Mutations in dynein link motor neuron degeneration to defects in retrograde transport

Science

Volumn 300, Issue 5620, 2003, Pages 808-812

  Hafezparast, Majid ^a   Klocke, Rainer ^b   Ruhrberg, Christiana ^c   Marquardt, Andreas ^b   Ahmad Annuar, Azlina ^a   Bowen, Samantha ^d   Lalli, Giovanna ^c   Witherden, Abi S ^a   Hummerich, Holger ^a   Nicholson, Sharon ^a   Morgan, P Jeffrey ^d   Oozageer, Ravi ^d   Priestley, John V ^e   Averill, Sharon ^e   King, Von R ^e   Ball, Simon ^f   Peters, Jo ^f   Toda, Takashi ^c   Yamamoto, Ayumu ^g   Hiraoka, Yasushi ^g   Augustin, Martin ^b   Korthaus, Dirk ^b   Wattler, Sigrid ^b   Wabnitz, Philipp ^b   Dickneite, Carmen ^b   Lampel, Stefan ^b   Boehme, Florian ^b   Peraus, Gisela ^b   Popp, Andreas ^b   Rudelius, Martina ^h   Schlegel, Juergen ^h   Fuchs, Helmut ⁱ   De Angelis, Martin Hrabe ⁱ   Schiavo, Giampietro ^c,j   Shima, David T ^c,j   Russ, Andreas P ^b   Stumm, Gabriele ^b   Martin, Joanne E ^d   Fisher, Elizabeth M C ^a   more..

^a NATIONAL HOSPITAL FOR NEUROLOGY AND NEUROSURGERY   (United Kingdom)

^b Ingenium Pharmaceuticals AG   (Germany)

^c IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

^d QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^e QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^f MRC MAMMALIAN GENETICS UNIT   (United Kingdom)

^g NATIONAL INSTITUTE OF INFORMATION AND COMMUNICATIONS TECHNOLOGY   (Japan)

^h TECHNICAL UNIVERSITY OF MUNICH   (Germany)

ⁱ Institute of Experimental Genetics   (Germany)

^j Eyetech Research Center   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

CYTOLOGY; DISEASES; GENETIC ENGINEERING; NEUROLOGY; PATHOLOGY;

MOTOR NEURONS;

MUTAGENESIS;

DYNEIN ADENOSINE TRIPHOSPHATASE;

MICROBIOLOGY; MUTATION;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CYTOPLASM; GENE MUTATION; HETEROZYGOSITY; HOMOZYGOTE; LEWY BODY; MISSENSE MUTATION; MOTOR NEURON DISEASE; MOUSE; MUSCLE ATROPHY; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; PROTEIN FUNCTION; SPINAL MUSCULAR ATROPHY;

ANIMALS; ANTERIOR HORN CELLS; APOPTOSIS; AXONAL TRANSPORT; CELL DIFFERENTIATION; CELL MOVEMENT; CENTRAL NERVOUS SYSTEM; CHROMOSOME MAPPING; DIMERIZATION; DYNEIN ATPASE; FEMALE; GANGLIA, SPINAL; GOLGI APPARATUS; HETEROZYGOTE; HOMOZYGOTE; LEWY BODIES; MALE; MICE; MICE, INBRED C3H; MICE, INBRED C57BL; MOTOR NEURON DISEASE; MOTOR NEURONS; MUTATION; MUTATION, MISSENSE; NERVE DEGENERATION; PEPTIDE FRAGMENTS; PHENOTYPE; POINT MUTATION; SPINAL NERVES; TETANUS TOXIN;

ANIMALIA;

EID: 0037734370     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1083129     Document Type: Article

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31. Supported by the Motor Neurone Disease Association, Cancer Research UK, the U.K. Medical Research Council, the Violet M. Richards Charity, the Annie Lindsell Trust, the University of Malaya, a German Human Genome Project grant, a CREST Research Project grant, and the Human Frontier Science Program. We thank C. Baker, N. Bermingham, J. Downward, and M. Maden for advice and constructive suggestions; G. Hansen, S. Kohlmann, A. Bareiss, B. Kohnke, and G. Piontek for technical assistance; L. Greensmith and group for samples; and R. Young for graphics.