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Volumn 30, Issue 2, 2013, Pages 209-225

T4 Report* Metabolomics in toxicology and preclinical research

(29)  Ramirez, Tzutzuy a   Daneshian, Mardas b   Kamp, Hennicke a   Bois, Frederic Y c   Clench, Malcolm R d   Coen, Muireann e   Donley, Beth f   Fischer, Steven M g   Ekman, Drew R h   Fabian, Eric a   Guillou, Claude i   Heuer, Joachim j   Hogberg, Helena T k   Jungnickel, Harald j   Keun, Hector C e   Krennrich, Gerhard a   Krupp, Eckart l   Luch, Andreas j   Noor, Fozia m   Peter, Erik n   more..


Author keywords

Metabolomics; Preclinical research; Regulatory toxicology; Toxicology

Indexed keywords

ANTIBODY SPECIFICITY; ARTICLE; ARTIFACT; BIOLOGY; CELL CULTURE; CELL INTERACTION; CROSS FERTILIZATION; DEVELOPMENTAL TOXICITY; FOOD INTAKE; GLYCOLYSIS; HUMAN; IN VITRO STUDY; METABOLISM; METABOLOMICS; MOLECULAR BIOLOGY; NONHUMAN; QUALITY CONTROL; QUANTITATIVE ANALYSIS; RISK ASSESSMENT; RISK FACTOR; SAFETY; SIGNAL NOISE RATIO; SPECIES DIFFERENCE; TARGET ORGAN; TOXICOLOGY; TRANSCRIPTOMICS; TRANSGENIC ORGANISM; TRANSGENIC PLANT; ANIMAL; BIOLOGICAL MODEL; METHODOLOGY; PREDICTIVE VALUE; REPRODUCIBILITY; TOXICITY TESTING;

EID: 84877593138     PISSN: 1868596X     EISSN: 18688551     Source Type: Journal    
DOI: 10.14573/altex.2013.2.209     Document Type: Article
Times cited : (191)

References (82)
  • 1
    • 80053490835 scopus 로고    scopus 로고
    • Can case study approaches speed implementation of the nrc report "toxicity testing in the 21st century: A vision and a strategy?
    • Andersen, M. E., Clewell, H. J., Carmichael, P. L., et al. (2011). Can case study approaches speed implementation of the NRC report: "Toxicity testing in the 21st century: a vision and a strategy?" ALTEX 28, 175-182.
    • (2011) ALTEX , vol.28 , pp. 175-182
    • Andersen, M.E.1    Clewell, H.J.2    Carmichael, P.L.3
  • 2
    • 79955960918 scopus 로고    scopus 로고
    • Linking energy metabolism to dysfunctions in mitochondrial respiration - A metabolomics in vitro approach
    • Balcke, G. U., Kolle, S. N., Kamp, H., et al. (2011). Linking energy metabolism to dysfunctions in mitochondrial respiration - a metabolomics in vitro approach. Toxicol Lett 203, 200-209.
    • (2011) Toxicol Lett , vol.203 , pp. 200-209
    • Balcke, G.U.1    Kolle, S.N.2    Kamp, H.3
  • 3
    • 84861744139 scopus 로고    scopus 로고
    • A roadmap for the development of alternative (non-Animal) methods for systemic toxicity testing - T4 report
    • Basketter, D. A., Clewell, H., Kimber, I., et al. (2012). A roadmap for the development of alternative (non-Animal) methods for systemic toxicity testing - t4 report. ALTEX 29, 3-91.
    • (2012) ALTEX , vol.29 , pp. 3-91
    • Basketter, D.A.1    Clewell, H.2    Kimber, I.3
  • 4
    • 79959310697 scopus 로고    scopus 로고
    • Toxicity Testing in the 21st century defining new risk assessment approaches based on perturbation of intracellular toxicity pathways
    • Bhattacharya, S., Zhang, Q., Carmichael, P. L., et al. (2011). Toxicity testing in the 21st century: defining new risk assessment approaches based on perturbation of intracellular toxicity pathways. PLoS One 6, e20887.
    • (2011) PLoS One , vol.6
    • Bhattacharya, S.1    Zhang, Q.2    Carmichael, P.L.3
  • 5
    • 84871013688 scopus 로고    scopus 로고
    • The use of biomarkers of toxicity for integrating in vitro hazard estimates into risk assessment for humans
    • Blaauboer, B. J., Boekelheide, K., Clewell, H. J., et al. (2012). The use of biomarkers of toxicity for integrating in vitro hazard estimates into risk assessment for humans. ALTEX 29, 411-425.
    • (2012) ALTEX , vol.29 , pp. 411-425
    • Blaauboer, B.J.1    Boekelheide, K.2    Clewell, H.J.3
  • 6
    • 79955724702 scopus 로고    scopus 로고
    • A mechanistic redefinition of adverse effects - A key step in the toxicity testing paradigm shift
    • Boekelheide, K. And Andersen, M. E. (2010). A mechanistic redefinition of adverse effects - a key step in the toxicity testing paradigm shift. ALTEX 27, 243-252.
    • (2010) ALTEX , vol.27 , pp. 243-252
    • Boekelheide, K.1    Andersen, M.E.2
  • 8
    • 45449111362 scopus 로고    scopus 로고
    • Systems toxi cology approach identifies coordinated metabolic responses to copper in a terrestrial non-model invertebrate, the earthworm Lumbricus rubellus
    • Bundy, J. G., Sidhu, J. K., Rana, F., et al. (2008). "Systems toxi cology" approach identifies coordinated metabolic responses to copper in a terrestrial non-model invertebrate, the earthworm Lumbricus rubellus. BMC Biol 6, 25.
    • (2008) BMC Biol , vol.6 , pp. 25
    • Bundy, J.G.1    Sidhu, J.K.2    Rana, F.3
  • 9
    • 58149263489 scopus 로고    scopus 로고
    • Metabolomics and fluxomics approaches
    • Cascante, M. And Marin, S. (2008). Metabolomics and fluxomics approaches. Essays Biochem 45, 67-81.
    • (2008) Essays Biochem , vol.45 , pp. 67-81
    • Cascante, M.1    Marin, S.2
  • 10
    • 79953663708 scopus 로고    scopus 로고
    • Consensus-phenotype integration of transcriptomic and metabolomic data implies a role for metabolism in the chemosensitivity of tumour cells
    • Cavill, R., Kamburov, A., Ellis, J. K., et al. (2011). Consensus-phenotype integration of transcriptomic and metabolomic data implies a role for metabolism in the chemosensitivity of tumour cells. PLoS Comput Biol 7, e1001113.
    • (2011) PLoS Comput Biol , vol.7
    • Cavill, R.1    Kamburov, A.2    Ellis, J.K.3
  • 11
    • 33646198860 scopus 로고    scopus 로고
    • Pharmaco-metabonomic phenotyping and personalized drug treatment
    • Clayton, T. A., Lindon, J. C., Cloarec, O., et al. (2006). Pharmaco-metabonomic phenotyping and personalized drug treatment. Nature 440, 1073-1077.
    • (2006) Nature , vol.440 , pp. 1073-1077
    • Clayton, T.A.1    Lindon, J.C.2    Cloarec, O.3
  • 12
    • 22044435932 scopus 로고    scopus 로고
    • Guidance on good cell culture practice. A report of the second ECVAM task force on good cell culture practice
    • Coecke, S., Balls, M., Bowe, G., et al. (2005). Guidance on good cell culture practice. A report of the second ECVAM task force on good cell culture practice. Altern Lab Anim 33, 261-287.
    • (2005) Altern Lab Anim , vol.33 , pp. 261-287
    • Coecke, S.1    Balls, M.2    Bowe, G.3
  • 13
    • 70449436364 scopus 로고    scopus 로고
    • Mechanistic aspects and novel biomarkers of responder and non-responder phenotypes in galactosamine-induced hepatitis
    • Coen, M., Want, E. J., Clayton, T. A., et al. (2009). Mechanistic aspects and novel biomarkers of responder and non-responder phenotypes in galactosamine-induced hepatitis. J Proteome Res 8, 5175-5187.
    • (2009) J Proteome Res , vol.8 , pp. 5175-5187
    • Coen, M.1    Want, E.J.2    Clayton, T.A.3
  • 14
    • 77952138048 scopus 로고    scopus 로고
    • Renal biomarker qualification submission: A dialog between the fda-emea and predictive safety testing consortium
    • Dieterle, F., Sistare, F., Goodsaid, F., et al. (2010). Renal biomarker qualification submission: a dialog between the FDA-EMEA and Predictive Safety Testing Consortium. Nat Biotechnol 28, 455-462.
    • (2010) Nat Biotechnol , vol.28 , pp. 455-462
    • Dieterle, F.1    Sistare, F.2    Goodsaid, F.3
  • 15
    • 36348960223 scopus 로고    scopus 로고
    • Prediction and classification of drug toxicity using probabilistic modeling of temporal metabolic data: The consortium on metabonomic toxicology screening approach
    • Ebbels, T. M., Keun, H. C., Beckonert, O. P., et al. (2007). Prediction and classification of drug toxicity using probabilistic modeling of temporal metabolic data: the consortium on metabonomic toxicology screening approach. J Proteome Res 6, 4407-4422.
    • (2007) J Proteome Res , vol.6 , pp. 4407-4422
    • Ebbels, T.M.1    Keun, H.C.2    Beckonert, O.P.3
  • 19
    • 4043136542 scopus 로고    scopus 로고
    • Specific modulation of astrocyte inflammation by inhibition of mixed lineage kinases with CEP-1347
    • Falsig, J., Porzgen, P., Lotharius, J., et al. (2004). Specific modulation of astrocyte inflammation by inhibition of mixed lineage kinases with CEP-1347. J Immunol 173, 2762-2770.
    • (2004) J Immunol , vol.173 , pp. 2762-2770
    • Falsig, J.1    Porzgen, P.2    Lotharius, J.3
  • 20
    • 84555178236 scopus 로고    scopus 로고
    • Comparative metabolomic and genomic analyses of TCDD-elicited metabolic disruption in mouse and rat liver
    • Forgacs, A. L., Kent, M. N., Makley, M. K., et al. (2012). Comparative metabolomic and genomic analyses of TCDD-elicited metabolic disruption in mouse and rat liver. Toxicol Sci 125, 41-55.
    • (2012) Toxicol Sci , vol.125 , pp. 41-55
    • Forgacs, A.L.1    Kent, M.N.2    Makley, M.K.3
  • 21
    • 82755163729 scopus 로고    scopus 로고
    • Biomarkers for drug-induced renal damage and nephrotoxicity-An overview for applied toxicology
    • Fuchs, T. C. And Hewitt, P. (2011). Biomarkers for drug-induced renal damage and nephrotoxicity-An overview for applied toxicology. AAPS J 13, 615-631.
    • (2011) AAPS J , vol.13 , pp. 615-631
    • Fuchs, T.C.1    Hewitt, P.2
  • 22
    • 0030601994 scopus 로고    scopus 로고
    • Tcell stimulus-induced crosstalk between lymphocytes and liver macrophages results in augmented cytokine release
    • Gantner, F., Leist, M., Kusters, S., et al. (1996). Tcell stimulus-induced crosstalk between lymphocytes and liver macrophages results in augmented cytokine release. Exp Cell Res 229, 137-146.
    • (1996) Exp Cell Res , vol.229 , pp. 137-146
    • Gantner, F.1    Leist, M.2    Kusters, S.3
  • 23
    • 79955448933 scopus 로고    scopus 로고
    • Application of laser postionization secondary neutral mass spectrometry/time-of-flight secondary ion mass spectrometry in nanotoxicology: Visualization of nanosilver in human macrophages and cellular responses
    • Haase, A., Arlinghaus, H. F., Tentschert, J., et al. (2011). Application of laser postionization secondary neutral mass spectrometry/time-of-flight secondary ion mass spectrometry in nanotoxicology: visualization of nanosilver in human macrophages and cellular responses. ACS Nano 5, 3059-3068.
    • (2011) ACS Nano , vol.5 , pp. 3059-3068
    • Haase, A.1    Arlinghaus, H.F.2    Tentschert, J.3
  • 24
    • 0036657443 scopus 로고    scopus 로고
    • Good cell culture practice ECVAM good cell culture practice task force report 1
    • Hartung, T., Balls, M., Bardouille, C., et al. (2002). Good cell culture practice. ECVAM good cell culture practice task force report 1. Altern Lab Anim 30, 407-414.
    • (2002) Altern Lab Anim , vol.30 , pp. 407-414
    • Hartung, T.1    Balls, M.2    Bardouille, C.3
  • 25
    • 35448948325 scopus 로고    scopus 로고
    • Food for thought .. on cell culture
    • Hartung, T. (2007). Food for thought ... on cell culture. ALTEX 24, 143-152.
    • (2007) ALTEX , vol.24 , pp. 143-152
    • Hartung, T.1
  • 26
    • 59849129394 scopus 로고    scopus 로고
    • Food for thought .. on the evolution of toxicology and the phasing out of animal testing
    • Hartung, T. And Leist, M. (2008). Food for thought ... on the evolution of toxicology and the phasing out of animal testing. ALTEX 25, 91-102.
    • (2008) ALTEX , vol.25 , pp. 91-102
    • Hartung, T.1    Leist, M.2
  • 27
    • 77953932768 scopus 로고    scopus 로고
    • Food for thought .. on evidence-based toxicology
    • Hartung, T. (2009a). Food for thought ... on evidence-based toxicology. ALTEX 26, 75-82.
    • (2009) ALTEX , vol.26 , pp. 75-82
    • Hartung, T.1
  • 28
    • 67650445156 scopus 로고    scopus 로고
    • Toxicology for the twenty-first century
    • Hartung, T. (2009b). Toxicology for the twenty-first century. Nature 460, 208-212.
    • (2009) Nature , vol.460 , pp. 208-212
    • Hartung, T.1
  • 29
    • 80052910975 scopus 로고    scopus 로고
    • Food for thought .. on mapping the human toxome
    • Hartung, T. And McBride, M. (2011). Food for thought ... on mapping the human toxome. ALTEX 28, 83-93.
    • (2011) ALTEX , vol.28 , pp. 83-93
    • Hartung, T.1    McBride, M.2
  • 31
    • 84867209142 scopus 로고    scopus 로고
    • Endocrine disruptor screening: Regulatory perspectives and needs
    • Hecker, M. And Hollert, H. (2011). Endocrine disruptor screening: regulatory perspectives and needs. Environmental Sciences Europe 23, 15.
    • (2011) Environmental Sciences Europe , vol.23 , pp. 15
    • Hecker, M.1    Hollert, H.2
  • 32
    • 69949140066 scopus 로고    scopus 로고
    • The suitability of BV2 cells as alternative model system for primary microglia cultures or for animal experiments examining brain inflammation
    • Henn, A., Lund, S., Hedtjarn, M., et al. (2009). The suitability of BV2 cells as alternative model system for primary microglia cultures or for animal experiments examining brain inflammation. ALTEX 26, 83-94.
    • (2009) ALTEX , vol.26 , pp. 83-94
    • Henn, A.1    Lund, S.2    Hedtjarn, M.3
  • 33
    • 79952763064 scopus 로고    scopus 로고
    • TLR2 hypersensitivity of astrocytes as functional consequence of previous inflammatory episodes
    • Henn, A., Kirner, S., and Leist, M. (2011). TLR2 hypersensitivity of astrocytes as functional consequence of previous inflammatory episodes. J Immunol 186, 3237-3247.
    • (2011) J Immunol , vol.186 , pp. 3237-3247
    • Henn, A.1    Kirner, S.2    Leist, M.3
  • 34
    • 0034659756 scopus 로고    scopus 로고
    • Phagocytosis of nonapoptotic cells dying by caspase-independent mechanisms
    • Hirt, U. A., Gantner, F., and Leist, M. (2000). Phagocytosis of nonapoptotic cells dying by caspase-independent mechanisms. J Immunol 164, 6520-6529.
    • (2000) J Immunol , vol.164 , pp. 6520-6529
    • Hirt, U.A.1    Gantner, F.2    Leist, M.3
  • 35
    • 77954209548 scopus 로고    scopus 로고
    • Standardization and omics science: Technical and social dimensions are inseparable and demand symmetrical study
    • Holmes, C., McDonald, F., Jones, M., et al. (2010). Standardization and omics science: technical and social dimensions are inseparable and demand symmetrical study. OMICS 14, 327-332.
    • (2010) OMICS , vol.14 , pp. 327-332
    • Holmes, C.1    McDonald, F.2    Jones, M.3
  • 36
    • 0035977862 scopus 로고    scopus 로고
    • Genetic variability in susceptibility and response to toxicants
    • Ingelman-Sundberg, M. (2001). Genetic variability in susceptibility and response to toxicants. Toxicol Lett 120, 259-268.
    • (2001) Toxicol Lett , vol.120 , pp. 259-268
    • Ingelman-Sundberg, M.1
  • 37
    • 84877297399 scopus 로고    scopus 로고
    • Perspectives on validation of high-throughput assays supporting 21st century toxicity testing
    • Judson, R., Kavlock, R., Martin, M., et al. (2013). Perspectives on validation of high-throughput assays supporting 21st century toxicity testing. ALTEX 30, 51-56.
    • (2013) ALTEX , vol.30 , pp. 51-56
    • Judson, R.1    Kavlock, R.2    Martin, M.3
  • 38
    • 84877591229 scopus 로고    scopus 로고
    • A personalized life: Biomarker monitoring from cradle to grave
    • Jungnickel, H. And Luch, A. (2012). A personalized life: biomarker monitoring from cradle to grave. EXS 101, 471-498.
    • (2012) EXS , vol.101 , pp. 471-498
    • Jungnickel, H.1    Luch, A.2
  • 39
    • 84862548045 scopus 로고    scopus 로고
    • Monitoring oxidative stress biomarkers in the lipidome: Is there a roadmap for "human inspection?
    • Jungnickel, H., Tentschert, J., and Luch, A. (2012). Monitoring oxidative stress biomarkers in the lipidome: is there a roadmap for "human inspection"? Curr Mol Med 12, 716-731.
    • (2012) Curr Mol Med , vol.12 , pp. 716-731
    • Jungnickel, H.1    Tentschert, J.2    Luch, A.3
  • 40
    • 84860308551 scopus 로고    scopus 로고
    • Compound selection for in vitro modeling of developmental neurotoxicity
    • Kadereit, S., Zimmer, B., van Thriel, C., et al. (2012). Compound selection for in vitro modeling of developmental neurotoxicity. Front Biosci 17, 2442-2460.
    • (2012) Front Biosci , vol.17 , pp. 2442-2460
    • Kadereit, S.1    Zimmer, B.2    Van Thriel, C.3
  • 41
    • 84856389498 scopus 로고    scopus 로고
    • CHO cells in biotechnology for production of recombinant proteins current state and further potential
    • Kim, J. Y., Kim, Y. G., and Lee, G. M. (2012). CHO cells in biotechnology for production of recombinant proteins: current state and further potential. Appl Microbiol Biotechnol 93, 917-930.
    • (2012) Appl Microbiol Biotechnol , vol.93 , pp. 917-930
    • Kim, J.Y.1    Kim, Y.G.2    Lee, G.M.3
  • 43
    • 81255159025 scopus 로고    scopus 로고
    • Identifying developmental toxicity pathways for a subset of ToxCast chemicals using human embryonic stem cells and metabolomics
    • Kleinstreuer, N. C., Smith, A. M., West, P. R., et al. (2011). Identifying developmental toxicity pathways for a subset of ToxCast chemicals using human embryonic stem cells and metabolomics. Toxicol Appl Pharmacol 257, 111-121.
    • (2011) Toxicol Appl Pharmacol , vol.257 , pp. 111-121
    • Kleinstreuer, N.C.1    Smith, A.M.2    West, P.R.3
  • 44
    • 84861213368 scopus 로고    scopus 로고
    • A testing strategy for the identification of mammalian, systemic endocrine disruptors with particular focus on steroids
    • Kolle, S. N., Ramirez, T., Kamp, H. G., et al. (2012). A testing strategy for the identification of mammalian, systemic endocrine disruptors with particular focus on steroids. Regul Toxicol Pharmacol 63, 259-278.
    • (2012) Regul Toxicol Pharmacol , vol.63 , pp. 259-278
    • Kolle, S.N.1    Ramirez, T.2    Kamp, H.G.3
  • 45
    • 78149477289 scopus 로고    scopus 로고
    • Reduced immunoproteasome formation and accumulation of immunoproteasomal precursors in the brains of lymphocytic choriomeningitis virus-infected mice
    • Kremer, M., Henn, A., Kolb, C., et al. (2010). Reduced immunoproteasome formation and accumulation of immunoproteasomal precursors in the brains of lymphocytic choriomeningitis virus-infected mice. J Immunol 185, 5549-5560.
    • (2010) J Immunol , vol.185 , pp. 5549-5560
    • Kremer, M.1    Henn, A.2    Kolb, C.3
  • 46
    • 0343618415 scopus 로고    scopus 로고
    • Metabolic depletion of ATP by fructose inversely controls CD95- and tumor necrosis factor receptor 1-mediated hepatic apoptosis
    • Latta, M., Kunstle, G., Leist, M., et al. (2000). Metabolic depletion of ATP by fructose inversely controls CD95- and tumor necrosis factor receptor 1-mediated hepatic apoptosis. J Exp Med 191, 1975-1985.
    • (2000) J Exp Med , vol.191 , pp. 1975-1985
    • Latta, M.1    Kunstle, G.2    Leist, M.3
  • 47
    • 59849124092 scopus 로고    scopus 로고
    • The dawning of a new age of toxicology
    • Leist, M., Hartung, T., and Nicotera, P. (2008a). The dawning of a new age of toxicology. ALTEX 25, 103-114.
    • (2008) ALTEX , vol.25 , pp. 103-114
    • Leist, M.1    Hartung, T.2    Nicotera, P.3
  • 48
    • 48949091622 scopus 로고    scopus 로고
    • Food for thought .. on the real success of 3R approaches
    • Leist, M., Kadereit, S., and Schildknecht, S. (2008b). Food for thought ... on the real success of 3R approaches. ALTEX 25, 17-32.
    • (2008) ALTEX , vol.25 , pp. 17-32
    • Leist, M.1    Kadereit, S.2    Schildknecht, S.3
  • 49
    • 79955432219 scopus 로고    scopus 로고
    • Food for thought .. considerations and guidelines for basic test method descriptions in toxicology
    • Leist, M., Efremova, L., and Karreman, C. (2010). Food for thought ... considerations and guidelines for basic test method descriptions in toxicology. ALTEX 27, 309-317.
    • (2010) ALTEX , vol.27 , pp. 309-317
    • Leist, M.1    Efremova, L.2    Karreman, C.3
  • 50
    • 84864593532 scopus 로고    scopus 로고
    • Validation and quality control of replacement alternatives - Current status and future challenges
    • Leist, M., Hasiwa, N., Daneshian, M., et al. (2012a). Validation and quality control of replacement alternatives - current status and future challenges. Toxicol Res 1, 8-22.
    • (2012) Toxicol Res , vol.1 , pp. 8-22
    • Leist, M.1    Hasiwa, N.2    Daneshian, M.3
  • 51
    • 84870984610 scopus 로고    scopus 로고
    • Novel technologies and an overall strategy to allow hazard assessment and risk prediction of chemicals, cosmetics, and drugs with animal-free methods
    • Leist, M., Lidbury, B. A., Yang, C., et al. (2012b). Novel technologies and an overall strategy to allow hazard assessment and risk prediction of chemicals, cosmetics, and drugs with animal-free methods. ALTEX 29, 373-388.
    • (2012) ALTEX , vol.29 , pp. 373-388
    • Leist, M.1    Lidbury, B.A.2    Yang, C.3
  • 52
    • 0037444362 scopus 로고    scopus 로고
    • Contemporary issues in toxicology the role of metabonomics in toxicology and its evaluation by the COMETproject
    • Lindon, J. C., Nicholson, J. K., Holmes, E., et al. (2003). Contemporary issues in toxicology the role of metabonomics in toxicology and its evaluation by the COMETproject. Toxicol Appl Pharmacol 187, 137-146.
    • (2003) Toxicol Appl Pharmacol , vol.187 , pp. 137-146
    • Lindon, J.C.1    Nicholson, J.K.2    Holmes, E.3
  • 53
    • 3242879742 scopus 로고    scopus 로고
    • Metabonomics: Systems biology in pharmaceutical research and development
    • Lindon, J. C., Holmes, E., and Nicholson, J. K. (2004). Metabonomics: systems biology in pharmaceutical research and development. Curr Opin Mol Ther 6, 265-272.
    • (2004) Curr Opin Mol Ther , vol.6 , pp. 265-272
    • Lindon, J.C.1    Holmes, E.2    Nicholson, J.K.3
  • 54
    • 84866395119 scopus 로고    scopus 로고
    • Nutrimetabolomic strategies to develop new biomarkers of intake and health effects
    • Llorach, R., Garcia-Aloy, M., Tulipani, S., et al. (2012). Nutrimetabolomic strategies to develop new biomarkers of intake and health effects. J Agric Food Chem 60, 8797-8808.
    • (2012) J Agric Food Chem , vol.60 , pp. 8797-8808
    • Llorach, R.1    Garcia-Aloy, M.2    Tulipani, S.3
  • 55
    • 84255171164 scopus 로고    scopus 로고
    • Toward in vitro biomarkers for developmental toxicity and their extrapolation to the in vivo situation
    • Louisse, J., Verwei, M., Woutersen, R. A., et al. (2012). Toward in vitro biomarkers for developmental toxicity and their extrapolation to the in vivo situation. Expert Opin Drug Metab Toxicol 8, 11-27.
    • (2012) Expert Opin Drug Metab Toxicol , vol.8 , pp. 11-27
    • Louisse, J.1    Verwei, M.2    Woutersen, R.A.3
  • 56
    • 84863629449 scopus 로고    scopus 로고
    • Metabolomics methods for the synthetic biology of secondary metabolism
    • Nguyen, Q. T., Merlo, M. E., Medema, M. H., et al. (2012). Metabolomics methods for the synthetic biology of secondary metabolism. FEBS Lett 586, 2177-2183.
    • (2012) FEBS Lett , vol.586 , pp. 2177-2183
    • Nguyen, Q.T.1    Merlo, M.E.2    Medema, M.H.3
  • 57
    • 70349767923 scopus 로고    scopus 로고
    • Effects of drugs in subtoxic concentrations on the metabolic fluxes in human hepatoma cell line Hep G2
    • Niklas, J., Noor, F., and Heinzle, E. (2009). Effects of drugs in subtoxic concentrations on the metabolic fluxes in human hepatoma cell line Hep G2. Toxicol Appl Pharmacol 240, 327-336.
    • (2009) Toxicol Appl Pharmacol , vol.240 , pp. 327-336
    • Niklas, J.1    Noor, F.2    Heinzle, E.3
  • 58
    • 36248970923 scopus 로고    scopus 로고
    • NRC Century: A Vision and a Strategy. Washington D.C., USA: The National Academies Press
    • NRC (2007). Toxicity Testing in the 21st Century: A Vision and a Strategy. Washington D.C., USA: The National Academies Press. http://www.nap.edu/openbook.php?record-id=11970
    • (2007) Toxicity Testing in the 21st
  • 59
    • 84858790233 scopus 로고    scopus 로고
    • Innovation: Metabolomics: The apogee of the omics trilogy
    • Patti, G. J., Yanes, O., and Siuzdak, G. (2012). Innovation: Metabolomics: the apogee of the omics trilogy. Nat Rev Mol Cell Biol 13, 263-269.
    • (2012) Nat Rev Mol Cell Biol , vol.13 , pp. 263-269
    • Patti, G.J.1    Yanes, O.2    Siuzdak, G.3
  • 60
    • 84862153039 scopus 로고    scopus 로고
    • The current status of alternatives to animal testing and predictive toxicology methods using liver microfluidic biochips
    • Prot, J. M. And Leclerc, E. (2012). The current status of alternatives to animal testing and predictive toxicology methods using liver microfluidic biochips. Ann Biomed Eng 40, 1228-1243.
    • (2012) Ann Biomed Eng , vol.40 , pp. 1228-1243
    • Prot, J.M.1    Leclerc, E.2
  • 61
    • 84856073205 scopus 로고    scopus 로고
    • Metabolomics and cardiovascular biomarker discovery
    • Rhee, E. P. And Gerszten, R. E. (2012). Metabolomics and cardiovascular biomarker discovery. Clin Chem 58, 139-147.
    • (2012) Clin Chem , vol.58 , pp. 139-147
    • Rhee, E.P.1    Gerszten, R.E.2
  • 62
    • 84863236978 scopus 로고    scopus 로고
    • Detailed mitochondrial phenotyping by high resolution metabolomics
    • Roede, J. R., Park, Y., Li, S., et al. (2012). Detailed mitochondrial phenotyping by high resolution metabolomics. PLoS One 7, e33020.
    • (2012) PLoS One , vol.7
    • Roede, J.R.1    Park, Y.2    Li, S.3
  • 63
    • 79956224108 scopus 로고    scopus 로고
    • An untargeted multi-technique metabolomics approach to studying intracellular metabolites of HepG2 cells exposed to 2 3 78-tetrachlorodibenzo-p- dioxin
    • Ruiz-Aracama, A., Peijnenburg, A., Kleinjans, J., et al. (2011). An untargeted multi-technique metabolomics approach to studying intracellular metabolites of HepG2 cells exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin. BMC Genomics 12, 251.
    • (2011) BMC Genomics , vol.12 , pp. 251
    • Ruiz-Aracama, A.1    Peijnenburg, A.2    Kleinjans, J.3
  • 64
    • 84860157434 scopus 로고    scopus 로고
    • Predictive modeling of chemical hazard by integrating numerical descriptors of chemical structures and short-term toxicity assay data
    • Rusyn, I., Sedykh, A., Low, Y., et al. (2012). Predictive modeling of chemical hazard by integrating numerical descriptors of chemical structures and short-term toxicity assay data. Toxicol Sci 127, 1-9.
    • (2012) Toxicol Sci , vol.127 , pp. 1-9
    • Rusyn, I.1    Sedykh, A.2    Low, Y.3
  • 65
    • 84864628423 scopus 로고    scopus 로고
    • Characterization of mouse cell line IMA 2.1 as a potential model system to study astrocyte functions
    • Schildknecht, S., Kirner, S., Henn, A., et al. (2012). Characterization of mouse cell line IMA 2.1 as a potential model system to study astrocyte functions. ALTEX 29, 261-274.
    • (2012) ALTEX , vol.29 , pp. 261-274
    • Schildknecht, S.1    Kirner, S.2    Henn, A.3
  • 66
    • 79956220666 scopus 로고    scopus 로고
    • Metabolomics: A second-generation platform for crop and food analysis
    • Shepherd, L. V., Fraser, P., and Stewart, D. (2011). Metabolomics: a second-generation platform for crop and food analysis. Bioanalysis 3, 1143-1159.
    • (2011) Bioanalysis , vol.3 , pp. 1143-1159
    • Shepherd, L.V.1    Fraser, P.2    Stewart, D.3
  • 67
    • 84858841248 scopus 로고    scopus 로고
    • Metabolomics-on-A-chip and predictive systems toxicology in microfluidic bioartificial organs
    • Shintu, L., Baudoin, R., Navratil, V., et al. (2012). Metabolomics-on-A-chip and predictive systems toxicology in microfluidic bioartificial organs. Anal Chem 84, 1840-1848.
    • (2012) Anal Chem , vol.84 , pp. 1840-1848
    • Shintu, L.1    Baudoin, R.2    Navratil, V.3
  • 68
    • 84873143423 scopus 로고    scopus 로고
    • Evidence-based toxicology for the 21st century opportunities and challenges
    • Stephens, M. L., Andersen, M., Becker, R. A., et al. (2013). Evidence-based toxicology for the 21st century: Opportunities and challenges. ALTEX 30, 74-104.
    • (2013) ALTEX , vol.30 , pp. 74-104
    • Stephens, M.L.1    Andersen, M.2    Becker, R.A.3
  • 69
    • 70449133447 scopus 로고    scopus 로고
    • Influence of strain and sex on the metabolic profile of rats in repeated dose toxicological studies
    • Strauss, V., Wiemer, J., Leibold, E., et al. (2009). Influence of strain and sex on the metabolic profile of rats in repeated dose toxicological studies. Toxicol Lett 191, 88-95.
    • (2009) Toxicol Lett , vol.191 , pp. 88-95
    • Strauss, V.1    Wiemer, J.2    Leibold, E.3
  • 70
    • 84859932922 scopus 로고    scopus 로고
    • Increased toxicity when fibrates and statins are administered in combination - A metabolomics approach with rats
    • Strauss, V., Mellert, W., Wiemer, J., et al. (2012). Increased toxicity when fibrates and statins are administered in combination - a metabolomics approach with rats. Toxicol Lett 211, 187-200.
    • (2012) Toxicol Lett , vol.211 , pp. 187-200
    • Strauss, V.1    Mellert, W.2    Wiemer, J.3
  • 71
    • 80052390004 scopus 로고    scopus 로고
    • Metabolic flux analysis gives an insight on verapamil induced changes in central metabolism of HL-1 cells
    • Strigun, A., Noor, F., Pironti, A., et al. (2011a). Metabolic flux analysis gives an insight on verapamil induced changes in central metabolism of HL-1 cells. J Biotechnol 155, 299-307.
    • (2011) J Biotechnol , vol.155 , pp. 299-307
    • Strigun, A.1    Noor, F.2    Pironti, A.3
  • 72
    • 79953680145 scopus 로고    scopus 로고
    • Metabolic profiling using HPLC allows classification of drugs according to their mechanisms of action in HL-1 cardiomyocytes
    • Strigun, A., Wahrheit, J., Beckers, S., et al. (2011b). Metabolic profiling using HPLC allows classification of drugs according to their mechanisms of action in HL-1 cardiomyocytes. Toxicol Appl Pharmacol 252, 183-191.
    • (2011) Toxicol Appl Pharmacol , vol.252 , pp. 183-191
    • Strigun, A.1    Wahrheit, J.2    Beckers, S.3
  • 73
    • 84856112404 scopus 로고    scopus 로고
    • Doxorubicin increases oxidative metabolism in HL-1 cardiomyocytes as shown by 13C metabolic flux analysis
    • Strigun, A., Wahrheit, J., Niklas, J., et al. (2012). Doxorubicin increases oxidative metabolism in HL-1 cardiomyocytes as shown by 13C metabolic flux analysis. Toxicol Sci 125, 595-606.
    • (2012) Toxicol Sci , vol.125 , pp. 595-606
    • Strigun, A.1    Wahrheit, J.2    Niklas, J.3
  • 74
    • 84877592682 scopus 로고    scopus 로고
    • TOF-SIMS analysis of cell membrane changes in functional impaired human macrophages after nanosilver treatment
    • in press
    • Tentschert, J., Draude, F., Jungnickel, H., et al. (in press). TOF-SIMS analysis of cell membrane changes in functional impaired human macrophages after nanosilver treatment. Surface and Interface Analysis.
    • Surface and Interface Analysis
    • Tentschert, J.1    Draude, F.2    Jungnickel, H.3
  • 75
    • 34547460023 scopus 로고    scopus 로고
    • The use of metabolomics for the discovery of new biomarkers of effect
    • van Ravenzwaay, B., Cunha, G. C., Leibold, E., et al. (2007). The use of metabolomics for the discovery of new biomarkers of effect. Toxicol Lett 172, 21-28.
    • (2007) Toxicol Lett , vol.172 , pp. 21-28
    • Van Ravenzwaay, B.1    Cunha, G.C.2    Leibold, E.3
  • 77
    • 84861571209 scopus 로고    scopus 로고
    • Metabolomics: A tool for early detection of toxicological effects and an opportunity for biology based grouping of chemicals-from QSAR to QBAR
    • van Ravenzwaay, B., Herold, M., Kamp, H., et al. (2012). Metabolomics: a tool for early detection of toxicological effects and an opportunity for biology based grouping of chemicals-from QSAR to QBAR. Mutat Res 746, 144-150.
    • (2012) Mutat Res , vol.746 , pp. 144-150
    • Van Ravenzwaay, B.1    Herold, M.2    Kamp, H.3
  • 78
    • 79958288447 scopus 로고    scopus 로고
    • Current standing and future prospects for the technologies proposed to transform toxicity testing in the 21st century
    • van Vliet, E. (2011). Current standing and future prospects for the technologies proposed to transform toxicity testing in the 21st century. ALTEX 28, 17-44.
    • (2011) ALTEX , vol.28 , pp. 17-44
    • Van Vliet, E.1
  • 79
    • 84865271285 scopus 로고    scopus 로고
    • Quantitative in vitro to in vivo extrapolation of cell-based toxicity assay results
    • Yoon, M., Campbell, J. L., Andersen, M. E., et al. (2012). Quantitative in vitro to in vivo extrapolation of cell-based toxicity assay results. Crit Rev Toxicol 42, 633-652.
    • (2012) Crit Rev Toxicol , vol.42 , pp. 633-652
    • Yoon, M.1    Campbell, J.L.2    Andersen, M.E.3
  • 80
    • 84855883877 scopus 로고    scopus 로고
    • Recent and potential developments of biofluid analyses in metabolomics
    • Zhang, A., Sun, H., Wang, P., et al. (2012a). Recent and potential developments of biofluid analyses in metabolomics. J Proteomics 75, 1079-1088.
    • (2012) J Proteomics , vol.75 , pp. 1079-1088
    • Zhang, A.1    Sun, H.2    Wang, P.3
  • 81
    • 84865593022 scopus 로고    scopus 로고
    • Serum metabolomics as a novel diagnostic approach for disease: A systematic review
    • Zhang, A., Sun, H., and Wang, X. (2012b). Serum metabolomics as a novel diagnostic approach for disease: a systematic review. Anal Bioanal Chem 404, 1239-1245.
    • (2012) Anal Bioanal Chem , vol.404 , pp. 1239-1245
    • Zhang, A.1    Sun, H.2    Wang, X.3
  • 82
    • 34547914464 scopus 로고    scopus 로고
    • Acute hepatotoxicity: A predictive model based on focused illumina microarrays
    • Zidek, N., Hellmann, J., Kramer, P. J., et al. (2007). Acute hepatotoxicity: a predictive model based on focused illumina microarrays. Toxicol Sci 99, 289-302.ij
    • (2007) Toxicol Sci , vol.99 , pp. 289-302
    • Zidek, N.1    Hellmann, J.2    Kramer, P.J.3


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