Increasing Scientific Confidence in Adverse Outcome Pathways: Application of Tailored Bradford-Hill Considerations for Evaluating Weight of Evidence

Regulatory Toxicology and Pharmacology

Volumn 72, Issue 3, 2015, Pages 514-537

  Becker, Richard A ^a   Ankley, Gerald T ^b   Edwards, Stephen W ^b   Kennedy, Sean W ^c   Linkov, Igor ^d   Meek, Bette ^e   Sachana, Magdalini ^f   Segner, Helmut ^g   Van Der Burg, Bart ^h   Villeneuve, Daniel L ^b   Watanabe, Haruna ⁱ   Barton Maclaren, Tara S ^j  

^a American Chemistry Council   (United States)

^b U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^c ENVIRONMENT CANADA   (Canada)

^d Engineer Research and Development Center   (United States)

^e UNIVERSITY OF OTTAWA   (Canada)

^f JOINT RESEARCH CENTRE   (Italy)

^g UNIVERSITY OF BERN   (Switzerland)

^h BIODETECTION SYSTEMS B V   (Netherlands)

ⁱ NATIONAL INSTITUTE FOR ENVIRONMENTAL STUDIES   (Japan)

^j HEALTH CANADA   (Canada)

more..

Author keywords

Adverse outcome pathway; Bradford Hill considerations; Mode of action; Weight of evidence

Indexed keywords

AROMATASE; AROMATASE INHIBITOR; AROMATIC HYDROCARBON RECEPTOR; CALCIUM ION; CHROMIUM; CYTOCHROME P450; ESTRADIOL; ESTROGEN; ESTROGEN RECEPTOR ALPHA; JUVENILE HORMONE DERIVATIVE; NEUROTOXIC ESTERASE; ORGANOPHOSPHATE; VITELLOGENIN;

ADVERSE OUTCOME; ARTICLE; CYTOTOXICITY; DECISION SUPPORT SYSTEM; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DUODENUM TUMOR; ENDOMETRIUM CANCER; ENZYME INHIBITION; ESTROGEN SYNTHESIS; HUMAN; MEDICAL RESEARCH; MULTICRITERIA DECISION ANALYSIS; NEUROPATHY; NEUROTOXICITY; NONHUMAN; OXIDATIVE STRESS; PRACTICE GUIDELINE; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REPRODUCTIVE TOXICITY; TOXICITY TESTING; TRANSCRIPTION INITIATION; VALIDATION PROCESS; ZEBRA FISH; ADVERSE DRUG REACTION; ANIMAL; DRUG EFFECTS; FEMALE; FISH; PROCEDURES; REPRODUCTION; RISK ASSESSMENT;

ANIMALS; AROMATASE INHIBITORS; DRUG-RELATED SIDE EFFECTS AND ADVERSE REACTIONS; FEMALE; FISHES; REPRODUCTION; RISK ASSESSMENT;

EID: 84930633666     PISSN: 02732300     EISSN: 10960295     Source Type: Journal    
DOI: 10.1016/j.yrtph.2015.04.004     Document Type: Article

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