In vitro acute and developmental neurotoxicity screening: an overview of cellular platforms and high-throughput technical possibilities

Archives of Toxicology

Volumn 91, Issue 1, 2017, Pages

  Schmidt, Béla Z ^a,b   Lehmann, Martin ^a,c   Gutbier, Simon ^d   Nembo, Erastus ^a,c   Noel, Sabrina ^e   Smirnova, Lena ^f   Forsby, Anna ^g,h   Hescheler, Jürgen ^c   Avci, Hasan X ^a,i   Hartung, Thomas ^f   Leist, Marcel ^d   Kobolák, Julianna ^a   Dinnyés, András ^a,j  

^a BIOTALENTUM LTD   (Hungary)

^b UNIVERSITY OF LEUVEN   (Belgium)

^c UNIVERSITY OF COLOGNE   (Germany)

^d UNIVERSITY OF KONSTANZ   (Germany)

^e UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

^f JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

^g Swedish Toxicology Sciences Research Center (Swetox)   (Sweden)

^h STOCKHOLM UNIVERSITY   (Sweden)

ⁱ UNIVERSITY OF SZEGED   (Hungary)

^j SZENT ISTVÁN UNIVERSITY   (Hungary)

more..

Author keywords

Assay development; Cell death; Developmental neurotoxicity; Electrophysiology; High throughput screening; In vitro testing; Neurodevelopment; Neurotoxicity; Stem cells

Indexed keywords

MICRORNA; REACTIVE OXYGEN METABOLITE; MUTAGENIC AGENT; NEUROTOXIN; TERATOGENIC AGENT;

ACUTE TOXICITY; BLOOD BRAIN BARRIER; CALCIUM TRANSPORT; CELL DIFFERENTIATION; CELL MEMBRANE POTENTIAL; CELL MIGRATION; CELL STRUCTURE; CELL VIABILITY; CELL VIABILITY ASSAY; CHRONIC TOXICITY; ELECTROPHYSIOLOGICAL PROCEDURES; EMBRYONIC STEM CELL; FLUOROMETRY; FUNCTIONAL DISEASE; GLIOSIS; HAZARD ASSESSMENT; HIGH CONTENT IMAGING; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN EMBRYONIC STEM CELL; IMPEDANCE; IN VITRO STUDY; METABOLOMICS; MICROSCOPY; MULTICHANNEL PARALLEL MICROSCOPY; MYELINATION; NERVE CELL; NEURAL STEM CELL; NEUROCHEMISTRY; NEUROLOGIC DISEASE; NEUROTOXICITY; NONHUMAN; PREDICTION; PRIMARY CELL; PRIORITY JOURNAL; REVIEW; SPECTROPHOTOMETRY; SYNAPTIC TRANSMISSION; SYNAPTOGENESIS; TOXICITY TESTING; TRANSCRIPTOMICS; ANIMAL; ANIMAL TESTING ALTERNATIVE; BIOLOGICAL MODEL; CELL CULTURE; CELL LINE; CYTOLOGY; DRUG EFFECTS; INDUCED PLURIPOTENT STEM CELL; LABORATORY AUTOMATION; METABOLISM; PRACTICE GUIDELINE; PROCEDURES; RISK ASSESSMENT; STANDARDS; TOXICOKINETICS; TOXICOLOGY; TRENDS;

ANIMAL TESTING ALTERNATIVES; ANIMALS; AUTOMATION, LABORATORY; BLOOD-BRAIN BARRIER; CELL LINE; CELLS, CULTURED; GUIDELINES AS TOPIC; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; INDUCED PLURIPOTENT STEM CELLS; MODELS, BIOLOGICAL; MUTAGENS; NEURAL STEM CELLS; NEURONS; NEUROTOXINS; RISK ASSESSMENT; TERATOGENS; TOXICITY TESTS, ACUTE; TOXICOKINETICS; TOXICOLOGY;

EID: 84983002040     PISSN: 03405761     EISSN: 14320738     Source Type: Journal    
DOI: 10.1007/s00204-016-1805-9     Document Type: Review

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