (64)
  • 1
    • 0037126181 scopus 로고    scopus 로고
    • Rotenone destroys dopaminergic neurons and induces parkinsonian symptoms in rats
    • Alam, M., and W. J. Schmidt. 2002. Rotenone destroys dopaminergic neurons and induces parkinsonian symptoms in rats. Behav. Brain Res. 136: 317-324.
    • (2002) Behav. Brain Res. , vol.136 , pp. 317-324
    • Alam, M.1    Schmidt, W.J.2
  • 2
    • 0030805622 scopus 로고    scopus 로고
    • A generalised increase in protein carbonyls in the brain in Parkinson's but not incidental Lewy body disease
    • Alam, Z. I., S. E. Daniel, A. J. Lees, D. C. Marsden, P. Jenner, and B. Halliwell. 1997. A generalised increase in protein carbonyls in the brain in Parkinson's but not incidental Lewy body disease. J. Neurochem. 69: 1326-1329.
    • (1997) J. Neurochem. , vol.69 , pp. 1326-1329
    • Alam, Z.I.1    Daniel, S.E.2    Lees, A.J.3    Marsden, D.C.4    Jenner, P.5    Halliwell, B.6
  • 3
    • 0031691460 scopus 로고    scopus 로고
    • Metabolic compromise with systemic 3-nitropropionic acid produces striatal apoptosis in Sprague-Dawley rats but not in BALB/c ByJ mice
    • Alexi, T., P. E. Hughes, B. Knusel, and A. J. Tobin. 1998. Metabolic compromise with systemic 3-nitropropionic acid produces striatal apoptosis in Sprague-Dawley rats but not in BALB/c ByJ mice. Exp. Neurol. 153: 74-93.
    • (1998) Exp. Neurol. , vol.153 , pp. 74-93
    • Alexi, T.1    Hughes, P.E.2    Knusel, B.3    Tobin, A.J.4
  • 4
    • 0033522924 scopus 로고    scopus 로고
    • Titrating the effects of mitochondrial complex I impairment in the cell physiology
    • Barrientos, A., and C. T. Moraes. 1999. Titrating the effects of mitochondrial complex I impairment in the cell physiology. J. Biol. Chem. 274: 16188-16197.
    • (1999) J. Biol. Chem. , vol.274 , pp. 16188-16197
    • Barrientos, A.1    Moraes, C.T.2
  • 7
    • 0035854087 scopus 로고    scopus 로고
    • Topological analysis of striatal lesions induced by 3-nitropropionic acid in the Lewis rat
    • Blum, D., D. Gall, L. Cuvelier, and S. N. Schiffmann. 2001. Topological analysis of striatal lesions induced by 3-nitropropionic acid in the Lewis rat. NeuroReport 12: 1769-1772.
    • (2001) NeuroReport , vol.12 , pp. 1769-1772
    • Blum, D.1    Gall, D.2    Cuvelier, L.3    Schiffmann, S.N.4
  • 9
    • 0035834360 scopus 로고    scopus 로고
    • Kinetic stabilization of the alpha-synuclein protofibril by a dopamine-alpha-synuclein adduct
    • Conway, K. A., J. C. Rochet, R. M. Bieganski, and P. T. J. Lansbury. 2001. Kinetic stabilization of the alpha-synuclein protofibril by a dopamine-alpha-synuclein adduct. Science 294: 1257-1258.
    • (2001) Science , vol.294 , pp. 1257-1258
    • Conway, K.A.1    Rochet, J.C.2    Bieganski, R.M.3    Lansbury, P.T.J.4
  • 10
    • 0032490114 scopus 로고    scopus 로고
    • Inhibitors of NADH-ubiquinone reductase: An overview
    • Degli Esposti, M. 1998. Inhibitors of NADH-ubiquinone reductase: An overview. Biochim. Biophys. Acta 1364: 222-235.
    • (1998) Biochim. Biophys. Acta , vol.1364 , pp. 222-235
    • Degli Esposti, M.1
  • 12
    • 0035006792 scopus 로고    scopus 로고
    • Proteasome inhibition in oxidative stress neurotoxicity: Implications for heat shock proteins
    • Ding, Q., and J. N. Keller. 2001. Proteasome inhibition in oxidative stress neurotoxicity: Implications for heat shock proteins. J. Neurochem. 77: 1010-1017.
    • (2001) J. Neurochem. , vol.77 , pp. 1010-1017
    • Ding, Q.1    Keller, J.N.2
  • 13
    • 0026484388 scopus 로고
    • The oxidant stress hypothesis in Parkinson's disease: Evidence supporting it
    • Fahn, S., and G. Cohen. 1992. The oxidant stress hypothesis in Parkinson's disease: Evidence supporting it. Ann. Neurol. 32: 804-812.
    • (1992) Ann. Neurol. , vol.32 , pp. 804-812
    • Fahn, S.1    Cohen, G.2
  • 14
    • 0031005815 scopus 로고    scopus 로고
    • Systemic administration of rotenone produces selective damage in the striatum and globus pallidus, but not in the substantia nigra
    • Ferrante, R. J., J. B. Schulz, N. W. Kowall, and M. F. Beal. 1997. Systemic administration of rotenone produces selective damage in the striatum and globus pallidus, but not in the substantia nigra. Brain Res. 753: 157-162.
    • (1997) Brain Res. , vol.753 , pp. 157-162
    • Ferrante, R.J.1    Schulz, J.B.2    Kowall, N.W.3    Beal, M.F.4
  • 15
    • 0031962268 scopus 로고    scopus 로고
    • Increased protein oxidation in human substantia nigra pars compacta in comparison with basal ganglia and prefrontal cortex measured with an improved dinitrophenylhydrazine assay
    • Floor, E., and M. G. Wetzel. 1998. Increased protein oxidation in human substantia nigra pars compacta in comparison with basal ganglia and prefrontal cortex measured with an improved dinitrophenylhydrazine assay. J. Neurochem. 70: 268-275.
    • (1998) J. Neurochem. , vol.70 , pp. 268-275
    • Floor, E.1    Wetzel, M.G.2
  • 17
    • 0031843721 scopus 로고    scopus 로고
    • The risk of Parkinson's disease with exposure to pesticides, farming, well water, and rural living
    • Gorell, J. M., C. C. Johnson, B. A. Rybicki, E. L. Peterson, and R. J. Richardson. 1998. The risk of Parkinson's disease with exposure to pesticides, farming, well water, and rural living. Neurology 50: 1346-1350.
    • (1998) Neurology , vol.50 , pp. 1346-1350
    • Gorell, J.M.1    Johnson, C.C.2    Rybicki, B.A.3    Peterson, E.L.4    Richardson, R.J.5
  • 18
    • 0029050583 scopus 로고
    • Low platelet mitochondrial complex I and complex II/III activity in early untreated Parkinson's disease
    • Haas, R. H., F. Nasirian, K. Nakano, D. Ward, M. Pay, R. Hill, and C. W. Shults. 1995. Low platelet mitochondrial complex I and complex II/III activity in early untreated Parkinson's disease. Ann. Neurol. 37: 714-722.
    • (1995) Ann. Neurol. , vol.37 , pp. 714-722
    • Haas, R.H.1    Nasirian, F.2    Nakano, K.3    Ward, D.4    Pay, M.5    Hill, R.6    Shults, C.W.7
  • 19
    • 0028812293 scopus 로고
    • Enzymatic oxidation of dopamine: The role of prostaglandin H synthase
    • Hastings, T. G. 1995. Enzymatic oxidation of dopamine: The role of prostaglandin H synthase. J. Neurochem. 64: 919-924.
    • (1995) J. Neurochem. , vol.64 , pp. 919-924
    • Hastings, T.G.1
  • 20
    • 0031771518 scopus 로고    scopus 로고
    • Interaction of alpha-phenyl-N-tert-butyl nitrone and alternative electron acceptors with complex I indicates a substrate reduction site upstream from the rotenone binding site
    • Hensley, K., Q. N. Pye, M. L. Maidt, C. A. Stewart, K. A. Robinson, F. Jaffrey, and R. A. Floyd. 1998. Interaction of alpha-phenyl-N-tert-butyl nitrone and alternative electron acceptors with complex I indicates a substrate reduction site upstream from the rotenone binding site. J. Neurochem. 71: 2549-2557.
    • (1998) J. Neurochem. , vol.71 , pp. 2549-2557
    • Hensley, K.1    Pye, Q.N.2    Maidt, M.L.3    Stewart, C.A.4    Robinson, K.A.5    Jaffrey, F.6    Floyd, R.A.7
  • 22
    • 0029866793 scopus 로고    scopus 로고
    • Purification and characterization of Lewy bodies from the brains of patients with diffuse Lewy body disease
    • Iwatsubo, T., H. Yamaguchi, M. Fujimuro, H. Yokosawa, Y. Ihara, J. Q. Trojanowski, and V. M. Lee. 1996. Purification and characterization of Lewy bodies from the brains of patients with diffuse Lewy body disease. Am. J. Pathol. 148: 1517-1529.
    • (1996) Am. J. Pathol. , vol.148 , pp. 1517-1529
    • Iwatsubo, T.1    Yamaguchi, H.2    Fujimuro, M.3    Yokosawa, H.4    Ihara, Y.5    Trojanowski, J.Q.6    Lee, V.M.7
  • 23
    • 0021680307 scopus 로고
    • + by dopamine neurons explains selectivity of parkinsonism-inducing neurotoxin, MPTP
    • + by dopamine neurons explains selectivity of parkinsonism-inducing neurotoxin, MPTP. Eur. J. Pharmacol. 106: 455-456.
    • (1984) Eur. J. Pharmacol. , vol.106 , pp. 455-456
    • Javitch, J.A.1    Snyder, S.H.2
  • 24
    • 0031899172 scopus 로고    scopus 로고
    • Oxidative mechanisms in nigral cell death in Parkinson's disease
    • Jenner, P. 1998. Oxidative mechanisms in nigral cell death in Parkinson's disease. Mov. Disord. 13: 24-34.
    • (1998) Mov. Disord. , vol.13 , pp. 24-34
    • Jenner, P.1
  • 25
    • 0034008852 scopus 로고    scopus 로고
    • Enhanced vulnerability to oxidative stress by alpha-synuclein mutations and C-terminal truncation
    • Kanda, S., J. F. Bishop, M. A. Eglitis, Y. Yang, and M. M. Mouradian. 2000. Enhanced vulnerability to oxidative stress by alpha-synuclein mutations and C-terminal truncation. Neuroscience 97: 279-284.
    • (2000) Neuroscience , vol.97 , pp. 279-284
    • Kanda, S.1    Bishop, J.F.2    Eglitis, M.A.3    Yang, Y.4    Mouradian, M.M.5
  • 27
    • 0033773403 scopus 로고    scopus 로고
    • Sensitization of neuronal cells to oxidative stress with mutated human alpha-synuclein
    • Ko, L., N. D. Mehta, M. Farrer, C. Easson, J. Hussey, S. Yen, J. Hardy, and S. H. Yen. 2000. Sensitization of neuronal cells to oxidative stress with mutated human alpha-synuclein. J. Neurochem. 75: 2546-2554.
    • (2000) J. Neurochem. , vol.75 , pp. 2546-2554
    • Ko, L.1    Mehta, N.D.2    Farrer, M.3    Easson, C.4    Hussey, J.5    Yen, S.6    Hardy, J.7    Yen, S.H.8
  • 29
    • 0020680904 scopus 로고
    • Chronic parkinsonism in humans due to a product of meperidine-analog synthesis
    • Langston, J. W., P. Ballard, J. W. Tetrud, and I. Irwin. 1983. Chronic parkinsonism in humans due to a product of meperidine-analog synthesis. Science 219: 979-980.
    • (1983) Science , vol.219 , pp. 979-980
    • Langston, J.W.1    Ballard, P.2    Tetrud, J.W.3    Irwin, I.4
  • 30
    • 0037016741 scopus 로고    scopus 로고
    • Membrane-bound alpha-synuclein has a high aggregation propensity and the ability to seed the aggregation of the cytosolic form
    • Lee, H. J., C. Choi, and S. J. Lee. 2002. Membrane-bound alpha-synuclein has a high aggregation propensity and the ability to seed the aggregation of the cytosolic form. J. Biol. Chem. 277: 671-678.
    • (2002) J. Biol. Chem. , vol.277 , pp. 671-678
    • Lee, H.J.1    Choi, C.2    Lee, S.J.3
  • 31
    • 0002014685 scopus 로고    scopus 로고
    • Formation and removal of alpha-synuclein aggregates in cells exposed to mitochondrial inhibitors
    • Lee, H. J., S. Y. Shin, C. Choi, Y. H. Lee, and S. J. Lee. 2001. Formation and removal of alpha-synuclein aggregates in cells exposed to mitochondrial inhibitors. J. Biol. Chem. 27: 27.
    • (2001) J. Biol. Chem. , vol.27 , pp. 27
    • Lee, H.J.1    Shin, S.Y.2    Choi, C.3    Lee, Y.H.4    Lee, S.J.5
  • 33
    • 0034624017 scopus 로고    scopus 로고
    • The parkinsonism-inducing drug 1-methyl-4-phenylpyridinium triggers intracellular dopamine oxidation: A novel mechanism of toxicity
    • Lotharius, J., and K. L. O'Malley. 2000. The parkinsonism-inducing drug 1-methyl-4-phenylpyridinium triggers intracellular dopamine oxidation: A novel mechanism of toxicity. J. Biol. Chem. 275: 38581-38588.
    • (2000) J. Biol. Chem. , vol.275 , pp. 38581-38588
    • Lotharius, J.1    O'Malley, K.L.2
  • 34
    • 0026718086 scopus 로고
    • Brain, skeletal muscle and platelet homogenate mitochondrial function in Parkinson's disease
    • Mann, V. M., J. M. Cooper, D. Krige, S. E. Daniel, A. H. Schapira, and C. D. Marsden. 1992. Brain, skeletal muscle and platelet homogenate mitochondrial function in Parkinson's disease. Brain 115(Pt 2): 333-342.
    • (1992) Brain , vol.115 , Issue.PART 2 , pp. 333-342
    • Mann, V.M.1    Cooper, J.M.2    Krige, D.3    Daniel, S.E.4    Schapira, A.H.5    Marsden, C.D.6
  • 38
    • 0032564134 scopus 로고    scopus 로고
    • Parkinson's disease, pesticides, and glutathione transferase polymorphisms
    • Menegon, A., P. G. Board, A. C. Blackburn, G. D. Mellick, and D. G. Le Couteur. 1998. Parkinson's disease, pesticides, and glutathione transferase polymorphisms. Lancet 352: 1344-1346.
    • (1998) Lancet , vol.352 , pp. 1344-1346
    • Menegon, A.1    Board, P.G.2    Blackburn, A.C.3    Mellick, G.D.4    Le Couteur, D.G.5
  • 41
    • 0021810979 scopus 로고
    • Inhibition of NADH-linked oxidation in brain mitochondria by 1-methyl-4-phenyl-pyridine, a metabolite of the neurotoxin. 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine
    • Nicklas, W. J., I. Vyas, and R. E. Heikkila. 1985. Inhibition of NADH-linked oxidation in brain mitochondria by 1-methyl-4-phenyl-pyridine, a metabolite of the neurotoxin. 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine. Life Sci. 36: 2503-2508.
    • (1985) Life Sci. , vol.36 , pp. 2503-2508
    • Nicklas, W.J.1    Vyas, I.2    Heikkila, R.E.3
  • 42
    • 0034127284 scopus 로고    scopus 로고
    • Major strain differences in response to chronic systemic administration of the mitochondrial toxin 3-nitropropionic acid in rats: Implications for neuroprotection studies
    • Ouary, S., N. Bizat, S. Altairac, H. Menetrat, V. Mittoux, F. Conde, P. Hantraye, and E. Brouillet. 2000. Major strain differences in response to chronic systemic administration of the mitochondrial toxin 3-nitropropionic acid in rats: Implications for neuroprotection studies. Neuroscience 97: 521-530.
    • (2000) Neuroscience , vol.97 , pp. 521-530
    • Ouary, S.1    Bizat, N.2    Altairac, S.3    Menetrat, H.4    Mittoux, V.5    Conde, F.6    Hantraye, P.7    Brouillet, E.8
  • 43
    • 0024848034 scopus 로고
    • Abnormalities of the electron transport chain in idiopathic Parkinson's disease
    • Parker, W. D., Jr., S. J. Boyson, and J. K. Parks. 1989. Abnormalities of the electron transport chain in idiopathic Parkinson's disease. Ann. Neurol. 26: 719-723.
    • (1989) Ann. Neurol. , vol.26 , pp. 719-723
    • Parker W.D., Jr.1    Boyson, S.J.2    Parks, J.K.3
  • 45
    • 0034126793 scopus 로고    scopus 로고
    • Immunocytochemical characterization of the mitochondrially encoded ND1 subunit of complex I (NADH:ubiquinone oxidoreductase) in rat brain
    • Pettus, E. H., R. Betarbet, B. Cottrell, D. C. Wallace, V. Madyastha, and J. T. Greenamyre. 2000. Immunocytochemical characterization of the mitochondrially encoded ND1 subunit of complex I (NADH:ubiquinone oxidoreductase) in rat brain. J. Neurochem. 75: 383-392.
    • (2000) J. Neurochem. , vol.75 , pp. 383-392
    • Pettus, E.H.1    Betarbet, R.2    Cottrell, B.3    Wallace, D.C.4    Madyastha, V.5    Greenamyre, J.T.6
  • 47
    • 0034884622 scopus 로고    scopus 로고
    • Proteasomal inhibition leads to formation of ubiquitin/alpha-synuclein-immunoreactive inclusions in PC12 cells
    • Rideout, H. J., K. E. Larsen, D. Sulzer, and L. Stefanis. 2001. Proteasomal inhibition leads to formation of ubiquitin/alpha-synuclein-immunoreactive inclusions in PC12 cells. J. Neurochem. 78: 899-908.
    • (2001) J. Neurochem. , vol.78 , pp. 899-908
    • Rideout, H.J.1    Larsen, K.E.2    Sulzer, D.3    Stefanis, L.4
  • 49
    • 0028978106 scopus 로고
    • Coenzyme Q10 and nicotinamide and a free radical spin trap protect against MPTP neurotoxicity
    • Schulz, J. B., D. R. Henshaw, R. T. Matthews, and M. F. Beal. 1995. Coenzyme Q10 and nicotinamide and a free radical spin trap protect against MPTP neurotoxicity. Exp. Neurol. 132: 279-283.
    • (1995) Exp. Neurol. , vol.132 , pp. 279-283
    • Schulz, J.B.1    Henshaw, D.R.2    Matthews, R.T.3    Beal, M.F.4
  • 50
    • 0031589740 scopus 로고    scopus 로고
    • Free radical scavengers protect dopaminergic cell lines from apoptosis induced by complex I inhibitors
    • Seaton, T. A., J. M. Cooper, and A. H. Schapira. 1997. Free radical scavengers protect dopaminergic cell lines from apoptosis induced by complex I inhibitors. Brain Res. 777: 110-118.
    • (1997) Brain Res. , vol.777 , pp. 110-118
    • Seaton, T.A.1    Cooper, J.M.2    Schapira, A.H.3
  • 51
    • 0011741508 scopus 로고    scopus 로고
    • The rotenone model of Parkinson's disease in vivo: Selective striatal oxidative damage and caspase-3 activation in nigrostriatal neurons
    • Sherer, T. B., R. Betarbet, and J. T. Greenamyre. 2002. The rotenone model of Parkinson's disease in vivo: Selective striatal oxidative damage and caspase-3 activation in nigrostriatal neurons. Soc. Neurosci. Abstr. 653.2.
    • (2002) Soc. Neurosci. Abstr. , vol.653 , pp. 2
    • Sherer, T.B.1    Betarbet, R.2    Greenamyre, J.T.3
  • 52
    • 0037104723 scopus 로고    scopus 로고
    • An in vitro model of Parkinson's disease: Linking mitochondrial impairment to altered alpha-synuclein metabolism and oxidative damage
    • Sherer, T. B., R. Betarbet, A. K. Stout, S. Lund, M. Baptista, A. V. Panov, M. R. Cookson, and J. T. Greenamyre. 2002. An in vitro model of Parkinson's disease: Linking mitochondrial impairment to altered alpha-synuclein metabolism and oxidative damage. J. Neurosci. 22: 7016-7026.
    • (2002) J. Neurosci. , vol.22 , pp. 7016-7026
    • Sherer, T.B.1    Betarbet, R.2    Stout, A.K.3    Lund, S.4    Baptista, M.5    Panov, A.V.6    Cookson, M.R.7    Greenamyre, J.T.8
  • 53
    • 0035830688 scopus 로고    scopus 로고
    • Chronic reduction in complex I function alters calcium signaling in SH-SY5Y neuroblastoma cells
    • Sherer, T. B., P. A. Trimmer, K. Borland, J. K. Parks, J. P. Bennett, Jr., and J. B. Tuttle. 2001. Chronic reduction in complex I function alters calcium signaling in SH-SY5Y neuroblastoma cells. Brain Res. 891: 94-105.
    • (2001) Brain Res. , vol.891 , pp. 94-105
    • Sherer, T.B.1    Trimmer, P.A.2    Borland, K.3    Parks, J.K.4    Bennett J.P., Jr.5    Tuttle, J.B.6
  • 54
    • 0034674652 scopus 로고    scopus 로고
    • Dityrosine cross-linking promotes formation of stable alpha-synuclein polymers: Implication of nitrative and oxidative stress in the pathogenesis of neurodegenerative synucleinopathies
    • Souza, J. M., B. I. Giasson, Q. Chen, V. M. Lee, and H. Ischiropoulos. 2000. Dityrosine cross-linking promotes formation of stable alpha-synuclein polymers: Implication of nitrative and oxidative stress in the pathogenesis of neurodegenerative synucleinopathies. J. Biol. Chem. 275: 18344-18349.
    • (2000) J. Biol. Chem. , vol.275 , pp. 18344-18349
    • Souza, J.M.1    Giasson, B.I.2    Chen, Q.3    Lee, V.M.4    Ischiropoulos, H.5
  • 56
    • 0036318336 scopus 로고    scopus 로고
    • The differential vulnerability of striatal projection neurons in 3-nitropropionic acid-treated rats does not match that typical of adult-onset Huntington's disease
    • Sun, Z., J. Xie, and A. Reiner. 2002. The differential vulnerability of striatal projection neurons in 3-nitropropionic acid-treated rats does not match that typical of adult-onset Huntington's disease. Exp. Neurol. 176: 55-65.
    • (2002) Exp. Neurol. , vol.176 , pp. 55-65
    • Sun, Z.1    Xie, J.2    Reiner, A.3
  • 58
    • 0034624274 scopus 로고    scopus 로고
    • Increased striatal dopamine turnover following acute administration of rotenone to mice
    • Thiffault, C., J. W. Langston, and D. A. Di Monte. 2000. Increased striatal dopamine turnover following acute administration of rotenone to mice. Brain Res. 885: 283-288.
    • (2000) Brain Res. , vol.885 , pp. 283-288
    • Thiffault, C.1    Langston, J.W.2    Di Monte, D.A.3
  • 59
    • 0035976835 scopus 로고    scopus 로고
    • Alpha-synuclein metabolism and aggregation is linked to ubiquitin-independent degradation by the proteasome
    • Tofaris, G. K., R. Layfield, and M. G. Spillantini, 2001. Alpha-synuclein metabolism and aggregation is linked to ubiquitin-independent degradation by the proteasome. FEBS Lett. 509: 22-26.
    • (2001) FEBS Lett. , vol.509 , pp. 22-26
    • Tofaris, G.K.1    Layfield, R.2    Spillantini, M.G.3
  • 60
    • 0019083215 scopus 로고
    • Generation of superoxide anion by the NADH dehydrogenase of bovine heart mitochondria
    • Turrens, J. F., and A. Boveris, 1980. Generation of superoxide anion by the NADH dehydrogenase of bovine heart mitochondria. Biochem. J. 191: 421-427.
    • (1980) Biochem. J. , vol.191 , pp. 421-427
    • Turrens, J.F.1    Boveris, A.2
  • 61
    • 0035816404 scopus 로고    scopus 로고
    • Pesticides directly accelerate the rate of alpha-synuclein fibril formation: A possible factor in Parkinson's disease
    • Uversky, V. N., J., Li, and A. L., Fink, 2001. Pesticides directly accelerate the rate of alpha-synuclein fibril formation: A possible factor in Parkinson's disease. FEBS Lett. 500: 105-108.
    • (2001) FEBS Lett. , vol.500 , pp. 105-108
    • Uversky, V.N.1    Li, J.2    Fink, A.L.3
  • 62
    • 0033966487 scopus 로고    scopus 로고
    • Alpha-synuclein up-regulation in substantia nigra dopaminergic neurons following administration of the parkinsonian toxin MPTP
    • Vila, M., S., Vukosavic, V., Jackson-Lewis, M., Neystat, M., Jakowec, and S. Przedborski, 2000. Alpha-synuclein up-regulation in substantia nigra dopaminergic neurons following administration of the parkinsonian toxin MPTP. J. Neurochem. 74: 721-729.
    • (2000) J. Neurochem. , vol.74 , pp. 721-729
    • Vila, M.1    Vukosavic, S.2    Jackson-Lewis, V.3    Neystat, M.4    Jakowec, M.5    Przedborski, S.6
  • 63
    • 0034740585 scopus 로고    scopus 로고
    • Δψm-Dependent and -independent production of reactive oxygen species by rat brain mitochondria
    • Votyakova, T. V., and I. J., Reynolds, 2001. Δψm-Dependent and -independent production of reactive oxygen species by rat brain mitochondria. J. Neurochem. 79: 266-277.
    • (2001) J. Neurochem. , vol.79 , pp. 266-277
    • Votyakova, T.V.1    Reynolds, I.J.2
  • 64
    • 0000737136 scopus 로고    scopus 로고
    • Neurochemistry and neuropharmacology of Parkinson's disease
    • R. L. Watts and Koller, Eds. McGraw-Hill, New York
    • Wooten, G. F. 1997. Neurochemistry and neuropharmacology of Parkinson's disease. In Movement Disorders: Neurologic Principles and Practice (R. L. Watts and Koller, Eds.), pp. 153-160. McGraw-Hill, New York.
    • (1997) Movement Disorders: Neurologic Principles and Practice , pp. 153-160
    • Wooten, G.F.1


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