Regulation of autophagy by mTOR-dependent and mTOR-independent pathways: Autophagy dysfunction in neurodegenerative diseases and therapeutic application of autophagy enhancers

Biochemical Society Transactions

Volumn 41, Issue 5, 2013, Pages 1103-1130

  Sarkar, Sovan ^a  

^a WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH   (United States)

Author keywords

Aggregation prone protein; Atg; Autophagy; Mammalian target of rapamycin (mTOR); Neurodegenerative disease; Small molecule autophagy enhancer

Indexed keywords

4 [4 (4' CHLORO 2 BIPHENYLYLMETHYL) 1 PIPERAZINYL] N [4 [3 DIMETHYLAMINO 1 (PHENYLTHIOMETHYL)PROPYLAMINO] 3 NITROBENZENESULFONYL]BENZAMIDE; AMIODARONE; CALPASTATIN; CYCLIC AMP; DIMEBON; FK 506 BINDING PROTEIN; FLUSPIRILENE; INITIATION FACTOR 4E BINDING PROTEIN 1; LITHIUM; LOPERAMIDE; MAMMALIAN TARGET OF RAPAMYCIN; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 2; MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR; MINOXIDIL; NICARDIPINE; NICLOSAMIDE; NIGULDIPINE; NIMODIPINE; NITRENDIPINE; PERHEXILINE; PIMOZIDE; QUININE SULFATE; RAPAMYCIN; ROTTLERIN; TOLAZAMIDE; TRIFLUOPERAZINE; UNINDEXED DRUG; VALPROIC ACID; VERAPAMIL;

APOPTOSIS; ARTICLE; AUTOLYSOSOME; AUTOPHAGOSOME; AUTOPHAGY; CELL SURVIVAL; DEGENERATIVE DISEASE; HUMAN; IN VIVO STUDY; LONGEVITY; LYSOSOME MEMBRANE; MACROAUTOPHAGY; MICROAUTOPHAGY; NONHUMAN; PRIORITY JOURNAL; PROTEIN AGGREGATION; SIGNAL TRANSDUCTION;

AUTOPHAGY; CELL SURVIVAL; HUMANS; MOLECULAR TARGETED THERAPY; NEURODEGENERATIVE DISEASES; SIGNAL TRANSDUCTION; SMALL MOLECULE LIBRARIES; TOR SERINE-THREONINE KINASES;

EID: 84884634690     PISSN: 03005127     EISSN: 14708752     Source Type: Journal    
DOI: 10.1042/BST20130134     Document Type: Article

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