Residual Structure and Dynamics in Parkinson's Disease-associated Mutants of α-Synuclein

Journal of Biological Chemistry

Volumn 276, Issue 49, 2001, Pages 45996-46003

  Bussell Jr , Robert ^a   Eliezer, David ^a  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GENES; MORPHOLOGY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROTEINS;

FIBRILLIZATION;

DISEASES;

A30P PROTEIN; A53T PROTEIN; ALPHA SYNUCLEIN; MUTANT PROTEIN; UNCLASSIFIED DRUG; WT PROTEIN; NERVE PROTEIN; SYNUCLEIN;

ALPHA SYNUCLEIN GENE; ARTICLE; AUTOSOMAL DOMINANT DISORDER; DYNAMICS; FIBER; GENE; LEWY BODY; MISSENSE MUTATION; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PARKINSON DISEASE; PATHOGENESIS; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN CONFORMATION; PROTEIN SECONDARY STRUCTURE; PROTEIN STRUCTURE; CHEMISTRY; GENETICS; HUMAN; METABOLISM; NUCLEAR MAGNETIC RESONANCE;

HUMAN; MUTATION, MISSENSE; NERVE TISSUE PROTEINS; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PARKINSON DISEASE; PROTEIN STRUCTURE, SECONDARY; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0035824545     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M106777200     Document Type: Article

References (55)

1. Maroteaux, L., Campanelli, J. T., and Scheller, R. H. (1988) J. Neurosci. 8, 2804-2815
2. Polymeropoulos, M. H., Higgins, J. J., Golbe, L. I., Johnson, W. G., Ide, S. E., Di Iorio, G., Sanges, G., Stenroos, E. S., Pho, L. T., Schaffer, A. A., Lazzarini, A. M., Nussbaum, R. L., and Duvoisin, R. C. (1996) Science 274, 1197-1199
3. Clayton, D. F., and George, J. M. (1998) Trends Neurosci. 21, 241-254
4. Kruger, R., Muller, T., and Riess, O. (2000) J. Neural Transm. 107, 31-40
5. Polymeropoulos, M. H., Lavedan, C., Leroy, E., Ide, S. E., Dehejia, A., Dutra, A., Pike, B., Root, H., Rubenstein, J., Boyer, R., Stenroos, E. S., Chandrasekharappa, S., Athanassiadou, A., Papapetropoulos, T., Johnson, W. G., Lazzarini, A. M., Duvoisin, R. C., Di Iorio, G., Golbe, L. I., and Nussbaum, R. L. (1997) Science 276, 2045-2047
6. Kruger, R., Kuhn, W., Muller, T., Woitalla, D., Graeber, M., Kosel, S., Przuntek, H., Epplen, J. T., Schols, L., and Riess, O. (1998) Nat. Genet. 18, 106-108
7. Arima, K., Mizutani, T., Alim, M. A., Tonozuka-Uehara, H., Izumiyama, Y., Hirai, S., and Ueda, K. (2000) Acta Neuropathol. 100, 115-121.
8. Spillantini, M. G., Schmidt, M. L., Lee, V. M., Trojanowski, J. Q., Jakes, R., and Goedert, M. (1997) Nature 388, 839-840
9. Spillantini, M. G., Crowther, R. A., Jakes, R., Hasegawa, M., and Goedert, M. (1998) Proc. Natl. Acad. Sci. U. S. A. 95, 6469-6473
10. Baba, M., Nakajo, S., Tu, P. H., Tomita, T., Nakaya, K., Lee, V. M., Trojanowski, J. Q., and Iwatsubo, T. (1998) Am. J. Pathol. 152, 879-884
11. Masliah, E., Rockenstein, E., Veinbergs, I., Mallory, M., Hashimoto, M., Takeda, A., Sagara, Y., Sisk, A., and Mucke, L. (2000) Science 287, 1265-1269
12. Feany, M. B., and Bender, W. W. (2000) Nature 404, 394-398
13. Abeliovich, A., Schmitz, Y., Farinas, I., Choi-Lundberg, D., Ho, W. H., Castillo, P. E., Shinsky, N., Verdugo, J. M., Armanini, M., Ryan, A., Hynes, M., Phillips, H., Sulzer, D., and Rosenthal, A. (2000) Neuron 25, 239-252
14. Yoshimoto, M., Iwai, A., Kang, D., Otero, D. A., Xia, Y., and Saitoh, T. (1995) Proc. Natl. Acad. Sci. U. S. A. 92, 9141-9145
15. Jensen, P. H., Hojrup, P., Hager, H., Nielsen, M. S., Jacobsen, L., Olesen, O. F., Gliemann, J., and Jakes, R. (1997) Biochem. J. 323, 539-546
16. Goedert, M. (2001) Clin. Chem. Lab. Med. 39, 308-312
17. Conway, K. A., Harper, J. D., and Lansbury, P. T. (1998) Nat. Med. 4, 1318-1320
18. El-Agnaf, O. M., Jakes, R., Curran, M. D., and Wallace, A. (1998) FEBS Lett. 440, 67-70
19. Giasson, B. I., Uryu, K., Trojanowski, J. Q., and Lee, V. M. (1999) J. Biol. Chem. 274, 7619-7622
20. Serpell, L. C., Berriman, J., Jakes, R., Goedert, M., and Crowther, R. A. (2000) Proc. Natl. Acad. Sci. U. S. A. 97, 4897-4902
21. Conway, K. A., Harper, J. D., and Lansbury, P. T., Jr. (2000) Biochemistry 39, 2552-2563
22. Narhi, L., Wood, S. J., Steavenson, S., Jiang, Y., Wu, G. M., Anafi, D., Kaufman, S. A., Martin, F., Sitney, K., Denis, P., Louis, J. C., Wypych, J., Biere, A. L., and Citron, M. (1999) J. Biol. Chem. 274, 9843-9846
23. Conway, K. A., Lee, S. J., Rochet, J. C., Ding, T. T., Williamson, R. E., and Lansbury, P. T., Jr. (2000) Proc. Natl. Acad. Sci. U. S. A. 97, 571-576
24. Lansbury, P. T., Jr. (1999) Proc. Natl. Acad. Sci. U. S. A. 96, 3342-3344
25. Uversky, V. N., Li, J., and Fink, A. L. (2001) J. Biol. Chem. 276, 10737-10744
26. Weinreb, P. H., Zhen, W., Poon, A. W., Conway, K. A., and Lansbury, P. T., Jr. (1996) Biochemistry 35, 13709-13715
27. Yao, J., Chung, J., Eliezer, D., Wright, P. E., and Dyson, H. J. (2001) Biochemistry 40, 3561-3571
28. Eliezer, D., Kutluay, E., Bussell, R., Jr., and Browne, G. (2001) J. Mol. Biol. 307, 1061-1073
29. Ueda, K., Fukushima, H., Masliah, E., Xia, Y., Iwai, A., Yoshimoto, M., Otero, D. A., Kondo, J., Ihara, Y., and Saitoh, T. (1993) Proc. Natl. Acad. Sci. U. S. A. 90, 11282-11286
30. Han, H., Weinreb, P. H., and Lansbury, P. T., Jr. (1995) Chem. Biol. 2, 163-169
31. Iwai, A., Yoshimoto, M., Masliah, E., and Saitoh, T. (1995) Biochemistry 34, 10139-10145
32. Delaglio, F., Grzesiek, S., Vuister, G. W., Zhu, G., Pfeifer, J., and Bax, A. (1995) J. Biomol. NMR 6, 277-293
33. Johnson, B. A., and Blevins, R. A. (1994) J. Biomol. NMR 4, 603-614
34. Wishart, D. S., Bigam, C. G., Holm, A., Hodges, R. S., and Sykes, B. D. (1995) J. Biomol. NMR 5, 67-81
35. Wishart, D. S., and Sykes, B. D. (1994) Methods Enzymol. 239, 363-392
36. Farrow, N. A., Muhandiram, R., Singer, A. U., Pascal, S. M., Kay, C. M., Gish, G., Shoelson, S. E., Pawson, T., Forman-Kay, J. D., and Kay, L. E. (1994) Biochemistry 33, 5984-6003
37. Peng, J. W., and Wagner, G. (1992) Biochemistry 31, 8571-8586
38. Farrow, N. A., Zhang, O., Szabo, A., Torchia, D. A., and Kay, L. E. (1995) J. Biomol. NMR 6, 153-162
39. Lefevre, J. F., Dayie, K. T., Peng, J. W., and Wagner, G. (1996) Biochemistry 35, 2674-2686
40. Lipari, G., and Szabo, A. (1982) J. Am. Chem. Soc. 104, 4546-4559
41. Lipari, G., and Szabo, A. (1982) J. Am. Chem. Soc. 104, 4559-4570
42. Tjandra, N., Szabo, A., and Bax, A. (1996) J. Am. Chem. Soc. 118, 6986-6991
43. Davidson, W. S., Jonas, A., Clayton, D. F., and George, J. M. (1998) J. Biol. Chem. 273, 9443-9449
44. Perrin, R. J., Woods, W. S., Clayton, D. F., and George, J. M. (2000) J. Biol. Chem. 275, 34393-34398
45. Cavanagh, J., Fairbrother, W. J., Palmer, A. G., III, and Skelton, N. J. (1996) Protein NMR Spectroscopy: Principles and Practice, pp. 243-300, Academic Press, San Diego
46. Eliezer, D., Chung, J., Dyson, H. J., and Wright, P. E. (2000) Biochemistry 39, 2894-2901
47. Eliezer, D., Yao, J., Dyson, H. J., and Wright, P. E. (1998) Nat. Struct. Biol. 5, 148-155
48. Chou, P. Y., and Fasman, G. D. (1978) Annu. Rev. Biochem. 47, 251-276
49. Giasson, B. I., Murray, I. V., Trojanowski, J. Q., and Lee, V. M. (2001) J. Biol. Chem. 276, 2380-2386
50. Jensen, P. H., Nielsen, M. S., Jakes, R., Dotti, C. G., and Goedert, M. (1998) J. Biol. Chem. 273, 26292-26294
51. McLean, P. J., Kawamata, H., Ribich, S., and Hyman, B. T. (2000) J. Biol. Chem. 275, 8812-8816
52. Okochi, M., Walter, J., Koyama, A., Nakajo, S., Baba, M., Iwatsubo, T., Meijer, L., Kahle, P. J., and Haass, C. (2000) J. Biol. Chem. 275, 390-397
53. Ostrerova, N., Petrucelli, L., Farrer, M., Mehta, N., Choi, P., Hardy, J., and Wolozin, B. (1999) J. Neurosci. 19, 5782-5791
54. Pronin, A. N., Morris, A. J., Surguchov, A., and Benovic, J. L. (2000) J. Biol. Chem. 275, 26515-26522
55. Jenco, J. M., Rawlingson, A., Daniels, B., and Morris, A. J. (1998) Biochemistry 37, 4901-4909