Acceleration of oligomerization, not fibrillization, is a shared property of both α-synuclein mutations linked to early-onset Parkinson's disease: Implications for pathogenesis and therapy

Proceedings of the National Academy of Sciences of the United States of America

Volumn 97, Issue 2, 2000, Pages 571-576

  Conway, Kelly A ^a   Lee, Seung Jae ^a   Rochet, Jean Christophe ^a   Ding, Tomas T ^a   Williamson, Robin E ^a   Lansbury Jr , Peter T ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Aggregation; Amyloid; Atomic force microscopy (AFM); Protofibril

Indexed keywords

ALPHA SYNUCLEIN;

ARTICLE; ATOMIC FORCE MICROSCOPY; FIELD FLOW FRACTIONATION; GEL FILTRATION CHROMATOGRAPHY; HUMAN; OLIGOMERIZATION; PARKINSON DISEASE; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN ANALYSIS;

AGE OF ONSET; ALPHA-SYNUCLEIN; AMINO ACID SUBSTITUTION; AMYLOID; CHROMATOGRAPHY, GEL; CIRCULAR DICHROISM; FLUORESCENCE; HUMANS; MICROSCOPY, ATOMIC FORCE; MUTATION; NERVE TISSUE PROTEINS; PARKINSON DISEASE; PROTEIN CONFORMATION; SYNUCLEINS; THIAZOLES; ULTRACENTRIFUGATION;

EID: 0034681163     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.97.2.571     Document Type: Article

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