Neuronal α-synucleinopathy with severe movement disorder in mice expressing A53T human α-synuclein

Neuron

Volumn 34, Issue 4, 2002, Pages 521-533

  Giasson, Benoit I ^a   Duda, John E ^a,b   Quinn, Shawn M ^a   Zhang, Bin ^a   Trojanowski, John Q ^a   Lee, Virginia M Y ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA SYNUCLEIN; MUTANT PROTEIN;

AGE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL INCLUSION; CENTRAL NERVOUS SYSTEM; CLINICAL FEATURE; CONTROLLED STUDY; DEATH; FIBER; GENE MUTATION; HUMAN; IMMUNOELECTRON MICROSCOPY; MOTOR DYSFUNCTION; MOUSE; NERVE CELL; NERVE DEGENERATION; NONHUMAN; ONSET AGE; PARALYSIS; PRIORITY JOURNAL; PROTEIN DEFECT; PROTEIN EXPRESSION; PROTEIN FUNCTION; TRANSGENIC MOUSE;

EID: 0037118259     PISSN: 08966273     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0896-6273(02)00682-7     Document Type: Article

References (50)

1. Mice lacking alpha-synuclein display functional deficits in the nigrostriatal dopamine system
2. Aggregation of α-synuclein in Lewy bodies of sporadic parkinson's disease and dementia with lewy bodies
3. Chronic systemic pesticide exposure reproduces features of Parkinson's disease
4. A vector for expressing foreign genes in the brains and hearts of transgenic mice
5. Progressive neuronopathy in transgenic mice expressing the human neurofilament heavy gene: A mouse model of amyotrophic lateral sclerosis
6. Prevalence of parkinsonism and Parkinson's disease in Europe: The EUROPARKINSON collaborative study
7. Widespread alterations of α-synuclein in multiple system atrophy
8. Immunohistochemical and biochemical studies demonstrate a distinct profile of α-synuclein permutations in multiple system atrophy
9. Novel antibodies to oxidized α-synuclein reveal abundant neuritic pathology in Lewy body diseases
10. Concurrence of α-synuclein and tau pathology in a Contursi kindred brain
11. A Drosophila model of Parkinson's disease
12. Neuropathology of Parkinson's disease
13. Neurodegeneration with brain iron accumulation, type 1 is characterized by α-, β- and γ-synuclein neuropathology
14. Characterization of a novel protein regulated during the critical period for song learning in the zebra finch
15. Mutant and wild type human α-synucleins assemble into elongated filaments with distinct morphologies in vitro
16. Oxidative damage linked to neurodegeneration by selective α-synuclein nitration in synucleinopathy lesions
17. A panel of epitope-specific antibodies detects protein domains distributed throughout human α-synuclein in Lewy bodies of Parkinson's disease
18. Prominent perikaryal expression of α- and β-synuclein in neurons of dorsal root ganglion and in medullary neurons
19. α-synuclein and Parkinson's disease
20. Clinical genetic analysis of Parkinson's disease in the Contursi kindred
21. Expression patterns of synuclein (non-β component of Alzheimer's disease amyloid precursor protein/α-synuclein) during murine brain development
22. α-synuclein cortical Lewy bodies correlate with dementia in Parkinson's disease
23. Age-dependent emergence and progression of a tauopathy in transgenic mice overexpressing the shortest human tau isoform
24. Identification of two distinct synucleins from human brain
25. Neurofilaments in health and disease
26. Subcellular localization of wild-type and Parkinson's disease-associated mutant α-synuclein in human and transgenic mouse brain
27. Neuronal intermediate filaments
28. A mutant neurofilament subunit causes massive, selective motor neuron death: Implications for the pathogenesis of human motor neuron disease
29. Comparison of modified Bielschowsky silver impregnation and anti- ubiquitin immunostaining of cortical and nigral Lewy bodies
30. Dopaminergic loss and inclusion body formation in α-synuclein mice: Implications for neurodegenerative disorders
31. β-amyloid peptides enhance α-synuclein accumulation and neuronal deficits in a transgenic mouse model linking Alzheimer's disease and Parkinson's disease
32. Lack of nigral pathology in transgenic mice expressing human α-synuclein driven by the tyrosine hydroxylase promoter
33. α-synuclein-immunoreactive cortical Lewy bodies are associated with cognitive impairment in Parkinson's disease
34. Consensus guidelines for the clinical and pathologic diagnosis of dementia with Lewy bodies (DLB): Report of the consortium on DLB international workshop
35. Synucleins are developmentally expressed, and α-synuclein regulates the size of the presynaptic vesicular pool in primary hippocampal neurons
36. Induction of α-synuclein aggregation by intracellular nitrative insult
37. Mutation in the α-synuclein gene identified in families with Parkinson's disease
38. Standardization of various applications of methacrylate embedding and silver methenamine for light and electron microscopy immunocytochemistry
39. Immunization with amyloid-β attenuates Alzheimer-disease-like pathology in the PDAPP mouse
40. Epitope map of neurofilament protein domains in cortical and peripheral nervous system Lewy bodies
41. Accumulation of NACP/α-synuclein in Lewy body disease and multiple system atrophy
42. Parkinson's disease: The clinical picture
43. α-synuclein in Lewy bodies
44. α-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with Lewy bodies
45. Clinical and pathological features of a Parkinsonian syndrome in a family with an Ala53Thr α-synuclein mutation
46. Distribution of tau protein in the normal human central and peripheral nervous system
47. Glial cytoplasmic inclusions in white matter oligodendrocytes of multiple system atrophy brains contain insoluble α-synuclein
48. Neuropathology in mice expressing human α-synuclein
49. α-synuclein fibrillogenesis is nucleation-dependent. Implications for the pathogenesis of Parkinson's disease
50. Reversal of neuropathology and motor dysfunction in a conditional model of Huntington's disease