An abbreviated protocol for multilineage neural differentiation of murine embryonic stem cells and its perturbation by methyl mercury

Reproductive Toxicology

Volumn 29, Issue 4, 2010, Pages 383-392

  Theunissen, P T ^a,b   Schulpen, S H W ^a   van Dartel, D A M ^a,b   Hermsen, S A B ^a   van Schooten, F J ^b   Piersma, A H ^a,c  

^a NATIONAL INSTITUTE FOR PUBLIC HEALTH AND THE ENVIRONMENT   (Netherlands)

^b MAASTRICHT UNIVERSITY   (Netherlands)

^c UTRECHT UNIVERSITY   (Netherlands)

Author keywords

Alternative test method; Developmental toxicity; Embryonic stem cells; Methyl mercury; Neural differentiation

Indexed keywords

METHYLMERCURY; BIOLOGICAL MARKER; MESSENGER RNA; METHYLMERCURIC CHLORIDE; METHYLMERCURY DERIVATIVE; NERVE PROTEIN; NEUROTOXIN;

ANIMAL CELL; ARTICLE; CELL LINEAGE; CELL STRUCTURE; CONTROLLED STUDY; EMBRYO; EMBRYONIC STEM CELL; ENDODERMIS; FLOW CYTOMETRY; GENE EXPRESSION; IMMUNOCYTOCHEMISTRY; IN VITRO STUDY; MESODERM; MOUSE; NERVE CELL DIFFERENTIATION; NEUROECTODERM; NEUROTOXICITY; NONHUMAN; SCREENING TEST; SENSITIVITY ANALYSIS; TOXICITY TESTING; ANIMAL; ANIMAL TESTING ALTERNATIVE; CELL CULTURE; CELL DIFFERENTIATION; CELL SURVIVAL; CYTOLOGY; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; IMMUNOHISTOCHEMISTRY; METABOLISM; NERVE CELL; PHYSIOLOGY; TOXICITY;

ANIMAL TESTING ALTERNATIVES; ANIMALS; BIOLOGICAL MARKERS; CELL DIFFERENTIATION; CELL LINEAGE; CELL SURVIVAL; CELLS, CULTURED; EMBRYONIC STEM CELLS; FLOW CYTOMETRY; GENE EXPRESSION REGULATION, DEVELOPMENTAL; IMMUNOHISTOCHEMISTRY; METHYLMERCURY COMPOUNDS; MICE; NERVE TISSUE PROTEINS; NEURAL PLATE; NEURONS; NEUROTOXINS; RNA, MESSENGER; TOXICITY TESTS;

ANIMALIA; MURINAE;

EID: 77953546209     PISSN: 08906238     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.reprotox.2010.04.003     Document Type: Article

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