Current approaches and future role of high content imaging in safety sciences and drug discovery

Altex

Volumn 31, Issue 4, 2014, Pages 479-493

  Van Vliet, Erwin ^a   Daneshian, Mardas ^b   Beilmann, Mario ^c   Davies, Anthony ^d   Fava, Eugenio ^e   Fleck, Roland ^f   Julé, Yvon ^g   Kansy, Manfred ^e   Kustermann, Stefan ^h   Macko, Peter ⁱ   Mundy, William R ^j   Roth, Adrian ^h   Shah, Imran ^k   Uteng, Marianne ^l   Van De Water, Bob ^m   Hartung, Thomas ^b,n   Leist, Marcel ^b  

^a Innovitox Consultation and Services   (Spain)

^b UNIVERSITY OF KONSTANZ   (Germany)

^c BOEHRINGER INGELHEIM PHARMA GMBH AND CO KG   (Germany)

^d Irish National Center for High Content Screening and Analysis (INCHSA)   (Ireland)

^e GERMAN CENTER FOR NEURODEGENERATIVE DISEASES DZNE   (Germany)

^f NATIONAL INSTITUTE FOR BIOLOGICAL STANDARDS AND CONTROL   (United Kingdom)

^g Biocellvia   (France)

^h Non Clinical Safety   (Switzerland)

ⁱ JOINT RESEARCH CENTRE   (Italy)

^j U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^k National Center for Computational Toxicology   (United States)

^l NOVARTIS PHARMA AG   (Switzerland)

^m LEIDEN UNIVERSITY   (Netherlands)

ⁿ JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

more..

Author keywords

Drug development; High content imaging; Mechanistic safety screening; Toxicity pathways; Toxicology

Indexed keywords

ADAPTATION; BIOLOGY; BIOSAFETY; CELL DEATH; CELL INTERACTION; CELLULAR IMMUNITY; CONCENTRATION RESPONSE; CONFERENCE PAPER; CYTOTOXICITY; DATA ANALYSIS; DATA BASE; DRUG DEVELOPMENT; DRUG INDUSTRY; HIGH CONTENT IMAGING; HUMAN; IMAGE ANALYSIS; IMAGE ENHANCEMENT; IMAGING AND DISPLAY; MICROSCOPY; NONHUMAN; QUALITY CONTROL; REPRODUCIBILITY; RISK ASSESSMENT; RNA INTERFERENCE; SIGNAL TRANSDUCTION; STANDARDIZATION; TOTAL QUALITY MANAGEMENT; ANIMAL; ANIMAL TESTING ALTERNATIVE; BIOLOGICAL MODEL; DANGEROUS GOODS; PREDICTIVE VALUE; PROCEDURES; THREE DIMENSIONAL IMAGING; TOXICITY TESTING;

DANGEROUS GOODS; DRUG;

ANIMAL TESTING ALTERNATIVES; ANIMALS; DRUG DISCOVERY; HAZARDOUS SUBSTANCES; IMAGING, THREE-DIMENSIONAL; MODELS, BIOLOGICAL; PHARMACEUTICAL PREPARATIONS; PREDICTIVE VALUE OF TESTS; REPRODUCIBILITY OF RESULTS; TOXICITY TESTS;

EID: 84910608382     PISSN: 1868596X     EISSN: 18688551     Source Type: Journal    
DOI: 10.14573/altex.1405271     Document Type: Conference Paper

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