메뉴 건너뛰기




Volumn 83, Issue 3, 2002, Pages 623-634

Mice expressing the α1B-adrenergic receptor induces a synucleinopathy with excessive tyrosine nitration but decreased phosphorylation

Author keywords

Adrenergic; Receptor; Synuclein; Transgenic

Indexed keywords

ALPHA 1 ADRENERGIC RECEPTOR; ALPHA SYNUCLEIN; META TYROSINE; TERAZOSIN; UBIQUITIN;

EID: 18644371727     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2002.01170.x     Document Type: Article
Times cited : (36)

References (52)
  • 1
    • 0025875693 scopus 로고
    • Abnormal automatic rhythms in ischemic purkinje fibers are modulated by a specific alpha1-adrenergic receptor subtype
    • Anyukovsky E. P. and Rosen M. R. (1991) Abnormal automatic rhythms in ischemic purkinje fibers are modulated by a specific alpha1-adrenergic receptor subtype. Circulation 83, 2076-2082.
    • (1991) Circulation , vol.83 , pp. 2076-2082
    • Anyukovsky, E.P.1    Rosen, M.R.2
  • 2
    • 0030068259 scopus 로고    scopus 로고
    • Excitatory actions of norepinephrine on mutiple classes of hippocampal CA1 interneurons
    • Bergles D. E., Doze V. A., Madison D. V. and Smith S. J. (1996) Excitatory actions of norepinephrine on mutiple classes of hippocampal CA1 interneurons. J Neurosci. 16, 572-585.
    • (1996) J. Neurosci. , vol.16 , pp. 572-585
    • Bergles, D.E.1    Doze, V.A.2    Madison, D.V.3    Smith, S.J.4
  • 4
    • 0029584895 scopus 로고
    • Regulation of vascular smooth muscle growth by alpha 1-adrenoreceptor subtypes in vitro and in situ
    • Chen L., Xin X., Eckhart A. D., Yang N. and Faber J. E. (1995) Regulation of vascular smooth muscle growth by alpha 1-adrenoreceptor subtypes in vitro and in situ. J Biol. Chem. 270, 30980-30988.
    • (1995) J. Biol. Chem. , vol.270 , pp. 30980-30988
    • Chen, L.1    Xin, X.2    Eckhart, A.D.3    Yang, N.4    Faber, J.E.5
  • 7
    • 0032540327 scopus 로고    scopus 로고
    • Stabilization of alpha-synuclein secondary structure upon binding to synthetic membranes
    • Davidson W. S., Jonas A., Clayton D. F. and George J. M. (1998) Stabilization of alpha-synuclein secondary structure upon binding to synthetic membranes. J Biol. Chem. 17, 9443-9449.
    • (1998) J. Biol. Chem. , vol.17 , pp. 9443-9449
    • Davidson, W.S.1    Jonas, A.2    Clayton, D.F.3    George, J.M.4
  • 8
    • 0035830913 scopus 로고    scopus 로고
    • Alpha-synuclein is phosphorylated by members of the Src family of protein-tyrosine kinases
    • Ellis C. E., Schwartzberg P. L., Grider T L., Fink D. W. and Nussbaum R. L. (2001) Alpha-synuclein is phosphorylated by members of the Src family of protein-tyrosine kinases. J Biol. Chem. 276, 3879-3884.
    • (2001) J. Biol. Chem. , vol.276 , pp. 3879-3884
    • Ellis, C.E.1    Schwartzberg, P.L.2    Grider, T.L.3    Fink, D.W.4    Nussbaum, R.L.5
  • 9
    • 0034704752 scopus 로고    scopus 로고
    • A Drosophila model of Parkinson's disease
    • Feany M. B. and Bender W. W. (2000) A Drosophila model of Parkinson's disease. Nature 23, 394-398.
    • (2000) Nature , vol.23 , pp. 394-398
    • Feany, M.B.1    Bender, W.W.2
  • 14
    • 0003142029 scopus 로고
    • The effects of drugs on behavioural models of central noradrenergic function
    • (D. J. Heal and D. A. Marsden, eds). Oxford University Press, New York
    • Heal D. J. (1990) The effects of drugs on behavioural models of central noradrenergic function. In: The Pharmacology of Noradrenaline in the Central Nervous System (D. J. Heal and D. A. Marsden, eds), pp. 266-315. Oxford University Press, New York.
    • (1990) The Pharmacology of Noradrenaline in the Central Nervous System , pp. 266-315
    • Heal, D.J.1
  • 17
    • 0032500599 scopus 로고    scopus 로고
    • Binding of alpha-synuclein to brain vesicles is abolished by familial Parkinson's disease mutation
    • Jensen P. H., Nielsen M. S., Jakes R., Dotti C. G. and Goedert M. (1998) Binding of alpha-synuclein to brain vesicles is abolished by familial Parkinson's disease mutation. J. Biol. Chem. 273, 26292-26294.
    • (1998) J. Biol. Chem. , vol.273 , pp. 26292-26294
    • Jensen, P.H.1    Nielsen, M.S.2    Jakes, R.3    Dotti, C.G.4    Goedert, M.5
  • 21
    • 0026022622 scopus 로고
    • A histometrical and comparative study on Purkinje cell loss and olivary nucleus cell loss in multiple system atrophy
    • Kume A., Takahashi A., Hashizume Y. and Asai J. (1991) A histometrical and comparative study on Purkinje cell loss and olivary nucleus cell loss in multiple system atrophy. J. Neurol. Sci. 101, 178-186.
    • (1991) J. Neurol. Sci. , vol.101 , pp. 178-186
    • Kume, A.1    Takahashi, A.2    Hashizume, Y.3    Asai, J.4
  • 22
    • 0023187990 scopus 로고
    • Mechanism of inverse regulation of alpha 1- and beta-adrenergic receptors
    • Kunos G. and Ishac E. J. N. (1987) Mechanism of inverse regulation of alpha 1- and beta-adrenergic receptors. Biochem. Pharmacol. 36, 1185-1191.
    • (1987) Biochem. Pharmacol. , vol.36 , pp. 1185-1191
    • Kunos, G.1    Ishac, E.J.N.2
  • 23
    • 0031774904 scopus 로고    scopus 로고
    • The definition of multiple system atrophy: A review of recent developments
    • Lantos P. L. (1998) The definition of multiple system atrophy: A review of recent developments. J. Neuropathol. Exp. Neurol. 57, 1099-1111.
    • (1998) J. Neuropathol. Exp. Neurol. , vol.57 , pp. 1099-1111
    • Lantos, P.L.1
  • 24
    • 0030010452 scopus 로고    scopus 로고
    • Different alpha-adrenoceptor subtypes mediate constriction of arterioles and venules
    • Leech C. J. and Faber J. E. (1996) Different alpha-adrenoceptor subtypes mediate constriction of arterioles and venules. Am. J. Physiol. 270, H710-H722.
    • (1996) Am. J. Physiol. , vol.270
    • Leech, C.J.1    Faber, J.E.2
  • 26
    • 0031842223 scopus 로고    scopus 로고
    • Oxidative damage to proteins, lipids, and DNA in cortical brain regions from patients with dementia with Lewy bodies
    • Lyras L., Perry R. H., Perry E. K., Ince P. G., Jenner A., Jenner P. and Halliwell B. (1998) Oxidative damage to proteins, lipids, and DNA in cortical brain regions from patients with dementia with Lewy bodies. J. Neurochem. 71, 302-312.
    • (1998) J. Neurochem. , vol.71 , pp. 302-312
    • Lyras, L.1    Perry, R.H.2    Perry, E.K.3    Ince, P.G.4    Jenner, A.5    Jenner, P.6    Halliwell, B.7
  • 27
    • 0033577494 scopus 로고    scopus 로고
    • Serotonin, via 5-HT2A receptors, increases EPSCs in layer V pyramidal cells of prefrontal cortex by an asynchronous mode of glutamate release
    • Marek G. J. and Aghajanian K. (1999) Serotonin, via 5-HT2A receptors, increases EPSCs in layer V pyramidal cells of prefrontal cortex by an asynchronous mode of glutamate release. Brain Res. 825, 161-171.
    • (1999) Brain Res. , vol.825 , pp. 161-171
    • Marek, G.J.1    Aghajanian, K.2
  • 28
    • 0034681471 scopus 로고    scopus 로고
    • Dopaminergic loss and inclusion body formation in alpha-synuclein mice: Implications for neurodegenerative disorders
    • Masliah E., Rockenstein E., Veinbergs I., Mallory M., Hashimoto M., Takeda A., Sagara Y., Sisk A. and Mucke L. (2000) Dopaminergic loss and inclusion body formation in alpha-synuclein mice: Implications for neurodegenerative disorders. Science 287, 1265-1269.
    • (2000) Science , vol.287 , pp. 1265-1269
    • Masliah, E.1    Rockenstein, E.2    Veinbergs, I.3    Mallory, M.4    Hashimoto, M.5    Takeda, A.6    Sagara, Y.7    Sisk, A.8    Mucke, L.9
  • 31
    • 0024843373 scopus 로고
    • Glial cytoplasmic inclusions in the CNS of patients with multiple system atrophy (striatonigral degeneration, olivopontocerebellar atrophy and Shy-Drager syndrome)
    • Papp M. I., Kahn J. E. and Lantos P. L. (1989) Glial cytoplasmic inclusions in the CNS of patients with multiple system atrophy (striatonigral degeneration, olivopontocerebellar atrophy and Shy-Drager syndrome). J. Neurol. Sci. 94, 79-100.
    • (1989) J. Neurol. Sci. , vol.94 , pp. 79-100
    • Papp, M.I.1    Kahn, J.E.2    Lantos, P.L.3
  • 33
    • 0035256622 scopus 로고    scopus 로고
    • 1B-adrenergic receptor causes a "seizure plus" syndrome'
    • 1B-adrenergic receptor causes a "seizure plus" syndrome'. Nat. Med. 7, 132-133.
    • (2001) Nat. Med. , vol.7 , pp. 132-133
    • Perez, D.M.1
  • 39
    • 0034714204 scopus 로고    scopus 로고
    • Synucleins are a novel class of substrates for G protein-coupled receptor kinases
    • Pronin A. N., Morris A. J., Surguchov A. and Benovic J. L. (2000) Synucleins are a novel class of substrates for G protein-coupled receptor kinases. J. Biol. Chem. 275, 26515-26522.
    • (2000) J. Biol. Chem. , vol.275 , pp. 26515-26522
    • Pronin, A.N.1    Morris, A.J.2    Surguchov, A.3    Benovic, J.L.4
  • 41
    • 0032749712 scopus 로고    scopus 로고
    • Inverse agonism and neutral antagonism at alpha (1a)- and alpha (1b)-adrenergic receptor subtypes
    • Rossier O., Abuin L., Fanelli F., Leonardi A. and Cotecchia S. (1999) Inverse agonism and neutral antagonism at alpha (1a)- and alpha (1b)-adrenergic receptor subtypes. Mol. Pharmacol. 56, 858-866.
    • (1999) Mol. Pharmacol. , vol.56 , pp. 858-866
    • Rossier, O.1    Abuin, L.2    Fanelli, F.3    Leonardi, A.4    Cotecchia, S.5
  • 44
    • 0035979233 scopus 로고    scopus 로고
    • Alpha-synuclein occurs in lipid-rich high molecular weight complexes, binds to fatty acids, and shows homology to the fatty acid-binding proteins
    • Sharon R., Goldberg M. S., Bar-Jose I., Betensky R. A., Shen J. and Selkoe D. J. (2001) Alpha-synuclein occurs in lipid-rich high molecular weight complexes, binds to fatty acids, and shows homology to the fatty acid-binding proteins. Proc. Natl. Acad. Sci. USA 98, 9110-9115.
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 9110-9115
    • Sharon, R.1    Goldberg, M.S.2    Bar-Jose, I.3    Betensky, R.A.4    Shen, J.5    Selkoe, D.J.6
  • 45
    • 0032589306 scopus 로고    scopus 로고
    • Central alpha 1-adrenoceptors: Their role in the modulation of attention and memory formation
    • Sirvia J. and MacDonald E. (1999) Central alpha 1-adrenoceptors: Their role in the modulation of attention and memory formation. Pharmacol. Ther. 83, 49-65.
    • (1999) Pharmacol. Ther. , vol.83 , pp. 49-65
    • Sirvia, J.1    MacDonald, E.2
  • 46
    • 0034674652 scopus 로고    scopus 로고
    • Dityrosine cross-linking promotes formation of stable α-synuclein polymers
    • Souza J. M., Giasson B. I., Chen Q., Lee V. M.-Y. and Ischiropoulos H. (2000) Dityrosine cross-linking promotes formation of stable α-synuclein polymers. J Biol. Chem. 275, 18344-18349.
    • (2000) J. Biol. Chem. , vol.275 , pp. 18344-18349
    • Souza, J.M.1    Giasson, B.I.2    Chen, Q.3    Lee, V.M.-Y.4    Ischiropoulos, H.5
  • 47
    • 0032712275 scopus 로고    scopus 로고
    • Brain alpha1-adrenergic neurotransmission is necessary for behavioral activation to environmental change in mice
    • Stone E. A., Zhang Y., Rosengarten H., Yeretsian J. and Quartermain D. (1999) Brain alpha1-adrenergic neurotransmission is necessary for behavioral activation to environmental change in mice. Neuroscience 94, 1245-1252.
    • (1999) Neuroscience , vol.94 , pp. 1245-1252
    • Stone, E.A.1    Zhang, Y.2    Rosengarten, H.3    Yeretsian, J.4    Quartermain, D.5
  • 48
    • 0035218155 scopus 로고    scopus 로고
    • Pharmacological evidence for the role of central alpha1B-adrenoceptors in the motor activity and spontaneous movement of mice
    • Stone E. A., Lin Y., Itteera A. and Quarterman D. (2001) Pharmacological evidence for the role of central alpha1B-adrenoceptors in the motor activity and spontaneous movement of mice. Neuropharmacology 40, 254-261.
    • (2001) Neuropharmacology , vol.40 , pp. 254-261
    • Stone, E.A.1    Lin, Y.2    Itteera, A.3    Quarterman, D.4
  • 49
    • 0037205095 scopus 로고    scopus 로고
    • Tyrosine 125 of alpha-synuclein plays a critical role for dimerization following nitrative stress
    • Takahashi T., Yamashita H., Nakamura T., Nagano Y. and Nakamura S. (2002) Tyrosine 125 of alpha-synuclein plays a critical role for dimerization following nitrative stress. Brain Res. 938, 73-80.
    • (2002) Brain Res. , vol.938 , pp. 73-80
    • Takahashi, T.1    Yamashita, H.2    Nakamura, T.3    Nagano, Y.4    Nakamura, S.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.