Dopamine neurons derived from embryonic stem cells function in an animal model of Parkinson's disease

Nature

Volumn 418, Issue 6893, 2002, Pages 50-56

  Kim, Jong Hoon ^a   Auerbach, Jonathan M ^a,b   Rodríguez Gómez, José A ^a   Velasco, Iván ^a   Gavin, Denise ^a   Lumelsky, Nadya ^a   Lee, Sang Hun ^a,c   Nguyen, John ^a,d   Sánchez Pernaute, Rosario ^a,e   Bankiewicz, Krys ^a,d   McKay, Ron ^a  

^a NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

^b Neuralstem Inc   (United States)

^c Hanyang University College of Medicine   (South Korea)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e MCLEAN HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOSYNTHESIS; BRAIN; CELLS; DISEASES; ELECTROPHYSIOLOGY;

NEURONS;

NEUROLOGY;

DOPAMINE; FIBROBLAST GROWTH FACTOR 8; SONIC HEDGEHOG PROTEIN;

BIOLOGY; DISEASE; NERVOUS SYSTEM DISORDER;

ADOPTIVE IMMUNOTHERAPY; ANIMAL BEHAVIOR; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL TRANSPLANTATION; CONTROLLED STUDY; DISEASE COURSE; DOPAMINERGIC NERVE CELL; ELECTROPHYSIOLOGY; EMBRYO CELL; FEMALE; INHIBITORY POSTSYNAPTIC POTENTIAL; NONHUMAN; PARKINSON DISEASE; PRIORITY JOURNAL; RAT; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SIGNAL TRANSDUCTION; STEM CELL TRANSPLANTATION;

ANIMALS; BLOTTING, WESTERN; CELL DIFFERENTIATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DISEASE MODELS, ANIMAL; DNA-BINDING PROTEINS; DOPAMINE; ELECTROPHYSIOLOGY; EMBRYO; FEMALE; MESENCEPHALON; NEOSTRIATUM; NEURONS; PARKINSON DISEASE; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; STEM CELL TRANSPLANTATION; STEM CELLS; TISSUE THERAPY; TRANSCRIPTION FACTORS; TRANSFECTION;

ANIMALIA; ERINACEIDAE;

EID: 0037019332     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/nature00900     Document Type: Article

References (43)

1. Transplantation of expanded mesencephalic precursors leads to recovery in parkinsonian rats
2. In vitro generation and transplantation of precursor-derived human dopamine neurons
3. Embryonic stem cell lines derived from human blastocysts
4. Derivation of pluripotent stem cells from cultured human primordial germ cells
5. Transplanted embryonic stem cells survive, differentiate and promote recovery in injured rat spinal cord
6. Correction of a genetic defect by nuclear transplantation and combined cell and gene therapy
7. HoxB4 confers definitive lymphoid-myeloid engraftment potential on embryonic stem cell and yolk sac hematopoietic progenitors
8. Efficient generation of midbrain and hindbrain neurons from mouse embryonic stem cells
9. Development of neuronal precursor cells and functional postmitotic neurons from embryonic stem cells in vitro
10. Fate of mesencephalic AHD2-expressing dopamine progenitor ceIls in NURR1 mutant mice
11. Dopamine neuron agenesis in Nurr1-deficient mice
12. Nurr1 is essential for the induction of the dopaminergic phenotype and the survival of ventral mesencephalic late dopaminergic precursor neurons
13. Selective agenesis of mesencephalic dopaminergic neurons in Nurr1-deficient mice
14. Differentiation of embryonic stem cells to insulin-secreting structures similar to pancreatic islets
15. Leukemia inhibitory factor modulates cardiogenesis in embryoid bodies in opposite fashions
16. Early cortical precursors do not undergo LIF-mediated astrocytic differentiation
17. PDX-1 is required for pancreatic outgrowth and differentiation of the rostral duodenum
18. Specification of dopaminergic and serotonergic neurons in the vertebrate CNS
19. Neural plate patterning: Upstream and downstream of the isthmic organizer
20. FGF and Shh signals control dopaminergic and serotonergic cell fate in the anterior neural plate
21. The caudal limit of Otx2 expression positions the isthmic organizer
22. Otx2, Gbx2 and Fgf8 interact to position and maintain a mid-hindbrain organizer
23. Telencephalon-restricted expression of BF-1, a new member of the HNF-3/fork head gene family, in the developing rat brain
24. Multiple developmental defects in Engrailed-1 mutant mice: An early mid-hindbrain deletion and patterning defects in forelimbs and sternum
25. A second independent pathway for development of mesencephalic dopaminergic neurons requires Lmx1b
26. The neostriatal mosaic: III. Biochemical and developmental dissociation of patch-matrix mesostriatal systems
27. Identified postnatal mesolimbic dopamine neurons in culture; morphology and electrophysiology
28. Electrophysiological characteristics of substantia nigra neurons in organotypic cultures: Spontaneous and evoked activities
29. Glutamate mediates an inhibitory postsynaptic potential in dopamine neurons
30. Dopamine-rich grafts in the neostriatum and/or nucleus accumbens: Effects on drug-induced behaviours and skilled paw-reaching
31. Restoration of complex sensorimotor behaviour and skilled forelimb use by a modified nigral cell suspension transplantation approach in the rat Parkinson model
32. Specific reinnervation of lesioned mouse striatum by grafted mesencephalic dopaminergic neurons
33. Target and neurotransmitter specificity of fetal central nervous system transplants: Importance for functional reinnervation
34. Cell replacement therapies for central nervous system disorders
35. Embryonic stem cells develop into functional dopaminergic neurons after transplantation in a Parkinson rat model
36. Serotonin1A receptor acts during development to establish normal anxiety-like behaviour in the adult
37. Schizophrenia: Diverse approaches to a complex disease
38. OTX2 homeoprotein in the developing central nervous system and migratory cells of the olfactory area
39. Reduced Nurr1 expression increases the vulnerability of mesencephalic dopamine neurons to MPTP-induced injury
40. Transplanted CNS stem cells form functional synapses in vivo
41. Forelimb akinesia in the rat Partinson model: Differential effects of dopamine agonists and nigral transplants as assessed by a new slepping test
42. The 'staircase test': A measure of independent forelimb reaching and grasping abilities in rats
43. CNS plasticity and assessment of forelimb sensorimotor outcome in unilateral rat models of stroke, cortical ablation, parkinsonism and spinal cord injury