Investigating oxidative stress and inflammatory responses elicited by silver nanoparticles using high-throughput reporter genes in HepG2 cells: Effect of size, surface coating, and intracellular uptake

Toxicology in Vitro

Volumn 27, Issue 6, 2013, Pages 2013-2021

  Prasad, Raju Y ^a   McGee, John K ^a   Killius, Micaela G ^a   Suarez, Danielle A ^a   Blackman, Carl F ^a   DeMarini, David M ^a   Simmons, Steven O ^a  

^a U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

Author keywords

Nanoparticles; NRF2; Oxidative stress; Reporter genes; Silver; Stress response

Indexed keywords

CERIUM OXIDE; CITRIC ACID; GLUTATHIONE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LENTIVIRUS VECTOR; POVIDONE; SILVER NANOPARTICLE; SILVER NITRATE; TRANSCRIPTION FACTOR AP 1; TRANSCRIPTION FACTOR NRF2;

ARTICLE; CELL STRAIN HEPG2; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYTOTOXICITY; EXPOSURE; HUMAN; HUMAN CELL; IN VITRO STUDY; INFLAMMATION; LIGHT SCATTERING; MASS SPECTROMETRY; OXIDATION REDUCTION STATE; OXIDATIVE STRESS; PARTICLE SIZE; REPORTER GENE;

3-(4,5-DIMETHYLTHIAZOL-2-YL)-2,5-DIPHENYLTETRAZOLIUM BROMIDE; 50% INHIBITORY CONCENTRATION; ACTIVATOR PROTEIN 1; AG NPS; AG(+); AGNO(3); ANTIOXIDANT RESPONSE ELEMENT; AP1; ARE; BSO; CEO(2); CERIUM OXIDE; DLS; DYNAMIC LIGHT SCATTERING; EC(50); EC(MAX); FBS; FETAL BOVINE SERUM; GLUTATHIONE; GSH; HALF MAXIMAL EFFECTIVE CONCENTRATION; HQ; HYDROQUINONE; IC(50); ICP-MS; IL-1B; INDUCTIVELY COUPLED PLASMA MASS SPECTROSCOPY; INTERLEUKIN 1B; L-BUTHIONINE (S,R)-SULFOXIMINE; MAXIMAL EFFECTIVE CONCENTRATION; MTT; NANOPARTICLES; NFΚB; NRF2; NUCLEAR FACTOR (ERYTHROID-DERIVED 2)-LIKE 2; NUCLEAR FACTOR KAPPA B; O-PHENYLENEDIAMINE; OPD; OXIDATIVE STRESS; PDI; POLYDISPERSITY INDEX; POLYVINYLPYRROLIDONE; PVP; REACTIVE OXYGEN SPECIES; REPORTER GENES; ROS; SILVER; SILVER ION; SILVER NANOPARTICLES; SILVER NITRATE; STRESS RESPONSE;

BIOLOGICAL TRANSPORT; CELL SURVIVAL; CERIUM; CITRIC ACID; GENES, REPORTER; GLUTATHIONE; HEP G2 CELLS; HUMANS; LUCIFERASES; METAL NANOPARTICLES; NF-E2-RELATED FACTOR 2; NF-KAPPA B; OXIDATIVE STRESS; PARTICLE SIZE; POVIDONE; REPLICATION PROTEIN C; SILVER; SILVER NITRATE;

EID: 84881249797     PISSN: 08872333     EISSN: 18793177     Source Type: Journal    
DOI: 10.1016/j.tiv.2013.07.005     Document Type: Article

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