New roles for astrocytes: Redefining the functional architecture of the brain

Trends in Neurosciences

Volumn 26, Issue 10, 2003, Pages 523-530

  Nedergaard, Maiken ^a   Ransom, Bruce ^b   Goldman, Steven A ^c  

^a NEW YORK MEDICAL COLLEGE   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

^c WEILL CORNELL MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM ION;

ASTROCYTE; BRAIN BLOOD FLOW; BRAIN FUNCTION; CALCIUM SIGNALING; CELL FUNCTION; CELL INTERACTION; ENDOTHELIUM CELL; GLIA CELL; GRAY MATTER; HUMAN; MICROVASCULATURE; NERVE CELL PLASTICITY; NERVOUS SYSTEM; NERVOUS SYSTEM DEVELOPMENT; PHYLOGENY; PRIORITY JOURNAL; REVIEW; SATELLITE CELL; SYNAPTOGENESIS;

EID: 0141533205     PISSN: 01662236     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tins.2003.08.008     Document Type: Review

References (68)

1. Virchow R. Uber das granulierte Anschen der Waudungen der Gerhirnventrikel. Allg. Z. Psychiatr. 3:1846;242.
2. Sulston J.E., et al. The embryonic cell lineage of the nematode Caenorhabditis elegans. Dev. Biol. 100:1983;64-119.
3. Bass N.H., et al. Quantitative cytoarchitectonic distribution of neurons, glia, and DNA in rat cerebral cortex. J. Comp. Neurol. 143:1971;481-490.
4. Kang J., et al. Astrocyte-mediated potentiation of inhibitory synaptic transmission. Nat. Neurosci. 1:1998;683-692.
5. Haydon P.G. Glia: listening and talking to the synapse. Nat. Rev. Neurosci. 2:2001;185-193.
6. Newman, E.A. New roles for astrocytes: regulation of synaptic function. Trends Neurosci. (in press).
7. Pfrieger F.W., Barres B.A. Synaptic efficacy enhanced by glial cells in vitro. Science. 277:1997;1684-1687.
8. Ullian E.M., et al. Control of synapse number by glia. Science. 291:2001;657-661.
9. Song H., et al. Astroglia induce neurogenesis from adult neural stem cells. Nature. 417:2002;39-44.
10. Horner, P. and Palmer, T. New roles for astrocytes: La vida loca! The nightlife of an astrocyte. Trends Neurosci. (in press).
11. Bushong E.A., et al. Protoplasmic astrocytes in CA1 stratum radiatum occupy separate anatomical domains. J. Neurosci. 22:2002;183-192.
12. Ogata K., Kosaka T. Structural and quantitative analysis of astrocytes in the mouse hippocampus. Neuroscience. 113:2002;221-233.
13. Chan-Ling T., Stone J. Factors determining the shape, spacing and distribution of astrocytes in the cat retina: The contact-spacing model of astrocyte interaction. J. Comp. Neurol. 303:1991;387-399.
14. Simard, M. et al. Signaling at the gliovascular interface. J. Neurosci. (in press).
15. Rohlmann A., Wolff J. Subcellular Topography and Plasticity of Gap Junction Distribution on Astrocytes. 1996;R.G. Landes Company.
16. + concentrations in astrocytes. Glia. 20:1997;299-307.
17. Grosche J., et al. Microdomains for neuron-glia interaction: parallel fiber signaling to Bergmann glial cells. Nat. Neurosci. 2:1999;139-143.
18. Kang J., Nedergaard M. Imaging Astrocytes in Acute Brain Slices. 1999;Cold Spring Harbor Laboratory Press.
19. Ransom B.R., Sontheimer H. The neurophysiology of glial cells. J. Clin. Neurophysiol. 9:1992;224-251.
20. Cornell-Bell A.H., et al. Glutamate induces calcium waves in cultured astrocytes: long-range glial signaling. Science. 247:1990;470-473.
21. Berridge M.J., et al. Calcium - a life and death signal. Nature. 395:1998;645-648.
22. 2+ channels in reactive astrocytes after brain injury, hypomyelination, and ischemia. J. Neurosci. 18:1998;2321-2334.
23. Verkhratsky A., et al. Glial calcium: homeostasis and signaling function. Physiol. Rev. 78:1998;99-141.
24. Bergles D.E., Jahr C.E. Glial contribution to glutamate uptake at Schaffer collateral-commissural synapses in the hippocampus. J. Neurosci. 18:1998;7709-7716.
25. Cornell-Bell A.H., et al. Glutamate induces calcium waves in cultured astrocytes: long-range glial signaling. Science. 247:1990;470-473.
26. 2+ waves trigger responses in microglial cells in brain slices. FASEB J. 16:2002;255-257.
27. Dani J.W., Smith S.J. The triggering of astrocytic calcium waves by NMDA-induced neuronal activation. Ciba Found. Symp. 188:1995;195-205.
28. 2+ oscillations in situ drive NMDAR-mediated neuronal excitation. Nat. Neurosci. 4:2001;803-812.
29. Nett W.J., et al. Hippocampal astrocytes in situ exhibit calcium oscillations that occur independent of neuronal activity. J. Neurophysiol. 87:2002;528-537.
30. Yuste R., et al. Neuronal domains in developing neocortex. Science. 257:1992;665-669.
31. 2+ transients. Nature. 375:1995;784-787.
32. 2+ spike frequency can optimize gene expression. Nature. 392:1998;936-941.
33. 2+ oscillations and waves by oscillating translocation and activation of protein kinase C. Curr. Biol. 11:2001;1089-1097.
34. Nedergaard M. Direct signaling from astrocytes to neurons in cultures of mammalian brain cells. Science. 263:1994;1768-1771.
35. Parpura V., et al. Glutamate-mediated astrocyte-neuron signalling. Nature. 369:1994;744-747.
36. Nedergaard M. Spreading depression as a contributor to ischemic brain damage. Adv. Neurol. 71:1996;75-83.
37. Hansen A.J., Nedergaard M. Brain ion homeostasis in cerebral ischemia. Neurochem. Pathol. 9:1988;195-209.
38. Mies G., et al. Correlation between peri-infarct DC shifts and ischaemic neuronal damage in rat. NeuroReport. 4:1993;709-711.
39. Basarsky T.A., et al. Imaging spreading depression and associated intracellular calcium waves in brain slices. J. Neurosci. 18:1998;7189-7199.
40. Kunkler P.E., Kraig R.P. Calcium waves precede electrophysiological changes of spreading depression in hippocampal organ cultures. J. Neurosci. 18:1998;3416-3425.
41. Anderson C.M., Swanson R.A. Astrocyte glutamate transport: review of properties, regulation, and physiological functions. Glia. 32:2000;1-14.
42. Martin D.L. Synthesis and release of neuroactive substances by glial cells. Glia. 5:1992;81-94.
43. Araque A., et al. SNARE protein-dependent glutamate release from astrocytes. J. Neurosci. 20:2000;666-673.
44. Jeremic A., et al. ATP stimulates calcium-dependent glutamate release from cultured astrocytes. J. Neurochem. 77:2001;664-675.
45. Bezzi P., et al. Prostaglandins stimulate calcium-dependent glutamate release in astrocytes. Nature. 391:1998;281-285.
46. Nedergaard M., et al. Beyond the role of glutamate as a neurotransmitter. Nat. Rev. Neurosci. 3:2002;748-755.
47. Ye Z.C., et al. Functional hemichannels in astrocytes: a novel mechanism of glutamate release. J. Neurosci. 23:2003;3588-3596.
48. Duan S., et al. P2X7 receptor-mediated release of excitatory amino acids from astrocytes. J. Neurosci. 23:2003;1320-1328.
49. del Zoppo G.J., Hallenbeck J.M. Advances in the vascular pathophysiology of ischemic stroke. Thromb. Res. 98:2000;73-81.
50. Abbott N.J. Astrocyte-endothelial interactions and blood-brain barrier permeability. J. Anat. 200:2002;629-638.
51. Tsacopoulos M., Magistretti P.J. Metabolic coupling between glia and neurons. J. Neurosci. 16:1996;877-885.
52. Wender R., et al. Astrocytic glycogen influences axon function and survival during glucose deprivation in central white matter. J. Neurosci. 20:2000;6804-6810.
53. Hertz L., Dienel G.A. Energy metabolism in the brain. Int. Rev. Neurobiol. 51:2002;1-102.
54. Chih C.P., et al. Do active cerebral neurons really use lactate rather than glucose? Trends Neurosci. 24:2001;573-578.
55. Zonta M., et al. Neuron-to-astrocyte signaling is central to the dynamic control of brain microcirculation. Nat. Neurosci. 6:2003;43-50.
56. Anderson C.M., Nedergaard M. Astrocyte-mediated control of cerebral microcirculation. Trends Neurosci. 26:2003;340-344.
57. Pfrieger, F. New roles for astrocytes: regulation of synaptogenesis. Trends Neurosci. (in press).
58. Charles A.C., et al. Intercellular calcium signaling via gap junctions in glioma cells. J. Cell Biol. 118:1992;195-201.
59. Hassinger T.D., et al. An extracellular signaling component in propagation of astrocytic calcium waves. Proc. Natl. Acad. Sci. U. S. A. 93:1996;13268-13273.
60. Arcuino G., et al. Intercellular calcium signaling mediated by point-source burst release of ATP. Proc. Natl. Acad. Sci. U. S. A. 99:2002;9840-9845.
61. Burnstock G. Potential therapeutic targets in the rapidly expanding field of purinergic signalling. Clin. Med. 2:2002;45-53.
62. Franke H., et al. P2X receptor expression on astrocytes in the nucleus accumbens of rats. Neuroscience. 108:2001;421-429.
63. John G.R., et al. Extracellular nucleotides differentially regulate interleukin-1β signaling in primary human astrocytes: implications for inflammatory gene expression. J. Neurosci. 21:2001;4134-4142.
64. Moran-Jimenez M.J., Matute C. Immunohistochemical localization of the P2Y(1) purinergic receptor in neurons and glial cells of the central nervous system. Brain Res. Mol. Brain Res. 78:2000;50-58.
65. Zhu Y., Kimelberg H.K. Developmental expression of metabotropic P2Y(1) and P2Y(2) receptors in freshly isolated astrocytes from rat hippocampus. J. Neurochem. 77:2001;530-541.
66. Cotrina M.L., et al. Connexins regulate calcium signaling by controlling ATP release. Proc. Natl. Acad. Sci. U. S. A. 95:1998;15735-15740.
67. Cotrina M.L., et al. ATP-mediated glia signaling. J. Neurosci. 20:2000;2835-2844.
68. Bennett, M.V. New roles for astrocytes: release of neuroactive substances by Cx-hemichannels. Trends Neurosci. (in press).