Presenilin is necessary for efficient proteolysis through the autophagy-lysosome system in a γ-secretase-independent manner

Journal of Neuroscience

Volumn 31, Issue 8, 2011, Pages 2781-2791

  Neely, Kara M ^a   Green, Kim N ^a   LaFerla, Frank M ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA SECRETASE; GAMMA SECRETASE INHIBITOR; PRESENILIN 1; PRESENILIN 2;

ANIMAL CELL; ARTICLE; AUTOPHAGY; CONTROLLED STUDY; EMBRYO; ENZYME ACTIVITY; FIBROBLAST; GENE DELETION; GENE SILENCING; MOUSE; NEUROBLASTOMA; NONHUMAN; PHAGOSOME; PRIORITY JOURNAL; PROTEIN DEGRADATION; WILD TYPE;

ALZHEIMER DISEASE; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; AUTOPHAGY; CELL LINE, TUMOR; CELLS, CULTURED; LYSOSOMES; MICE; NEURONS; PRESENILIN-1; PRESENILIN-2; PROTEINS;

EID: 79951985639     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.5156-10.2010     Document Type: Article

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