Quantitative high-throughput screening: A titration-based approach that efficiently identifies biological activities in large chemical libraries

Proceedings of the National Academy of Sciences of the United States of America

Volumn 103, Issue 31, 2006, Pages 11473-11478

  Inglese, James ^a   Auld, Douglas S ^a   Jadhav, Ajit ^a   Johnson, Ronald L ^a   Simeonov, Anton ^a   Yasgar, Adam ^a   Zheng, Wei ^a   Austin, Christopher P ^a  

^a NATIONAL HUMAN GENOME RESEARCH INSTITUTE   (United States)

Author keywords

1,536 well; Chemical genomics; Enzyme assay; PubChem; Pyruvate kinase

Indexed keywords

PYRUVATE KINASE;

ACCURACY; ARTICLE; CELL FUNCTION; CHEMICAL STRUCTURE; CONCENTRATION (PARAMETERS); ENZYME ACTIVITY; FALSE NEGATIVE RESULT; FALSE POSITIVE RESULT; FOLLOW UP; GENE IDENTIFICATION; GENE PROBE; HIGH THROUGHPUT SCREENING; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RELIABILITY; TITRIMETRY;

COMBINATORIAL CHEMISTRY TECHNIQUES; DATABASES, FACTUAL; DRUG DESIGN; HUMANS; LIGANDS; MOLECULAR STRUCTURE; PYRUVATE KINASE; STRUCTURE-ACTIVITY RELATIONSHIP; TITRIMETRY;

EID: 33746789921     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0604348103     Document Type: Article

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