메뉴 건너뛰기




Volumn 30, Issue 4, 2013, Pages 427-444

Generation of genetically-modified human differentiated cells for toxicological tests and the study of neurodegenerative diseases

Author keywords

Alpha synuclein; Dopaminergic neurons; LUHMES; Neurotoxicity

Indexed keywords

1 METHYL 4 PHENYLPYRIDINIUM; ALPHA SYNUCLEIN; ASCORBIC ACID; DEUBIQUITINASE; GREEN FLUORESCENT PROTEIN; PROTEIN VARIANT; RED FLUORESCENT PROTEIN;

EID: 84893041165     PISSN: 1868596X     EISSN: 18688551     Source Type: Journal    
DOI: 10.14573/altex.2013.4.427     Document Type: Article
Times cited : (63)

References (64)
  • 1
    • 77957740998 scopus 로고    scopus 로고
    • Targeting nmnat1 to axons and synapses transforms its neuroprotective potency in vivo
    • Babetto, E., Beirowski, B., Janeckova, L., et al. (2010). Targeting NMNAT1 to axons and synapses transforms its neuroprotective potency in vivo. J Neurosci 30, 13291-13304.
    • (2010) J Neurosci , vol.30 , pp. 13291-13304
    • Babetto, E.1    Beirowski, B.2    Janeckova, L.3
  • 2
    • 84861744139 scopus 로고    scopus 로고
    • A roadmap for the development of alternative (non-animal) methods for systemic toxicity testing - T4 report
    • Basketter, D. A., Clewell, H., Kimber, I., et al. (2012). A roadmap for the development of alternative (non-animal) methods for systemic toxicity testing - t4 report. ALTEX 29, 3-91.
    • (2012) ALTEX , vol.29 , pp. 3-91
    • Basketter, D.A.1    Clewell, H.2    Kimber, I.3
  • 3
    • 58849126602 scopus 로고    scopus 로고
    • Non-nuclear wld(s) determines its neuroprotective efficacy for axons and synapses in vivo
    • Beirowski, B., Babetto, E., Gilley, J., et al. (2009). Non-nuclear Wld(S) determines its neuroprotective efficacy for axons and synapses in vivo. J Neurosci 29, 653-668.
    • (2009) J Neurosci , vol.29 , pp. 653-668
    • Beirowski, B.1    Babetto, E.2    Gilley, J.3
  • 4
    • 13944261492 scopus 로고    scopus 로고
    • Botulinum neurotoxin c initiates two different programs for neurite degeneration and neuronal apoptosis
    • Berliocchi, L., Fava, E., Leist, M., et al. (2005). Botulinum neurotoxin C initiates two different programs for neurite degeneration and neuronal apoptosis. J Cell Biol 168, 607-618.
    • (2005) J Cell Biol , vol.168 , pp. 607-618
    • Berliocchi, L.1    Fava, E.2    Leist, M.3
  • 5
    • 0015817744 scopus 로고
    • Morphology and growth, tumorigenicity, and cytogenetics of human neuroblastoma cells in continuous culture
    • Biedler, J. L., Helson, L., and Spengler, B. A. (1973). Morphology and growth, tumorigenicity, and cytogenetics of human neuroblastoma cells in continuous culture. Cancer Res 33, 2643-2652.
    • (1973) Cancer Res , vol.33 , pp. 2643-2652
    • Biedler, J.L.1    Helson, L.2    Spengler, B.A.3
  • 6
    • 0018121341 scopus 로고
    • Multiple neurotransmitter synthesis by human neuroblastoma cell lines and clones
    • Biedler, J. L., Roffler-Tarlov, S., Schachner, M., and Freedman, L. S. (1978). Multiple neurotransmitter synthesis by human neuroblastoma cell lines and clones. Cancer Res 38, 3751-3757.
    • (1978) Cancer Res , vol.38 , pp. 3751-3757
    • Biedler, J.L.1    Roffler-Tarlov, S.2    Schachner, M.3    Freedman, L.S.4
  • 7
    • 67649756320 scopus 로고    scopus 로고
    • Impaired mitochondrial dynamics and function in the pathogenesis of parkinson's disease
    • Büeler, H. (2009). Impaired mitochondrial dynamics and function in the pathogenesis of Parkinson's disease. Exp Neurol 218, 235-246.
    • (2009) Exp Neurol , vol.218 , pp. 235-246
    • Büeler, H.1
  • 8
    • 0032544036 scopus 로고    scopus 로고
    • An 85-kb tandem triplication in the slow wallerian degeneration (wlds) mouse
    • Coleman, M. P., Conforti, L., Buckmaster, E. A., et al. (1998). An 85-kb tandem triplication in the slow Wallerian degeneration (Wlds) mouse. Proc Natl Acad Sci U S A 95, 9985-9990.
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 9985-9990
    • Coleman, M.P.1    Conforti, L.2    Buckmaster, E.A.3
  • 9
    • 33845487124 scopus 로고    scopus 로고
    • NAD(+) and axon degeneration revisited: Nmnat1 cannot substitute for wld(s) to delay wallerian degeneration
    • Conforti, L., Fang, G., Beirowski, B., et al. (2007). NAD(+) and axon degeneration revisited: Nmnat1 cannot substitute for Wld(S) to delay Wallerian degeneration. Cell Death Differ 14, 116-127.
    • (2007) Cell Death Differ , vol.14 , pp. 116-127
    • Conforti, L.1    Fang, G.2    Beirowski, B.3
  • 10
    • 0036787779 scopus 로고    scopus 로고
    • Overexpression of parkinson's disease-associated alpha-synuclein a53t by recombinant adeno-associated virus in mice does not increase the vulnerability of dopaminergic neurons to mptp
    • Dong, Z., Ferger, B., Feldon, J., and Büeler, H. (2002). Overexpression of Parkinson's disease-associated alpha-synuclein A53T by recombinant adeno-associated virus in mice does not increase the vulnerability of dopaminergic neurons to MPTP. J Neurobiol 53, 1-10.
    • (2002) J Neurobiol , vol.53 , pp. 1-10
    • Dong, Z.1    Ferger, B.2    Feldon, J.3    Büeler, H.4
  • 11
    • 0035015174 scopus 로고    scopus 로고
    • Analysis of the aphthovirus 2a/2b polyprotein "cleavage" mechanism indicates not a proteolytic reaction but a novel translational effect: A putative ribosomal "skip
    • Donnelly, M. L., Luke, G., Mehrotra, A., et al. (2001). Analysis of the aphthovirus 2A/2B polyprotein "cleavage" mechanism indicates not a proteolytic reaction but a novel translational effect: a putative ribosomal "skip." J Gen Virol 82, 1013-1025.
    • (2001) J Gen Virol , vol.82 , pp. 1013-1025
    • Donnelly, M.L.1    Luke, G.2    Mehrotra, A.3
  • 12
    • 0346733034 scopus 로고    scopus 로고
    • Defined inflammatory states in astrocyte cultures: Correlation with susceptibility towards cd95-driven apoptosis
    • Falsig, J., Latta, M., and Leist, M. (2004). Defined inflammatory states in astrocyte cultures: correlation with susceptibility towards CD95-driven apoptosis. J Neurochem 88, 181-193.
    • (2004) J Neurochem , vol.88 , pp. 181-193
    • Falsig, J.1    Latta, M.2    Leist, M.3
  • 13
    • 33846856920 scopus 로고    scopus 로고
    • RNA interference-mediated knockdown of alpha-synuclein protects human dopaminergic neuroblastoma cells from mpp(+) toxicity and reduces dopamine transport
    • Fountaine, T. M. and Wade-Martins, R. (2007). RNA interference-mediated knockdown of alpha-synuclein protects human dopaminergic neuroblastoma cells from MPP(+) toxicity and reduces dopamine transport. J Neurosci Res 85, 351-363.
    • (2007) J Neurosci Res , vol.85 , pp. 351-363
    • Fountaine, T.M.1    Wade-Martins, R.2
  • 14
    • 0345704610 scopus 로고
    • Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor
    • Greene, L. A. and Tischler, A. S. (1976). Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor. Proc Natl Acad Sci U S A 73, 2424-2428.
    • (1976) Proc Natl Acad Sci U S A , vol.73 , pp. 2424-2428
    • Greene, L.A.1    Tischler, A.S.2
  • 15
    • 0033940543 scopus 로고    scopus 로고
    • Additive effects of caspase inhibitor and lazaroid on the survival of transplanted rat and human embryonic dopamine neurons
    • Hansson, O., Castilho, R. F., Kaminski Schierle, G. S., et al. (2000). Additive effects of caspase inhibitor and lazaroid on the survival of transplanted rat and human embryonic dopamine neurons. Exp Neurol 164, 102-111.
    • (2000) Exp Neurol , vol.164 , pp. 102-111
    • Hansson, O.1    Castilho, R.F.2    Kaminski Schierle, G.S.3
  • 16
    • 0019790274 scopus 로고
    • Astroglial cells provide a template for the positioning of developing cerebellar neurons in vitro
    • Hatten, M. E. and Liem, R. K. (1981). Astroglial cells provide a template for the positioning of developing cerebellar neurons in vitro. J Cell Biol 90, 622-630.
    • (1981) J Cell Biol , vol.90 , pp. 622-630
    • Hatten, M.E.1    Liem, R.K.2
  • 17
    • 0021952476 scopus 로고
    • Neuronal regulation of astroglial morphology and proliferation in vitro
    • Hatten, M. E. (1985). Neuronal regulation of astroglial morphology and proliferation in vitro. J Cell Biol 100, 384-396.
    • (1985) J Cell Biol , vol.100 , pp. 384-396
    • Hatten, M.E.1
  • 18
    • 0023758546 scopus 로고
    • A segment of the 5' nontranslated region of encephalomyocarditis virus rna directs internal entry of ribosomes during in vitro translation
    • Jang, S. K., Kräusslich, H. G., Nicklin, M. J., et al. (1988). A segment of the 5' nontranslated region of encephalomyocarditis virus RNA directs internal entry of ribosomes during in vitro translation. J Virol 62, 2636-2643.
    • (1988) J Virol , vol.62 , pp. 2636-2643
    • Jang, S.K.1    Kräusslich, H.G.2    Nicklin, M.J.3
  • 19
    • 0033573116 scopus 로고    scopus 로고
    • Neural stem cells in the adult human brain
    • Johansson, C. B., Svensson, M., Wallstedt, L., et al. (1999). Neural stem cells in the adult human brain. Exp Cell Res 253, 733-736.
    • (1999) Exp Cell Res , vol.253 , pp. 733-736
    • Johansson, C.B.1    Svensson, M.2    Wallstedt, L.3
  • 20
    • 0036300266 scopus 로고    scopus 로고
    • AiO, combining dna/protein programs and oligo-management
    • Karreman, C. (2002). AiO, combining DNA/protein programs and oligo-management. Bioinformatics 18, 884-885.
    • (2002) Bioinformatics , vol.18 , pp. 884-885
    • Karreman, C.1
  • 21
    • 25644442285 scopus 로고    scopus 로고
    • Wild-type alpha-synuclein interacts with pro-apoptotic proteins pkcdelta and bad to protect dopaminergic neuronal cells against mpp+-induced apoptotic cell death
    • Kaul, S., Anantharam, V., Kanthasamy, A., and Kanthasamy, A. G. (2005). Wild-type alpha-synuclein interacts with pro-apoptotic proteins PKCdelta and BAD to protect dopaminergic neuronal cells against MPP+-induced apoptotic cell death. Brain Res Mol Brain Res 139, 137-152.
    • (2005) Brain Res Mol Brain Res , vol.139 , pp. 137-152
    • Kaul, S.1    Anantharam, V.2    Kanthasamy, A.3    Kanthasamy, A.G.4
  • 23
    • 78149477289 scopus 로고    scopus 로고
    • Reduced immunoproteasome formation and accumulation of immunoproteasomal precursors in the brains of lymphocytic choriomeningitis virus-infected mice
    • Kremer, M., Henn, A., Kolb, C., et al. (2010). Reduced immunoproteasome formation and accumulation of immunoproteasomal precursors in the brains of lymphocytic choriomeningitis virus-infected mice. J Immunol 185, 5549-5560.
    • (2010) J Immunol , vol.185 , pp. 5549-5560
    • Kremer, M.1    Henn, A.2    Kolb, C.3
  • 24
    • 26244451017 scopus 로고    scopus 로고
    • A new versatile and compact lentiviral vector
    • Leander Johansen, J., Dagø, L., Tornøe, J., et al. (2005). A new versatile and compact lentiviral vector. Mol Biotechnol 29, 47-56.
    • (2005) Mol Biotechnol , vol.29 , pp. 47-56
    • Leander Johansen, J.1    Dagø, L.2    Tornøe, J.3
  • 25
    • 77954060569 scopus 로고    scopus 로고
    • Derivation of neural crest cells from human pluripotent stem cells
    • Lee, G., Chambers, S. M., Tomishima, M. J., and Studer, L. (2010). Derivation of neural crest cells from human pluripotent stem cells. Nat Protoc 5, 688-701.
    • (2010) Nat Protoc , vol.5 , pp. 688-701
    • Lee, G.1    Chambers, S.M.2    Tomishima, M.J.3    Studer, L.4
  • 26
    • 0035109909 scopus 로고    scopus 로고
    • Effect of the overexpression of wild-type or mutant alpha-synuclein on cell susceptibility to insult
    • Lee, M., Hyun, D., Halliwell, B., and Jenner, P. (2001). Effect of the overexpression of wild-type or mutant alpha-synuclein on cell susceptibility to insult. J. Neurochem 76, 998-1009.
    • (2001) J. Neurochem , vol.76 , pp. 998-1009
    • Lee, M.1    Hyun, D.2    Halliwell, B.3    Jenner, P.4
  • 27
    • 0037135193 scopus 로고    scopus 로고
    • Expression of mutant alpha-synucleins enhances dopamine transporter-mediated mpp+ toxicity in vitro
    • Lehmensiek, V., Tan, E. M., Schwarz, J., and Storch, A. (2002). Expression of mutant alpha-synucleins enhances dopamine transporter-mediated MPP+ toxicity in vitro. Neuroreport 13, 1279-1283.
    • (2002) Neuroreport , vol.13 , pp. 1279-1283
    • Lehmensiek, V.1    Tan, E.M.2    Schwarz, J.3    Storch, A.4
  • 28
    • 48949091622 scopus 로고    scopus 로고
    • Food for thought ... on the real success of 3r approaches
    • Leist, M., Kadereit, S., and Schildknecht, S. (2008). Food for thought ... on the real success of 3R approaches. ALTEX 25, 17-32.
    • (2008) ALTEX , vol.25 , pp. 17-32
    • Leist, M.1    Kadereit, S.2    Schildknecht, S.3
  • 29
    • 79955432219 scopus 로고    scopus 로고
    • Food for thought ... Considerations and guidelines for basic test method descriptions in toxicology
    • Leist, M., Efremova, L., and Karreman C. (2010). Food for thought ... considerations and guidelines for basic test method descriptions in toxicology. ALTEX 27, 309-317.
    • (2010) ALTEX , vol.27 , pp. 309-317
    • Leist, M.1    Efremova, L.2    Karreman, C.3
  • 30
    • 84870984610 scopus 로고    scopus 로고
    • Novel technologies and an overall strategy to allow hazard assessment and risk prediction of chemicals, cosmetics, and drugs with animal-free methods
    • Leist, M., Lidbury, B. A., Yang, C., et al. (2012). Novel technologies and an overall strategy to allow hazard assessment and risk prediction of chemicals, cosmetics, and drugs with animal-free methods. ALTEX 29, 373-388.
    • (2012) ALTEX , vol.29 , pp. 373-388
    • Leist, M.1    Lidbury, B.A.2    Yang, C.3
  • 31
    • 77952544603 scopus 로고    scopus 로고
    • Comparison between proliferative and neuron-like sh-sy5y cells as an in vitro model for parkinson disease studies
    • Lopes, F. M., Schröder, R., da Frota, M. L. Jr., et al. (2010). Comparison between proliferative and neuron-like SH-SY5Y cells as an in vitro model for Parkinson disease studies. Brain Res 1337, 85-94.
    • (2010) Brain Res , vol.1337 , pp. 85-94
    • Lopes, F.M.1    Schröder, R.2    Da Frota Jr., M.L.3
  • 32
    • 0037064078 scopus 로고    scopus 로고
    • Effect of mutant alpha-synuclein on dopamine homeostasis in a new human mesencephalic cell line
    • Lotharius, J., Barg, S., Wiekop, P., et al. (2002). Effect of mutant alpha-synuclein on dopamine homeostasis in a new human mesencephalic cell line. J Biol Chem 277, 38884-38894.
    • (2002) J Biol Chem , vol.277 , pp. 38884-38894
    • Lotharius, J.1    Barg, S.2    Wiekop, P.3
  • 33
    • 21844442345 scopus 로고    scopus 로고
    • Progressive degeneration of human mesencephalic neuron-derived cells triggered by dopamine-dependent oxidative stress is dependent on the mixed-lineage kinase pathway
    • Lotharius, J., Falsig, J., van Beek, J., et al. (2005). Progressive degeneration of human mesencephalic neuron-derived cells triggered by dopamine-dependent oxidative stress is dependent on the mixed-lineage kinase pathway. J Neurosci 25, 6329-6342.
    • (2005) J Neurosci , vol.25 , pp. 6329-6342
    • Lotharius, J.1    Falsig, J.2    Van Beek, J.3
  • 34
    • 0024373441 scopus 로고
    • Absence of wallerian degeneration does not hinder regeneration in peripheral nerve
    • Lunn, E. R., Perry, V. H., Brown, M. C., et al. (1989). Absence of Wallerian degeneration does not hinder regeneration in peripheral nerve. Eur J Neurosci 1, 27-33.
    • (1989) Eur J Neurosci , vol.1 , pp. 27-33
    • Lunn, E.R.1    Perry, V.H.2    Brown, M.C.3
  • 35
    • 0035195636 scopus 로고    scopus 로고
    • Wallerian degeneration of injured axons and synapses is delayed by a ube4b/nmnat chimeric gene
    • Mack, T. G., Reiner, M., Beirowski, B., et al. (2001). Wallerian degeneration of injured axons and synapses is delayed by a Ube4b/Nmnat chimeric gene. Nat Neurosci 4, 1199-1206.
    • (2001) Nat Neurosci , vol.4 , pp. 1199-1206
    • Mack, T.G.1    Reiner, M.2    Beirowski, B.3
  • 36
    • 84874644235 scopus 로고    scopus 로고
    • Site-specific interaction between α-synuclein and membranes probed by nmr-observed methionine oxidation rates
    • Maltsev, A. S., Chen, J., Levine, R. L., and Bax., A. (2013). Site-specific interaction between α-synuclein and membranes probed by NMR-observed methionine oxidation rates. J Am Chem Soc 135, 2943-2946.
    • (2013) J Am Chem Soc , vol.135 , pp. 2943-2946
    • Maltsev, A.S.1    Chen, J.2    Levine, R.L.3
  • 37
    • 0038334899 scopus 로고    scopus 로고
    • Alpha-synuclein overexpression protects against paraquat-induced neurodegeneration
    • Manning-Bog, A. B., McCormack, A. L., Purisai, M. G., et al. (2003). Alpha-synuclein overexpression protects against paraquat-induced neurodegeneration. J Neurosci 23, 3095-3099.
    • (2003) J Neurosci , vol.23 , pp. 3095-3099
    • Manning-Bog, A.B.1    McCormack, A.L.2    Purisai, M.G.3
  • 38
    • 59149093045 scopus 로고    scopus 로고
    • Ubiquitin-fusion protein system: A powerful tool for ectopic protein expression in mammalian cells
    • Matentzoglu, K. and Scheffner, M. (2009). Ubiquitin-fusion protein system: a powerful tool for ectopic protein expression in mammalian cells. Biotechniques 46, 21-28.
    • (2009) Biotechniques , vol.46 , pp. 21-28
    • Matentzoglu, K.1    Scheffner, M.2
  • 39
    • 33646476833 scopus 로고    scopus 로고
    • Increased sensitivity to mptp in human alpha-synuclein a30p transgenic mice
    • Nieto, M., Gil-Bea, F. J., Dalfó, E., et al. (2006). Increased sensitivity to MPTP in human alpha-synuclein A30P transgenic mice. Neurobiol Aging 27, 848-856.
    • (2006) Neurobiol Aging , vol.27 , pp. 848-856
    • Nieto, M.1    Gil-Bea, F.J.2    Dalfó, E.3
  • 40
    • 0021176611 scopus 로고
    • Retinoic acid-induced differentiation of cultured human neuroblastoma cells: A comparison with phorbolester-induced differentiation
    • Påhlman, S., Ruusala, A. I., Abrahamsson, L., et al. (1984). Retinoic acid-induced differentiation of cultured human neuroblastoma cells: a comparison with phorbolester-induced differentiation. Cell Differ 14, 135-144.
    • (1984) Cell Differ , vol.14 , pp. 135-144
    • Påhlman, S.1    Ruusala, A.I.2    Abrahamsson, L.3
  • 41
    • 33847314150 scopus 로고    scopus 로고
    • Tyrosine hydroxylase expression is unstable in human immortalized mesencephalic cell line-studies in vitro and after intracerebral grafting in vivo
    • Paul, G., Christophersen, N. S., Raymon, H., et al. (2007). Tyrosine hydroxylase expression is unstable in human immortalized mesencephalic cell line-studies in vitro and after intracerebral grafting in vivo. Mol Cell Neurosci 34, 390-399.
    • (2007) Mol Cell Neurosci , vol.34 , pp. 390-399
    • Paul, G.1    Christophersen, N.S.2    Raymon, H.3
  • 42
    • 84864510172 scopus 로고    scopus 로고
    • Uncoupling of atp-depletion and cell death in human dopaminergic neurons
    • Pöltl, D., Schildknecht, S., Karreman, C., and Leist, M. (2012). Uncoupling of ATP-depletion and cell death in human dopaminergic neurons. Neurotoxicology 33, 769-779.
    • (2012) Neurotoxicology , vol.33 , pp. 769-779
    • Pöltl, D.1    Schildknecht, S.2    Karreman, C.3    Leist, M.4
  • 43
    • 0035017068 scopus 로고    scopus 로고
    • Sensitivity to mptp is not increased in parkinson's disease-associated mutant alpha-synuclein transgenic mice
    • Rathke-Hartlieb, S., Kahle, P. J., Neumann, M., et al. (2001). Sensitivity to MPTP is not increased in Parkinson's disease-associated mutant alpha-synuclein transgenic mice. J Neurochem 77, 1181-1184.
    • (2001) J Neurochem , vol.77 , pp. 1181-1184
    • Rathke-Hartlieb, S.1    Kahle, P.J.2    Neumann, M.3
  • 44
    • 70350031056 scopus 로고    scopus 로고
    • Requirement of a dopaminergic neuronal phenotype for toxicity of low concentrations of 1-methyl-4-phenylpyridinium to human cells
    • Schildknecht, S., Pöltl, D., Nagel, D. M., et al. (2009). Requirement of a dopaminergic neuronal phenotype for toxicity of low concentrations of 1-methyl-4-phenylpyridinium to human cells. Toxicol Appl Pharmacol 241, 23-35.
    • (2009) Toxicol Appl Pharmacol , vol.241 , pp. 23-35
    • Schildknecht, S.1    Pöltl, D.2    Nagel, D.M.3
  • 45
    • 79953151438 scopus 로고    scopus 로고
    • Neuroprotection by minocycline caused by direct and specific scavenging of peroxynitrite
    • Schildknecht, S., Pape, R., Müller, N., et al. (2011). Neuroprotection by minocycline caused by direct and specific scavenging of peroxynitrite. J Biol Chem 286, 4991-5002.
    • (2011) J Biol Chem , vol.286 , pp. 4991-5002
    • Schildknecht, S.1    Pape, R.2    Müller, N.3
  • 46
    • 84876790040 scopus 로고    scopus 로고
    • Oxidative and nitrative alpha-synuclein modifications and proteostatic stress: Implications for disease mechanisms and interventions in synucleinopathies
    • Schildknecht, S., Gerding, H. R., Karreman, C., et al. (2013). Oxidative and nitrative alpha-synuclein modifications and proteostatic stress: implications for disease mechanisms and interventions in synucleinopathies. J Neurochem 125, 491-511.
    • (2013) J Neurochem , vol.125 , pp. 491-511
    • Schildknecht, S.1    Gerding, H.R.2    Karreman, C.3
  • 47
    • 0038404962 scopus 로고    scopus 로고
    • Role of alpha-synuclein in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine- induced parkinsonism in mice
    • Schlüter, O. M., Fornai, F., Alessandrí, M. G., et al. (2003). Role of alpha-synuclein in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine- induced parkinsonism in mice. Neuroscience 118, 985-1002.
    • (2003) Neuroscience , vol.118 , pp. 985-1002
    • Schlüter, O.M.1    Fornai, F.2    Alessandrí, M.G.3
  • 48
    • 81055127451 scopus 로고    scopus 로고
    • Rapid, complete and large-scale generation of post-mitotic neurons from the human luhmes cell line
    • Scholz, D., Pöltl, D., Genewsky, A., et al. (2011). Rapid, complete and large-scale generation of post-mitotic neurons from the human LUHMES cell line. J Neurochem 119, 957-971.
    • (2011) J Neurochem , vol.119 , pp. 957-971
    • Scholz, D.1    Pöltl, D.2    Genewsky, A.3
  • 49
    • 84868113574 scopus 로고    scopus 로고
    • Control of aβ release from human neurons by differentiation status and ret signaling
    • Scholz, D., Chernyshova, Y., and Leist, M. (2013). Control of Aβ release from human neurons by differentiation status and RET signaling. Neurobiol Aging 34, 184-199.
    • (2013) Neurobiol Aging , vol.34 , pp. 184-199
    • Scholz, D.1    Chernyshova, Y.2    Leist, M.3
  • 50
    • 0031589740 scopus 로고    scopus 로고
    • Free radical scavengers protect dopaminergic cell lines from apoptosis induced by complex i inhibitors
    • Seaton, T. A., Cooper, J. M., and Schapira, A. H. (1997). Free radical scavengers protect dopaminergic cell lines from apoptosis induced by complex I inhibitors. Brain Res 777, 110-118.
    • (1997) Brain Res , vol.777 , pp. 110-118
    • Seaton, T.A.1    Cooper, J.M.2    Schapira, A.H.3
  • 51
    • 0344198025 scopus 로고    scopus 로고
    • Mechanism of toxicity in rotenone models of parkinson's disease
    • Sherer, T. B., Betarbet, R., Testa, C. M., et al. (2003). Mechanism of toxicity in rotenone models of Parkinson's disease. J Neurosci 23, 10756-10764.
    • (2003) J Neurosci , vol.23 , pp. 10756-10764
    • Sherer, T.B.1    Betarbet, R.2    Testa, C.M.3
  • 52
    • 0242300619 scopus 로고    scopus 로고
    • Alpha-synuclein locus triplication causes parkinson's disease
    • Singleton, A. B., Farrer, M., Johnson, J., et al. (2003). Alpha-Synuclein locus triplication causes Parkinson's disease. Science 302, 841.
    • (2003) Science , vol.302 , pp. 841
    • Singleton, A.B.1    Farrer, M.2    Johnson, J.3
  • 53
    • 0035789203 scopus 로고    scopus 로고
    • Deletion of the alpha-synuclein locus in a subpopulation of c57bl/6j inbred mice
    • Specht, C. G. and Schoepfer, R. (2001). Deletion of the alpha-synuclein locus in a subpopulation of C57BL/6J inbred mice. BMC Neurosci 2, 11.
    • (2001) BMC Neurosci , vol.2 , pp. 11
    • Specht, C.G.1    Schoepfer, R.2
  • 55
    • 79955379993 scopus 로고    scopus 로고
    • Assessment of chemical-induced impairment of human neurite outgrowth by multiparametric live cell imaging in high-density cultures
    • Stiegler, N. V., Krug, A. K., Matt, F., and Leist, M. (2011). Assessment of chemical-induced impairment of human neurite outgrowth by multiparametric live cell imaging in high-density cultures. Toxicol Sci 121, 73-87.
    • (2011) Toxicol Sci , vol.121 , pp. 73-87
    • Stiegler, N.V.1    Krug, A.K.2    Matt, F.3    Leist, M.4
  • 56
    • 84864511648 scopus 로고    scopus 로고
    • Translating neurobehavioural endpoints of developmental neurotoxicity tests into in vitro assays and readouts
    • van Thriel, C., Westerink, R. H., Beste, C., et al. (2012). Translating neurobehavioural endpoints of developmental neurotoxicity tests into in vitro assays and readouts. Neurotoxicology 33, 911-924.
    • (2012) Neurotoxicology , vol.33 , pp. 911-924
    • Van Thriel, C.1    Westerink, R.H.2    Beste, C.3
  • 57
    • 3843117589 scopus 로고    scopus 로고
    • Reinitiation involving upstream orfs regulates atf4 mrna translation in mammalian cells
    • Vattem, K. M. and Wek, R. C. (2004). Reinitiation involving upstream ORFs regulates ATF4 mRNA translation in mammalian cells. Proc Natl Acad Sci U S A 101, 11269-11274.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 11269-11274
    • Vattem, K.M.1    Wek, R.C.2
  • 58
    • 36448961246 scopus 로고    scopus 로고
    • Vesicular monoamine transporter 2 regulates the sensitivity of rat dopaminergic neurons to disturbed cytosolic dopamine levels
    • Vergo, S., Johansen, J. L., Leist, M., and Lotharius, J. (2007). Vesicular monoamine transporter 2 regulates the sensitivity of rat dopaminergic neurons to disturbed cytosolic dopamine levels. Brain Res 1185, 18-32.
    • (2007) Brain Res , vol.1185 , pp. 18-32
    • Vergo, S.1    Johansen, J.L.2    Leist, M.3    Lotharius, J.4
  • 59
    • 45649085606 scopus 로고    scopus 로고
    • VCP binding influences intracellular distribution of the slow wallerian degeneration protein, wld(s)
    • Wilbrey, A. L., Haley, J. E., Wishart, T. M., et al. (2008). VCP binding influences intracellular distribution of the slow Wallerian degeneration protein, Wld(S). Mol Cell Neurosci 38, 325-340.
    • (2008) Mol Cell Neurosci , vol.38 , pp. 325-340
    • Wilbrey, A.L.1    Haley, J.E.2    Wishart, T.M.3
  • 60
    • 69449100026 scopus 로고    scopus 로고
    • Alpha-synuclein knockdown attenuates mpp+ induced mitochondrial dysfunction of sh-sy5y cells
    • Wu, F., Poon, W. S., Lu, G., et al. (2009). Alpha-synuclein knockdown attenuates MPP+ induced mitochondrial dysfunction of SH-SY5Y cells. Brain Res 1292, 173-179.
    • (2009) Brain Res , vol.1292 , pp. 173-179
    • Wu, F.1    Poon, W.S.2    Lu, G.3
  • 61
    • 41049097832 scopus 로고    scopus 로고
    • Increased dopaminergic neuron sensitivity to 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine (mptp) in transgenic mice expressing mutant a53t alpha-synuclein
    • Yu, W. H., Matsuoka, Y., Sziráki, I., et al. (2008). Increased dopaminergic neuron sensitivity to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in transgenic mice expressing mutant A53T alpha-synuclein. Neurochem Res 33, 902-911.
    • (2008) Neurochem Res , vol.33 , pp. 902-911
    • Yu, W.H.1    Matsuoka, Y.2    Sziráki, I.3
  • 62
    • 84860471851 scopus 로고    scopus 로고
    • Role of alpha-synuclein protein levels in mitochondrial morphology and cell survival in cell lines
    • Zhu, M., Li, W., and Lu, C. (2012). Role of alpha-synuclein protein levels in mitochondrial morphology and cell survival in cell lines. PLoS One 7, e36377.
    • (2012) PLoS One , vol.7
    • Zhu, M.1    Li, W.2    Lu, C.3
  • 63
    • 79957868414 scopus 로고    scopus 로고
    • Sensitivity of dopaminergic neuron differentiation from stem cells to chronic low-dose methylmercury exposure
    • Zimmer, B., Schildknecht, S., Kuegler, P. B., et al. (2011a). Sensitivity of dopaminergic neuron differentiation from stem cells to chronic low-dose methylmercury exposure. Toxicol Sci 121, 357-367.
    • (2011) Toxicol Sci , vol.121 , pp. 357-367
    • Zimmer, B.1    Schildknecht, S.2    Kuegler, P.B.3
  • 64
    • 79951678616 scopus 로고    scopus 로고
    • Coordinated waves of gene expression during neuronal differentiation of embryonic stem cells as basis for novel approaches to developmental neurotoxicity testing
    • Zimmer, B., Kuegler, P. B., Baudis, B., et al. (2011b). Coordinated waves of gene expression during neuronal differentiation of embryonic stem cells as basis for novel approaches to developmental neurotoxicity testing. Cell Death Differ 18, 383-395.
    • (2011) Cell Death Differ , vol.18 , pp. 383-395
    • Zimmer, B.1    Kuegler, P.B.2    Baudis, B.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.