A multi-laboratory evaluation of microelectrode array-based measurements of neural network activity for acute neurotoxicity testing

NeuroToxicology

Volumn 60, Issue , 2017, Pages 280-292

  Vassallo, Andrea ^a,b   Chiappalone, Michela ^a   De Camargos Lopes, Ricardo ^a,c   Scelfo, Bibiana ^d   Novellino, Antonio ^e   Defranchi, Enrico ^e   Palosaari, Taina ^d   Weisschu, Timo ^f   Ramirez, Tzutzuy ^f   Martinoia, Sergio ^b   Johnstone, Andrew F M ^g   Mack, Cina M ^g   Landsiedel, Robert ^f   Whelan, Maurice ^d   Bal Price, Anna ^d   Shafer, Timothy J ^g  

^a ISTITUTO ITALIANO DI TECNOLOGIA   (Italy)

^b UNIVERSITY OF GENOA   (Italy)

^c University of Santa Maria   (Brazil)

^d JOINT RESEARCH CENTRE   (Italy)

^e eTT   (Italy)

^f Experimental Toxicology and Ecology   (Germany)

^g U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

Author keywords

Cross laboratory comparison; Microelectrode array; Screening

Indexed keywords

CHLORPYRIFOS OXON; DELTAMETHRIN; DOMOIC ACID; GLYPHOSATE; ORGANOPHOSPHATE INSECTICIDE; PARACETAMOL; PHTHALIC ACID DIMETHYL ESTER; UNCLASSIFIED DRUG; INSECTICIDE; NEUROTOXIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; ARTIFICIAL NEURAL NETWORK; BRAIN CELL CULTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; ELECTRIC ACTIVITY; MEAN BURST DURATION; MEAN BURST RATE; MEAN FIRING RATE; MEAN FIRING RATE IN BURST; MICROELECTRODE ARRAY; NEUROTOXICITY; NONHUMAN; PARAMETERS; PRIORITY JOURNAL; RAT; TOXICITY TESTING; ANIMAL; CELL CULTURE; DEVICES; DRUG EFFECTS; EVALUATION STUDY; IC50; MICROELECTRODE; NERVE CELL; PHYSIOLOGY; PRECLINICAL STUDY; PROCEDURES; TOXICOLOGY;

ANIMALS; CELLS, CULTURED; DRUG EVALUATION, PRECLINICAL; INHIBITORY CONCENTRATION 50; INSECTICIDES; MICROELECTRODES; NEURONS; NEUROTOXINS; RATS; TOXICOLOGY;

EID: 84962407428     PISSN: 0161813X     EISSN: 18729711     Source Type: Journal    
DOI: 10.1016/j.neuro.2016.03.019     Document Type: Article

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