Expression of mutant α-synuclein causes increased susceptibility to dopamine toxicity

Human Molecular Genetics

Volumn 9, Issue 18, 2000, Pages 2683-2689

  Tabrizi, Sarah J ^a   Orth, Michael ^a   Max Wilkinson, J ^b   Taanman, Jan Willem ^a   Warner, Thomas T ^a   Mark Cooper, J ^a   Schapira, Anthony H V ^a,c  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

^c UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA SYNUCLEIN; DOPAMINE; MUTANT PROTEIN;

ARTICLE; CELL DEATH; CONTROLLED STUDY; CYTOPLASM; DISEASE PREDISPOSITION; DOPAMINERGIC NERVE CELL; GENE MUTATION; HUMAN; HUMAN CELL; MALE; MODEL; MONOAMINE NERVE CELL; NERVE DEGENERATION; PARKINSON DISEASE; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION;

ALPHA-SYNUCLEIN; BLOTTING, WESTERN; CELL DEATH; CELL LINE; CELL SIZE; DOPAMINE; DRUG TOXICITY; ECDYSTERONE; GENE EXPRESSION; GENETIC PREDISPOSITION TO DISEASE; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MUTATION; NERVE TISSUE PROTEINS; NEURONS; PARKINSON DISEASE; PARKINSON DISEASE, SECONDARY; SYNUCLEINS; TRANSFECTION;

EID: 0034326816     PISSN: 09646906     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (35)

1. Mutation in the α-synuclein gene identified in families with Parkinson's disease
2. Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease
3. Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism
4. The ubiquitin pathway in Parkinson's disease
5. The role of inheritance in sporadic Parkinson's disease: Evidence from a longitudinal study of dopaminergic function in twins
6. Parkinson's disease in twins: An etiologic study
7. Genetics of Parkinson's disease
8. Reduced expression of the G209A α-synuclein allele in familial parkinsonism
9. Sequencing of the α-synuclein gene in a large series of cases of familial Parkinson's disease fails to reveal any further mutations
10. The role of alpha-synuclein gene mutation in patients with sporadic Parkinson's disease in the UK
11. Low frequency of α-synuclein mutations in familial Parkinson's disease
12. Alpha-synuclein in Lewy bodies
13. Dopaminergic loss and inclusion body formation in α-synuclein mice: Implications for neuro-degenerative disorders
14. Potential oxidative pathways of brain catecholamines
15. Oxidative pathways for catecholamines in the genesis of neuromelanin and cytotoxic quinones
16. Quantitation of fluorescence of biogenic monoamines
17. Binding of alpha-synuclein to brain vesicles is abolished by familial Parkinson's disease mutation
18. Synucleins are developmentally expressed, and alpha-synuclein regulates the size of the presynaptic vesicular pool in primary hippocampal neurons
19. α-synuclein shares physical and functional homology with 14-3-3-proteins
20. Case-control study of early life dietary factors in Parkinson's disease
21. A Drosophilia model of Parkinson's disease
22. Overexpression of human alpha-synuclein causes dopamine neuron death in rat primary culture and immortalized mesencephalon-derived cells
23. α-synuclein and Parkinson's disease: Selective neurodegenerative effect of α-synuclein fragment on dopaminergic neurons in vitro and in vivo
24. Characterization of the precursor protein of the non A beta component of senile plaques (NACP) in the human central nervous system
25. Increased expression of rat synuclein in the substantia nigra pars compacta identified by mRNA differential display in a model of developmental target injury
26. Mice lacking α-synuclein display functional deficits in the nigrostriatal dopamine system
27. Dopamine and L-dopa induced cytotoxicity towards catecholaminergic neuroblastoma
28. Dopamine induces apoptosis-like cell death in cultured sympathetic neurons-A possible novel pathogenetic mechanism in Parkinson's disease
29. Comparison of neurotoxicity following repeated administration of L-dopa, D-dopa and dopamine to embryogenic mesencephalic dopamine neurons in cultures derived from Fischer 344 and Sprague-Dawley donors
30. Peroxynitrite and nitrite induced oxidation of dopamine: Implications for nitric oxide in dopaminergic cell loss
31. Role of oxidation in the neurotoxic effects of intrastriatal dopamine injections
32. Oxidative stress induces amyloid-like aggregate formation of NACP-α-synuclein in vitro
33. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
34. Electrophoretic transfer of protein form polyacrylamide gels to nitrocellulose sheets: Procedure and some applications
35. The metabolism of rat brain mitochondria; preparation and characterisation