α-Synuclein Affects the MAPK Pathway and Accelerates Cell Death

Journal of Biological Chemistry

Volumn 276, Issue 48, 2001, Pages 45320-45329

  Iwata, Atsushi ^a,b   Maruyama, Mieko ^a   Kanazawa, Ichiro ^b   Nukina, Nobuyuki ^a  

^a RIKEN BRAIN SCIENCE INSTITUTE   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; DISEASES; ENZYME INHIBITION; ENZYMES;

MULTIPLE SYSTEM ATROPHY;

BIOCHEMISTRY;

ALPHA SYNUCLEIN; MITOGEN ACTIVATED PROTEIN KINASE; UO 126; 1,3 BUTADIENE DERIVATIVE; 1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 14 3 3 PROTEIN; 14-3-3 PROTEIN; COMPLEMENTARY DNA; DYE; ENZYME INHIBITOR; GLUTATHIONE TRANSFERASE; HYBRID PROTEIN; NERVE PROTEIN; NITRILE; SYNUCLEIN; TETRAZOLIUM; THIAZOLE DERIVATIVE; THIAZOLYL BLUE; TYROSINE 3 MONOOXYGENASE;

ARTICLE; CELL DEATH; CELL VIABILITY; DIFFUSE LEWY BODY DISEASE; ENZYME PHOSPHORYLATION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; PARKINSON DISEASE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SHY DRAGER SYNDROME; SIGNAL TRANSDUCTION; AMINO ACID SEQUENCE; APOPTOSIS; CELL LINE; CELL SURVIVAL; CHEMISTRY; DOSE RESPONSE; GENE LIBRARY; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; METABOLISM; MOLECULAR GENETICS; MUTATION; NICK END LABELING; NORTHERN BLOTTING; PHOSPHORYLATION; PHYSIOLOGY; PLASMID; PROTEIN BINDING; SEQUENCE HOMOLOGY; SERODIAGNOSIS; TIME;

CERVUS ELAPHUS;

AMINO ACID SEQUENCE; APOPTOSIS; BLOTTING, NORTHERN; BUTADIENES; CELL DEATH; CELL LINE; CELL SURVIVAL; DNA, COMPLEMENTARY; DOSE-RESPONSE RELATIONSHIP, DRUG; DYES; ENZYME INHIBITORS; GENE LIBRARY; GLUTATHIONE TRANSFERASE; HUMAN; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; IN SITU NICK-END LABELING; MAP KINASE SIGNALING SYSTEM; MOLECULAR SEQUENCE DATA; MUTATION; NERVE TISSUE PROTEINS; NITRILES; PHOSPHORYLATION; PLASMIDS; PRECIPITIN TESTS; PROTEIN BINDING; RECOMBINANT FUSION PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; SIGNAL TRANSDUCTION; TETRAZOLIUM SALTS; THIAZOLES; TIME FACTORS; TRANSFECTION; TYROSINE 3-MONOOXYGENASE;

EID: 0035976959     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M103736200     Document Type: Article

References (66)

1. Maroteaux, L., Campanelli, J. T., and Scheller, R. H. (1988) J. Neurosci. 8, 2804-2815
2. Baba, M., Nakajo, S., Tu, P. H., Tomita, T., Nakaya, K., Lee, V. M., Trojanowski, J. Q., and Iwatsubo, T. (1998) Am. J. Pathol. 152, 879-884
3. Spillantini, M. G., Schmidt, M. L., Lee, V. M., Trojanowski, J. Q., Jakes, R., and Goedert, M. (1997) Nature 388, 839-840
4. Spillantini, M. G., Crowther, R. A., Jakes, R., Cairns, N. J., Lantos, P. L., and Goedert, M. (1998) Neurosci. Lett. 251, 205-208
5. Tu, P. H., Galvin, J. E., Baba, M., Giasson, B., Tomita, T., Leight, S., Nakajo, S., Iwatsubo, T., Trojanowski, J. Q., and Lee, V. M. (1998) Ann. Neurol. 44, 415-422
6. Dickson, D. W., Liu, W., Hardy, J., Farrer, M., Mehta, N., Uitti, R., Mark, M., Zimmerman, T., Golbe, L., Sage, J., Sima, A., D'Amato, C., Albin, R., Gilman, S., and Yen, S. H. (1999) Am. J. Pathol. 155, 1241-1251
7. Sherman, M. Y., and Goldberg, A. L. (2001) Neuron 29, 15-32
8. Dickson, D. W., Lin, W., Liu, W. K., and Yen, S. H. (1999) Brain Pathol. 9, 721-732
9. Galvin, J. E., Lee, V. M., and Trojanowski, J. Q. (2001) Arch. Neurol. 58, 186-190
10. Polymeropoulos, M. H., Lavedan, C., Leroy, E., Ide, S. E., Dehejia, A., Dutra, A., Pike, B., Root, H., Rubenstein, J., Boyer, R., Stenroos, E. S., Chandrasekharappa, S., Athanassiadou, A., Papapetropoulos, T., Johnson, W. G., Lazzarini, A. M., Duvoisin, R. C., Di Iorio, G., Golbe, L. I., and Nussbaum, R. L. (1997) Science 276, 2045-2047
11. Kruger, R., Kuhn, W., Muller, T., Woitalla, D., Graeber, M., Kosel, S., Przuntek, H., Epplen, J. T., Schols, L., and Riess, O. (1998) Nat. Genet. 18, 106-108
12. Giasson, B. I., Uryu, K., Trojanowski, J. Q., and Lee, V. M. (1999) J. Biol. Chem. 274, 7619-7622
13. Narhi, L., Wood, S. J., Steavenson, S., Jiang, Y., Wu, G. M., Anafi, D., Kaufman, S. A., Martin, F., Sitney, K., Denis, P., Louis, J. C., Wypych, J., Biere, A. L., and Citron, M. (1999) J. Biol. Chem. 274, 9843-9846
14. Paik, S. R., Shin, H. J., Lee, J. H., Chang, C. S., and Kim, J. (1999) Biochem. J. 340, 821-828
15. Hashimoto, M., Hsu, L. J., Xia, Y., Takeda, A., Sisk, A., Sundsmo, M., and Masliah, E. (1999) Neuroreport 10, 717-721
16. Hashimoto, M., Takeda, A., Hsu, L. J., Takenouchi, T., and Masliah, E. (1999) J. Biol. Chem. 274, 28849-28852
17. Giasson, B. I., Murray, I. V., Trojanowski, J. Q., and Lee, V. M. (2001) J. Biol. Chem. 276, 2380-2386
18. Masliah, E., Rockenstein, E., Veinbergs, I., Mallory, M., Hashimoto, M., Takeda, A., Sagara, Y., Sisk, A., and Mucke, L. (2000) Science 287, 1265-1269
19. Feany, M. B., and Bender, W. W. (2000) Nature 404, 394-398
20. Ostrerova-Golts, N., Petrucelli, L., Hardy, J., Lee, J. M., Farer, M., and Wolozin, B. (2000) J. Neurosci. 20, 6048-6054
21. Kanda, S., Bishop, J. F., Eglitis, M. A., Yang, Y., and Mouradian, M. M. (2000) Neuroscience 97, 279-284
22. Hsu, L. J., Sagara, Y., Arroyo, A., Rockenstein, E., Sisk, A., Mallory, M., Wong, J., Takenouchi, T., Hashimoto, M., and Masliah, E. (2000) Am. J. Pathol. 157, 401-410
23. Souza, J. M., Giasson, B. I., Chen, Q., Lee, V. M., and Ischiropoulos, H. (2000) J. Biol. Chem. 275, 18344-18349
24. Giasson, B. I., Duda, J. E., Murray, I. V., Chen, Q., Souza, J. M., Hurtig, H. I., Ischiropoulos, H., Trojanowski, J. Q., and Lee, V. M. (2000) Science 290, 985-989
25. Duda, J. E., Giasson, B. I., Chen, Q., Gur, T. L., Hurtig, H. I., Stern, M. B., Gollomp, S. M., Ischiropoulos, H., Lee, V. M., and Trojanowski, J. Q. (2000) Am. J. Pathol. 157, 1439-1445
26. Ostrerova, N., Petrucelli, L., Farrer, M., Mehta, N., Choi, P., Hardy, J., and Wolozin, B. (1999) J. Neurosci. 19, 5782-5791
27. Iwata, A., Miura, S., Kanazawa, I., Sawada, M., and Nukina, N. (2001) J. Neurochem. 77, 239-252
28. Ishizawa, M., Kobayashi, Y., Miyamura, T., and Matsuura, S. (1991) Nucleic Acids Res. 19, 5792
29. Mosmann, T. (1983) J. Immunol. Methods 65, 55-63
30. Hill, C. S., and Treisman, R. (1995) Cell 80, 199-211
31. Hodge, C., Liao, J., Stofega, M., Guan, K., Carter-Su, C., and Schwartz, J. (1998) J. Biol. Chem. 273, 31327-31336
32. Gille, H., Kortenjann, M., Thomae, O., Moomaw, C., Slaughter, C., Cobb, M. H., and Shaw, P. E. (1995) EMBO J. 14, 951-962
33. Blackshear, P. J., Stumpo, D. J., Huang, J. K., Nemenoff, R. A., and Spach, D. H. (1987) J. Biol. Chem. 262, 7774-7781
34. Gould, G. W., Cuenda, A., Thomson, F. J., and Cohen, P. (1995) Biochem. J. 311, 735-738
35. Hibi, M., Lin, A., Smeal, T., Minden, A., and Karin, M. (1993) Genes Dev. 7, 2135-2148
36. Derijard, B., Hibi, M., Wu, I. H., Barrett, T., Su, B., Deng, T., Karin, M., and Davis, R. J. (1994) Cell 76, 1025-1037
37. Schiemann, W. P., and Nathanson, N. M. (1994) J. Biol. Chem. 269, 6376-6382
38. Berra, E., Diaz-Meco, M. T., Lozano, J., Frutos, S., Municio, M. M., Sanchez, P., Sanz, L., and Moscat, J. (1995) EMBO J. 14, 6157-6163
39. Crews, C. M., Alessandrini, A., and Erikson, R. L. (1992) Science 258, 478-480
40. Macdonald, S. G., Crews, C. M., Wu, L., Driller, J., Clark, R., Erikson, R. L., and McCormick, F. (1993) Mol. Cell. Biol. 13, 6615-6620
41. Derijard, B., Raingeaud, J., Barrett, T., Wu, I. H., Han, J., Ulevitch, R. J., and Davis, R. J. (1995) Science 267, 682-685
42. Han, J., Lee, J. D., Jiang, Y., Li, Z., Feng, L., and Ulevitch, R. J. (1996) J. Biol. Chem. 271, 2886-2891
43. Kyriakis, J. M., Banerjee, P., Nikolakaki, E., Dai, T., Rubie, E. A., Ahmad, M. F., Avruch, J., and Woodgett, J. R. (1994) Nature 369, 156-160
44. Gupta, S., Barrett, T., Whitmarsh, A. J., Cavanagh, J., Sluss, H. K., Derijard, B., and Davis, R. J. (1996) EMBO J. 15, 2760-2770
45. Lee, J. C., Laydon, J. T., McDonnell, P. C., Gallagher, T. F., Kumar, S., Green, D., McNulty, D., Blumenthal, M. J., Heys, J. R., Landvatter, S. W., Strickler, J. E., McLaughlin, M. M., Siemens, I. R., Fisher, S. M., Livi, G. P., White, J. R., Adams, J. L., Young, P. R. (1994) Nature 372, 739-746
46. Goto, S., Yamamoto, H., Fukunaga, K., Iwasa, T., Matsukado, Y., and Miyamoto, E. (1985) J. Neurochem. 45, 276-283
47. Tian, J., and Karin, M. (1999) J. Biol. Chem. 274, 15173-15180
48. Okochi, M., Walter, J., Koyama, A., Nakajo, S., Baba, M., Iwatsubo, T., Meijer, L., Kahle, P. J., and Haass, C. (2000) J. Biol. Chem. 275, 390-397
49. Pronin, A. N., Morris, A. J., Surguchov, A., and Benovic, J. L. (2000) J. Biol. Chem. 275, 26515-26522
50. Ellis, C. E., Schwartzberg, P. L., Grider, T. L., Fink, D. W., and Nussbaum, R. L. (2000) J. Biol. Chem. 276, 3879-3884
51. Nakamura, T., Yamashita, H., Takahashi, T., and Nakamura, S. (2001) Biochem. Biophys. Res. Commun. 280, 1085-1092
52. Favata, M. F., Horiuchi, K. Y., Manos, E. J., Daulerio, A. J., Stradley, D. A., Feeser, W. S., Van Dyk, D. E., Pitts, W. J., Earl, R. A., Hobbs, F., Copeland, R. A., Magolda, R. L., Scherle, P. A., and Trzaskos, J. M. (1998) J. Biol. Chem. 273, 18623-18632
53. Cano, E., Hazzalin, C. A., and Mahadevan, L. C. (1994) Mol. Cell. Biol. 14, 7352-7362
54. Sanchez, I., Hughes, R. T., Mayer, B. J., Yee, K., Woodgett, J. R., Avruch, J., Kyriakis, J. M., and Zon, L. I. (1994) Nature 372, 794-798
55. Lee, M., Hyun, D. H., Halliwell, B., and Jenner, P. (2001) J. Neurochem. 76, 998-1009
56. Clerk, A., Fuller, S. J., Michael, A., and Sugden, P. H. (1998) J. Biol. Chem. 273, 7228-7234
57. Ushio-Fukai, M., Alexander, R. W., Akers, M., and Griendling, K. K. (1998) J. Biol. Chem. 273, 15022-15029
58. Volonté, D., Galbiati, F., Pestell, R. G., and Lisanti, M. P. (2000) J. Biol. Chem. 276, 8094-8103
59. Jenco, J. M., Rawlingson, A., Daniels, B., and Morris, A. J. (1998) Biochemistry 37, 4901-4909
60. Wilkie, N., Morton, C., Ng, L. L., and Boarder, M. R. (1996) J. Biol. Chem. 271, 32447-32453
61. Ito, Y., Nakashima, S., and Nozawa, Y. (1998) J. Neurochem. 71, 2278-2285
62. Pages, G., Brunet, A., L'Allemain, G., and Pouyssegur, J. (1994) EMBO J. 13, 3003-3010
63. Nakamura, S., Kawamoto, Y., Nakano, S., Akiguchi, I., and Kimura, J. (1998) J. Neuropathol. Exp. Neurol. 57, 690-698
64. Abeliovich, A., Schmitz, Y., Farinas, I., Choi-Lundberg, D., Ho, W. H., Castillo, P. E., Shinsky, N., Verdugo, J. M., Armanini, M., Ryan, A., Hynes, M., Phillips, H., Sulzer, D., and Rosenthal, A. (2000) Neuron 25, 239-252
65. Cox, M. E., and Parsons, S. J. (1997) J. Neurochem. 69, 1119-1130
66. Bloch-Shilderman, E., Jiang, H., Abu-Raya, S., Linial, M., and Lazarovici, P. (2001) J. Pharmacol. Exp. Ther. 296, 704-711