Fiber diffraction of synthetic α-synuclein filaments shows amyloid-like cross-β conformation

Proceedings of the National Academy of Sciences of the United States of America

Volumn 97, Issue 9, 2000, Pages 4897-4902

  Serpell, Louise C ^a   Berriman, John ^a   Jakes, Ross ^a   Goedert, Michel ^a   Crowther, R Anthony ^a  

^a MRC LABORATORY OF MOLECULAR BIOLOGY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA SYNUCLEIN; AMYLOID; RECOMBINANT PROTEIN; SYNTHETIC PEPTIDE;

ANIMAL TISSUE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL INCLUSION; CIRCULAR DICHROISM; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DEMENTIA; ELECTRON DIFFRACTION; FIBER; HUMAN; HUMAN TISSUE; LEWY BODY; NEUROPATHOLOGY; NONHUMAN; PARKINSON DISEASE; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN SECONDARY STRUCTURE; RAT; SHY DRAGER SYNDROME; X RAY DIFFRACTION;

ALPHA-SYNUCLEIN; AMYLOID; ANIMALS; CIRCULAR DICHROISM; GAMMA-SYNUCLEIN; HUMANS; MICROSCOPY, ELECTRON; NERVE TISSUE PROTEINS; PHOSPHOPROTEINS; PROTEIN CONFORMATION; RATS; RECOMBINANT PROTEINS; SONGBIRDS; SYNUCLEINS; X-RAY DIFFRACTION;

ANIMALIA; TAENIOPYGIA GUTTATA;

EID: 0034712918     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.97.9.4897     Document Type: Article

References (55)

1. Lewy, F. (1912) in Handbuch der Neurologie, eds. Lewandowsky, M. & Abelsdorff, G. (Springer, Berlin), Vol. 3, pp. 920-933.
2. Trétiakoff, M. C. (1919) Ph.D. thesis, (University of Paris).
3. Okazaki, H., Lipkin, L. E. & Aronson, S. M. (1961) J. Neuropathol. Exp. Neurol. 21, 442-449.
4. Kosaka, K. (1978) Acta Neuropathol. 42, 127-134.
5. Duffy, P. E. & Tennyson, V. M. (1965) J. Neuropathol. Exp. Neurol. 24, 398-414.
6. Polymeropoulos, M. H., Lavedan, C., Leroy, E., Ide, S. E., Dehejia, A., Dutra, A., Pike, B., Root, H., Rubenstein, J., Boyer, R., et al. (1997) Science 276, 2045-2047.
7. Spillantini, M. G., Schmidt, M. L., Lee, V. M.-Y., Trojanowski, J. Q., Jakes, R. & Goedert, M. (1997) Nature (London) 388, 839-840.
8. Spillantini, M. G., Crowther, R. A., Jakes, R., Hasegawa, M. & Goedert, M. (1998) Proc. Natl. Acad. Sci. USA 95, 6469-6473.
9. Wakabayashi, K., Yoshimoto, M., Tsuji, S. & Takahashi, H. (1998) Neurosci. Lett. 249, 180-182.
10. Mezey, E., Dehejia, A., Harta, G., Papp, M. I, Polymeropoulos, M. H. & Brownstein, M. J. (1998) Nat. Med. 4, 755-757.
11. Spillantini, M. G., Crowther, R. A., Jakes, R., Cairns, N. J., Lantos, P. L. & Goedert, M. (1998) Neurosci. Lett. 251, 205-208.
12. Tu, P.-H., Galvin, J. E., Baba, M., Giasson, B., Tomita, T., Leight, S., Nakajo, S., Iwatsubo, T., Trojanowski, J. Q. & Lee, V. M.-Y. (1998) Ann. Neurol. 44, 415-422.
13. Uéda, K., Fukushima, H., Masliah, E., Xia, Y., Iwai, A., Yoshimoto, M., Otero, D. A., Kondo, J., Ihara, Y. & Saitoh, T. (1993) Proc. Natl. Acad. Sci. USA 90, 11282-11286.
14. Jakes, R., Spillantini, M. G. & Goedert, M. (1994) FEBS Lett. 345, 27-32.
15. Tobe, T., Nakajo, S., Tanaka, A., Mitoya, A., Omata, K., Nakaya, K., Tomita, M. & Nakamura, Y. (1992) J. Neurochem. 59, 1624-1629.
16. Ji, H., Liu, Y. E., Jia, T., Wang, M., Liu, J., Xiao, G., Joseph, B. K., Rosen, C. & Shi, Y. E. (1997) Cancer Res. 57, 759-764.
17. Buchman, V. L., Hunter, H. J. A., Pinon, L. G. P., Thompson, J., Privalova, E. M., Ninkina, N. N. & Davies, A. M. (1998) J. Neurosci. 18, 9335-9341.
18. Krüger, R., Kuhn, W., Müller, T., Woitalla, D., Graeber, M., Kösel, S., Przuntek, H., Epplen, J. T., Schöls, L. & Riess, O. (1998) Nat. Genet. 18, 106-108.
19. Maroteaux, L. & Scheller, R. H. (1991) Mol. Brain Res. 11, 335-343.
20. George, J. M., Jin, H., Woods, W. S. & Clayton, D. F. (1995) Neuron 15, 361-372.
21. Crowther, R. A., Jakes, R., Spillantini, M. G. & Goedert, M. (1998) FEBS Lett. 436, 309-312.
22. El-Agnaf, O. M. A., Jakes, R., Curran, M. D. & Wallace, A. (1998) FEBS Lett. 440, 67-70.
23. Conway, K. A., Harper, J. D. & Lansbury, P. T. (1998) Nat. Med. 4, 1318-1320.
24. Giasson, B. I., Uryu, K., Trojanowski, J. Q. & Lee, V. M.-Y. (1999) J. Biol. Chem. 274, 7619-7622.
25. Narhi, L., Wood, S. J., Steavenson, S., Jiang, Y., Wu, G. M., Anafi, D., Kaufman, S. A., Martin, F., Sitney, K., Denis, P., et al. (1999) J. Biol. Chem. 274, 9843-9846.
26. Wood, S. J., Wypych, J., Steavenson, S., Louis, J.-C., Citron, M. & Biere, A. L. (1999) J. Biol. Chem. 274, 19509-19512.
27. Conway, K. A., Lee, S.-J., Rochet, J.-C., Ding, T. T., Williamson, R. E. & Lansbury, P. T. (2000) Proc. Natl. Acad. Sci. USA 97, 571-576.
28. Jensen, P. H., Nielsen, M. H., Jakes, R., Dotti, C. G. & Goedert, M. (1998) J. Biol. Chem. 273, 26292-26294.
29. Cohen, A. S. & Calkins, E. (1959) Nature (London) 183, 1202-1203.
30. Eanes, E. D. & Glenner, G. G. (1968) J. Histochem. Cytochem. 16, 673-677.
31. Sunde, M., Serpell, L. C., Bartlam, M., Fraser, P. E., Pepys, M. B. & Blake, C. C. F. (1997) J. Mol. Biol. 273, 729-739.
32. Jakes, R., Crowther, R. A., Lee, V. M.-Y., Trojanowski, J. O., Iwatsubo, T. & Goedert, M. (1999) Neurosci. Lett. 269, 13-16.
33. Leslie, A. G. W. (1992) Joint CCP4 and ESF-EAMCB Newsletter on Protein Crystallography, No. 26.
34. Crowther, R. A. (1991) Proc. Natl. Acad. Sci. USA 88, 2288-2292.
35. Baba, M., Nakajo, S., Tu, P.-H., Tomita, T., Nakaya, K., Lee, V. M.-Y., Trojanowski, J. Q. & Iwatsubo, T. (1998) Am. J. Pathol. 152, 879-884.
36. Gai, W. P., Power, J. H. T., Blumbergs, P. C., Culvenor, J. G. & Jensen, P. H. (1999) J. Neurochem. 73, 2093-2100.
37. Goedert, M., Spillantini, M. G., Cairns, N. J. & Crowther, R. A. (1992) Neuron 8, 159-168.
38. Novak, M., Kabat, J. & Wischik, C. M. (1993) EMBO J. 12, 365-370.
39. Lincoln, S., Gwinn-Hardy, K., Goudreau, J., Chartier-Harlin, M. C., Baker, M., Mouroux, V., Richard, F., Destée, A., Becquet, E., Amouyel, P., et al. (1999) Neurosci. Lett. 259, 65-66.
40. Lincoln, S., Crook, R., Chartier-Harlin, M. C., Gwinn-Hardy, K., Baker, M., Mouroux, V., Richard, F., Becquet, E., Amouyel, P., Destée, A., et al. (1999) Neurosci. Lett. 269, 107-109.
41. Flowers, J. M., Leigh, P. N., Davies, A. M., Ninkina, N. N., Buchman, V. L., Vaughan, J., Wood, N. W. & Powell, J. F. (1999) Neurosci. Lett. 274, 21-24.
42. Bennett, C. M., Bishop, J. F., Leng, Y., Chock, P. B., Chase, T. N. & Mouradian, M. M. (1999) J. Biol. Chem. 274, 33855-33858.
43. Zagorski, M. G., Yang, J., Shao, H., Ma, K., Zeng, H. & Hong, A. (1999) Methods Enzymol. 309, 189-204.
44. Serio, T. R., Cashikar, A. G., Moslehi, J. J., Kowal, A. S. & Lindquist, S. L. (1999) Methods Enzymol. 309, 649-673.
45. Weinreb, P. H., Zhen, W., Poon, A. W., Conway, K. A. & Lansbury, P. T. (1996) Biochemistry 35, 13709-13715.
46. Pan, K.-M., Baldwin, M. A., Nguyen, J. T., Gaseet, M., Serban, A., Groth, D., Mehlhorn, I., Huang, Z., Fletterick, R. J., Cohen, F. E. & Prusiner, S. B. (1993) Proc. Natl. Acad. Sci. USA 90, 10962-10966.
47. Barrow, C. J. & Zagorski, M. G. (1991) Science 253, 179-182.
48. Hilbich, C., Kisters-Woike, B., Reed, J., Masters, C. L. & Beyreuther, K. (1991) J. Mol. Biol. 218, 149-163.
49. Geddes, A. J., Parker, K. D., Atkins, E. D. T. & Beighton, E. A. J. (1968) J. Mol. Biol. 32, 343-358.
50. Blake, C. C. F. & Serpell, L. C. (1996) Structure 4, 989-998.
51. Sunde, M. & Blake, C. C. F. (1998) Quart. Rev. Biophys. 31, 1-39.
52. Goedert, M., Spillantini, M. G. & Davies, S. W. (1998) Curr. Opin. Neurobiol. 8, 619-632.
53. Perutz, M. F. (1999) Trends Biochem. Sci. 24, 58-63.
54. Kirschner, D. A., Inouye, H., Duffy, L. K., Sinclair, A., Lind, M. & Selkoe, D. J. (1987) Proc. Natl. Acad. Sci. USA 84, 6953-6957.
55. Schweers, O., Schönbrunn-Hanebeck, E., Marx, A. & Mandelkow, E. (1994) J. Biol. Chem. 269, 24290-24297.