Analysis of intracytoplasmic hyaline bodies in a hepatocellular carcinoma: Demonstration of p62 as major constituent

American Journal of Pathology

Volumn 154, Issue 6, 1999, Pages 1701-1710

  Stumptner, Cornelia ^a   Heid, Hans ^b   Fuchsbichler, Andrea ^a   Hauser, Hubert ^a   Mischinger, Hans Jörg ^a   Zatloukal, Kurt ^a   Denk, Helmut ^a  

^a MEDICAL UNIVERSITY OF GRAZ   (Austria)

^b GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ARTICLE; CASE REPORT; CELL INCLUSION; ELECTRON MICROSCOPY; HUMAN; HUMAN TISSUE; IMMUNOBLOTTING; IMMUNOFLUORESCENCE MICROSCOPY; IMMUNOHISTOCHEMISTRY; LIVER CELL CARCINOMA; MALE; MICROSCOPY; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

EID: 0033058534     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9440(10)65426-0     Document Type: Article

References (36)

1. Norkin SA, Campagna-Pinto D: Cytoplasmic hyaline inclusions in hepatoma. Arch Pathol 1968, 86:25-32
2. Dekker A, Krause JR: Hyaline globules in human neoplasms. Arch Pathol 1973, 95:178-181
3. Thung SN, Gerber MA, Sarno E, Popper H: Distribution of five antigens in hepatocellular carcinoma. Lab Invest 1979, 41:101-105
4. Mac Donald K, Bedard YC: Cytologic, ultrastructural and immunologic features of intracytoplasmic hyaline bodies in fine needle aspirates of hepatocellular carcinoma. Acta Cytol 1990, 34:197-200
5. Haratake J, Horie A, Setojima M: Globular cytoplasmic inclusion bodies in a metastatic hepatocellular carcinoma of the iliac bone. Ultrastruct Pathol 1990, 14:283-288
6. Nakashima O, Sugihara S, Eguchi A, Taguchi J, Watanabe J, Kojiro M: Pathomorphologic study of pale bodies in hepatocellular carcinoma. Acta Pathol Jpn 1992, 42:414-418
7. Chedid A, Chejfec G, Eichorst M, Villamil F, Terg R, Telenta M, Hojman R: Antigenic markers of hepatocellular carcinoma. Cancer 1990, 65:84-87
8. Hoso M, Nakanuma Y: Clinicopathological characteristics of hepatocellular carcinoma bearing Mallory bodies: an autopsy study. Liver 1990, 10:264-268
9. Terada T, Hoso M, Nakanuma Y: Mallory body clustering in adenomatous hyperplasia in human cirrhotic livers: report of four cases. Hum Pathol 1989, 20:886-890
10. Callea F, Favret M, Marino C, Brisigotti M: Pathology of hepatocellular carcinoma. J Surg Oncol Suppl 1993, 3:168-169
11. Anthony PP: Tumours and tumour-like lesions of the liver and biliary tract. Pathology of the Liver, ed 3. Edited by Mac Sween RNM, Anthony PP, Scheuer PJ, Burt AD, Portmann BC. Churchill Livingstone, Edinburgh, 1994, pp 635-711
12. Denk H, Franke WW, Kerjaschki D, Eckersdorfer R: Mallory bodies in experimental animals and in man. Int Rev Exp Pathol 1979, 20:77-121
13. Zatloukal K, Denk H, Spurej G, Lackinger E, Preisegger KH, Franke WW: High molecular weight component of Mallory bodies detected by a monoclonal antibody. Lab Invest 1990, 62:427-434
14. Hutter H, Zatloukal K, Winter G, Stumptner C, Denk H: Disturbance of keratin homeostasis in griseofulvin-intoxicated mouse liver. Lab Invest 1993, 69:576-582
15. Denk H, Franke WW, Dragosics B, Zeiler I: Pathology of cytoskeleton in liver cells: demonstration of Mallory bodies (alcoholic hyalin) in murine and human hepatocytes by immunofluorescence microscopy using antibodies to cytokeratin polypeptides from hepatocytes. Hepatology 1981, 1:9-20
16. Jensen K, Gluud C: The Mallory body: theories on development and pathological significance. Hepatology 1994, 20:1330-1342
17. Salmhofer H, Rainer I, Zatloukal K, Denk H: Posttranslational events involved in griseofulvin-induced keratin cytoskeleton alterations. Hepatology 1994, 20:731-740
18. lck SH2 domain. Proc Natl Acad Sci USA 1996, 93:5991-5995
19. lck and its regulation by phosphorylation of Scr-59 in the lck unique N-terminal region. Proc Natl Acad Sci USA 1995, 92:12338-12342
20. Brion JP, Couck AM, Anderton BH: Isolated PHF and PHF-tau (A68) polypeptides in Alzheimer's disease contain epitopes from the whole sequence of different tau isoforms and modified sites recognized by RT97 and 8D8 anti-neurofilament antibodies. Neurobiol Aging 1992, 18:54-55
21. Höger TH, Zatloukal K, Waizenegger I, Krohne G: Characterization of a second highly conserved B-type lamin present in cells previously thought to contain only a single B-type lamin. Chromosoma 1990, 99:379-390
22. Bradford MM: A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976, 72:248-254
23. Pasquali C, Fialka I, Huber LA: Preparative two-dimensional gel electrophoresis of membrane proteins. Electrophoresis 1997, 18:2573-2581
24. Yokoo H, Minick OT, Batti F, Kent G: Morphologic variants of alcoholic hyalin. Am J Pathol 1972, 69:25-40
25. Wiggers KD, French SW, French BA, Carr BN: The ultrastructure of Mallory body filaments. Lab Invest 1973, 29:652-658
26. Lowe J, Blanchard A, Morell K, Lennox G, Reynolds L, Billet M, Landon M, Mayer RJ: Ubiquitin is a common factor in intermediate filament inclusion bodies of diverse type in man, including those of Parkinson's disease, Pick's disease, and Alzheimer's disease, as well as Rosenthal fibers in cerebellar astrocytomas, cytoplasmic bodies in muscle, and Mallory bodies in alcoholic liver disease. J Pathol 1988, 155:9-15
27. Lowe J, Mayer RJ, Landon M: Ubiquitin in neurodegenerative disease. Brain Pathol 1993, 3:55-65
28. lck, belongs to a new class of ubiquitin-binding proteins. J Biol Chem 1996, 271: 20235-20237
29. Nukina N, Kosik KS, Selkoe DJ: Recognition of Alzheimer paired helical filaments by monoclonal neurofilament antibodies is due to crossreaction with tau protein. Proc Natl Acad Sci USA 1987, 84: 3415-3419
30. Lichtenberg-Kraag B, Mandelkow EM, Biernat J, Steiner B, Schröter C, Gustke N, Meyer HE, Mandelkow E: Phosphorylation-dependent epitopes of neurofilament antibodies on tau protein and relationship with Alzheimer tau. Proc Natl Acad Sci USA 1992, 89:5384-5388
31. Vincent I, Rosado M, Davies P: Mitotic mechanisms in Alzheimer's disease? J Cell Biol 1996, 132:413-425
32. Kondratick CM, Vandre DD: Alzheimer's disease neurofibrillary tangles contain mitosis-specific phosphoepitopes. J Neurochem 1996, 67:2405-2416
33. Davis FM, Isao TY, Fowler SK, Rao PN: Monoclonal antibodies to mitotic cells. Proc Natl Acad Sci USA 1983, 80:2926-2930
34. Westendorf JM, Rao PN, Gerace L: Cloning of cDNAs for M-phase phosphoproteins recognized by the MPM2 monoclonal antibody and determination of the phosphorylated epitope. Proc Natl Acad Sci USA 1994, 91:714-718
35. Renzi L, Gersch MS, Campbell MS, Wu L, Osmani SA, Gorhsky GJ: MPM-2 antibody-reactive phosphorylations can be created in detergent-extracted cells by kinetochore-bound and soluble kinases. J Cell Sci 1997, 110:2013-2025
36. Preisegger KH, Zatloukal K, Spurej G, Riegelnegg D, Denk H: Common epitopes of human and murine Mallory bodies and Lewy bodies as revealed by a neurofilament antibody. Lab Invest 1992, 66:193-199