MPP+ increases α-synuclein expression and ERK/MAP-kinase phosphorylation in human neuroblastoma SH-SY5Y cells

Brain Research

Volumn 935, Issue 1-2, 2002, Pages 32-39

  Gómez Santos, Cristina ^a   Ferrer, Isidre ^b   Reiriz, Julia ^b   Vials, Francesc ^a   Barrachina, Marta ^b   Ambrosio, Santiago ^a  

^a L'Hospitalet del Llobregat E 08907   (Spain)

^b UNIVERSITY OF BARCELONA   (Spain)

Author keywords

Synuclein Map kinase; MPP+; Parkinson's disease; SH SY5Y

Indexed keywords

1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; 1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; ALPHA SYNUCLEIN; DRUG METABOLITE; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE; STRESS ACTIVATED PROTEIN KINASE;

APOPTOSIS; ARTICLE; CELL ADHESION; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INHIBITION; HUMAN; HUMAN CELL; METABOLITE; NERVE CELL LESION; NEUROBLASTOMA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

1-METHYL-4-PHENYLPYRIDINIUM; ALPHA-SYNUCLEIN; BRAIN; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; GENE EXPRESSION; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MAP KINASE KINASE KINASES; MITOGEN-ACTIVATED PROTEIN KINASES; NERVE TISSUE PROTEINS; NEUROBLASTOMA; NEURONS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PARKINSON DISEASE; PHOSPHORYLATION; STAUROSPORINE; SYNUCLEINS; TUMOR CELLS, CULTURED; UP-REGULATION;

EID: 0037052633     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(02)02422-8     Document Type: Article

References (56)

1. Wild-type but not Parkinson's disease-related Ala-53-Thr mutant α-synuclein protects neuronal cells from apoptotic stimuli
2. + toxicity in rat striatal slices: Relationship between non-selective effects and free radical production
3. Chronic systemic pesticide exposure reproduces features of Parkinson's disease
4. Hydrogen peroxide activation of multiple mitogen-activated protein kinases in an oligodendrocyte cell line: Role of extracellular signal-regulated kinase in hydrogen peroxide-induced cell death
5. +-induced mitochondrial dysfunction is potentiated by dopamine
6. Interaction among mitochondria, mitogen-activated protein kinases, and nuclear factor-kB in cellular models of Parkinson's disease
7. +-induced dopaminergic neuronal cell death: Role of caspases, ROS, and JNK
8. Synucleins in synaptic plasticity and neurodegenerative disorders
9. Accelerated in vitro fibril formation by a mutant α-synuclein linked to early-onset Parkinson disease
10. Characterisation of isolated α-synuclein filaments from substantia nigra of Parkinson's disease brain
11. + in rat striatal slices
12. Survival function of ERK1/2 as IL-3-activated, staurosporine-resistant Bcl-2 kinases
13. Aggregates from mutant and wild-type α-synuclein proteins and NAC peptide induce apoptotic cell death in human neuroblastoma cells by formation of beta-sheet and amyloid-like filaments
14. Phosphorylated MAP kinase (ERK1, ERK2) expression is associated with early tau deposition in neurones and glial cells, but not with increased nuclear DNA vulnerability and cell death, in Alzheimer disease. Pick's disease, progressive supranuclear palsy and corticobasal degeneration
15. α-Synuclein and Parkinson's disease: Selective neurodegenerative effect of α-synuclein fragment on dopaminergic neurons in vitro and in vivo
16. Rat α-synuclein interacts with Tat binding protein 1, a component of the 26S proteasomal complex
17. Mutant and wild type human α-synucleins assemble into elongated filaments with distinct morphologies in vitro
18. Oxidative damage linked to neurodegeneration by selective α-synuclein nitration in synucleinopathy lesions
19. Low concentrations of 1-methyl-4-phenylpyridinium ion induce caspase-mediated apoptosis in human SH-SY5Y neuroblastoma cells
20. Role of cytochrome c as a stimulator of α-synuclein aggregation in Lewy body disease
21. α-Synuclein forms a complex with transcriptional factor Elk-1
22. Regulation of phospholipase D2: Selective inhibition of mammalian phospholipase D isoenzymes by α- and β-synucleins
23. Binding of α-synuclein to brain vesicles is abolished by familiar Parkinson's disease mutation
24. α-Synuclein binds to tau and stimulates the protein kinase A-catalyzed tau phosphorylation of serine residues 262 and 356
25. Release and aggregation of cytochrome c and α-synuclein are inhibited by the antiparkinsonian drugs, talipexole and pramipexole
26. Enhanced vulnerability to oxidative stress by α-synuclein mutations and C-terminal truncation
27. Synuclein expression is decreased in rat substantia nigra following induction of apoptosis by intrastriatal 6-hydroxydopamine
28. Sensitization of neuronal cells to oxidative stress with mutated human α-synuclein
29. MPTP induces α-synuclein aggregation in the substantia nigra of baboons
30. Ala30Pro mutation in the gene encoding α-synuclein in parkinson's disease
31. Novel α-synuclein-immunoreactive proteins in brain samples from the Contursi kindred Parkinson's, and Alzheimer disease
32. The p42/p44 MAP kinase pathway prevents apoptosis induced by anchorage and serum removal
33. Direct binding and functional coupling of α-synuclein to the dopamine transporters accelerate dopamine-induced apoptosis
34. Effect of the overexpression of wild-type or mutant α-synuclein on cell susceptibility to insult
35. Staurosporine- and H-7-induced cell death in SH-SY5Y neuroblastoma cells is associated with caspase-2 and caspase-3 activation, but not with activation of the FAS/FAS-L-caspase-8 signaling pathway
36. Alpha-synuclein and Parkinson's disease
37. Dopamine induces apoptosis through an oxidation-involved SAPK/JNK activation pathway
38. Alpha synuclein in neurodegenerative disorders: Murderer or accomplice?
39. JNK and p38 stress kinases - Degenerative effectors of signal-transduction-cascades in the nervous system
40. 2 in PC12 cells
41. Mitogen-activated protein kinase pathways mediates peroxynitrite-induced apoptosis in human dopaminergic neuroblastoma SH-SY5Y cells
42. Constitutive phosphorylation of the Parkinson's disease associated α-synuclein
43. α-Synuclein shares physical and functional homology with 14-3-3 proteins
44. Mutation in the α-synuclein gene identified in families with Parkinson's disease
45. Role of neuronal nitric oxide in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced dopaminergic neurotoxicity
46. Induction of neuronal death by α-synuclein
47. CEO-1347/KT-7515, an inhibitor of c-jun N-terminal kinase activation, attenuates the 1-methyl-4-phenyltetrahydropyridine-mediated loss of nigrostriatal dopaminergic neurons in vivo
48. MPTP activates c-Jun NH2-terminal kinase (JNK) and its upstream regulatory kinase MKK4 in nigrostriatal neurons in vivo
49. The stress-activated protein kinase pathways
50. Anisomycin affects both pro- and antiapoptotic mechanisms in PC12 cells
51. Molecular cloning of cDNA encoding an unrecognized component of amyloid in Alzheimer disease
52. Protein kinase C activation by acidic proteins including 14-3-3
53. α-Synuclein up-regulation in substantia nigra dopaminergic neurons following administration of the parkinsonian toxin MPTP
54. Confluence of vascular endothelial cells induces cell cycle exit by inhibiting p42/p44 mitogen activated protein kinase activity
55. Alpha-synuclein immunoreactivity in glial cytoplasmic inclusions in multiple system atrophy
56. Kinase suppressor of Ras is ceramide-activated protein kinase