Neural differentiation of human induced pluripotent stem cells follows developmental principles but with variable potency

Proceedings of the National Academy of Sciences of the United States of America

Volumn 107, Issue 9, 2010, Pages 4335-4340

  Hu, Bao Yang ^a   Weick, Jason P ^a   Yu, Junying ^b   Ma, Li Xiang ^a   Zhang, Xiao Qing ^a   Thomson, James A ^b   Zhang, Su Chun ^a,b  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

^b UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

Author keywords

Motor neurons; Neural development; Regeneration; Reprogramming; Transplantation

Indexed keywords

BONE MORPHOGENETIC PROTEIN; FIBROBLAST GROWTH FACTOR; GLIAL FIBRILLARY ACIDIC PROTEIN; MORPHOGEN; OCTAMER TRANSCRIPTION FACTOR 4; PROTEIN S100B; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR HOXB4; TRANSCRIPTION FACTOR OTX2; TRANSCRIPTION FACTOR PAX6; TRANSCRIPTION FACTOR SOX1; UNCLASSIFIED DRUG;

ARTICLE; ASTROCYTE; CONTROLLED STUDY; EMBRYONIC STEM CELL; GENETIC TRANSCRIPTION; GLIA CELL; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; NERVE CELL CULTURE; NERVE CELL DIFFERENTIATION; NEUROEPITHELIUM; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; PRODUCTIVITY; SCREENING; TRANSGENE;

BONE MORPHOGENETIC PROTEINS; CELL DIFFERENTIATION; CELL LINE; FIBROBLAST GROWTH FACTORS; FLOW CYTOMETRY; HUMANS; IMMUNOHISTOCHEMISTRY; NEURONS; PLURIPOTENT STEM CELLS; POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TRANSGENES;

EID: 77749279749     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0910012107     Document Type: Article

References (34)

1. Perrier AL, et al. (2004) Derivation of midbrain dopamine neurons from human embryonic stem cells. Proc Natl Acad Sci USA 101:12543-12548.
2. Li XJ, et al. (2005) Specification of motoneurons from human embryonic stem cells. Nat Biotechnol 23:215-221.
3. Roy NS, et al. (2006) Functional engraftment of human ES cell-derived dopaminergic neurons enriched by coculture with telomerase-immortalized midbrain astrocytes. Nat Med 12:1259-1268.
4. Watanabe K, et al. (2007) A ROCK inhibitor permits survival of dissociated human embryonic stem cells. Nat Biotechnol 25:681-686.
5. Yang L, et al. (2008) Human cardiovascular progenitor cells develop from a KDR+ embryonic-stem-cell-derived population. Nature 453:524-528.
6. Hu BY, Du ZW, Li XJ, Ayala M, Zhang SC (2009) Human oligodendrocytes from embryonic stem cells: Conserved SHH signaling networks and divergent FGF effects. Development 136:1443-1452.
7. Zhao XY, et al. (2009) iPS cells produce viable mice through tetraploid complementation. Nature 461:86-90.
8. Boland MJ, et al. (2009) Adult mice generated from induced pluripotent stem cells. Nature 461:91-94.
9. Okita K, Ichisaka T, Yamanaka S (2007) Generation of germline-competent induced pluripotent stem cells. Nature 448:313-317.
10. Park IH, et al. (2008) Reprogramming of human somatic cells to pluripotency with defined factors. Nature 451:141-146.
11. Yu J, et al. (2007) Induced pluripotent stem cell lines derived from human somatic cells. Science 318:1917-1920.
12. Takahashi K, et al. (2007) Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 131:861-872.
13. Dimos JT, et al. (2008) Induced pluripotent stem cells generated from patients with ALS can be differentiated into motor neurons. Science 321:1218-1221.
14. Ebert AD, et al. (2009) Induced pluripotent stem cells from a spinal muscular atrophy patient. Nature 457:277-280.
15. Lee G, et al. (2009) Modelling pathogenesis and treatment of familial dysautonomia using patient-specific iPSCs. Nature 461:402-406.
16. Yu J, et al. (2009) Human induced pluripotent stem cells free of vector and transgene sequences. Science 324:797-801.
17. Soldner F, et al. (2009) Parkinson's disease patient-derived induced pluripotent stem cells free of viral reprogramming factors. Cell 136:964-977.
18. Kaji K, et al. (2009) Virus-free induction of pluripotency and subsequent excision of reprogramming factors. Nature 458:771-775.
19. Raya A, et al. (2009) Disease-corrected haematopoietic progenitors from Fanconi anaemia induced pluripotent stem cells. Nature 460:53-59.
20. Karumbayaram S, et al. (2009) Directed differentiation of human-induced pluripotent stem cells generates active motor neurons. Stem Cells 27:806-811.
21. Choi KD, et al. (2009) Hematopoietic and endothelial differentiation of human induced pluripotent stem cells. Stem Cells 27:559-567.
22. Abeyta MJ, et al. (2004) Unique gene expression signatures of independently-derived human embryonic stem cell lines. Hum Mol Genet 13:601-608.
23. Reubinoff BE, Pera MF, Fong CY, Trounson A, Bongso A (2000) Embryonic stem cell lines from human blastocysts: Somatic differentiation in vitro. Nat Biotechnol 18:399-404.
24. Thomson JA, et al. (1998) Embryonic stem cell lines derived from human blastocysts. Science 282:1145-1147.
25. Pankratz MT, et al. (2007) Directed neural differentiation of human embryonic stem cells via an obligated primitive anterior stage. Stem Cells 25:1511-1520.
26. Zhang SC, Wernig M, Duncan ID, Brüstle O, Thomson JA (2001) In vitro differentiation of transplantable neural precursors from human embryonic stem cells. Nat Biotechnol 19:1129-1133.
27. Yan Y, et al. (2005) Directed differentiation of dopaminergic neuronal subtypes from human embryonic stem cells. Stem Cells 23:781-790.
28. Johnson MA, Weick JP, Pearce RA, Zhang SC (2007) Functional neural development from human embryonic stem cells: Accelerated synaptic activity via astrocyte coculture. J Neurosci 27:3069-3077.
29. Hu BY, Zhang SC (2009) Differentiation of spinal motor neurons from pluripotent human stem cells. Nat Protoc 4:1295-1304.
30. Osafune K, et al. (2008) Marked differences in differentiation propensity among human embryonic stem cell lines. Nat Biotechnol 26:313-315.
31. Wu H, et al. (2007) Integrative genomic and functional analyses reveal neuronal subtype differentiation bias in human embryonic stem cell lines. Proc Natl Acad Sci USA 104:13821-13826.
32. LaVaute TM, et al. (2009) Regulation of neural specification from human embryonic stem cells by BMP and FGF. Stem Cells 27:1741-1749.
33. Chambers SM, et al. (2009) Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling. Nat Biotechnol 27:275-280.
34. Du ZW, Hu BY, Ayala M, Sauer B, Zhang SC (2009) Cre recombination- mediated cassette exchange for building versatile transgenic human embryonic stem cells lines. Stem Cells 27:1032-1041.