Alpha synuclein is present in Lewy bodies in sporadic Parkinson's disease

Molecular Psychiatry

Volumn 3, Issue 6, 1998, Pages 493-499

  Mezey, E ^a   Dehejia, A M ^b   Harta, G ^b   Suchy, S F ^b   Nussbaum, R L ^a   Brownstein, M J ^b   Polymeropoulos, M H ^a,b  

^a NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

^b NATIONAL HUMAN GENOME RESEARCH INSTITUTE   (United States)

Author keywords

Alpha synuclein; Alzheimer's disease; Diffuse Lewy body disease (DLBD); Lewy body; Parkinson's disease; Pick's disease; Ubiquitin

Indexed keywords

ALPHA SYNUCLEIN; PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CARBOXY TERMINAL SEQUENCE; HUMAN; LEWY BODY; MISSENSE MUTATION; NERVE CELL DEGENERATION; PARKINSON DISEASE; PATHOGENESIS; PRIORITY JOURNAL;

EID: 0031794794     PISSN: 13594184     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.mp.4000446     Document Type: Article

References (23)

1. Parkinson J. An Essay on the Shaking Palsy. Sherwood, Necly and Jones: London, 1817.
2. Polymeropoulos MH, Lavedan C, Leroy E, Ide SE, Dehejia A, Dutra A et al. Mutation in the a-synuclein gene identified in families with Parkinson's disease. Science 1997: 276: 2045-2047.
3. Kruger R, Kuhn W, Muller T et a! AlaSOPro mutation in the gene encoding alpha-synuclein in Parkinson's disease. Ara( Genet 1998; 18: 106-108.
4. Maroteaux L, Scheller RH. The rat brain synucleins; family of proteins transiently associated with neuronal membrane. Brain lies Mol Brain Res 1991; 11: 335-343.
5. Jakes R, Spillantini MG, Goedert M. Identification of two distinct synucleins from human brain. FEBS Lett 1994; 345: 27-32.
6. George JM, Jin H, Woods WS, Clayton DP. Characterization of a novel protein regulated during the critical period for song learning in the zebra finch. Neuron 1995; 15: 361-372.
7. Ueda K, Fukushima H, Masliah E, Xia Y, Iwai A, Yoshimoto M et al. Molecular cloning of cDNA encoding an unrecognized component of amyloid in Alzheimer disease. Proc Natl Acad Sci USA 1993, 90: 11282-11286.
8. Xia Y, Rohan de Suva HA, Rosi BL, Yamaoka LH, Rimmler JB, Pericak-Vance MA et al. Genetic studies in Alzheimer's disease with an NACP/alpha-synuclein polymorphism. Ann Neural 199G: 40: 207-215.
9. Lewy F. Zur pathologischen Anatomie der Paralysis agitans. Dtsch Z Nervenheikd 1913; 50: 50-55.
10. Kosaka K, Yoshimura M, Ikeda K, Budka H. Diffuse Lewy body disease: progressive dementia with abundant cortical Lewy bodies " and senile changes of varying degree - a new disease? Clin Neuropathol 1984; 31: 85-192.
11. Pollanen MS, Dickson DW, Bergeron CM. Pathology and biology of the Leu-y body. J Neuropathol Exp Neural 1993; 52: 183-191.
12. Iwatsubo T, Saido TC, Mann DM, Loo VM, Trojanowski JQ. Fulllength amyloid-beta (1-42(43)) and amino-terminally modified and truncated amyloid-beta 42(43) deposit in diffuse plaques. Am J Pathol 1996; 149: 1823-1830.
13. Gai WP, Blessing WW, Blumbergs PC. Ubiquitin-positive degenerating neuntes in the brainstem in Parkinson's disease. Brain 1995; 118: 1447-1459.
14. Lennox G, Löwe J, Landon M, Byrne EJ, Mayer RJ, Godwin-Austen RB. Diffuse Leu-y body disease: correlative neuropathology using anti-ubiquitin immunocytochemistry. J Neural Neurosurg Psychiatry 1989; 52: 1236-1247.
15. Hill WD, Lee VM, Hurtig HI, Murray JM, Trojanowski JQ. Epitopes located in spatially separate domains of each neurofilament subunit are present in Parkinson's disease Lewy bodies. J Conip Neural 1991; 309: 150-160.
16. Dickson DW, Crystal H, Mattiace LA, Kress Y, Schwagerl A, Ksiezak-Reding H et al. Diffuse Lewy body disease: light and electron microscopic immunocytochemistry of senile plaques. Ada Neuropathol 1989; 78: 572-584.
17. Dickson DW, Wertkin A, Kress Y, Ksiezak-Reding H, Yen SH. Ubiquitin immunoreactive structures in normal human brains. Distribution and developmental aspects. Lab Invest 1990; 03: 87-99.
18. Schmidt M, Murray J, Trojanowski J. Continuity of neuropil threads with tangle-bearing and tangle-free neurons in Alzheimer's disease cortex. A confocal laser scanning microscopy study. Alolec Chem Neuropathol 1993; 18: 299-312.
19. Braak H, Braak E, Grundke-Iqbal I et al. Occurrence of neuropil threads in the senile human brain and in Alzheimer's disease: a third location of paired helical filaments outside of neurofibrillary tangles and neuritic plaques. Neurosci Lett 198G; 65: 351-355.
20. Spillantini MG, Schmidt ML, Lee VM, Trojanowski JQ, Jakes R, Goedert M. Nature 1997; 388: 839-840.
21. Grüne T, Reinheckel T, Davies KJ. Degradation of oxidized proteins in mammalian cells. FASED J 1997; 11: 526-534.
22. Horwich AL, Weissman JS. Deadly conformations-protein misfolding in prion disease. Cell 1997; 89: 499-510.
23. Lindquist S. Mad cows meet psi-chotic yeast: the expansion of the prion hypothesis. Cell 1997: 89: 495-198.