Translating neurobehavioural endpoints of developmental neurotoxicity tests into in vitro assays and readouts

NeuroToxicology

Volumn 33, Issue 4, 2012, Pages 911-924

  Van Thriel, Christoph ^a   Westerink, Remco H S ^b   Beste, Christian ^c   Bale, Ambuja S ^d   Lein, Pamela J ^e   Leist, Marcel ^f  

^a LEIBNIZ RESEARCH CENTRE FOR WORKING ENVIRONMENT AND HUMAN FACTORS   (Germany)

^b UTRECHT UNIVERSITY   (Netherlands)

^c RUHR UNIVERSITY BOCHUM   (Germany)

^d U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

^f UNIVERSITY OF KONSTANZ   (Germany)

Author keywords

Electrophysiology neurogenetics; Neurite growth; Neurodifferentiation; Neurotransmitter; Stem cells

Indexed keywords

2,2',4,4' TETRABROMODIPHENYL ETHER; BRAIN DERIVED NEUROTROPHIC FACTOR; CHLORPYRIFOS; FLAME RETARDANT; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; ORGANOPHOSPHATE PESTICIDE; POLYCHLORINATED BIPHENYL; SOLVENT; UNCLASSIFIED DRUG;

ALLELE; ARTICLE; ASSAY; CELL MATURATION; CELL STRUCTURE; COGNITION; COGNITIVE DEFECT; DENDRITE; DEVELOPMENTAL NEUROTOXICITY; EMBRYONIC STEM CELL; EX VIVO STUDY; GENETIC DIFFERENCE; GENETICS; HUMAN; IMAGING GENETICS; IN VITRO STUDY; IN VIVO STUDY; LONG TERM POTENTIATION; MOLECULAR DYNAMICS; NERVE CELL DIFFERENTIATION; NERVE CELL PLASTICITY; NERVE FIBER; NERVOUS SYSTEM PARAMETERS; NETWORK FORMATION ASSAY; NEUROBEHAVIORAL TEST; NEUROBIOLOGY; NEUROLOGIC EXAMINATION; NEURON FUNCTIONAL INTEGRITY; NEURONAL CONNECTIVITY; NEUROTOXICITY; NONHUMAN; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; RISK ASSESSMENT; SINGLE NUCLEOTIDE POLYMORPHISM; SOLVENT NEUROTOXICITY; TOXICITY TESTING;

ANIMALS; BEHAVIOR; BEHAVIOR, ANIMAL; CELLS, CULTURED; ENDPOINT DETERMINATION; GENE-ENVIRONMENT INTERACTION; GENETIC PREDISPOSITION TO DISEASE; HUMANS; NERVOUS SYSTEM; NEURAL STEM CELLS; NEURONS; NEUROSCIENCES; NEUROTOXICITY SYNDROMES; PHENOTYPE; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, N-METHYL-D-ASPARTATE; SOLVENTS; TOXICITY TESTS; TRANSLATIONAL MEDICAL RESEARCH;

ANIMALIA;

EID: 84864511648     PISSN: 0161813X     EISSN: 18729711     Source Type: Journal    
DOI: 10.1016/j.neuro.2011.10.002     Document Type: Article

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