Interpreting in vitro developmental toxicity test battery results: The consideration of toxicokinetics

Reproductive Toxicology

Volumn 55, Issue , 2015, Pages 73-80

  Bosgra, Sieto ^a   Westerhout, Joost ^a  

^a TNO   (Netherlands)

Author keywords

In vitro test battery; In vitro in vivo extrapolation; Protein binding; TK modeling; Toxicokinetics

Indexed keywords

2 ETHYLHEXANOIC ACID; AMMONIUM DERIVATIVE; CYCLOSPORIN A; DIETHYLSTILBESTROL; ENDOSULFAN; GLUPHOSINATE AMMONIUM; HEXANOIC ACID DERIVATIVE; METHOXYACETIC ACID; METHYLHEXANOIC ACID; METHYLMERCURIC CHLORIDE; PHTHALIC ACID 2 ETHYLHEXYL MONOESTER; RETINOIC ACID; UNCLASSIFIED DRUG; VALPROIC ACID; TERATOGENIC AGENT;

ANIMAL EXPERIMENT; ARTICLE; CLINICAL OBSERVATION; CONTROLLED STUDY; DEVELOPMENTAL TOXICITY; IN VITRO STUDY; IN VIVO STUDY; MOUSE; MOUSE DEFENSE TEST BATTERY; NONHUMAN; PREDICTIVE VALUE; PROTEIN BINDING; QUANTITATIVE ANALYSIS; RAT; REPRODUCTIVE TOXICITY; RISK ASSESSMENT; SIMULATION; TOXICOKINETICS; ANIMAL; BIOASSAY; BIOLOGICAL MODEL; FEMALE; PREGNANCY; TOXICITY TESTING;

ANIMALS; BIOLOGICAL ASSAY; FEMALE; MODELS, BIOLOGICAL; PREGNANCY; RATS; RISK ASSESSMENT; TERATOGENS; TOXICITY TESTS; TOXICOKINETICS;

EID: 84937959352     PISSN: 08906238     EISSN: 18731708     Source Type: Journal    
DOI: 10.1016/j.reprotox.2014.11.001     Document Type: Article

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