An in vitro blood-brain barrier model for high throughput (HTS) toxicological screening

Toxicology in Vitro

Volumn 22, Issue 3, 2008, Pages 799-811

  Culot, Maxime ^a   Lundquist, Stefan ^b   Vanuxeem, Dorothée ^a   Nion, Stéphane ^c   Landry, Christophe ^a   Delplace, Yannick ^c   Dehouck, Marie Pierre ^a   Berezowski, Vincent ^a   Fenart, Laurence ^a   Cecchelli, Roméo ^a  

^a UNIVERSITÉ D'ARTOIS   (France)

^b ASTRAZENECA   (United Kingdom)

^c Cellial Technologies   (France)

Author keywords

Blood brain barrier; Drug discovery; Endothelial cells; High throughput screening; In vitro model; Toxicity

Indexed keywords

GLYCOPROTEIN P; MULTIDRUG RESISTANCE PROTEIN 1; MULTIDRUG RESISTANCE PROTEIN 4; MULTIDRUG RESISTANCE PROTEIN 5;

ARTICLE; BLOOD BRAIN BARRIER; CONTROLLED STUDY; HIGH THROUGHPUT SCREENING; IN VITRO STUDY; MODEL; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; RISK ASSESSMENT; SCREENING;

ANIMALS; BLOOD-BRAIN BARRIER; BLOTTING, WESTERN; CARRIER PROTEINS; CATTLE; CELLS, CULTURED; CHEMISTRY, PHARMACEUTICAL; DATA INTERPRETATION, STATISTICAL; DRUG EVALUATION, PRECLINICAL; ENDOTHELIAL CELLS; ENDOTHELIUM, VASCULAR; MICROSCOPY, FLUORESCENCE; P-GLYCOPROTEINS; PERMEABILITY; PHARMACEUTICAL PREPARATIONS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA; TIGHT JUNCTIONS;

ANIMALIA;

EID: 40249118217     PISSN: 08872333     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tiv.2007.12.016     Document Type: Article

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