-
1
-
-
0020022916
-
Mechanisms of intracellular protein breakdown
-
Hershko, A. and Ciechanover, A. (1982) Mechanisms of intracellular protein breakdown. Annu. Rev. Biochem., 51, 335-364.
-
(1982)
Annu. Rev. Biochem.
, vol.51
, pp. 335-364
-
-
Hershko, A.1
Ciechanover, A.2
-
2
-
-
0032867676
-
The 26S proteasome: A molecular machine designed for controlled proteolysis
-
Voges, D., Zwickl, P. and Baumeister, W. (1999) The 26S proteasome: a molecular machine designed for controlled proteolysis. Annu. Rev. Biochem., 68, 1015-1068.
-
(1999)
Annu. Rev. Biochem.
, vol.68
, pp. 1015-1068
-
-
Voges, D.1
Zwickl, P.2
Baumeister, W.3
-
3
-
-
0022490771
-
Catabolism of intracellular protein: Molecular aspects
-
Beynon, R.J. and Bond, J.S. (1986) Catabolism of intracellular protein: molecular aspects. Am. J. Physiol., 251 (2 Pt 1), C141-152.
-
(1986)
Am. J. Physiol.
, vol.251
, Issue.2 PART 1
-
-
Beynon, R.J.1
Bond, J.S.2
-
4
-
-
0033791650
-
Autophagy, cytoplasm-to-vacuole targeting pathway, and pexophagy in yeast and mammalian cells
-
Kim, J. and Klionsky, D.J. (2000) Autophagy, cytoplasm-to-vacuole targeting pathway, and pexophagy in yeast and mammalian cells. Annu. Rev. Biochem., 69, 303-342.
-
(2000)
Annu. Rev. Biochem.
, vol.69
, pp. 303-342
-
-
Kim, J.1
Klionsky, D.J.2
-
5
-
-
0034537290
-
Autophagy as a regulated pathway of cellular degradation
-
Klionsky, D.J. and Emr, S.D. (2000) Autophagy as a regulated pathway of cellular degradation. Science, 290, 1717-1721.
-
(2000)
Science
, vol.290
, pp. 1717-1721
-
-
Klionsky, D.J.1
Emr, S.D.2
-
6
-
-
0027240439
-
Autophagic vacuoles fuse with the prelysosomal compartment in cultured rat fibroblasts
-
Punnonen, E.T., Autio, S., Kaija, H. and Reunanen, H. (1993) Autophagic vacuoles fuse with the prelysosomal compartment in cultured rat fibroblasts. Eur. J. Cell. Biol., 61, 54-66.
-
(1993)
Eur. J. Cell. Biol.
, vol.61
, pp. 54-66
-
-
Punnonen, E.T.1
Autio, S.2
Kaija, H.3
Reunanen, H.4
-
7
-
-
0019730097
-
Mechanisms of intralysosomal degradation with special reference to autophagocytosis and heterophagocytosis of cell organelles
-
Glaumann, H., Ericsson, J.L. and Marzella, L. (1981) Mechanisms of intralysosomal degradation with special reference to autophagocytosis and heterophagocytosis of cell organelles. Intl. Rev. Cytol., 73, 149-182.
-
(1981)
Intl. Rev. Cytol.
, vol.73
, pp. 149-182
-
-
Glaumann, H.1
Ericsson, J.L.2
Marzella, L.3
-
8
-
-
0033671965
-
Retention of mutant α1-antitrypsin Z in endoplasmic reticulum is associated with an autophagic response
-
Teckman, J.H. and Perlmutter, D.H. (2000) Retention of mutant α1-antitrypsin Z in endoplasmic reticulum is associated with an autophagic response. Am. J. Physiol. Gastrointest. Physiol., 279, G961-G974.
-
(2000)
Am. J. Physiol. Gastrointest. Physiol.
, vol.279
-
-
Teckman, J.H.1
Perlmutter, D.H.2
-
9
-
-
0026673455
-
Ultrastructural features of spongiform encephalopathy transmitted to mice from three species of bovidae
-
Jeffrey, M., Scott, J.R., Williams, A. and Fraser, H. (1992) Ultrastructural features of spongiform encephalopathy transmitted to mice from three species of bovidae. Acta Neuropathol. (Berl), 84, 559-569.
-
(1992)
Acta Neuropathol. (Berl)
, vol.84
, pp. 559-569
-
-
Jeffrey, M.1
Scott, J.R.2
Williams, A.3
Fraser, H.4
-
10
-
-
0031036896
-
Apoptosis and autophagy in nigral neurons of patients with Parkinson's disease
-
Anglade, P., Vyas, S., Javoy-Agid, F., Herrero, M.T., Michel, P.P., Marqurez, J., Mouatt-Prigent, A., Ruberg, M., Hirsch, E.C. and Agid, Y. (1997) Apoptosis and autophagy in nigral neurons of patients with Parkinson's disease. Histol. Histopathol., 12, 25-31.
-
(1997)
Histol. Histopathol.
, vol.12
, pp. 25-31
-
-
Anglade, P.1
Vyas, S.2
Javoy-Agid, F.3
Herrero, M.T.4
Michel, P.P.5
Marqurez, J.6
Mouatt-Prigent, A.7
Ruberg, M.8
Hirsch, E.C.9
Agid, Y.10
-
11
-
-
0035341254
-
Mitochondrial abnormalities in Alzheimer's disease
-
Hirai, K., Aliev, G., Nunomura, A., Fujioka, H., Russell, R.L., Atwood, C.S., Johnson, A.B., Kress, Y., Vinters, H.V., Tabaton, M. et al. (2001) Mitochondrial abnormalities in Alzheimer's disease. J. Neurosci., 21, 3017-3023.
-
(2001)
J. Neurosci.
, vol.21
, pp. 3017-3023
-
-
Hirai, K.1
Aliev, G.2
Nunomura, A.3
Fujioka, H.4
Russell, R.L.5
Atwood, C.S.6
Johnson, A.B.7
Kress, Y.8
Vinters, H.V.9
Tabaton, M.10
-
12
-
-
0035894855
-
Expression of A53T mutant but not wild-type alpha-synuclein in PC12 cells induces alterations of the ubiquitin-dependent degradation system, loss of dopamine release, and autophagic cell death
-
Stefanis, L., Larsen, K.E., Rideout, H.J., Sulzer, D. and Greene, L.A. (2001) Expression of A53T mutant but not wild-type alpha-synuclein in PC12 cells induces alterations of the ubiquitin-dependent degradation system, loss of dopamine release, and autophagic cell death. J. Neurosci., 21, 9549-9560.
-
(2001)
J. Neurosci.
, vol.21
, pp. 9549-9560
-
-
Stefanis, L.1
Larsen, K.E.2
Rideout, H.J.3
Sulzer, D.4
Greene, L.A.5
-
13
-
-
0034849783
-
Autophagic cell death and its execution by lysosomal cathepsins
-
Uchiyama, Y. (2001) Autophagic cell death and its execution by lysosomal cathepsins. Arch. Histol. Cytol., 64, 233-246.
-
(2001)
Arch. Histol. Cytol.
, vol.64
, pp. 233-246
-
-
Uchiyama, Y.1
-
14
-
-
0034307476
-
Huntingtin expression stimulates endosomal-lysosomal activity, endosome tubulation, and autophagy
-
Kegel, K.B., Kim, M., Sapp, E., McIntyre, C., Castaño, J.G., Aronin, N. and DiFiglia, M. (2000) Huntingtin expression stimulates endosomal-lysosomal activity, endosome tubulation, and autophagy. J. Neurosci., 20, 7268-7278.
-
(2000)
J. Neurosci.
, vol.20
, pp. 7268-7278
-
-
Kegel, K.B.1
Kim, M.2
Sapp, E.3
McIntyre, C.4
Castaño, J.G.5
Aronin, N.6
DiFiglia, M.7
-
15
-
-
0035364748
-
Expanded CAG repeats in exon 1 of the Huntington's disease gene stimulate dopamine-mediated striatal neuron autophagy and degeneration
-
Petersén, Å., Larsen, K.E., Behr, G.G., Romero, N., Przedborski, S., Brundin, P. and Sulzer, D. (2001) Expanded CAG repeats in exon 1 of the Huntington's disease gene stimulate dopamine-mediated striatal neuron autophagy and degeneration. Hum. Mol. Genet., 10, 1243-1254.
-
(2001)
Hum. Mol. Genet.
, vol.10
, pp. 1243-1254
-
-
Petersén, Å.1
Larsen, K.E.2
Behr, G.G.3
Romero, N.4
Przedborski, S.5
Brundin, P.6
Sulzer, D.7
-
16
-
-
0036566266
-
Aggregate-prone proteins with polyglutamine and polyalanine expansions are degraded by autophagy
-
Ravikumar, B., Duden, R. and Rubinsztein, D.C. (2002) Aggregate-prone proteins with polyglutamine and polyalanine expansions are degraded by autophagy. Hum. Mol. Genet., 11, 1107-1117.
-
(2002)
Hum. Mol. Genet.
, vol.11
, pp. 1107-1117
-
-
Ravikumar, B.1
Duden, R.2
Rubinsztein, D.C.3
-
17
-
-
0038364056
-
Raised intracellular glucose concentrations reduced aggregation and cell death caused by mutant huntingtin exon 1 by decreasing mTOR phosphorylation and inducing autophagy
-
Ravikumar, B., Stewart A., Kita, H., Kato, K., Duden, R. and Rubinsztein, D.C. (2003) Raised intracellular glucose concentrations reduced aggregation and cell death caused by mutant huntingtin exon 1 by decreasing mTOR phosphorylation and inducing autophagy Hum. Mol. Genet., 12, 985-994.
-
(2003)
Hum. Mol. Genet.
, vol.12
, pp. 985-994
-
-
Ravikumar, B.1
Stewart, A.2
Kita, H.3
Kato, K.4
Duden, R.5
Rubinsztein, D.C.6
-
18
-
-
0030752709
-
Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain
-
DiFiglia, M., Sapp, E., Chase, K.O., Davies, S.W., Bates, G.P., Vonsattel, J.P. and Aronin, N. (1997) Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain. Science, 277, 1990-1993.
-
(1997)
Science
, vol.277
, pp. 1990-1993
-
-
DiFiglia, M.1
Sapp, E.2
Chase, K.O.3
Davies, S.W.4
Bates, G.P.5
Vonsattel, J.P.6
Aronin, N.7
-
19
-
-
18544410106
-
Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation
-
Davies, S.W., Turmaine, M., Cozens, B.A., DiFiglia, M., Sharp, A.H., Ross, C.A., Scherzinger, E., Wanker, E.E., Mangiarini, L. and Bates, G.P. (1997) Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation. Cell, 90, 537-548.
-
(1997)
Cell
, vol.90
, pp. 537-548
-
-
Davies, S.W.1
Turmaine, M.2
Cozens, B.A.3
DiFiglia, M.4
Sharp, A.H.5
Ross, C.A.6
Scherzinger, E.7
Wanker, E.E.8
Mangiarini, L.9
Bates, G.P.10
-
20
-
-
0033556160
-
Generation of neuronal intranuclear inclusions by polyglutamine-GFP: Analysis of inclusion clearance and toxicity as a function of polyglutamine length
-
Moulder, K.L., Onodera, O., Burke, J.R., Strittmatter, W.J. and Johnson, E.M., Jr (1999) Generation of neuronal intranuclear inclusions by polyglutamine-GFP: analysis of inclusion clearance and toxicity as a function of polyglutamine length. J. Neurosci., 19, 705-715.
-
(1999)
J. Neurosci.
, vol.19
, pp. 705-715
-
-
Moulder, K.L.1
Onodera, O.2
Burke, J.R.3
Strittmatter, W.J.4
Johnson Jr., E.M.5
-
21
-
-
0035503511
-
Huntingtin aggregate-associated axonal degeneration is an early pathological event in Huntington's disease mice
-
Li, H., Li, S.-H., Yu, Z.-X., Shelbourne, P. and Li, X.-J. (2001) Huntingtin aggregate-associated axonal degeneration is an early pathological event in Huntington's disease mice. J. Neurosci., 21, 8473-8481.
-
(2001)
J. Neurosci.
, vol.21
, pp. 8473-8481
-
-
Li, H.1
Li, S.-H.2
Yu, Z.-X.3
Shelbourne, P.4
Li, X.-J.5
-
22
-
-
0034733607
-
Inhibiting caspase cleavage of huntingtin reduces toxicity and aggregate formation in neuronal and nonneuronal cells
-
Wellington, C.L., Singaraja, R., Ellerby, L.M., Savill, J., Roy, S., Leavitt, B., Cattaneo, E., Hackam, A., Sharp, A., Thornberry, N. et al. (2000) Inhibiting caspase cleavage of huntingtin reduces toxicity and aggregate formation in neuronal and nonneuronal cells. J. Biol. Chem., 275, 19831-19838.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 19831-19838
-
-
Wellington, C.L.1
Singaraja, R.2
Ellerby, L.M.3
Savill, J.4
Roy, S.5
Leavitt, B.6
Cattaneo, E.7
Hackam, A.8
Sharp, A.9
Thornberry, N.10
-
23
-
-
0035940412
-
Caspase 3-cleaved N-terminal fragments of wild-type and mutant huntingtin are present in normal and Huntington's disease brains, associate with membranes, and undergo calpain-dependent proteolysis
-
Kim, Y.J., Yi, Y., Sapp, E., Wang, Y., Cuiffo, B., Kegel, K.B., Qin, Z.-H. and Aronin, N. (2001) Caspase 3-cleaved N-terminal fragments of wild-type and mutant huntingtin are present in normal and Huntington's disease brains, associate with membranes, and undergo calpain-dependent proteolysis. Proc. Natl Acad. Sci. USA, 98, 12784-12789.
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 12784-12789
-
-
Kim, Y.J.1
Yi, Y.2
Sapp, E.3
Wang, Y.4
Cuiffo, B.5
Kegel, K.B.6
Qin, Z.-H.7
Aronin, N.8
-
24
-
-
0037096376
-
Calpain activation in Huntington's disease
-
Gafni, J. and Ellerby, L.M. (2002) Calpain activation in Huntington's disease. J. Neurosci., 22, 4842-4849.
-
(2002)
J. Neurosci.
, vol.22
, pp. 4842-4849
-
-
Gafni, J.1
Ellerby, L.M.2
-
25
-
-
0029057609
-
Comparison of cathepsin protease activities in brain tissue from normal cases and cases with Alzheimer's disease, Lewy body dementia, Parkinson's disease and Huntington's disease
-
Mantle, D., Falkous, G., Ishiura, S., Perry, R.H. and Perry, E.K. (1995) Comparison of cathepsin protease activities in brain tissue from normal cases and cases with Alzheimer's disease, Lewy body dementia, Parkinson's disease and Huntington's disease. J. Neurol. Sci., 131, 65-70.
-
(1995)
J. Neurol. Sci.
, vol.131
, pp. 65-70
-
-
Mantle, D.1
Falkous, G.2
Ishiura, S.3
Perry, R.H.4
Perry, E.K.5
-
26
-
-
8044257699
-
The phosphatidylinositol 3-kinase inhibitors wortmannin and LY294002 inhibit autophagy in isolated rat hepatocytes
-
Blommaart, E.F., Krause, U., Schellens, J.P., Vreeling-Sindelarova, H. and Meijer, A.J. (1997) The phosphatidylinositol 3-kinase inhibitors wortmannin and LY294002 inhibit autophagy in isolated rat hepatocytes. Eur. J. Biochem., 243, 240-246.
-
(1997)
Eur. J. Biochem.
, vol.243
, pp. 240-246
-
-
Blommaart, E.F.1
Krause, U.2
Schellens, J.P.3
Vreeling-Sindelarova, H.4
Meijer, A.J.5
-
27
-
-
0033978633
-
Distinct classes of phosphatidylinositol 3′-kinases are involved in signaling pathways that control macroautophagy in HT-29 cells
-
Petiot, A., Ogier-Denis, E., Blommaart, E.F.C., Meijer, A.J. and Codogno, P. (2000) Distinct classes of phosphatidylinositol 3′-kinases are involved in signaling pathways that control macroautophagy in HT-29 cells. J. Biol. Chem., 275, 992-998.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 992-998
-
-
Petiot, A.1
Ogier-Denis, E.2
Blommaart, E.F.C.3
Meijer, A.J.4
Codogno, P.5
-
28
-
-
0027905021
-
Phosphatidylinositol 3-kinase encoded by yeast VPS34 gene essential for protein sorting
-
Schu, P.V., Takegawa, K., Fry, M.M., Stack, J.H., Waterfield, M.D. and Emr, S.D. (1993) Phosphatidylinositol 3-kinase encoded by yeast VPS34 gene essential for protein sorting. Science, 260, 88-91.
-
(1993)
Science
, vol.260
, pp. 88-91
-
-
Schu, P.V.1
Takegawa, K.2
Fry, M.M.3
Stack, J.H.4
Waterfield, M.D.5
Emr, S.D.6
-
29
-
-
0035945343
-
Human VPS34 is required for internal vesicle formation within multi-vesicular endosomes
-
Futter, C.E., Collinson, L.M., Backer, J.M. and Hopkins C.R. (2001) Human VPS34 is required for internal vesicle formation within multi-vesicular endosomes. J. Cell Biol., 155, 1251-1264.
-
(2001)
J. Cell Biol.
, vol.155
, pp. 1251-1264
-
-
Futter, C.E.1
Collinson, L.M.2
Backer, J.M.3
Hopkins, C.R.4
-
30
-
-
0032870475
-
Autophagy is activated by apoptotic signaling in sympathetic neurons: An alternative mechanism of death execution
-
Xue, L., Fletcher, G.C. and Tolkovsky, A.M. (1999) Autophagy is activated by apoptotic signaling in sympathetic neurons: an alternative mechanism of death execution. Mol. Cell. Neurosci., 14, 180-198.
-
(1999)
Mol. Cell. Neurosci.
, vol.14
, pp. 180-198
-
-
Xue, L.1
Fletcher, G.C.2
Tolkovsky, A.M.3
-
31
-
-
0036685158
-
Inhibition of mitochondrial permeability transition and release of cytochrome c by antiapoptotic nucleoside analogues
-
Xu, L., Borutaite, V. and Tolkovsky, A.M. (2002) Inhibition of mitochondrial permeability transition and release of cytochrome c by antiapoptotic nucleoside analogues. Biochem. Pharmacol., 64, 441-449.
-
(2002)
Biochem. Pharmacol.
, vol.64
, pp. 441-449
-
-
Xu, L.1
Borutaite, V.2
Tolkovsky, A.M.3
-
32
-
-
0031593675
-
Bafilomycin A1 prevents maturation of autophagic vacuoles by inhibiting fusion between autophagosomes and lysosomes in rat hepatoma cell line, H-4-11-E cells
-
Yamamoto, A., Tagawa, Y., Yoshimori, T., Moriyama Y., Masaki, R. and Tashiro, Y. (1998) Bafilomycin A1 prevents maturation of autophagic vacuoles by inhibiting fusion between autophagosomes and lysosomes in rat hepatoma cell line, H-4-11-E cells. Cell Struct. Funct., 23, 33-42.
-
(1998)
Cell Struct. Funct.
, vol.23
, pp. 33-42
-
-
Yamamoto, A.1
Tagawa, Y.2
Yoshimori, T.3
Moriyama, Y.4
Masaki, R.5
Tashiro, Y.6
-
33
-
-
0033081766
-
Mutant huntingtin expression in clonal striatal cells: Dissociation of inclusion formation and neuronal survival by caspase inhibition
-
Kim, M., Lee, H.-S., LaForet, G., McIntyre, C., Martin, EL., Chang, P., Kim, T.W., William, M., Reddy, P.H., Tagle, D. et al. (1999) Mutant huntingtin expression in clonal striatal cells: dissociation of inclusion formation and neuronal survival by caspase inhibition. J. Neurosci., 19, 964-973.
-
(1999)
J. Neurosci.
, vol.19
, pp. 964-973
-
-
Kim, M.1
Lee, H.-S.2
LaForet, G.3
McIntyre, C.4
Martin, E.L.5
Chang, P.6
Kim, T.W.7
William, M.8
Reddy, P.H.9
Tagle, D.10
-
34
-
-
0035912780
-
The target of rapamycin (TOR) proteins
-
Raught, B., Gingras, A.-C. and Sonnenberg, N. (2001) The target of rapamycin (TOR) proteins. Proc. Natl Acad. Sci. USA, 98, 7037-7044.
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 7037-7044
-
-
Raught, B.1
Gingras, A.-C.2
Sonnenberg, N.3
-
35
-
-
0025340880
-
Studies on the mechanisms of autophagy: Maturation of the autophagic vacuoles
-
Dunn, W.A., Jr (1990) Studies on the mechanisms of autophagy: maturation of the autophagic vacuoles. J. Cell. Biol., 110, 1935-1945.
-
(1990)
J. Cell. Biol.
, vol.110
, pp. 1935-1945
-
-
Dunn Jr., W.A.1
-
36
-
-
0034796148
-
Expression of cathepsin B, L, S, and D by gastric epithelial cells implicates them as antigen presenting cells in local immune responses
-
Barrera, C.A., Ye, G., Espejo. R., Gunasena, S., Almanza, R., Leary, J.F., Crowe, S.E., Ernst, P.B. and Reyes, V.E. (2001) Expression of cathepsin B, L, S, and D by gastric epithelial cells implicates them as antigen presenting cells in local immune responses. Hum. Immunol., 62, 1081-1091.
-
(2001)
Hum. Immunol.
, vol.62
, pp. 1081-1091
-
-
Barrera, C.A.1
Ye, G.2
Espejo, R.3
Gunasena, S.4
Almanza, R.5
Leary, J.F.6
Crowe, S.E.7
Ernst, P.B.8
Reyes, V.E.9
-
37
-
-
0023065242
-
Intracellular protein catabolism and its control during nutrient deprivation and supply
-
Mortimore, G.E. and Poso, A.R. (1987) Intracellular protein catabolism and its control during nutrient deprivation and supply. Annu. Rev. Nutr., 7, 539-564.
-
(1987)
Annu. Rev. Nutr.
, vol.7
, pp. 539-564
-
-
Mortimore, G.E.1
Poso, A.R.2
-
38
-
-
0032455357
-
An ultrastructural and immunohistochemical study of PC12 cells during apoptosis induced by serum deprivation with special reference to autophagy and lysosomal cathepsins
-
Ohsawa, Y., Isahara, K., Kanamori, S., Shibata, M., Kametaka, S., Gotow, T., Watanami, E. and Uchiyama, Y. (1998) An ultrastructural and immunohistochemical study of PC12 cells during apoptosis induced by serum deprivation with special reference to autophagy and lysosomal cathepsins. Arch. Histol. Cytol., 61, 395-403.
-
(1998)
Arch. Histol. Cytol.
, vol.61
, pp. 395-403
-
-
Ohsawa, Y.1
Isahara, K.2
Kanamori, S.3
Shibata, M.4
Kametaka, S.5
Gotow, T.6
Watanami, E.7
Uchiyama, Y.8
-
39
-
-
0035869544
-
Tissue-specific proteolysis of huntingtin (htt) in human brain: Evidence of enhanced levels of N- and C-terminal htt fragments in Huntington's disease striatum
-
Mende-Mueller, L.M., Toneff, T., Hwang, S.R., Chesselet, M.F. and Hook, V.Y. (2001) Tissue-specific proteolysis of huntingtin (htt) in human brain: evidence of enhanced levels of N- and C-terminal htt fragments in Huntington's disease striatum. J. Neurosci., 21, 1830-1837.
-
(2001)
J. Neurosci.
, vol.21
, pp. 1830-1837
-
-
Mende-Mueller, L.M.1
Toneff, T.2
Hwang, S.R.3
Chesselet, M.F.4
Hook, V.Y.5
-
40
-
-
0032502715
-
Caspase cleavage of gene products associated with triple expansion disorders generates truncated fragments containing the polyglutamine tract
-
Wellington, C.L., Ellerby, L.M., Hachman, A.S., Margolis, R.L., Trifiro, M.A., Singaraja, R., McCutcheon, K., Salvesen, G.S., Propp, S.S., Bromm, M. et al. (1998) Caspase cleavage of gene products associated with triple expansion disorders generates truncated fragments containing the polyglutamine tract. J. Biol. Chem., 273, 9158-9167.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 9158-9167
-
-
Wellington, C.L.1
Ellerby, L.M.2
Hachman, A.S.3
Margolis, R.L.4
Trifiro, M.A.5
Singaraja, R.6
McCutcheon, K.7
Salvesen, G.S.8
Propp, S.S.9
Bromm, M.10
-
41
-
-
0034646426
-
Effects of heat shock, heat shock protein 40 (HDJ-2), and proteasome inhibition on protein aggregation in cellular models of Huntington's disease
-
Wyttenbach, A., Carmichael, J., Swartz, J., Furlong, R.A., Narain, Y., Rankin, J. and Rubinsztein, D.C. (2000) Effects of heat shock, heat shock protein 40 (HDJ-2), and proteasome inhibition on protein aggregation in cellular models of Huntington's disease. Proc. Natl Acad. Sci. USA, 97, 2898-2903.
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, pp. 2898-2903
-
-
Wyttenbach, A.1
Carmichael, J.2
Swartz, J.3
Furlong, R.A.4
Narain, Y.5
Rankin, J.6
Rubinsztein, D.C.7
-
42
-
-
0035947372
-
Impairment of the ubiquitin-proteasome system by protein aggregation
-
Bence, N.F., Sampat, R.M. and Kopito, R.R. (2001) Impairment of the ubiquitin-proteasome system by protein aggregation. Science, 292, 1552-1555.
-
(2001)
Science
, vol.292
, pp. 1552-1555
-
-
Bence, N.F.1
Sampat, R.M.2
Kopito, R.R.3
-
43
-
-
0035336658
-
Altered proteasomal function due to the expression of polyglutamine-expanded truncated N-terminal huntingtin induces apoptosis by caspase activation through mitochondrial cytochrome c release
-
Jana, N.R., Zemskov, E.A., Wang, G.H. and Nukina, N. (2001) Altered proteasomal function due to the expression of polyglutamine-expanded truncated N-terminal huntingtin induces apoptosis by caspase activation through mitochondrial cytochrome c release. Hum. Mol. Genet., 10, 1049-1059.
-
(2001)
Hum. Mol. Genet.
, vol.10
, pp. 1049-1059
-
-
Jana, N.R.1
Zemskov, E.A.2
Wang, G.H.3
Nukina, N.4
-
44
-
-
0035889973
-
Proteasomal-dependent aggregate reversal and absence of cell death in a conditional mouse model of Huntington's disease
-
Martin-Aparicio, E., Yamamoto, A., Hernández, F., Hen, R., Avila, J. and Lucas, J.J. (2001) Proteasomal-dependent aggregate reversal and absence of cell death in a conditional mouse model of Huntington's disease. J. Neurosci., 21, 8772-8781.
-
(2001)
J. Neurosci.
, vol.21
, pp. 8772-8781
-
-
Martin-Aparicio, E.1
Yamamoto, A.2
Hernández, F.3
Hen, R.4
Avila, J.5
Lucas, J.J.6
-
45
-
-
0036671821
-
Proteases acting on mutant huntingtin generate cleaved products that differentially build up cytoplasmic and nuclear inclusions
-
Lunkes, A., Lindenberg, K.S., Ben-Haiem, L., Weber, C., Devys, D., Landwehrmeyer, G.B., Mandel, J.L. and Trottier, Y. (2002) Proteases acting on mutant huntingtin generate cleaved products that differentially build up cytoplasmic and nuclear inclusions. Mol. Cell, 10, 259-269.
-
(2002)
Mol. Cell
, vol.10
, pp. 259-269
-
-
Lunkes, A.1
Lindenberg, K.S.2
Ben-Haiem, L.3
Weber, C.4
Devys, D.5
Landwehrmeyer, G.B.6
Mandel, J.L.7
Trottier, Y.8
-
46
-
-
0035179456
-
Mutant protein in Huntington disease is resistant to proteolysis in affected brain
-
Dyer, R.B. and McMurray, C.T. (2001) Mutant protein in Huntington disease is resistant to proteolysis in affected brain. Nat. Genet., 29, 270-278.
-
(2001)
Nat. Genet.
, vol.29
, pp. 270-278
-
-
Dyer, R.B.1
McMurray, C.T.2
-
47
-
-
0005677775
-
3-Methyladenine: Specific inhibitor of autophagic/lysosomal protein degradation in isolated rat hepatocytes
-
Seglen, P.O. and Gorden, P.B. (1982) 3-Methyladenine: specific inhibitor of autophagic/lysosomal protein degradation in isolated rat hepatocytes. Proc. Natl Acad. Sci. USA, 79, 1889-1892.
-
(1982)
Proc. Natl. Acad. Sci. USA
, vol.79
, pp. 1889-1892
-
-
Seglen, P.O.1
Gorden, P.B.2
-
48
-
-
0025195944
-
Enzymatically active lysosomal proteases are associated with amyloid deposits in Alzheimer brain
-
Cataldo, A.M. and Nixon, R.A. (1990) Enzymatically active lysosomal proteases are associated with amyloid deposits in Alzheimer brain. Proc. Natl Acad. Sci. USA, 87, 3861-3865.
-
(1990)
Proc. Natl. Acad. Sci. USA
, vol.87
, pp. 3861-3865
-
-
Cataldo, A.M.1
Nixon, R.A.2
-
49
-
-
0028947294
-
Gene expression and cellular content of cathepsin D in Alzheimer's disease brain: Evidence for early up-regulation of the endosomal-lysosomal system
-
Cataldo, A.M., Barnett, J.L., Berman, S.A., Li, J., Quarless, S., Bursztajin, S., Lippa, C. and Nixon, R.A. (1995) Gene expression and cellular content of cathepsin D in Alzheimer's disease brain: evidence for early up-regulation of the endosomal-lysosomal system. Neuron, 14, 671-680.
-
(1995)
Neuron
, vol.14
, pp. 671-680
-
-
Cataldo, A.M.1
Barnett, J.L.2
Berman, S.A.3
Li, J.4
Quarless, S.5
Bursztajin, S.6
Lippa, C.7
Nixon, R.A.8
-
50
-
-
0028841090
-
Elevated cathepsin D expression in kainate-evoked rat brain neurodegeneration
-
Hetman, M., Filipkowski, R.K., Domagala, W. and Kaczmarek, L. (1995) Elevated cathepsin D expression in kainate-evoked rat brain neurodegeneration. Exp. Neurol., 136, 53-63.
-
(1995)
Exp. Neurol.
, vol.136
, pp. 53-63
-
-
Hetman, M.1
Filipkowski, R.K.2
Domagala, W.3
Kaczmarek, L.4
-
51
-
-
0036830228
-
The neuropathogenic contributions of lysosomal dysfunction
-
Bahr, B.A. and Bendiske, J. (2002) The neuropathogenic contributions of lysosomal dysfunction. J. Neurochem., 83, 481-489.
-
(2002)
J. Neurochem.
, vol.83
, pp. 481-489
-
-
Bahr, B.A.1
Bendiske, J.2
-
52
-
-
0032959390
-
Regulation of a novel pathway for cell death by lysosomal aspartic and cysteine proteases
-
Isahara, K., Ohsawa, Y., Kanamori, S., Shibata, M., Waguri, S., Sato, N., Gotow, T., Watanabe, T., Momoi, T., Urase, K. and Kominami, E. (1999) Regulation of a novel pathway for cell death by lysosomal aspartic and cysteine proteases. Neuroscience, 91, 233-249.
-
(1999)
Neuroscience
, vol.91
, pp. 233-249
-
-
Isahara, K.1
Ohsawa, Y.2
Kanamori, S.3
Shibata, M.4
Waguri, S.5
Sato, N.6
Gotow, T.7
Watanabe, T.8
Momoi, T.9
Urase, K.10
Kominami, E.11
-
53
-
-
0034509103
-
Programmed cell death (PCD), Apoptosis, autophagic PCD, or both?
-
Bursch, W., Ellinger, A., Gerner, C., Frohwein, U. and Schulte-Hermann, R. (2000) Programmed cell death (PCD), Apoptosis, autophagic PCD, or both? Ann. NY Acad. Sci., 926, 1-12.
-
(2000)
Ann. NY Acad. Sci.
, vol.926
, pp. 1-12
-
-
Bursch, W.1
Ellinger, A.2
Gerner, C.3
Frohwein, U.4
Schulte-Hermann, R.5
-
54
-
-
0036310279
-
Microinjection of cathepsin D induces caspase-dependent apoptosis in fibrolasts
-
Roberg, K., Kågedal, K. and Õllinger, K. (2002). Microinjection of cathepsin D induces caspase-dependent apoptosis in fibrolasts. Am. J. Pathol., 161, 89-96.
-
(2002)
Am. J. Pathol.
, vol.161
, pp. 89-96
-
-
Roberg, K.1
Kågedal, K.2
Õllinger, K.3
-
55
-
-
0033591047
-
Expression of extended polyglutamine sequentially activates initiator and effector caspases
-
Miyashita, T., Matsui, J., Ohtsuka, Y., Mami, U., Fujishima, S., Okamura-Oho, Y., Inoue, T. and Yamada, M. (1999) Expression of extended polyglutamine sequentially activates initiator and effector caspases. Biochem. Biophys. Res. Comm., 257, 724-730.
-
(1999)
Biochem. Biophys. Res. Comm.
, vol.257
, pp. 724-730
-
-
Miyashita, T.1
Matsui, J.2
Ohtsuka, Y.3
Mami, U.4
Fujishima, S.5
Okamura-Oho, Y.6
Inoue, T.7
Yamada, M.8
-
56
-
-
0023767087
-
Autophagy of mitochondria in rat liver assessed by immunogold procedures
-
Knechi E., Martinez-Ramón, A. and Grisolia, S. (1988) Autophagy of mitochondria in rat liver assessed by immunogold procedures. J. Histochem. Cytochem., 36, 1433-1440.
-
(1988)
J. Histochem. Cytochem.
, vol.36
, pp. 1433-1440
-
-
Knechi, E.1
Martinez-Ramón, A.2
Grisolia, S.3
-
57
-
-
0035487007
-
The mitochondrial permeability transition initiates autophagy in rat hepatocytes
-
Elmore, S.P., Qian, T., Grisson, S.F. and Lemasters, J.J. (2001) The mitochondrial permeability transition initiates autophagy in rat hepatocytes. FASEB J., 15, 2287-2287.
-
(2001)
FASEB J.
, vol.15
, pp. 2287
-
-
Elmore, S.P.1
Qian, T.2
Grisson, S.F.3
Lemasters, J.J.4
-
58
-
-
0037109770
-
Methamphetamine-induced degeneration of dopaminergic neurons involves autophagy and upregulation of dopamine synthesis
-
Larsen, K.E., Fon, E.A., Hastings, T.G., Edwards, R.H. and Sulzer, D. (2002) Methamphetamine-induced degeneration of dopaminergic neurons involves autophagy and upregulation of dopamine synthesis. J. Neurosci., 22, 8951-8960.
-
(2002)
J. Neurosci.
, vol.22
, pp. 8951-8960
-
-
Larsen, K.E.1
Fon, E.A.2
Hastings, T.G.3
Edwards, R.H.4
Sulzer, D.5
-
59
-
-
0035793580
-
Lysosomal protease pathways to apoptosis: Cleavage of Bid, not pro-caspases, is the most likely route
-
Stoka, V, Turk, B., Sehendel, SL., Kim, T.-H., Cirman, T., Snipas, S.J., Ellerby, L.M., Bredesen, D., Freeze, H., Abrahamson, M. et al. (2001) Lysosomal protease pathways to apoptosis: cleavage of Bid, not pro-caspases, is the most likely route. J. Biol. Chem., 276, 3149-3157.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 3149-3157
-
-
Stoka, V.1
Turk, B.2
Sehendel, S.L.3
Kim, T.-H.4
Cirman, T.5
Snipas, S.J.6
Ellerby, L.M.7
Bredesen, D.8
Freeze, H.9
Abrahamson, M.10
-
60
-
-
0029099015
-
Transfected cathepsin D stimulates high density cancer cell growth by inactivating secreted growth inhibitors
-
Liaudet, E., Derocq, D., Rochefort, H. and Garcia, M. (1995) Transfected cathepsin D stimulates high density cancer cell growth by inactivating secreted growth inhibitors. Cell Growth Diff., 6, 1045-1052.
-
(1995)
Cell Growth Diff.
, vol.6
, pp. 1045-1052
-
-
Liaudet, E.1
Derocq, D.2
Rochefort, H.3
Garcia, M.4
-
61
-
-
0025925091
-
+-ATPase, inhibits acidification and protein degradation in lysosomes of cultured cells
-
+-ATPase, inhibits acidification and protein degradation in lysosomes of cultured cells. J. Biol Chem., 266, 17707-17712.
-
(1991)
J. Biol Chem.
, vol.266
, pp. 17707-17712
-
-
Yoshimori, T.1
Yamamoto, A.2
Moriyama, Y.3
Futai, M.4
Tashiro, Y.5
-
62
-
-
0035896592
-
Pro-caspase-8 is predominantly localized in mitochondria and released into cytoplasm upon apoptotic stimulation
-
Qin, Z.-H., Wang, Y., Kikly, K.K., Sapp, E., Kegel, K.B., Aronin, N. and DiFiglia, M. (2001) Pro-caspase-8 is predominantly localized in mitochondria and released into cytoplasm upon apoptotic stimulation. J. Biol. Chem., 276, 8079-8086.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 8079-8086
-
-
Qin, Z.-H.1
Wang, Y.2
Kikly, K.K.3
Sapp, E.4
Kegel, K.B.5
Aronin, N.6
DiFiglia, M.7
-
63
-
-
0021061819
-
Rapid colourmetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays
-
Mosmann, T.T. (1983) Rapid colourmetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J. Immunol Meth., 65, 55-63.
-
(1983)
J. Immunol. Meth.
, vol.65
, pp. 55-63
-
-
Mosmann, T.T.1
-
64
-
-
0035909330
-
Histone deacetylase inhibitors arrest polyglutamine-dependent neurodegeneration in Drosophila
-
Steffan, J.S., Bodai, L., Pallos, J., Poelman, M., McCampbell, A., Apostol, B.L., Kazantsey, A., Schmidt, E., Zhu, Y.Z., Greenwald, M. et al. (2001) Histone deacetylase inhibitors arrest polyglutamine-dependent neurodegeneration in Drosophila. Nature, 413, 739-743.
-
(2001)
Nature
, vol.413
, pp. 739-743
-
-
Steffan, J.S.1
Bodai, L.2
Pallos, J.3
Poelman, M.4
McCampbell, A.5
Apostol, B.L.6
Kazantsey, A.7
Schmidt, E.8
Zhu, Y.Z.9
Greenwald, M.10
-
65
-
-
0036121310
-
Arfaptin 2 regulates the aggregation of mutant huntingtin protein
-
Peters, P.J., Ning, K., Palacios, F., Boshans, R.L., Kazantsev, A., Thompson, L.M., Woodman, B., Bates, G.P. and D'Souza-Schorey, C. (2002) Arfaptin 2 regulates the aggregation of mutant huntingtin protein. Nat. Cell Biol., 4, 240-245.
-
(2002)
Nat. Cell Biol.
, vol.4
, pp. 240-245
-
-
Peters, P.J.1
Ning, K.2
Palacios, F.3
Boshans, R.L.4
Kazantsev, A.5
Thompson, L.M.6
Woodman, B.7
Bates, G.P.8
D'Souza-Schorey, C.9
-
66
-
-
0034703634
-
Formic acid dissolves aggregates of an N-terminal huntingtin fragment containing an expanded polyglutamine tract: Applying to quantification of protein components of the aggregates
-
Hazeki, N., Takamoto, T., Goto, J. and Kanazawa, I. (2000) Formic acid dissolves aggregates of an N-terminal huntingtin fragment containing an expanded polyglutamine tract: applying to quantification of protein components of the aggregates. Biochem. Biophy. Res. Comm., 277, 386-393.
-
(2000)
Biochem. Biophy. Res. Comm.
, vol.277
, pp. 386-393
-
-
Hazeki, N.1
Takamoto, T.2
Goto, J.3
Kanazawa, I.4
|