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Volumn 155, Issue 4, 1999, Pages 1173-1181

Non-Aβ component of Alzheimer's disease amyloid (NAC) revisited: NAC and α-Synuclein are not associated with Aβ amyloid

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA SYNUCLEIN; AMYLOID; AMYLOID BETA PROTEIN; TAU PROTEIN; NERVE PROTEIN; SNCA PROTEIN, HUMAN; SNCA PROTEIN, RAT; SYNAPTOPHYSIN; SYNUCLEIN;

EID: 0032589409     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9440(10)65220-0     Document Type: Article
Times cited : (152)

References (47)
  • 4
    • 0031944830 scopus 로고    scopus 로고
    • Nigral and cortical Lewy bodies and dystrophic nigral neurites in Parkinson's disease and cortical Lewy body disease contain α-synuclein immunoreactivity
    • Irizarry MC, Growdon W, Gomez-Isla T, Newell K, George JM, Clayton DF, Hyman BT: Nigral and cortical Lewy bodies and dystrophic nigral neurites in Parkinson's disease and cortical Lewy body disease contain α-synuclein immunoreactivity, J Neuropathol Exp Neurol 1998, 57:334-337
    • (1998) J Neuropathol Exp Neurol , vol.57 , pp. 334-337
    • Irizarry, M.C.1    Growdon, W.2    Gomez-Isla, T.3    Newell, K.4    George, J.M.5    Clayton, D.F.6    Hyman, B.T.7
  • 8
    • 0031715398 scopus 로고    scopus 로고
    • NACP/α-synuclein immunoreactivity in fibrillary components of neuronal, and oligodendroglial cytoplasmic inclusions in the pontine nuclei in multiple system atrophy
    • Arima K, Uéda K, Sunohara N, Arakawa K, Hirai S, Nakamura M, Tonozuka-Uehara H, Kawai M: NACP/α-synuclein immunoreactivity in fibrillary components of neuronal, and oligodendroglial cytoplasmic inclusions in the pontine nuclei in multiple system atrophy Acta Neuropathol 1998, 96:439-444
    • (1998) Acta Neuropathol , vol.96 , pp. 439-444
    • Arima, K.1    Uéda, K.2    Sunohara, N.3    Arakawa, K.4    Hirai, S.5    Nakamura, M.6    Tonozuka-Uehara, H.7    Kawai, M.8
  • 12
    • 0032584686 scopus 로고    scopus 로고
    • Filamentous α-synuclein inclusions link multiple system atrophy with Parkinson's disease, and dementia with Lewy bodies
    • Spillantini MG, Crowther RA, Jakes H, Cairns NJ, Lantos PL, Goedert M: Filamentous α-synuclein inclusions link multiple system atrophy with Parkinson's disease, and dementia with Lewy bodies. Neurosci Lett 1998, 251:205-208
    • (1998) Neurosci Lett , vol.251 , pp. 205-208
    • Spillantini, M.G.1    Crowther, R.A.2    Jakes, H.3    Cairns, N.J.4    Lantos, P.L.5    Goedert, M.6
  • 13
    • 0032546895 scopus 로고    scopus 로고
    • α-Synuclein immunoreactivity in glial cytoplasmic inclusions in multiple system atrophy
    • Wakabayashi K, Yoshimoto M, Tsuji S, Takahashi H: α-Synuclein immunoreactivity in glial cytoplasmic inclusions in multiple system atrophy. Neurosci Lett 1998, 249:180-182
    • (1998) Neurosci Lett , vol.249 , pp. 180-182
    • Wakabayashi, K.1    Yoshimoto, M.2    Tsuji, S.3    Takahashi, H.4
  • 15
    • 0032568534 scopus 로고    scopus 로고
    • α-synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with Lewy bodies
    • Spillantini MG, Crowther RA, Jakes R, Hasegawa M, Goedert M: α-synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with Lewy bodies. Proc Natl Acad Sci USA 1998, 95:6469-6473
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 6469-6473
    • Spillantini, M.G.1    Crowther, R.A.2    Jakes, R.3    Hasegawa, M.4    Goedert, M.5
  • 16
    • 0031661141 scopus 로고    scopus 로고
    • Abnormal distribution of the non-Ab component of Alzheimer's disease amyloid precursor/α-synuclein in Lewy body disease as revealed by proteinase K and formic acid pretreatment
    • Takeda A, Hashimoto M, Mallory M, Sundsmo M, Hansen L, Sisk A, Masliah E: Abnormal distribution of the non-Ab component of Alzheimer's disease amyloid precursor/α-synuclein in Lewy body disease as revealed by proteinase K and formic acid pretreatment. Lab Invest 1998, 78:1169-1177
    • (1998) Lab Invest , vol.78 , pp. 1169-1177
    • Takeda, A.1    Hashimoto, M.2    Mallory, M.3    Sundsmo, M.4    Hansen, L.5    Sisk, A.6    Masliah, E.7
  • 17
    • 0031715399 scopus 로고    scopus 로고
    • Accumulation of α-synuclein/NACP is a cytopathological feature common to Lewy body disease and multiple system atrophy
    • Wakabayashi K, Hayashi S, Kakita A, Yamada M, Toyoshima Y, Yoshimoto M, Takahashi H: Accumulation of α-synuclein/NACP is a cytopathological feature common to Lewy body disease and multiple system atrophy. Acta Neuropathol 1998, 96:445-452
    • (1998) Acta Neuropathol , vol.96 , pp. 445-452
    • Wakabayashi, K.1    Hayashi, S.2    Kakita, A.3    Yamada, M.4    Toyoshima, Y.5    Yoshimoto, M.6    Takahashi, H.7
  • 19
    • 0023722437 scopus 로고
    • Synuclein: A neuron-specific protein localized to the nucleus, and presynaptic nerve terminal
    • Maroteaux L, Campanelli JT, Scheller RH: Synuclein: a neuron-specific protein localized to the nucleus, and presynaptic nerve terminal. J Neurosci 1988, 8:2804-2815
    • (1988) J Neurosci , vol.8 , pp. 2804-2815
    • Maroteaux, L.1    Campanelli, J.T.2    Scheller, R.H.3
  • 20
    • 0032102455 scopus 로고    scopus 로고
    • The synucleins: A family of proteins involved in synaptic function, plasticity, neurodegeneration and disease
    • Clayton DF, George JM: The synucleins: a family of proteins involved in synaptic function, plasticity, neurodegeneration and disease. Trends Neurosci 1998, 21:249-254
    • (1998) Trends Neurosci , vol.21 , pp. 249-254
    • Clayton, D.F.1    George, J.M.2
  • 21
    • 0031763264 scopus 로고    scopus 로고
    • The synuclein family
    • Laveden C: The synuclein family. Genome Res 1998, 8:871-880
    • (1998) Genome Res , vol.8 , pp. 871-880
    • Laveden, C.1
  • 22
    • 0028277520 scopus 로고
    • Identification of two distinct synucleins from human brain
    • Jakes R, Spillantini MG, Goedert M: Identification of two distinct synucleins from human brain. FEBS Lett 1994, 345:27-32
    • (1994) FEBS Lett , vol.345 , pp. 27-32
    • Jakes, R.1    Spillantini, M.G.2    Goedert, M.3
  • 23
    • 0028985267 scopus 로고
    • The precursor protein of non-Aβ component of Alzheimer's disease amyloid is a presynaptic protein of the central nervous system
    • Iwai A, Masliah E, Yoshimoto M, Ge N, Flanagan L, de Silva HAR, Kittel A, Saitoh T: The precursor protein of non-Aβ component of Alzheimer's disease amyloid is a presynaptic protein of the central nervous system. Neuron 1995, 14:467-475
    • (1995) Neuron , vol.14 , pp. 467-475
    • Iwai, A.1    Masliah, E.2    Yoshimoto, M.3    Ge, N.4    Flanagan, L.5    De Silva, H.A.R.6    Kittel, A.7    Saitoh, T.8
  • 25
    • 0028984925 scopus 로고
    • Non-Aβ component of Alzheimer's disease amyloid (NAC) is amyloidogenic
    • Iwai A, Yoshimoto M, Masliah E, Saitoh T: Non-Aβ component of Alzheimer's disease amyloid (NAC) is amyloidogenic. Biochemistry 1995, 34:10139-10145
    • (1995) Biochemistry , vol.34 , pp. 10139-10145
    • Iwai, A.1    Yoshimoto, M.2    Masliah, E.3    Saitoh, T.4
  • 26
    • 0030025635 scopus 로고    scopus 로고
    • Altered presynaptic protein NACP is associated with plaque formation and neurodegeneration in Alzheimer's disease
    • Masliah E, Iwai A, Mallory M, Uéda K, Saitoh T: Altered presynaptic protein NACP is associated with plaque formation and neurodegeneration in Alzheimer's disease. Am J Pathol 1996, 148:201-210
    • (1996) Am J Pathol , vol.148 , pp. 201-210
    • Masliah, E.1    Iwai, A.2    Mallory, M.3    Uéda, K.4    Saitoh, T.5
  • 29
    • 0025908356 scopus 로고
    • The consortium to establish a registry of Alzheimer's disease (CERAD). II. Standardization of the neuropathological assessment of Alzheimer's disease
    • Mirra SS, Heyman A, McKeel D, Sumi SM, Grain BJ, Brownlee LM, Vogel FS, Hughes JP, van Belle G, Berg L, participating CERAD neuropathologists: The consortium to establish a registry of Alzheimer's disease (CERAD). II. Standardization of the neuropathological assessment of Alzheimer's disease. Neurology 1991, 41:479-486
    • (1991) Neurology , vol.41 , pp. 479-486
    • Mirra, S.S.1    Heyman, A.2    McKeel, D.3    Sumi, S.M.4    Grain, B.J.5    Brownlee, L.M.6    Vogel, F.S.7    Hughes, J.P.8    Van Belle, G.9    Berg, L.10
  • 32
    • 0031959497 scopus 로고    scopus 로고
    • Secretion of Alzheimer's disease Aβ amyloid peptide by activated human platelets
    • Li Q-X, Whyte S, Tanner JE, Evin G, Beyreuther K, Masters CL: Secretion of Alzheimer's disease Aβ amyloid peptide by activated human platelets. Lab Invest 1998, 78:461-469
    • (1998) Lab Invest , vol.78 , pp. 461-469
    • Li, Q.-X.1    Whyte, S.2    Tanner, J.E.3    Evin, G.4    Beyreuther, K.5    Masters, C.L.6
  • 35
  • 36
    • 0031051539 scopus 로고    scopus 로고
    • Delayed localization of synelfin (synuclein, NACP) to presynaptic terminals in cultured rat hippocampal neurons
    • Withers GS, George JM, Banker GA, Clayton DF: Delayed localization of synelfin (synuclein, NACP) to presynaptic terminals in cultured rat hippocampal neurons. Brain Res Dev Brain Res 1997, 99:87-94
    • (1997) Brain Res Dev Brain Res , vol.99 , pp. 87-94
    • Withers, G.S.1    George, J.M.2    Banker, G.A.3    Clayton, D.F.4
  • 37
    • 0026635881 scopus 로고
    • Tangle-associated neuritic clusters: A new lesion in Alzheimer's disease and aging suggests that aggregates of dystrophic neurites are not necessarily associated with β/A4
    • Munoz DG, Wang D: Tangle-associated neuritic clusters: a new lesion in Alzheimer's disease and aging suggests that aggregates of dystrophic neurites are not necessarily associated with β/A4. Am J Pathol 1992, 140:1167-1178
    • (1992) Am J Pathol , vol.140 , pp. 1167-1178
    • Munoz, D.G.1    Wang, D.2
  • 38
    • 0032545154 scopus 로고    scopus 로고
    • Degenerative terminals of the perforant pathway are human α-synuclein-immunoreactive in the hippocampus of patients with diffuse Lewy body disease
    • Iseki E, Marui W, Kosaka K, Ariyama H, Ueda K, Iwatsubo T: Degenerative terminals of the perforant pathway are human α-synuclein-immunoreactive in the hippocampus of patients with diffuse Lewy body disease. Neurosci Lett 1998, 258:81-84
    • (1998) Neurosci Lett , vol.258 , pp. 81-84
    • Iseki, E.1    Marui, W.2    Kosaka, K.3    Ariyama, H.4    Ueda, K.5    Iwatsubo, T.6
  • 39
    • 0025943418 scopus 로고
    • Hippocampal degeneration differentiates diffuse Lewy body disease (DLBD) form Alzheimer s disease: Light and electron microscopic immunocytochemistry of CA2-3 neurites specific to DLBD
    • Dickson DW, Ruan D, Crystal H, Mark MH, Davies P, Kress Y, Yen S-H: Hippocampal degeneration differentiates diffuse Lewy body disease (DLBD) form Alzheimer s disease: light and electron microscopic immunocytochemistry of CA2-3 neurites specific to DLBD. Neurology 1991, 41:1402-1409
    • (1991) Neurology , vol.41 , pp. 1402-1409
    • Dickson, D.W.1    Ruan, D.2    Crystal, H.3    Mark, M.H.4    Davies, P.5    Kress, Y.6    Yen, S.-H.7
  • 40
    • 0031925215 scopus 로고    scopus 로고
    • Dementia with Lewy bodies: A distinct non-Alzheimer dementia syndrome?
    • Ince PG, Perry EK, Morris CM: Dementia with Lewy bodies: a distinct non-Alzheimer dementia syndrome? Brain Pathol 1998, 8:299-324
    • (1998) Brain Pathol , vol.8 , pp. 299-324
    • Ince, P.G.1    Perry, E.K.2    Morris, C.M.3
  • 42
    • 0344301876 scopus 로고    scopus 로고
    • Changes in presynaptic protein NACP/α-synuclein in an ischemic gerbil hippocampus
    • Ishimaru H, Uéda K, Takahashi A, Maruyama Y: Changes in presynaptic protein NACP/α-synuclein in an ischemic gerbil hippocampus. Brain Res 1998, 788:311-314
    • (1998) Brain Res , vol.788 , pp. 311-314
    • Ishimaru, H.1    Uéda, K.2    Takahashi, A.3    Maruyama, Y.4
  • 43
    • 0032540327 scopus 로고    scopus 로고
    • Stabilization of α-synuclein secondary structure upon binding to synthetic membrane
    • Davidson WS, Jonas A, Clayton DF, George JM: Stabilization of α-synuclein secondary structure upon binding to synthetic membrane. J Biol Chem 1998, 273:9443-9449
    • (1998) J Biol Chem , vol.273 , pp. 9443-9449
    • Davidson, W.S.1    Jonas, A.2    Clayton, D.F.3    George, J.M.4
  • 44
    • 0031866281 scopus 로고    scopus 로고
    • Expression pattern of synucleins (non-Aβ component of Alzheimer's disease amyloid precursor protein/α-synuclein) during murine brain development
    • Hsu LJ, Mallory M, Xia Y, Veinbergs I, Hashimoto M, Yoshimoto M, Thai LJ, Saitoh T, Masliah E: Expression pattern of synucleins (non-Aβ component of Alzheimer's disease amyloid precursor protein/α-synuclein) during murine brain development. J Neurochem 1998, 338-344
    • (1998) J Neurochem , pp. 338-344
    • Hsu, L.J.1    Mallory, M.2    Xia, Y.3    Veinbergs, I.4    Hashimoto, M.5    Yoshimoto, M.6    Thai, L.J.7    Saitoh, T.8    Masliah, E.9
  • 45
    • 0032533733 scopus 로고    scopus 로고
    • The N-terminal region of non-Aβ component of Alzheimer's disease amyloid is responsible for its tendency to assume β-sheet, and aggregate to form fibrils
    • El-Agnaf OMA, Bodies AM, Guthrie DJS, Harriott P, Irvine GB: The N-terminal region of non-Aβ component of Alzheimer's disease amyloid is responsible for its tendency to assume β-sheet, and aggregate to form fibrils. Eur J Biochem 1998, 258:157-163
    • (1998) Eur J Biochem , vol.258 , pp. 157-163
    • El-Agnaf, O.M.A.1    Bodies, A.M.2    Guthrie, D.J.S.3    Harriott, P.4    Irvine, G.B.5
  • 46
    • 0032573597 scopus 로고    scopus 로고
    • Aggregates from mutant and wild-type α-synuclein proteins and NAC peptide induce apoptotic cell death in human neuroblastoma cells by formation of β-sheet and amyloid-like filaments
    • El-Agnaf OMA, Jakes R, Curran MD, Middleton D, Ingenito R, Bianchi E, Pessi A, Neill D, Wallace A: Aggregates from mutant and wild-type α-synuclein proteins and NAC peptide induce apoptotic cell death in human neuroblastoma cells by formation of β-sheet and amyloid-like filaments. FEBS Lett 1998, 440:71-75
    • (1998) FEBS Lett , vol.440 , pp. 71-75
    • El-Agnaf, O.M.A.1    Jakes, R.2    Curran, M.D.3    Middleton, D.4    Ingenito, R.5    Bianchi, E.6    Pessi, A.7    Neill, D.8    Wallace, A.9
  • 47
    • 0029257497 scopus 로고
    • The core Alzheimer's peptide NAC forms amyloid fibrils which seed and are seeded by β-amyloid: Is NAC a common trigger or target in neurodegenerative disease?
    • Han H, Weinreb PH, Lansbury PT: The core Alzheimer's peptide NAC forms amyloid fibrils which seed and are seeded by β-amyloid: is NAC a common trigger or target in neurodegenerative disease? Chem Biol 1995, 2:163-169
    • (1995) Chem Biol , vol.2 , pp. 163-169
    • Han, H.1    Weinreb, P.H.2    Lansbury, P.T.3


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