Profiling of drugs and environmental chemicals for functional impairment of neural crest migration in a novel stem cell-based test battery

Archives of Toxicology

Volumn 88, Issue 5, 2014, Pages 1109-1126

  Zimmer, B ^a   Pallocca, G ^b   Dreser, N ^b   Foerster, S ^b   Waldmann, T ^b   Westerhout, J ^c   Julien, S ^d   Krause, K H ^d   Van Thriel, C ^f   Hengstler, J G ^f   Sachinidis, A ^e   Bosgra, S ^c   Leist, M ^b  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b UNIVERSITY OF KONSTANZ   (Germany)

^c TNO   (Netherlands)

^d UNIVERSITY OF GENEVA MEDICAL SCHOOL   (Switzerland)

^e UNIVERSITY OF COLOGNE   (Germany)

^f TU DORTMUND UNIVERSITY   (Germany)

Author keywords

Developmental toxicity testing; hESC based test system; Neural crest migration assay; Test battery based compound screening

Indexed keywords

ABIRATERONE; ARSENIC TRIOXIDE; BETA INTERFERON; CHLORPROMAZINE; CYPROCONAZOLE; ENVIRONMENTAL CHEMICAL; GEFITINIB; GELDANAMYCIN; POLYBROMINATED DIPHENYL ETHER; TRIADIMEFON; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL MIGRATION; CONCENTRATION (PARAMETERS); CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DATA MINING; DEVELOPMENTAL TOXICITY; EMBRYONIC STEM CELL; HEK293 CELL LINE; HUMAN; HUMAN CELL; IN VIVO STUDY; MIGRATION INHIBITION; MOUSE; NEURAL CREST CELL; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; ANIMAL; CELL DIFFERENTIATION; CELL MOTION; CYTOLOGY; DOSE RESPONSE; DRUG EFFECTS; NEURAL CREST; PROCEDURES; THEORETICAL MODEL; TOXICITY TESTING;

ANIMALS; CELL DIFFERENTIATION; CELL MOVEMENT; DOSE-RESPONSE RELATIONSHIP, DRUG; EMBRYONIC STEM CELLS; HEK293 CELLS; HUMANS; MICE; MODELS, THEORETICAL; NEURAL CREST; TOXICITY TESTS;

EID: 84901307535     PISSN: 03405761     EISSN: 14320738     Source Type: Journal    
DOI: 10.1007/s00204-014-1231-9     Document Type: Article

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