-
1
-
-
0030274647
-
Genomic sciences and the medicine of tomorrow
-
Drews, J. Genomic sciences and the medicine of tomorrow. Nature Biotechnol. 14, 1516-1518 (1996).
-
(1996)
Nature Biotechnol.
, vol.14
, pp. 1516-1518
-
-
Drews, J.1
-
3
-
-
0031024171
-
Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings
-
Lipinski, C. A., Lombardo, F., Dominy, B. W. & Feeney, P. J. Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. Adv. Drug Del. Rev. 23, 3-25 (1997).
-
(1997)
Adv. Drug Del. Rev.
, vol.23
, pp. 3-25
-
-
Lipinski, C.A.1
Lombardo, F.2
Dominy, B.W.3
Feeney, P.J.4
-
5
-
-
0038458880
-
Prioritizing the human genome: Knowledge management for drug discovery
-
Golden, J. B. Prioritizing the human genome: Knowledge management for drug discovery. Curr. Opin. Drug Discov. Dev. 6, 310-316 (2003).
-
(2003)
Curr. Opin. Drug Discov. Dev.
, vol.6
, pp. 310-316
-
-
Golden, J.B.1
-
6
-
-
0037323955
-
Towards a tractable genome: Knowledge management in drug discovery
-
Golden, J. Towards a tractable genome: Knowledge management in drug discovery. Curr. Drug Discov. 17-20 (2003).
-
(2003)
Curr. Drug Discov.
, pp. 17-20
-
-
Golden, J.1
-
7
-
-
33644876210
-
DrugBank: A comprehensive resource for in silico drug discovery and exploration
-
Wishart, D. S. et al. DrugBank: A comprehensive resource for in silico drug discovery and exploration. Nucleic Acids Res. 43, D668-D672 (2006).
-
(2006)
Nucleic Acids Res.
, vol.43
-
-
Wishart, D.S.1
-
8
-
-
33749234216
-
Drugs, their targets and the nature and number of drug targets
-
Imming, P., Sinning, C. & Meyer, A. Drugs, their targets and the nature and number of drug targets. Nature Rev. Drug Discov. 5, 821-834 (2006).
-
(2006)
Nature Rev. Drug Discov.
, vol.5
, pp. 821-834
-
-
Imming, P.1
Sinning, C.2
Meyer, A.3
-
9
-
-
33646532662
-
Progress and problems in the exploration of therapeutic targets
-
Zheng, C., Han, L., Yap, C. W., Xie, B. & Chen, Y. Progress and problems in the exploration of therapeutic targets. Drug Discov. Today 11, 412-420 (2006).
-
(2006)
Drug Discov. Today
, vol.11
, pp. 412-420
-
-
Zheng, C.1
Han, L.2
Yap, C.W.3
Xie, B.4
Chen, Y.5
-
10
-
-
33646754515
-
Therapeutic targets: Progress of their explorations and investigation of their characteristics
-
Zheng, C. J. et al. Therapeutic targets: Progress of their explorations and investigation of their characteristics. Pharma. Rev. 58, 259-279 (2006).
-
(2006)
Pharma. Rev.
, vol.58
, pp. 259-279
-
-
Zheng, C.J.1
-
11
-
-
0029947186
-
Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells
-
Druker, B. J. et al. Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells. Nature Med. 2, 561-566 (1996).
-
(1996)
Nature Med.
, vol.2
, pp. 561-566
-
-
Druker, B.J.1
-
12
-
-
19744365702
-
A small molecule-kinase interaction map for clinical kinase inhibitors
-
Fabian, M. A. et al. A small molecule-kinase interaction map for clinical kinase inhibitors. Nature Biotechnol. 23, 329-336 (2005).
-
(2005)
Nature Biotechnol.
, vol.23
, pp. 329-336
-
-
Fabian, M.A.1
-
13
-
-
19944429284
-
A novel mode of Gleevec binding is revealed by the structure of spleen tyrosine kinase
-
Atwell, S. et al. A novel mode of Gleevec binding is revealed by the structure of spleen tyrosine kinase. J. Biol. Chem. 279, 55827-55832 (2004).
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 55827-55832
-
-
Atwell, S.1
-
14
-
-
0034254249
-
Inhibition of c-kit receptor tyrosine kinase activity by STI 571, a selective tyrosine kinase inhibitor
-
Heinrich, M. C. et al. Inhibition of c-kit receptor tyrosine kinase activity by STI 571, a selective tyrosine kinase inhibitor. Blood 96, 925-932 (2000).
-
(2000)
Blood
, vol.96
, pp. 925-932
-
-
Heinrich, M.C.1
-
15
-
-
4644259265
-
Kinase inhibition with BAY 43-9006 in renal cell carcinoma
-
Ahmad, T. & Eisen, T. Kinase inhibition with BAY 43-9006 in renal cell carcinoma. Clin. Cancer Res. 10, 6388S-6392S (2004).
-
(2004)
Clin. Cancer Res.
, vol.10
-
-
Ahmad, T.1
Eisen, T.2
-
16
-
-
1642540579
-
Unexpected nanomolar inhibition of carbonic anhydrase by COX-2-selective celecoxib: New pharmacological opportunities due to related binding site recognition
-
Weber, A. et al. Unexpected nanomolar inhibition of carbonic anhydrase by COX-2-selective celecoxib: New pharmacological opportunities due to related binding site recognition. J. Med. Chem. 47, 550-557 (2004).
-
(2004)
J. Med. Chem.
, vol.47
, pp. 550-557
-
-
Weber, A.1
-
17
-
-
33746156959
-
Global mapping of pharmacological space
-
Paolini, G. V., Shapland, R. H. B., van Hoorn, W. P., Mason, J. S. & Hopkins, A. L. Global mapping of pharmacological space. Nature Biotechnol. 24, 805-815 (2006).
-
(2006)
Nature Biotechnol.
, vol.24
, pp. 805-815
-
-
Paolini, G.V.1
Shapland, R.H.B.2
van Hoorn, W.P.3
Mason, J.S.4
Hopkins, A.L.5
-
18
-
-
32344446028
-
Can we rationally design promiscuous drugs?
-
Hopkins, A. L., Mason, J. S. & Overington, J. P. Can we rationally design promiscuous drugs?. Curr. Opin. Struct. Biol. 16, 127-136 (2006).
-
(2006)
Curr. Opin. Struct. Biol.
, vol.16
, pp. 127-136
-
-
Hopkins, A.L.1
Mason, J.S.2
Overington, J.P.3
-
19
-
-
0028961335
-
SCOP: A structural classification of proteins database for the investigation of sequences and structures
-
Murzin, A. G., Brenner, S. E., Hubbard, T. & Chothia, C. SCOP: A structural classification of proteins database for the investigation of sequences and structures. J. Mol. Biol. 274, 536-540 (1995).
-
(1995)
J. Mol. Biol.
, vol.274
, pp. 536-540
-
-
Murzin, A.G.1
Brenner, S.E.2
Hubbard, T.3
Chothia, C.4
-
20
-
-
9144257886
-
The Pfam Protein Families Database
-
Bateman, A. et al. The Pfam Protein Families Database. Nucleic Acids Res. 32, D138-D141 (2004).
-
(2004)
Nucleic Acids Res.
, vol.32
-
-
Bateman, A.1
-
21
-
-
0037079014
-
The structure of the protein universe and genome evolution
-
Koonin, E. V., Wolf, Y. I. & Karev, G. P. The structure of the protein universe and genome evolution. Nature 420, 218-223 (2002).
-
(2002)
Nature
, vol.420
, pp. 218-223
-
-
Koonin, E.V.1
Wolf, Y.I.2
Karev, G.P.3
-
22
-
-
0034995092
-
Completeness in structural genomics
-
Vitkup, D., Melamud, E., Moult, J. & Sander, C. Completeness in structural genomics. Nature Struct. Biol. 8, 559-566 (2001).
-
(2001)
Nature Struct. Biol.
, vol.8
, pp. 559-566
-
-
Vitkup, D.1
Melamud, E.2
Moult, J.3
Sander, C.4
-
23
-
-
0033954256
-
The Protein Data Bank
-
Berman, H. M. et al. The Protein Data Bank. Nucleic Acid Res. 28, 235-242 (2000).
-
(2000)
Nucleic Acid Res.
, vol.28
, pp. 235-242
-
-
Berman, H.M.1
-
24
-
-
0003436550
-
-
in 12th Edn (John Hopkins University Press, Baltimore)
-
McKusick, V. A. in Mendelian Inheritance in Man 12th Edn (John Hopkins University Press, Baltimore, 1998).
-
(1998)
Mendelian Inheritance in Man
-
-
McKusick, V.A.1
-
25
-
-
33751526393
-
-
NIHCM 24 pp (National Institute for Health Care Management Research and Educational Foundation)
-
NIHCM 24 pp (National Institute for Health Care Management Research and Educational Foundation, 2002).
-
(2002)
-
-
-
27
-
-
0034681683
-
The Nobel chronicles
-
Raju, T. N. The Nobel chronicles. Lancet 355, 1022 (2000).
-
(2000)
Lancet
, vol.355
, pp. 1022
-
-
Raju, T.N.1
|