From transient transcriptome responses to disturbed neurodevelopment: Role of histone acetylation and methylation as epigenetic switch between reversible and irreversible drug effects

Archives of Toxicology

Volumn 88, Issue 7, 2014, Pages 1451-1468

  Balmer, Nina V ^a   Klima, Stefanie ^a   Rempel, Eugen ^b   Ivanova, Violeta N ^a   Kolde, Raivo ^c   Weng, Matthias K ^a   Meganathan, Kesavan ^d   Henry, Margit ^d   Sachinidis, Agapios ^d   Berthold, Michael R ^a   Hengstler, Jan G ^e   Rahnenführer, Jörg ^b   Waldmann, Tanja ^a   Leist, Marcel ^a  

^a UNIVERSITY OF KONSTANZ   (Germany)

^b TU DORTMUND UNIVERSITY   (Germany)

^c OÜ Quretec ^*  (Estonia)

^d UNIVERSITY OF COLOGNE   (Germany)

^e LEIBNIZ RESEARCH CENTRE FOR WORKING ENVIRONMENT AND HUMAN FACTORS   (Germany)

Author keywords

Developmental toxicity; Embryonic stem cell; Histone deacetylase; Histone modification; Valproic acid

Indexed keywords

HISTONE; HISTONE H3; TRANSCRIPTION FACTOR OTX2; TRANSCRIPTION FACTOR PAX6; TRANSCRIPTOME; TRICHOSTATIN A; VALPROIC ACID; EYE PROTEIN; HISTONE DEACETYLASE INHIBITOR; HOMEODOMAIN PROTEIN; HYDROXAMIC ACID; PAIRED BOX TRANSCRIPTION FACTOR; REPRESSOR PROTEIN;

ARTICLE; CELL STRESS; CHEMICAL STRESS; CONTROLLED STUDY; DEVELOPMENTAL STAGE; DEVELOPMENTAL TOXICITY; DRUG EFFECT; DRUG EXPOSURE; EMBRYO; EMBRYONIC STEM CELL; EPIGENETICS; GENE EXPRESSION; HISTONE ACETYLATION; HISTONE METHYLATION; HUMAN; HUMAN CELL; NERVE CELL DIFFERENTIATION; NERVOUS SYSTEM DEVELOPMENT; NEUROEPITHELIUM; PRIORITY JOURNAL; PROMOTER REGION; TRANSCRIPTOMICS; ACETYLATION; CELL DIFFERENTIATION; CYTOLOGY; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETIC EPIGENESIS; GENETICS; METABOLISM; METHYLATION; TIME; TOXICITY;

ACETYLATION; CELL DIFFERENTIATION; EMBRYONIC STEM CELLS; EPIGENESIS, GENETIC; EYE PROTEINS; GENE EXPRESSION REGULATION; HISTONE DEACETYLASE INHIBITORS; HISTONES; HOMEODOMAIN PROTEINS; HUMANS; HYDROXAMIC ACIDS; METHYLATION; PAIRED BOX TRANSCRIPTION FACTORS; REPRESSOR PROTEINS; TIME FACTORS; TRANSCRIPTOME; VALPROIC ACID;

EID: 84903439132     PISSN: 03405761     EISSN: 14320738     Source Type: Journal    
DOI: 10.1007/s00204-014-1279-6     Document Type: Article

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