Metabolic Biomarkers of Prenatal Alcohol Exposure in Human Embryonic Stem Cell-Derived Neural Lineages

Alcoholism: Clinical and Experimental Research

Volumn 36, Issue 8, 2012, Pages 1314-1324

  Palmer, Jessica A ^a,b   Poenitzsch, Ashley M ^a   Smith, Susan M ^a   Conard, Kevin R ^b   West, Paul R ^b   Cezar, Gabriela G ^a,b  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

^b Stemina Biomarker Discovery Inc   (United States)

Author keywords

5' Methylthioadenosine; Fetal alcohol syndrome; Human embryonic stem cells; Indoleacetaldehyde; l Kynurenine; LC MS; Metabolomics; Neural progenitors

Indexed keywords

5' METHYLTHIOADENOSINE; 5' METYLTHIOADENOSINE; ACETALDEHYDE; ALCOHOL; BIOLOGICAL MARKER; INDOLEACETALDEHYDE; KYNURENINE; LEVOTHYROXINE; SUCCINYLADENOSINE; THYROXINE; TRYPTOPHAN; UNCLASSIFIED DRUG;

ALCOHOL METABOLISM; ARTICLE; CELL LINEAGE; CELL TYPE; COMPARATIVE STUDY; CONTROLLED STUDY; ELECTRON SPIN RESONANCE; EMBRYOID BODY; EMBRYONIC STEM CELL; HUMAN; HUMAN CELL; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLITE; METABOLOMICS; NERVE CELL; NERVOUS SYSTEM DEVELOPMENT; NEURAL STEM CELL; PRENATAL EXPOSURE; PRIORITY JOURNAL; SUPERNATANT;

ADULT; APOPTOSIS; BIOLOGICAL MARKERS; CELL COUNT; CELL LINEAGE; CELLS, CULTURED; CENTRAL NERVOUS SYSTEM DEPRESSANTS; DATABASES, GENETIC; DOSE-RESPONSE RELATIONSHIP, DRUG; EMBRYONIC DEVELOPMENT; EMBRYONIC STEM CELLS; ETHANOL; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; METABOLOMICS; NEURAL STEM CELLS; NEURONS; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TANDEM MASS SPECTROMETRY;

EID: 84864551960     PISSN: 01456008     EISSN: 15300277     Source Type: Journal    
DOI: 10.1111/j.1530-0277.2011.01732.x     Document Type: Article

References (54)

1. Avila MA, García-Trevijano ER, Lu SC, Corrales FJ, Mato JM (2004) Methylthioadenosine. Int J Biochem Cell Biol 36:2125-2130.
2. Badawy AA, Doughrty DM, Marsh-Richard DM, Steptoe A (2009) Activation of liver tryptophan pyrrolase mediates the decrease in tryptophan availability to the brain after acute alcohol consumption by normal subjects. Alcohol Alcohol 44:267-271.
3. Ben-Hur T, Idelson M, Khaner H, Pera M, Reinhartz E, Itzik A, Reubinoff BE (2004) Transplantation of human embryonic stem cell-derived neural progenitors improves behavioral deficit in Parkinsonian rats. Stem Cells 22:1246-1255.
4. Bernal J, Nunez J (1995) Thyroid hormones and brain development. Eur J Endocrinol 133:390-398.
5. Bonner AB, Brien S, Preedy VR (1993) The urinary excretion of tryptophan and tryptophan metabolites in the chronic ethanol-fed rat. J Pharm Pharmacol 45:81-85.
6. Buck KJ, Harris RA (1991) Neuroadaptive responses to chronic ethanol. Alcohol Clin Exp Res 15:460-470.
7. Cezar GG, Quam JA, Smith AM, Rosa GJM, Piekarczyk MS, Brown JF, Gage FH, Muotri AR (2007) Identification of small molecules from human embryonic stem cells using metabolomics. Stem Cells Dev 16:869-882.
8. Chan D, Bar-Oz B, Pellerin B, Paciorek C, Klein J, Kapur B, Farine D, Koren G (2003) Population baseline of meconium fatty acid ethyl esters among infants of nondrinking women in Jerusalem and Toronto. Ther Drug Monit 25:271-278.
9. Chirino-Galindo G, Baiza-Gutman LA, Barrera-Escorcia E, Palomar-Morales M (2009) Polyamines protect rat embryo in vitro from high glucose-induced developmental delay and dysmorphogenesis. Birth Defects Res B Dev Reprod Toxicol 86:58-64.
10. Cudd TA, Chen WJ, West JR (2002) Fetal and maternal thyroid hormone responses to ethanol exposure during the third trimester equivalent of gestation in sheep. Alcohol Clin Exp Res 26:53-58.
11. Desiderio MA, Sessa A, Perin A (1987) Polyamines and diamine oxidase activity in maternal, embryonal, and fetal tissues of rat after chronic ethanol consumption. Biochem Biophys Res Commun 142:843-848.
12. Druse MJ, Kuo A, Tajuddin N (1991) Effects of in utero ethanol exposure on the developing serotonergic system. Alcohol Clin Exp Res 15:678-684.
13. Ernhart CB, Sokol RJ, Martier S, Moron P, Nadler D, Ager JW, Wolf A (1987) Alcohol teratogenicity in the human: a detailed assessment of specificity, critical period, and threshold. Am J Obstet Gynecol 156:33-39.
14. Fernstrom JD, Wurtman RJ (1971) Brain serotonin content: physiological dependence on plasma tryptophan levels. Science 173:149-152.
15. Fiehn O (2002) Metabolomics-the link between genotypes and phenotypes. Plant Mol Biol 48:155-171.
16. Finkelstein JD, Cello JP, Kyle WE (1974) Ethanol-induced changes in methionine metabolism in rat liver. Biochem Biophys Res Commun 61:525-531.
17. Fozard JR, Prat ML, Prakash NJ, Grove J, Schechter PJ, Sjoerdsma A, Koch-Weser J (1980) L-Ornithine decarboxylase: an essential role in early mammalian embryogenesis. Science 208:505-509.
18. Grijota-Martínez C, Díez D, Morreale de Escobar G, Bernal J, Morte B (2011) Lack of action of exogenously administered T3 on the fetal rat brain despite expression of the monocarboxylate transporter 8. Endocrinology 152:1713-1721.
19. Guerri C (2002) Mechanisms involved in central nervous system dysfunctions induced by prenatal ethanol exposure. Neurotox Res 4:327-335.
20. Hannigan JH, Bellisario RL (1990) Lower serum thyroxine levels in rats following prenatal exposure to ethanol. Alcohol Clin Exp Res 14:456-460.
21. Kornguth SE, Rutledge JJ, Sunderland E, Siegel F, Carlson I, Smollens J, Juhl U, Young B (1979) Impeded cerebellar development and reduced serum thyroxine levels associated with fetal alcohol intoxication. Brain Res 177:347-360.
22. Krijt J, Kmoch S, Hartmannová H, Havlícek V, Sebesta I (1999) Identification and determination of succinyladenosine in human cerebrospinal fluid. J Chromatogr B Biomed Sci Appl 726:53-58.
23. Latchney SE, Lioy DT, Henry EC, Gasiewicz TA, Strathmann FG, Mayer-Pröschel M, Opanashuk LA (2011) Neural precursor cell proliferation is disrupted through activation of the aryl hydrocarbon receptor by 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin. Stem Cells Dev 20:313-326.
24. Lauder JM (1977) The effects of early hypo- and hyperthyroidism on the development of rat cerebellar cortex. III. Kinetics of cell proliferation in the external granular layer. Brain Res 126:31-51.
25. Lin GW, Lin TY, Jin L (1990) Gestational ethanol consumption on tissue amino acid levels: decreased free histidine and tryptophan in fetal tissues with concomitant increase in urinary histamine excretion. Alcohol Clin Exp Res 14:430-437.
26. Lindon JC, Holmes E, Nicholson JK (2003) So what's the deal with metabonomics? Anal Chem 75:384A-391A.
27. Litten RZ, Bradley AM, Moss HB (2010) Alcohol biomarkers in applied settings: recent advances and future research opportunities. Alcohol Clin Exp Res 34:955-967.
28. Maier SE, Chen WJ, West JR (1996) Prenatal binge-like alcohol exposure alters neurochemical profiles in fetal rat brain. Pharmacol Biochem Behav 55:521-529.
29. Mendez JD (1989) Polyamines and human reproduction, in The Physiology of Polyamines (Bachrach U, Heimer Y eds), vol. 1, pp 23-28. CRC Press, Boca Raton, FL.
30. Miller MW (2006) Brain Development. Oxford University Press, New York.
31. Nilsson GE, Tottmar O (1987) Effects of biogenic aldehydes and aldehyde dehydrogenase inhibitors on rat brain tryptophan hydroxylase activity in vitro. Brain Res 409:374-379.
32. Opitz CA, Litzenburger UM, Sahm F, Ott M, Tritschler I, Trump S, Schumacher T, Jestaedt L, Schrenk D, Weller M, Jugold M, Guillemin GJ, Miller CL, Lutz C, Radlwimmer B, Lehmann I, von Deimling A, Wick W, Platten M (2011) An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor. Nature 478:197-203.
33. Pharoah PO, Buttfield IH, Hetzel BS (1971) Neurological damage to the fetus resulting from severe iodine deficiency during pregnancy. Lancet 1:308-310.
34. Prock TL, Miranda RC (2007) Embryonic cerebral cortical progenitors are resistant to apoptosis, but increase expression of suicide receptor DISC-complex genes and suppress autophagy following ethanol exposure. Alcohol Clin Exp Res 31:694-703.
35. Reubinoff BE, Pera MF, Fong CY (2000) Embryonic stem cell lines from human blastocysts: somatic differentiation in vitro. Nat Biotechnol 18:399-404.
36. Sari Y, Hammad LA, Saleh MM, Rebec GV, Mechref Y (2010) Alteration of selective neurotransmitters in fetal brains of prenatally alcohol-treated C57BL/6 mice: quantitative analysis using liquid chromatography/tandem mass spectrometry. Int J Dev Neurosci 28:263-269.
37. Seo BW, Sparks AJ, Medora K, Amin S, Schantz SL (1999) Learning and memory in rats gestationally and lactationally exposed to 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD). Neurotoxicol Teratol 21:231-239.
38. Sessa A, Perin A (1997) Ethanol and polyamine metabolism: physiologic and pathologic implications: a review. Alcohol Clin Exp Res 21:318-325.
39. Seyoum G, Persaud TV (1994) In vitro effect of S-adenosyl methionine on ethanol embryopathy in the rat. Exp Toxicol Pathol 46:177-181.
40. Shibley IA Jr, Gavigan MD, Pennington SN (1995) Ethanol's effect on tissue polyamines and ornithine decarboxylase activity: a concise review. Alcohol Clin Exp Res 19:209-215.
41. Shukla PK, Sittig LJ, Ullmann TM, Redei EE (2011) Candidate placental biomarkers for intrauterine alcohol exposure. Alcohol Clin Exp Res 35:559-565.
42. Smith CA, Want EJ, O'Maille G, Abagyan R, Siuzdak G (2006) XCMS: processing mass spectrometry data for metabolite profiling using nonlinear peak alignment, matching, and identification. Anal Chem 78:779-787.
43. Sufrin JR, Spiess AJ, Kramer DL, Libby PR, Porter CW (1989) Synthesis and antiproliferative effects of novel 5'-fluorinated analogues of 5'-deoxy-5'-(methylthio)adenosine. J Med Chem 32:997-1001.
44. Tautenhahn R, Böttcher C, Neumann S (2008) Highly sensitive feature detection for high resolution LC/MS. BMC Bioinformatics 9:504.
45. Thadani PV, Slotkin TA, Schanberg SM (1977) Effects of late prenatal or early postnatal ethanol exposure on ornithine decarboxylase activity in brain and heart of developing rats. Neuropharmacology 16:289-293.
46. Thomas JD, Abou EJ, Dominguez HD (2009) Prenatal choline supplementation mitigates the adverse effects of prenatal alcohol exposure on development in rats. Neurotoxicol Teratol 31:303-311.
47. Thomas JD, Idrus NM, Monk BR, Dominguez HD (2010) Prenatal choline supplementation mitigates behavioral alterations associated with prenatal alcohol exposure in rats. Birth Defects Res A Clin Mol Teratol 88:827-837.
48. Thomson JA, Itskovitz-Eldor J, Shapiro SS, Waknitz MA, Swiergiel JJ, Marshall VS, Jones JM (1998) Embryonic stem cell lines derived from human blastocysts. Science 282:1145-1147.
49. Visser WE, Friesema EC, Jansen J, Visser TJ (2008) Thyroid hormone transport in and out of cells. Trends Endocrinol Metab 19:50-56.
50. Walcher BN, Miller RR Jr (2008) Ethanol-induced increased endogenous homocysteine levels and decreased ratios of SAM/SAH are only partially attenuated by exogenous glycine in developing chick brains. Comp Biochem Physiol C Toxicol Pharmacol 147:11-16.
51. West PR, Weir AM, Smith AM, Donley EL, Cezar GG (2010) Predicting human developmental toxicity of pharmaceuticals using human embryonic stem cells and metabolomics. Toxicol Appl Pharmacol 247:18-27.
52. Yakovleva T, Bazov I, Watanabe H, Hauser KF, Bakalkin G (2011) Transcriptional control of maladaptive and protective responses in alcoholics: a role of the NF-κB system. Brain Behav Immun 25(Suppl 1):S29-S38.
53. Zhang SC (2006) Neural subtype specification from embryonic stem cells. Brain Pathol 16:132-142.
54. Zhang SC, Wering M, Duncan ID, Brustle O, Thomson JA (2001) In vitro differentiation of transplantable neural precursors from human embryonic stem cells. Nat Biotechnol 19:1129-1133.