메뉴 건너뛰기




Volumn 2015, Issue 100, 2015, Pages

Human pluripotent stem cell based developmental toxicity assays for chemical safety screening and systems biology data generation

Author keywords

Cytotoxicity; Developmental biology; Developmental toxicity; Differentiation; Embryoid body; Embryopathy; Human embryonic stem cells; Immunoprecipitation; Issue 100; Neuroectodermal progenitor cells; Neurotoxicity

Indexed keywords

ANIMAL TESTING ALTERNATIVE; DRUG EFFECTS; HUMAN; PLURIPOTENT STEM CELL; PROCEDURES; SYSTEMS BIOLOGY; TOXICITY TESTING;

EID: 84940605691     PISSN: 1940087X     EISSN: None     Source Type: Journal    
DOI: 10.3791/52333     Document Type: Article
Times cited : (44)

References (39)
  • 3
    • 59849124092 scopus 로고    scopus 로고
    • The dawning of a new age of toxicology
    • Leist, M., Hartung, T., Nicotera, P. The dawning of a new age of toxicology. ALTEX. 25, (2), 103-114 (2008).
    • (2008) ALTEX , vol.25 , Issue.2 , pp. 103-114
    • Leist, M.1    Hartung, T.2    Nicotera, P.3
  • 4
    • 77954696793 scopus 로고    scopus 로고
    • Markers of murine embryonic and neural stem cells, neurons and astrocytes: Reference points for developmental neurotoxicity testing
    • Kuegler, P. B., et al. Markers of murine embryonic and neural stem cells, neurons and astrocytes: reference points for developmental neurotoxicity testing. ALTEX. 27, (1), 17-42 (2010).
    • (2010) ALTEX , vol.27 , Issue.1 , pp. 17-42
    • Kuegler, P.B.1
  • 5
    • 84903535623 scopus 로고    scopus 로고
    • Human oocytes reprogram adult somatic nuclei of a type 1 diabetic to diploid pluripotent stem cells
    • Yamada, M., et al. Human oocytes reprogram adult somatic nuclei of a type 1 diabetic to diploid pluripotent stem cells. Nature. (2014).
    • (2014) Nature
    • Yamada, M.1
  • 6
    • 62149125434 scopus 로고    scopus 로고
    • Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling
    • Chambers, S. M., et al. Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling. Nature Biotechnology. 27, (3), 275-280 (2009).
    • (2009) Nature Biotechnology , vol.27 , Issue.3 , pp. 275-280
    • Chambers, S.M.1
  • 7
    • 84891298711 scopus 로고    scopus 로고
    • Directing human embryonic stem cell differentiation towards a renal lineage generates a self-organizing kidney
    • Takasato, M., et al. Directing human embryonic stem cell differentiation towards a renal lineage generates a self-organizing kidney. Nature cell biology. 16, (1), 118-126 (2014).
    • (2014) Nature Cell Biology , vol.16 , Issue.1 , pp. 118-126
    • Takasato, M.1
  • 8
    • 84864758119 scopus 로고    scopus 로고
    • Evaluation of Developmental Toxicants and Signaling Pathways in a Functional Test Based on the Migration of Human Neural Crest Cells
    • Zimmer, B., et al. Evaluation of Developmental Toxicants and Signaling Pathways in a Functional Test Based on the Migration of Human Neural Crest Cells. Environmental Health Perspectives. 120, (8), 1116-1122 (2012).
    • (2012) Environmental Health Perspectives , vol.120 , Issue.8 , pp. 1116-1122
    • Zimmer, B.1
  • 9
    • 84878048659 scopus 로고    scopus 로고
    • Molecular and Functional Evidence of HCN4 and Caveolin-3 Interaction During Cardiomyocyte Differentiation from Human Embryonic Stem Cells
    • Bosman, A., et al. Molecular and Functional Evidence of HCN4 and Caveolin-3 Interaction During Cardiomyocyte Differentiation from Human Embryonic Stem Cells. Stem Cells and Development. 22, (11), 1717-1727 (2013).
    • (2013) Stem Cells and Development , vol.22 , Issue.11 , pp. 1717-1727
    • Bosman, A.1
  • 10
    • 34247580093 scopus 로고    scopus 로고
    • Developmental changes in cardiomyocytes differentiated from human embryonic stem cells: A molecular and electrophysiological approach
    • Sartiani, L., et al. Developmental changes in cardiomyocytes differentiated from human embryonic stem cells: A molecular and electrophysiological approach. Stem Cells. 25, (5), 1136-1144 (2007).
    • (2007) Stem Cells , vol.25 , Issue.5 , pp. 1136-1144
    • Sartiani, L.1
  • 11
    • 54249098708 scopus 로고    scopus 로고
    • Chemically defined medium supporting cardiomyocyte differentiation of human embryonic stem cells
    • Xu, X. Q., et al. Chemically defined medium supporting cardiomyocyte differentiation of human embryonic stem cells. Differentiation. 76, (9), 958-970 (2008).
    • (2008) Differentiation , vol.76 , Issue.9 , pp. 958-970
    • Xu, X.Q.1
  • 12
    • 84871938700 scopus 로고    scopus 로고
    • Comparative analysis of cardiomyocyte differentiation from human embryonic stem cells under 3-D and 2-D culture conditions
    • Pal, R., Mamidi, M. K., Das, A. K., Bhonde, R. Comparative analysis of cardiomyocyte differentiation from human embryonic stem cells under 3-D and 2-D culture conditions. Journal of Bioscience and Bioengineering. 115, (2), 200-206 (2013).
    • (2013) Journal of Bioscience and Bioengineering , vol.115 , Issue.2 , pp. 200-206
    • Pal, R.1    Mamidi, M.K.2    Das, A.K.3    Bhonde, R.4
  • 13
    • 84891848152 scopus 로고    scopus 로고
    • Spheroid Culture for Enhanced Differentiation of Human Embryonic Stem Cells to Hepatocyte-Like Cells
    • Subramanian, K., et al. Spheroid Culture for Enhanced Differentiation of Human Embryonic Stem Cells to Hepatocyte-Like Cells. Stem Cells and Development. 23, (2), 124-131 (2014).
    • (2014) Stem Cells and Development , vol.23 , Issue.2 , pp. 124-131
    • Subramanian, K.1
  • 14
    • 84873326803 scopus 로고    scopus 로고
    • Hepatic Differentiation and Maturation of Human Embryonic Stem Cells Cultured in a Perfused Three-Dimensional Bioreactor
    • Sivertsson, L., Synnergren, J., Jensen, J., Bjorquist, P., Ingelman-Sundberg, M. Hepatic Differentiation and Maturation of Human Embryonic Stem Cells Cultured in a Perfused Three-Dimensional Bioreactor. Stem Cells and Development. 22, (4), 581-594 (2013).
    • (2013) Stem Cells and Development , vol.22 , Issue.4 , pp. 581-594
    • Sivertsson, L.1    Synnergren, J.2    Jensen, J.3    Bjorquist, P.4    Ingelman-Sundberg, M.5
  • 15
    • 79953056240 scopus 로고    scopus 로고
    • Cytosine arabinoside induces ectoderm and inhibits mesoderm expression in human embryonic stem cells during multilineage differentiation
    • Jagtap, S., et al. Cytosine arabinoside induces ectoderm and inhibits mesoderm expression in human embryonic stem cells during multilineage differentiation. British Journal of Pharmacology. 162, (8), 1743-1756 (2011).
    • (2011) British Journal of Pharmacology , vol.162 , Issue.8 , pp. 1743-1756
    • Jagtap, S.1
  • 16
    • 84872346334 scopus 로고    scopus 로고
    • Human embryonic stem cell-derived test systems for developmental neurotoxicity: A transcriptomics approach
    • Krug, A. K., et al. Human embryonic stem cell-derived test systems for developmental neurotoxicity: a transcriptomics approach. Archives of Toxicology. 87, (1), 123-143 (2013).
    • (2013) Archives of Toxicology , vol.87 , Issue.1 , pp. 123-143
    • Krug, A.K.1
  • 17
    • 84890566376 scopus 로고    scopus 로고
    • Test systems of developmental toxicity: State-of-the art and future perspectives
    • Leist, M., et al. Test systems of developmental toxicity: state-of-the art and future perspectives. Archives of Toxicology. 87, (12), 2037-2042 (2013).
    • (2013) Archives of Toxicology , vol.87 , Issue.12 , pp. 2037-2042
    • Leist, M.1
  • 18
    • 0034136393 scopus 로고    scopus 로고
    • Differentiation of human embryonic stem cells into embryoid bodies compromising the three embryonic germ layers
    • Itskovitz-Eldor, J., et al. Differentiation of human embryonic stem cells into embryoid bodies compromising the three embryonic germ layers. Molecular medicine. 6, (2), 88-95 (2000).
    • (2000) Molecular Medicine , vol.6 , Issue.2 , pp. 88-95
    • Itskovitz-Eldor, J.1
  • 19
    • 27244436044 scopus 로고    scopus 로고
    • Growth and differentiation of embryoid bodies derived from human embryonic stem cells: Effect of glucose and basic fibroblast growth factor
    • Khoo, M. L. M., et al. Growth and differentiation of embryoid bodies derived from human embryonic stem cells: Effect of glucose and basic fibroblast growth factor. Biology of Reproduction. 73, (6), 1147-1156 (2005).
    • (2005) Biology of Reproduction , vol.73 , Issue.6 , pp. 1147-1156
    • Khoo, M.1
  • 20
    • 79955749942 scopus 로고    scopus 로고
    • Physical Passaging of Embryoid Bodies Generated from Human Pluripotent Stem Cells
    • Son, M. Y., Kim, H. J., Kim, M. J., Cho, S. Physical Passaging of Embryoid Bodies Generated from Human Pluripotent Stem Cells. Plos One. 6, (5), (2011).
    • (2011) Plos One , vol.6 , Issue.5
    • Son, M.Y.1    Kim, H.J.2    Kim, M.J.3    Cho, S.4
  • 21
    • 71949126099 scopus 로고    scopus 로고
    • The potential of embryonic stem cells combined with -omics technologies as model systems for toxicology
    • Winkler, J., Sotiriadou, I., Chen, S., Hescheler, J., Sachinidis, A. The potential of embryonic stem cells combined with -omics technologies as model systems for toxicology. Current medicinal chemistry. 16, (36), 4814-4827 (2009).
    • (2009) Current Medicinal Chemistry , vol.16 , Issue.36 , pp. 4814-4827
    • Winkler, J.1    Sotiriadou, I.2    Chen, S.3    Hescheler, J.4    Sachinidis, A.5
  • 22
    • 77950669886 scopus 로고    scopus 로고
    • Induced pluripotent stem cells as a model for accelerated patientand disease-specific drug discovery
    • Gunaseeli, I., Doss, M. X., Antzelevitch, C., Hescheler, J., Sachinidis, A. Induced pluripotent stem cells as a model for accelerated patientand disease-specific drug discovery. Current medicinal chemistry. 17, (8), 759-766 (2010).
    • (2010) Current Medicinal Chemistry , vol.17 , Issue.8 , pp. 759-766
    • Gunaseeli, I.1    Doss, M.X.2    Antzelevitch, C.3    Hescheler, J.4    Sachinidis, A.5
  • 23
    • 0342313474 scopus 로고    scopus 로고
    • Teratogen update: Thalidomide: A review, with a focus on ocular findings and new potential uses
    • Miller, M. T., Stromland, K. Teratogen update: Thalidomide: A review, with a focus on ocular findings and new potential uses. Teratology. 60, (5), 306-321 (1999).
    • (1999) Teratology , vol.60 , Issue.5 , pp. 306-321
    • Miller, M.T.1    Stromland, K.2
  • 24
    • 0021848841 scopus 로고
    • Teratogen Update - Clinical Aspects of Thalidomide Embryopathy - A Continuing Preoccupation
    • Newman, C. G. H. Teratogen Update - Clinical Aspects of Thalidomide Embryopathy - A Continuing Preoccupation. Teratology. 32, (1), 133-144 (1985).
    • (1985) Teratology , vol.32 , Issue.1 , pp. 133-144
    • Newman, C.1
  • 25
    • 0019841837 scopus 로고
    • In vivo assessment of the teratogenic potential of drugs in humans
    • Stern, L. In vivo assessment of the teratogenic potential of drugs in humans. Obstetrics and gynecology. 58, (5 Suppl), 3S-8S (1981).
    • (1981) Obstetrics and Gynecology , vol.58 , Issue.5 , pp. 3S-8S
    • Stern, L.1
  • 26
    • 0022390094 scopus 로고
    • Diethylstilbestrol, Genetics, Teratogenesis, and Tumor Spectrum in Humans
    • Lynch, H. T., Reich, J. W. Diethylstilbestrol, Genetics, Teratogenesis, and Tumor Spectrum in Humans. Medical Hypotheses. 16, (3), 315-332 (1985).
    • (1985) Medical Hypotheses , vol.16 , Issue.3 , pp. 315-332
    • Lynch, H.T.1    Reich, J.W.2
  • 27
    • 0242525186 scopus 로고    scopus 로고
    • Behavioral teratology of mercury and its compounds
    • Satoh, H. Behavioral teratology of mercury and its compounds. Tohoku Journal of Experimental Medicine. 201, (1), 1-9 (2003).
    • (2003) Tohoku Journal of Experimental Medicine , vol.201 , Issue.1 , pp. 1-9
    • Satoh, H.1
  • 28
    • 84865506513 scopus 로고    scopus 로고
    • Identification of Thalidomide-Specific Transcriptomics and Proteomics Signatures during Differentiation of Human Embryonic Stem Cells
    • Meganathan, K., et al. Identification of Thalidomide-Specific Transcriptomics and Proteomics Signatures during Differentiation of Human Embryonic Stem Cells. Plos One. 7, (8), (2012).
    • (2012) Plos One , vol.7 , Issue.8
    • Meganathan, K.1
  • 29
    • 84865776716 scopus 로고    scopus 로고
    • Epigenetic changes and disturbed neural development in a human embryonic stem cell-based model relating to the fetal valproate syndrome
    • Balmer, N. V., et al. Epigenetic changes and disturbed neural development in a human embryonic stem cell-based model relating to the fetal valproate syndrome. Human Molecular Genetics. 21, (18), 4104-4114 (2012).
    • (2012) Human Molecular Genetics , vol.21 , Issue.18 , pp. 4104-4114
    • Balmer, N.V.1
  • 30
    • 84901850014 scopus 로고    scopus 로고
    • Developmental neurotoxicity - Challenges in the 21st Century and In Vitro Opportunities
    • Smirnova, L., Hogberg, H. T., Leist, M., Hartung, T. Developmental neurotoxicity - Challenges in the 21st Century and In Vitro Opportunities. ALTEX. 31, (2), 129-156 (2014).
    • (2014) ALTEX , vol.31 , Issue.2 , pp. 129-156
    • Smirnova, L.1    Hogberg, H.T.2    Leist, M.3    Hartung, T.4
  • 31
    • 79955432219 scopus 로고    scopus 로고
    • Food for thought… considerations and guidelines for basic test method descriptions in toxicology
    • Leist, M., Efremova, L., Karreman, C. Food for thought… considerations and guidelines for basic test method descriptions in toxicology. ALTEX. 27, (4), 309-317 (2010).
    • (2010) ALTEX , vol.27 , Issue.4 , pp. 309-317
    • Leist, M.1    Efremova, L.2    Karreman, C.3
  • 32
    • 79951678616 scopus 로고    scopus 로고
    • Coordinated waves of gene expression during neuronal differentiation of embryonic stem cells as basis for novel approaches to developmental neurotoxicity testing
    • Zimmer, B., et al. Coordinated waves of gene expression during neuronal differentiation of embryonic stem cells as basis for novel approaches to developmental neurotoxicity testing. Cell Death and Differentiation. 18, (3), 383-395 (2011).
    • (2011) Cell Death and Differentiation , vol.18 , Issue.3 , pp. 383-395
    • Zimmer, B.1
  • 33
    • 84941256924 scopus 로고    scopus 로고
    • Experion RNA StdSens Analysis Kit for RNA analysis by Electrophoresis. Available from: http://www.bio-rad.com/webroot/web/pdf/lsr/literature/10000976B%20%20RNA%20STDSENS%20MANUAL.PDF (2014).
    • (2014)
  • 34
    • 84941256925 scopus 로고    scopus 로고
    • Affymetix GeneChip 3 IVT Express Kit for Target RNA preparation, Fragmentation and hybridization. Available from: http://microarray.csc.mrc.ac.uk/downloads/3'%20IVT%20Express%20Manual.pdf (2014).
    • (2014) Fragmentation and Hybridization
  • 35
    • 84941256926 scopus 로고    scopus 로고
    • Affymetrix GeneChip Hybridization, Wash and Stain Kit. Available from: http://www.affymetrix.com/catalog/131467/AFFY/Hybridization,- Wash,-and-Stain-Kit#1_1(2014).
    • (2014) Wash and Stain Kit
  • 36
    • 84941256927 scopus 로고    scopus 로고
    • Affymetrix GeneChip Operating Software. Available from: http://www.affymetrix.com/estore/partners_programs/programs/developer/gcos_sdk/gcos_sdk_overview.affx#1_1 (2014).
    • (2014)
  • 37
    • 84941256928 scopus 로고    scopus 로고
    • Partek Genomics Suite. Available from: http://www.partek.com/pgs (2014).
    • (2014)
  • 38
    • 84941256929 scopus 로고    scopus 로고
    • ChIP DNA Clean and Concentrator. Available from: http://www.zymoresearch.com/dna/dna-clean-up/pcr-dna-clean-up-concentration/chipdna-clean-concentrator (2014).
    • (2014)


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.