-
1
-
-
0001509014
-
Paralysis agitans. I. Pathologische Anatomie
-
(eds Lewandowsky, M. & Abelsdorff, G.) (Springer-Verlag, Berlin
-
Lewy, F. Paralysis agitans. I. Pathologische Anatomie. In Handbuch der Neurologie Vol. 3 (eds Lewandowsky, M. & Abelsdorff, G.) 920-933 (Springer-Verlag, Berlin, 1912).
-
(1912)
Handbuch der Neurologie
, vol.3
, pp. 920-933
-
-
Lewy, F.1
-
3
-
-
0028171592
-
Amygdala pathology in Parkinson's disease
-
Braak, H. et al. Amygdala pathology in Parkinson's disease. Acta Neuropathol. 88, 493-500 (1994).
-
(1994)
Acta Neuropathol.
, vol.88
, pp. 493-500
-
-
Braak, H.1
-
4
-
-
0030744876
-
Mutation in the α-synuclein gene identified in families with Parkinson's disease
-
Polymeropoulos, M. H. et al. Mutation in the α-synuclein gene identified in families with Parkinson's disease. Science 276, 2045-2047 (1997).
-
(1997)
Science
, vol.276
, pp. 2045-2047
-
-
Polymeropoulos, M.H.1
-
5
-
-
0030882856
-
α-Synuclein in Lewy bodies
-
Spillantini, M. G. et al. α-Synuclein in Lewy bodies. Nature 388, 839-840 (1997).
-
(1997)
Nature
, vol.388
, pp. 839-840
-
-
Spillantini, M.G.1
-
6
-
-
70549084415
-
Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease
-
Satake, W. et al. Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease. Nat. Genet. 41, 1303-1307 (2009).
-
(2009)
Nat. Genet.
, vol.41
, pp. 1303-1307
-
-
Satake, W.1
-
7
-
-
70549088602
-
Genome-wide association study reveals genetic risk underlying Parkinson's disease
-
Simón-Sánchez, J. et al. Genome-wide association study reveals genetic risk underlying Parkinson's disease. Nat. Genet. 41, 1308-1311 (2009).
-
(2009)
Nat. Genet.
, vol.41
, pp. 1308-1311
-
-
Simón-Sánchez, J.1
-
8
-
-
0037333666
-
Staging of brain pathology related to sporadic Parkinson's disease
-
Braak, H. et al. Staging of brain pathology related to sporadic Parkinson's disease. Neurobiol. Aging 24, 197-211 (2003).
-
(2003)
Neurobiol. Aging
, vol.24
, pp. 197-211
-
-
Braak, H.1
-
9
-
-
0036511037
-
Friedrich heinrich lewy (1885-1950) and his work
-
Holdorff, B. Friedrich Heinrich Lewy (1885-1950) and his work. J. Hist. Neurosci. 11, 19-28 (2002).
-
(2002)
J. Hist. Neurosci.
, vol.11
, pp. 19-28
-
-
Holdorff, B.1
-
10
-
-
77956827954
-
Who was the man who discovered the "lewy bodies"?
-
Rodrigues e Silva, A. M. et al. Who was the man who discovered the "Lewy bodies"? Mov. Disord. 25, 1765-1773 (2010).
-
(2010)
Mov. Disord.
, vol.25
, pp. 1765-1773
-
-
Rodrigues E Silva, A.M.1
-
11
-
-
0031204008
-
What's in a name? Dr. Lewey and the Lewy body
-
Sweeney, P. J., Lloyd, M. F. & Daroff, R. B. What's in a name? Dr. Lewey and the Lewy body. Neurology 49, 629-630 (1997).
-
(1997)
Neurology
, vol.49
, pp. 629-630
-
-
Sweeney, P.J.1
Lloyd, M.F.2
Daroff, R.B.3
-
12
-
-
0003096420
-
Zur pathologischen Anatomie der Paralysis agitans [German]
-
Lewy, F. H. Zur pathologischen Anatomie der Paralysis agitans [German]. Dtsch. Z. f. Nervenheilk. 50, 50-55 (1913).
-
(1913)
Dtsch. Z. F. Nervenheilk.
, vol.50
, pp. 50-55
-
-
Lewy, F.H.1
-
13
-
-
51849175000
-
Beitrag zur Histopathologie der myoklonischen Epilepsie [German]
-
Lafora, G. R. & Glueck, B. Beitrag zur Histopathologie der myoklonischen Epilepsie [German]. Z. ges. Neurol. Psychiat. 6, 1-14 (1911).
-
(1911)
Z. Ges. Neurol. Psychiat.
, vol.6
, pp. 1-14
-
-
Lafora, G.R.1
Glueck, B.2
-
14
-
-
0001770484
-
Sur un cas de tremblement parkinsonien hémiplégique symptomatique d'une tumeur du pédoncule cérébral [French]
-
Blocq, P. & Marinesco, G. Sur un cas de tremblement parkinsonien hémiplégique symptomatique d'une tumeur du pédoncule cérébral [French]. C. R. Soc. Biol. 5, 105-111 (1893).
-
(1893)
C. R. Soc. Biol.
, vol.5
, pp. 105-111
-
-
Blocq, P.1
Marinesco, G.2
-
16
-
-
0000056069
-
Zur Pathologie der Paralysis Agitans und des Postenzephalitischen Parkinsonismus [German]
-
Hassler, R. Zur Pathologie der Paralysis agitans und des postenzephalitischen Parkinsonismus [German]. J. Psychol. Neurol. 48, 387-455 (1938).
-
(1938)
J. Psychol. Neurol.
, vol.48
, pp. 387-455
-
-
Hassler, R.1
-
17
-
-
34250554673
-
Die Entstehung der Einschlusskörper und ihre Bedeutung für die systematische Einordnung der sogenannten Viruskrankheiten [German]
-
Lewy, F. H. Die Entstehung der Einschlusskörper und ihre Bedeutung für die systematische Einordnung der sogenannten Viruskrankheiten [German]. Dtsch. Z. f. Nervenheilk. 124, 93-100 (1932).
-
(1932)
Dtsch. Z. F. Nervenheilk.
, vol.124
, pp. 93-100
-
-
Lewy F., .H.1
-
18
-
-
77954385676
-
The propagation of prion-like protein inclusions in neurodegenerative diseases
-
Goedert M., Clavaguera, F. & Tolnay, M. The propagation of prion-like protein inclusions in neurodegenerative diseases. Trends Neurosci. 33, 317-325 (2010).
-
(2010)
Trends Neurosci.
, vol.33
, pp. 317-325
-
-
Goedert, M.1
Clavaguera, F.2
Tolnay, M.3
-
19
-
-
33748514647
-
Historical introduction: The diseases of the basal ganglia
-
Lewy, F. H. Historical introduction: the diseases of the basal ganglia. Res. Publ. Ass. Nerv. Ment. Dis. 21, 1-20 (1942).
-
(1942)
Res. Publ. Ass. Nerv. Ment. Dis.
, vol.21
, pp. 1-20
-
-
Lewy, F.H.1
-
20
-
-
33745919520
-
Epidemiology of Parkinson's disease
-
de Lau, L. M. & Breteler, M. M. Epidemiology of Parkinson's disease. Lancet Neurol. 5, 525-535 (2006).
-
(2006)
Lancet Neurol.
, vol.5
, pp. 525-535
-
-
De Lau, L.M.1
Breteler, M.M.2
-
21
-
-
80051552956
-
Dementia in Parkinson's disease: A 20-year neuropsychological study (Sydney Multicentre Study)
-
Reid, W. G., Hely, M. A., Morris, J. G., Loy, C. & Halliday, G. M. Dementia in Parkinson's disease: a 20-year neuropsychological study (Sydney Multicentre Study). J. Neurol. Neurosurg. Psychiatry 82, 1033-1037 (2011).
-
(2011)
J. Neurol. Neurosurg. Psychiatry
, vol.82
, pp. 1033-1037
-
-
Reid, W.G.1
Hely, M.A.2
Morris, J.G.3
Loy, C.4
Halliday, G.M.5
-
22
-
-
57049182374
-
Neuroanatomy and pathology of sporadic Parkinson's disease
-
Braak, H. & Del Tredici, K. Neuroanatomy and pathology of sporadic Parkinson's disease. Adv. Anat. Embryol. Cell Biol. 201, 1-119 (2009).
-
(2009)
Adv. Anat. Embryol. Cell Biol.
, vol.201
, pp. 1-119
-
-
Braak, H.1
Del Tredici, K.2
-
23
-
-
0031990490
-
Ala 30Pro mutation in the gene encoding α-synuclein in Parkinson's disease
-
Krüger, R. et al. Ala30Pro mutation in the gene encoding α-synuclein in Parkinson's disease. Nat. Genet. 18, 106-108 (1998).
-
(1998)
Nat. Genet.
, vol.18
, pp. 106-108
-
-
Krüger, R.1
-
24
-
-
10744230149
-
The new mutation, E46K, of α-synuclein causes Parkinson and Lewy body dementia
-
Zarranz, J. J. et al. The new mutation, E46K, of α-synuclein causes Parkinson and Lewy body dementia. Ann. Neurol. 55, 164-173 (2004).
-
(2004)
Ann. Neurol.
, vol.55
, pp. 164-173
-
-
Zarranz, J.J.1
-
25
-
-
0035409575
-
Alpha-synuclein and neurodegenerative diseases
-
Goedert, M. Alpha-synuclein and neurodegenerative diseases. Nat. Rev. Neurosci. 2, 492-501 (2001).
-
(2001)
Nat. Rev. Neurosci.
, vol.2
, pp. 492-501
-
-
Goedert, M.1
-
26
-
-
0242300619
-
α-Synuclein locus triplication causes Parkinson's disease
-
Singleton, A. B. et al. α-Synuclein locus triplication causes Parkinson's disease. Science 302, 841 (2003).
-
(2003)
Science
, vol.302
, pp. 841
-
-
Singleton, A.B.1
-
27
-
-
4644290985
-
α-Synuclein locus duplication in a case of familial Parkinson's disease
-
Chartier-Harlin, M. C. et al. α-Synuclein locus duplication in a case of familial Parkinson's disease. Lancet 364, 1167-1169 (2004).
-
(2004)
Lancet
, vol.364
, pp. 1167-1169
-
-
Chartier-Harlin, M.C.1
-
28
-
-
4644236043
-
Causal relation between α-synuclein gene duplication and familial Parkinson's disease
-
Ibanez, P. et al. Causal relation between α-synuclein gene duplication and familial Parkinson's disease. Lancet 364, 1169-1171 (2004).
-
(2004)
Lancet
, vol.364
, pp. 1169-1171
-
-
Ibanez, P.1
-
29
-
-
0342950666
-
Increased susceptibility to sporadic Parkinson's disease by a certain combined α-synuclein/apolipoprotein e genotype
-
Krüger, R. et al. Increased susceptibility to sporadic Parkinson's disease by a certain combined α-synuclein/apolipoprotein E genotype. Ann. Neurol. 45, 611-617 (1999).
-
(1999)
Ann. Neurol.
, vol.45
, pp. 611-617
-
-
Krüger, R.1
-
30
-
-
84862689309
-
The neuropathology of genetic Parkinson's disease
-
Poulopoulos, M., Levy, O. A. & Alcalay, R. N. The neuropathology of genetic Parkinson's disease. Mov. Disord. 27, 831-842 (2012).
-
(2012)
Mov. Disord.
, vol.27
, pp. 831-842
-
-
Poulopoulos, M.1
Levy, O.A.2
Alcalay, R.N.3
-
31
-
-
83555166040
-
Pale neurites, premature α-synuclein aggregates with centripetal extension from axon collaterals
-
Kanazawa, T. et al. Pale neurites, premature α-synuclein aggregates with centripetal extension from axon collaterals. Brain Pathol. 22, 67-78 (2012).
-
(2012)
Brain Pathol.
, vol.22
, pp. 67-78
-
-
Kanazawa, T.1
-
32
-
-
84861563520
-
Direct observation of the interconversion of normal and toxic forms of α-synuclein
-
Cremades, N. et al. Direct observation of the interconversion of normal and toxic forms of α-synuclein. Cell 149, 1048-1059 (2012).
-
(2012)
Cell
, vol.149
, pp. 1048-1059
-
-
Cremades, N.1
-
33
-
-
41149115508
-
Evidence that incidental Lewy body disease is pre-symptomatic Parkinson's disease
-
Dickson, D. W. et al. Evidence that incidental Lewy body disease is pre-symptomatic Parkinson's disease. Acta Neuropathol. 115, 437-444 (2008).
-
(2008)
Acta Neuropathol.
, vol.115
, pp. 437-444
-
-
Dickson, D.W.1
-
34
-
-
0037183533
-
Alpha-synuclein studies are negative in post-encephalitic parkinsonism of von Economo
-
Josephs, K. A., Parisi, J. E. & Dickson, D. W. Alpha-synuclein studies are negative in post-encephalitic parkinsonism of von Economo. Neurology 59, 645-646 (2002).
-
(2002)
Neurology
, vol.59
, pp. 645-646
-
-
Josephs, K.A.1
Parisi, J.E.2
Dickson, D.W.3
-
35
-
-
0032568534
-
α-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with Lewy bodies
-
Spillantini, M. G., Crowther, R. A., Jakes, R., Hasegawa, M. & Goedert, M. α-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with Lewy bodies. Proc. Natl Acad. Sci. USA 95, 6469-6473 (1998).
-
(1998)
Proc. Natl Acad. Sci. USA
, vol.95
, pp. 6469-6473
-
-
Spillantini, M.G.1
Crowther, R.A.2
Jakes, R.3
Hasegawa, M.4
Goedert, M.5
-
36
-
-
0034712918
-
Fibre diffraction of synthetic α-synuclein filaments shows amyloid-like cross-β conformation
-
Serpell, L. C., Berriman, J., Jakes, R., Goedert, M. & Crowther, R. A. Fibre diffraction of synthetic α-synuclein filaments shows amyloid-like cross-β conformation. Proc. Natl Acad. Sci. USA 97, 4897-4902 (2000).
-
(2000)
Proc. Natl Acad. Sci. USA
, vol.97
, pp. 4897-4902
-
-
Serpell, L.C.1
Berriman, J.2
Jakes, R.3
Goedert, M.4
Crowther, R.A.5
-
37
-
-
47249110199
-
The fold of α-synuclein fibrils
-
Vilar, M. et al. The fold of α-synuclein fibrils. Proc. Natl Acad. Sci. USA 105, 8637-8642 (2008).
-
(2008)
Proc. Natl Acad. Sci. USA
, vol.105
, pp. 8637-8642
-
-
Vilar, M.1
-
38
-
-
0036174010
-
α-Synuclein is phosphorylated in synucleinopathy lesions
-
Fujiwara, H. et al. α-Synuclein is phosphorylated in synucleinopathy lesions. Nat. Cell Biol. 4, 160-164 (2002).
-
(2002)
Nat. Cell Biol.
, vol.4
, pp. 160-164
-
-
Fujiwara, H.1
-
39
-
-
33749570292
-
Phosphorylation of Ser-129 is the dominant modification of α-synuclein in familial and sporadic Lewy body disease
-
Anderson, J. P. et al. Phosphorylation of Ser-129 is the dominant modification of α-synuclein in familial and sporadic Lewy body disease. J. Biol. Chem. 281, 29739-29752 (2006).
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 29739-29752
-
-
Anderson, J.P.1
-
40
-
-
0344305371
-
Morphogenesis of Lewy bodies: Dissimilar incorporation of α-synuclein, ubiquitin, and p62
-
Kuusisto, E., Parkkinen, L. & Alazuloff, I. Morphogenesis of Lewy bodies: dissimilar incorporation of α-synuclein, ubiquitin, and p62. J. Neuropathol. Exp. Neurol. 62, 1241-1253 (2003).
-
(2003)
J. Neuropathol. Exp. Neurol.
, vol.62
, pp. 1241-1253
-
-
Kuusisto, E.1
Parkkinen, L.2
Alazuloff, I.3
-
41
-
-
33144489150
-
Diagnosis and management of dementia with Lewy bodies: Third report of the DLB Consortium
-
McKeith, I. et al. Diagnosis and management of dementia with Lewy bodies: third report of the DLB Consortium. Neurology 65, 1863-1872 (2005).
-
(2005)
Neurology
, vol.65
, pp. 1863-1872
-
-
McKeith, I.1
-
42
-
-
77957308459
-
The first autopsied case of diffuse Lewy body disease (DLBD); Re-examination by recent immunostaining methods
-
Kosaka, K. & Manabe, Y. The first autopsied case of diffuse Lewy body disease (DLBD); re-examination by recent immunostaining methods. Neuropathology 30, 458-462 (2010).
-
(2010)
Neuropathology
, vol.30
, pp. 458-462
-
-
Kosaka, K.1
Manabe, Y.2
-
43
-
-
0035169488
-
Lewy body pathology in Alzheimer's disease
-
Kotzbauer, P. T., Trojanowski, J. Q. & Lee, V. M. Lewy body pathology in Alzheimer's disease. J. Mol. Neurosci. 17, 225-232 (2001).
-
(2001)
J. Mol. Neurosci.
, vol.17
, pp. 225-232
-
-
Kotzbauer, P.T.1
Trojanowski, J.Q.2
Lee, V.M.3
-
44
-
-
33746064033
-
Emerging evidence for the neuroprotective role of α-synuclein
-
Lee, H. G., Zhu, X., Takeda, A., Perry, G. & Smith, M. A. Emerging evidence for the neuroprotective role of α-synuclein. Exp. Neurol. 200, 1-7 (2006).
-
(2006)
Exp. Neurol.
, vol.200
, pp. 1-7
-
-
Lee, H.G.1
Zhu, X.2
Takeda, A.3
Perry, G.4
Smith, M.A.5
-
45
-
-
11144353869
-
Parkinson's disease α-synuclein mutations exhibit defective axonal transport in cultured neurons
-
Saha, A. R. et al. Parkinson's disease α-synuclein mutations exhibit defective axonal transport in cultured neurons. J. Cell Sci. 117, 1017-1024 (2004).
-
(2004)
J. Cell Sci.
, vol.117
, pp. 1017-1024
-
-
Saha, A.R.1
-
46
-
-
41149129792
-
Reduced striatal tyrosine hydroxylase in incidental Lewy body disease
-
Beach, T. G. et al. Reduced striatal tyrosine hydroxylase in incidental Lewy body disease. Acta Neuropathol. 115, 445-451 (2008).
-
(2008)
Acta Neuropathol.
, vol.115
, pp. 445-451
-
-
Beach, T.G.1
-
47
-
-
78149365318
-
Cell type-specific sequestration of choline acetyltransferase and tyrosine hydroxylase within Lewy bodies
-
Dugger, B. N. & Dickson, D. W. Cell type-specific sequestration of choline acetyltransferase and tyrosine hydroxylase within Lewy bodies. Acta Neuropathol. 120, 633-639 (2010).
-
(2010)
Acta Neuropathol.
, vol.120
, pp. 633-639
-
-
Dugger, B.N.1
Dickson, D.W.2
-
48
-
-
84871004211
-
Spinal cord lesions in sporadic Parkinson's disease
-
Del Tredici, K. & Braak, H. Spinal cord lesions in sporadic Parkinson's disease. Acta Neuropathol. 124, 643-664 (2012).
-
(2012)
Acta Neuropathol.
, vol.124
, pp. 643-664
-
-
Del Tredici, K.1
Braak, H.2
-
49
-
-
33947200337
-
Parkinson's disease: Lesions in dorsal horn layer I, involvement of parasympathetic and sympathetic pre-and postganglionic neurons
-
Braak, H., Sastre, M., Bohl, J. R., de Vos, R. A. & Del Tredici, K. Parkinson's disease: lesions in dorsal horn layer I, involvement of parasympathetic and sympathetic pre-and postganglionic neurons. Acta Neuropathol. 113, 421-429 (2007).
-
(2007)
Acta Neuropathol.
, vol.113
, pp. 421-429
-
-
Braak, H.1
Sastre, M.2
Bohl, J.R.3
De Vos, R.A.4
Del Tredici, K.5
-
50
-
-
0025346316
-
Parkinson's disease: An immunohistochemical study of Lewy body-containing neurons in the enteric nervous system
-
Wakabayashi, K., Takahashi, H., Ohama, E. & Ikuta, F. Parkinson's disease: an immunohistochemical study of Lewy body-containing neurons in the enteric nervous system. Acta Neuropathol. 79, 581-583 (1990).
-
(1990)
Acta Neuropathol.
, vol.79
, pp. 581-583
-
-
Wakabayashi, K.1
Takahashi, H.2
Ohama, E.3
Ikuta, F.4
-
51
-
-
81955167987
-
A comparison between rectal and colonic biopsies to detect Lewy pathology in Parkinson's disease
-
Pouclet, H. et al. A comparison between rectal and colonic biopsies to detect Lewy pathology in Parkinson's disease. Neurobiol. Dis. 45, 305-309 (2012).
-
(2012)
Neurobiol. Dis.
, vol.45
, pp. 305-309
-
-
Pouclet, H.1
-
52
-
-
0030662269
-
Neuropathology of autonomic nervous system in Parkinson's disease
-
Wakabayashi, K. & Takahashi, H. Neuropathology of autonomic nervous system in Parkinson's disease. Eur. Neurol. 38 (Suppl. 2), 2-7 (1997).
-
(1997)
Eur. Neurol.
, vol.38
, Issue.SUPPL. 2
, pp. 2-7
-
-
Wakabayashi, K.1
Takahashi, H.2
-
53
-
-
34247846268
-
Analysis of the adrenal gland is useful for evaluating pathology of the peripheral autonomic nervous system in Lewy body disease
-
Fumimura, Y. et al. Analysis of the adrenal gland is useful for evaluating pathology of the peripheral autonomic nervous system in Lewy body disease. J. Neuropathol. Exp. Neurol. 66, 354-362 (2007).
-
(2007)
J. Neuropathol. Exp. Neurol.
, vol.66
, pp. 354-362
-
-
Fumimura, Y.1
-
54
-
-
77953022918
-
Lewy pathology in the submandibular gland of individuals with incidental Lewy body disease and sporadic Parkinson's disease
-
Del Tredici, K., Hawkes, C. H., Ghebremedhin, E. & Braak, H. Lewy pathology in the submandibular gland of individuals with incidental Lewy body disease and sporadic Parkinson's disease. Acta Neuropathol. 119, 703-713 (2010).
-
(2010)
Acta Neuropathol.
, vol.119
, pp. 703-713
-
-
Del Tredici, K.1
Hawkes, C.H.2
Ghebremedhin, E.3
Braak, H.4
-
55
-
-
0032926674
-
Lewy body-type degeneration in cardiac plexus in Parkinson's disease and incidental Lewy body diseases
-
Iwanaga, K. et al. Lewy body-type degeneration in cardiac plexus in Parkinson's disease and incidental Lewy body diseases. Neurology 52, 1269-1271 (1999).
-
(1999)
Neurology
, vol.52
, pp. 1269-1271
-
-
Iwanaga, K.1
-
56
-
-
22144465494
-
Cardiac sympathetic denervation precedes neuronal loss in the sympathetic ganglia in Lewy body disease
-
Orimo, S. et al. Cardiac sympathetic denervation precedes neuronal loss in the sympathetic ganglia in Lewy body disease. Acta Neuropathol. 109, 583-588 (2005).
-
(2005)
Acta Neuropathol.
, vol.109
, pp. 583-588
-
-
Orimo, S.1
-
57
-
-
71449128214
-
Diminished tyrosine hydroxylase immunoreactivity in the cardiac conduction system and myocardium in Parkinson's disease: An anatomical study
-
Ghebremedhin, E., Del Tredici, K., Langston, J. W. & Braak, H. Diminished tyrosine hydroxylase immunoreactivity in the cardiac conduction system and myocardium in Parkinson's disease: an anatomical study. Acta Neuropathol. 118, 777-784 (2009).
-
(2009)
Acta Neuropathol.
, vol.118
, pp. 777-784
-
-
Ghebremedhin, E.1
Del Tredici, K.2
Langston, J.W.3
Braak, H.4
-
58
-
-
0026348872
-
Pathology of Parkinson's disease. Changes other than in the nigrostriatal pathway
-
Jellinger, K. A. Pathology of Parkinson's disease. Changes other than in the nigrostriatal pathway. Mol. Chem. Neuropathol. 14, 153-197 (1991).
-
(1991)
Mol. Chem. Neuropathol.
, vol.14
, pp. 153-197
-
-
Jellinger, K.A.1
-
59
-
-
1942520420
-
Challenges in Parkinson's disease: Restoration of the nigrostriatal dopamine system is not enough
-
Lang, A. E. & Obeso, J. A. Challenges in Parkinson's disease: restoration of the nigrostriatal dopamine system is not enough. Lancet Neurol. 3, 309-316 (2004).
-
(2004)
Lancet Neurol.
, vol.3
, pp. 309-316
-
-
Lang, A.E.1
Obeso, J.A.2
-
60
-
-
33645755812
-
The Parkinson's complex: Parkinsonism is just the tip of the iceberg
-
Langston, J. W. The Parkinson's complex: parkinsonism is just the tip of the iceberg. Ann. Neurol. 59, 591-596 (2006).
-
(2006)
Ann. Neurol.
, vol.59
, pp. 591-596
-
-
Langston, J.W.1
-
61
-
-
71849089219
-
Neuropathology of non-motor features of Parkinson's disease
-
Dickson, D. W. et al. Neuropathology of non-motor features of Parkinson's disease. Parkinsonism Relat. Disord. 15 (Suppl. 3), S1-S5 (2009).
-
(2009)
Parkinsonism Relat. Disord.
, vol.15
, Issue.SUPPL. 3
-
-
Dickson, D.W.1
-
62
-
-
60549085946
-
Overview of the extranigral aspects of Parkinson disease
-
Lim, S. Y., Fox, S. H. & Lang, A. E. Overview of the extranigral aspects of Parkinson disease. Arch. Neurol. 66, 167-172 (2009).
-
(2009)
Arch. Neurol.
, vol.66
, pp. 167-172
-
-
Lim, S.Y.1
Fox, S.H.2
Lang, A.E.3
-
63
-
-
33646082266
-
α-Synuclein pathology of the spinal and peripheral autonomic nervous system in neurologically unimpaired elderly subjects
-
Bloch, A., Probst, A., Bissig, H., Adams, H. & Tolnay, M. α-Synuclein pathology of the spinal and peripheral autonomic nervous system in neurologically unimpaired elderly subjects. Neuropathol. Appl. Neurobiol. 12, 284-295 (2006).
-
(2006)
Neuropathol. Appl. Neurobiol.
, vol.12
, pp. 284-295
-
-
Bloch, A.1
Probst, A.2
Bissig, H.3
Adams, H.4
Tolnay, M.5
-
64
-
-
77953433969
-
Evidence in favour of Braak staging of Parkinson's disease
-
Dickson, D. W., Uchikado, H., Fujishiro, H. & Tsuboi, Y. Evidence in favour of Braak staging of Parkinson's disease. Mov. Disord. 25 (Suppl. 1), S78-S82 (2010).
-
(2010)
Mov. Disord.
, vol.25
, Issue.SUPPL. 1
-
-
Dickson, D.W.1
Uchikado, H.2
Fujishiro, H.3
Tsuboi, Y.4
-
65
-
-
84861739631
-
Evaluation of the braak hypothesis: How far can it explain the pathogenesis of parkinson's disease?
-
Halliday, G., McCann, H. & Shepherd, C. Evaluation of the Braak hypothesis: how far can it explain the pathogenesis of Parkinson's disease? Expert Rev. Neurother. 12, 673-686 (2012).
-
(2012)
Expert Rev. Neurother.
, vol.12
, pp. 673-686
-
-
Halliday, G.1
McCann, H.2
Shepherd, C.3
-
66
-
-
33750377224
-
Pathology associated with sporadic Parkinson's disease - Where does it end?
-
Braak, H. et al. Pathology associated with sporadic Parkinson's disease - where does it end? J. Neural Transm. 70, 89-97 (2006).
-
(2006)
J. Neural Transm.
, vol.70
, pp. 89-97
-
-
Braak, H.1
-
67
-
-
33747821466
-
Alzheimer disease with amygdala Lewy bodies: A distinct form of α-synucleinopathy
-
Uchikado, H., Lin, W. L., De Lucia, M. W. & Dickson, D. W. Alzheimer disease with amygdala Lewy bodies: a distinct form of α-synucleinopathy. J. Neuropathol. Exp. Neurol. 65, 685-697 (2006).
-
(2006)
J. Neuropathol. Exp. Neurol.
, vol.65
, pp. 685-697
-
-
Uchikado, H.1
Lin, W.L.2
De Lucia, M.W.3
Dickson, D.W.4
-
68
-
-
3042830032
-
Lewy body-related α-synucleinopathy in aging
-
Saito, Y. et al. Lewy body-related α-synucleinopathy in aging. J. Neuropathol. Exp. Neurol. 63, 742-749 (2004).
-
(2004)
J. Neuropathol. Exp. Neurol.
, vol.63
, pp. 742-749
-
-
Saito, Y.1
-
69
-
-
67349279396
-
Unified staging system for Lewy body disorders: Correlation with nigrostriatal degeneration, cognitive impairment and motor dysfunction
-
Beach, T. G. et al. Unified staging system for Lewy body disorders: correlation with nigrostriatal degeneration, cognitive impairment and motor dysfunction. Acta Neuropathol. 117, 613-634 (2009).
-
(2009)
Acta Neuropathol.
, vol.117
, pp. 613-634
-
-
Beach, T.G.1
-
70
-
-
71849092190
-
Neuropathological assessment of Parkinson's disease: Refining the diagnostic criteria
-
Dickson, D. W. et al. Neuropathological assessment of Parkinson's disease: refining the diagnostic criteria. Lancet Neurol. 8, 1150-1157 (2009).
-
(2009)
Lancet Neurol.
, vol.8
, pp. 1150-1157
-
-
Dickson, D.W.1
-
71
-
-
32544442518
-
Gastric α-synuclein immunoreactive inclusions in Meissner's and Auerbach's plexuses in cases staged for Parkinson's disease-related brain pathology
-
Braak, H., de Vos, R. A., Bohl, J. & Del Tredici, K. Gastric α-synuclein immunoreactive inclusions in Meissner's and Auerbach's plexuses in cases staged for Parkinson's disease-related brain pathology. Neurosci. Lett. 396, 67-72 (2006).
-
(2006)
Neurosci. Lett.
, vol.396
, pp. 67-72
-
-
Braak, H.1
De Vos, R.A.2
Bohl, J.3
Del Tredici, K.4
-
72
-
-
84859834711
-
Lewy pathology and neurodegeneration in premotor Parkinson's disease
-
Del Tredici, K. & Braak, H. Lewy pathology and neurodegeneration in premotor Parkinson's disease. Mov. Disord. 27, 597-607 (2012).
-
(2012)
Mov. Disord.
, vol.27
, pp. 597-607
-
-
Del Tredici, K.1
Braak, H.2
-
73
-
-
84871028956
-
Parkinson's disease is not associated with gastrointestinal myenteric ganglion neuron loss
-
Annerino, D. M. et al. Parkinson's disease is not associated with gastrointestinal myenteric ganglion neuron loss. Acta Neuropathol. 124, 665-680 (2012).
-
(2012)
Acta Neuropathol.
, vol.124
, pp. 665-680
-
-
Annerino, D.M.1
-
74
-
-
84861697687
-
Is alpha-synuclein in the colon a biomarker for premotor Parkinson's disease?
-
Shannon, K. M., Keshavarzian, A., Dodiya, H. B., Jakate, S. & Kordower, J. H. Is alpha-synuclein in the colon a biomarker for premotor Parkinson's disease? Evidence from 3 cases. Mov. Disord. 27, 716-719 (2012).
-
(2012)
Evidence from 3 Cases. Mov. Disord.
, vol.27
, pp. 716-719
-
-
Shannon, K.M.1
Keshavarzian, A.2
Dodiya, H.B.3
Jakate, S.4
Kordower, J.H.5
-
75
-
-
33646109064
-
α-Synuclein pathology in the spinal cord of neurologically asymptomatic aged individuals
-
Klos, K. J. et al. α-Synuclein pathology in the spinal cord of neurologically asymptomatic aged individuals. Neurology 66, 1100-1102 (2006).
-
(2006)
Neurology
, vol.66
, pp. 1100-1102
-
-
Klos, K.J.1
-
76
-
-
77954862456
-
Molecular and clinical prodrome of Parkinson disease: Implications for treatment
-
Schapira, A. H. & Tolosa, E. Molecular and clinical prodrome of Parkinson disease: implications for treatment. Nat. Rev. Neurol. 6, 309-317 (2010).
-
(2010)
Nat. Rev. Neurol.
, vol.6
, pp. 309-317
-
-
Schapira, A.H.1
Tolosa, E.2
-
77
-
-
43249110200
-
Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation
-
Li, J. Y. et al. Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation. Nat. Med. 14, 501-503 (2008).
-
(2008)
Nat. Med.
, vol.14
, pp. 501-503
-
-
Li, J.Y.1
-
78
-
-
43249114934
-
Lewy body-like pathology in long-term embryonic nigral transplants in Parkinson's disease
-
Kordower, J. H., Chu, Y., Hauser, R. A., Freeman, T. B. & Olanow, C. W. Lewy body-like pathology in long-term embryonic nigral transplants in Parkinson's disease. Nat. Med. 14, 504-506 (2008).
-
(2008)
Nat. Med.
, vol.14
, pp. 504-506
-
-
Kordower, J.H.1
Chu, Y.2
Hauser, R.A.3
Freeman, T.B.4
Olanow, C.W.5
-
79
-
-
84980053683
-
Relationship of neighbouring tissue and gliosis to α-synuclein pathology in a fetal transplant for Parkinson's disease
-
Ahn, T. B., Langston, W. J., Aachi, V. R. & Dickson, D. W. Relationship of neighbouring tissue and gliosis to α-synuclein pathology in a fetal transplant for Parkinson's disease. Am. J. Neurodegener. Dis. 1, 49-59 (2012).
-
(2012)
Am. J. Neurodegener. Dis.
, vol.1
, pp. 49-59
-
-
Ahn, T.B.1
Langston, W.J.2
Aachi, V.R.3
Dickson, D.W.4
-
80
-
-
77949820437
-
Characterization of Lewy body pathology in 12-and 16-year-old intrastriatal mesencephalic grafts surviving in a patient with Parkinson's disease
-
Li, J. Y. et al. Characterization of Lewy body pathology in 12-and 16-year-old intrastriatal mesencephalic grafts surviving in a patient with Parkinson's disease. Mov. Disord. 25, 1091-1096 (2010).
-
(2010)
Mov. Disord.
, vol.25
, pp. 1091-1096
-
-
Li, J.Y.1
-
81
-
-
70449532484
-
A stable proportion of Lewy body-bearing neurons in the substantia nigra suggests a model in which the Lewy body causes neuronal death
-
Greffard, S. et al. A stable proportion of Lewy body-bearing neurons in the substantia nigra suggests a model in which the Lewy body causes neuronal death. Neurobiol. Aging 31, 99-103 (2010).
-
(2010)
Neurobiol. Aging
, vol.31
, pp. 99-103
-
-
Greffard, S.1
-
82
-
-
84862620376
-
A unifying role for prions in neurodegenerative diseases
-
Prusiner, S. B. A unifying role for prions in neurodegenerative diseases. Science 336, 1511-1513 (2012).
-
(2012)
Science
, vol.336
, pp. 1511-1513
-
-
Prusiner, S.B.1
-
83
-
-
84858259953
-
Disentangling the relationship between Lewy bodies and nigral neuronal loss in Parkinson's disease
-
Parkkinen, L. et al. Disentangling the relationship between Lewy bodies and nigral neuronal loss in Parkinson's disease. J. Parkinsons Dis. 1, 277-286 (2011).
-
(2011)
J. Parkinsons Dis.
, vol.1
, pp. 277-286
-
-
Parkkinen, L.1
-
84
-
-
75749135592
-
A timeline for Parkinson's disease
-
Hawkes, C. J., Del Tredici, K. & Braak, H. A timeline for Parkinson's disease. Parkinsonism Relat. Disord. 16, 79-84 (2010).
-
(2010)
Parkinsonism Relat. Disord.
, vol.16
, pp. 79-84
-
-
Hawkes, C.J.1
Del Tredici, K.2
Braak, H.3
-
85
-
-
0029773625
-
Occurrence of Parkinson's syndrome in type i Gaucher disease
-
Neudorfer, O. et al. Occurrence of Parkinson's syndrome in type I Gaucher disease. Q. J. Med. 89, 691-694 (1996).
-
(1996)
Q. J. Med.
, vol.89
, pp. 691-694
-
-
Neudorfer, O.1
-
86
-
-
70350319531
-
Multicenter analysis of glucocerebrosidase mutations in Parkinson's disease
-
Sidransky, E. et al. Multicenter analysis of glucocerebrosidase mutations in Parkinson's disease. N. Engl. J. Med. 361, 1651-1661 (2009).
-
(2009)
N. Engl. J. Med.
, vol.361
, pp. 1651-1661
-
-
Sidransky, E.1
-
87
-
-
78650821421
-
The incidence of parkinsonism in patients with type 1 Gaucher disease: Data from the ICGG Gaucher Registry
-
Rosenbloom, B. et al. The incidence of parkinsonism in patients with type 1 Gaucher disease: data from the ICGG Gaucher Registry. Blood Cells Mol. Dis. 46, 95-102 (2011).
-
(2011)
Blood Cells Mol. Dis.
, vol.46
, pp. 95-102
-
-
Rosenbloom, B.1
-
88
-
-
78149410222
-
Glucocerebrosidase is present in α-synuclein inclusions in Lewy body disorders
-
Goker-Alpan, O., Stubblefield, B. K., Giasson, B. I. & Sidransky E. Glucocerebrosidase is present in α-synuclein inclusions in Lewy body disorders. Acta Neuropathol. 120, 641-649 (2010).
-
(2010)
Acta Neuropathol.
, vol.120
, pp. 641-649
-
-
Goker-Alpan, O.1
Stubblefield, B.K.2
Giasson, B.I.3
Sidransky, E.4
-
89
-
-
80052028927
-
Exploring the link between glucocerebrosidase mutations and parkinsonism
-
Westbroek, W., Gustafson, A. M. & Sidransky, E. Exploring the link between glucocerebrosidase mutations and parkinsonism. Trends Mol. Med. 17, 485-493 (2011).
-
(2011)
Trends Mol. Med.
, vol.17
, pp. 485-493
-
-
Westbroek, W.1
Gustafson, A.M.2
Sidransky, E.3
-
90
-
-
8844266996
-
Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease
-
Paisán-Ruíz, C. et al. Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease. Neuron 44, 595-600 (2004).
-
(2004)
Neuron
, vol.44
, pp. 595-600
-
-
Paisán-Ruíz, C.1
-
91
-
-
8844233579
-
Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology
-
Zimprich, A. et al. Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology. Neuron 44, 601-607 (2004).
-
(2004)
Neuron
, vol.44
, pp. 601-607
-
-
Zimprich, A.1
-
92
-
-
32044466285
-
Lrrk2 and Lewy body disease
-
Ross, O. A. et al. Lrrk2 and Lewy body disease. Ann. Neurol. 59, 388-393 (2006).
-
(2006)
Ann. Neurol.
, vol.59
, pp. 388-393
-
-
Ross, O.A.1
-
93
-
-
0032499264
-
Mutations in the Parkin gene cause autosomal recessive juvenile parkinsonism
-
Kitada, T. et al. Mutations in the Parkin gene cause autosomal recessive juvenile parkinsonism. Nature 392, 605-608 (1998).
-
(1998)
Nature
, vol.392
, pp. 605-608
-
-
Kitada, T.1
-
94
-
-
2442668926
-
Hereditary early-onset Parkinson's disease caused by mutations in PINK1
-
Valente, E. M. et al. Hereditary early-onset Parkinson's disease caused by mutations in PINK1. Science 304, 1158-1160 (2004).
-
(2004)
Science
, vol.304
, pp. 1158-1160
-
-
Valente, E.M.1
-
95
-
-
33745602748
-
Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin
-
Park, J. et al. Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin. Nature 441, 1157-1161 (2006).
-
(2006)
Nature
, vol.441
, pp. 1157-1161
-
-
Park, J.1
-
96
-
-
33745589773
-
Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin
-
Clark, I. E. et al. Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin. Nature 441, 1162-1166 (2006).
-
(2006)
Nature
, vol.441
, pp. 1162-1166
-
-
Clark, I.E.1
-
97
-
-
84864267876
-
PINK1 is activated by mitochondrial membrane depolarization and stimulates Parkin E3 ligase activity by phosphorylating serine 65
-
Kondapalli, C. et al. PINK1 is activated by mitochondrial membrane depolarization and stimulates Parkin E3 ligase activity by phosphorylating serine 65. Open Biol. 2, 120080 (2012).
-
(2012)
Open Biol.
, vol.2
, pp. 120080
-
-
Kondapalli, C.1
-
99
-
-
0037428241
-
Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism
-
Bonifati, V. et al. Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism. Science 299, 256-259 (2003).
-
(2003)
Science
, vol.299
, pp. 256-259
-
-
Bonifati, V.1
-
100
-
-
2942684871
-
The Parkinson's disease protein DJ-1 is neuroprotective due to cysteine-sulfinic acid-driven mitochondrial localization
-
Canet-Avilés, R. M. et al. The Parkinson's disease protein DJ-1 is neuroprotective due to cysteine-sulfinic acid-driven mitochondrial localization. Proc. Natl Acad. Sci. USA 101, 9103-9108 (2004).
-
(2004)
Proc. Natl Acad. Sci. USA
, vol.101
, pp. 9103-9108
-
-
Canet-Avilés, R.M.1
-
101
-
-
0037337815
-
Neuronal loss is greater in the locus coeruleus than nucleus basalis and substantia nigra in Alzheimer and Parkinson diseases
-
Zarow, C., Lyness, S. A., Mortimer, J. A. & Chui, H. C. Neuronal loss is greater in the locus coeruleus than nucleus basalis and substantia nigra in Alzheimer and Parkinson diseases. Arch. Neurol. 60, 337-341 (2003).
-
(2003)
Arch. Neurol.
, vol.60
, pp. 337-341
-
-
Zarow, C.1
Lyness, S.A.2
Mortimer, J.A.3
Chui, H.C.4
-
102
-
-
77950855127
-
PINK1-linked parkinsonism is associated with Lewy body pathology
-
Samaranch, L. et al. PINK1-linked parkinsonism is associated with Lewy body pathology. Brain 133, 1128-1142 (2010).
-
(2010)
Brain
, vol.133
, pp. 1128-1142
-
-
Samaranch, L.1
-
103
-
-
0024843373
-
Glial cytoplasmic inclusions in the CNS of patients with multiple system atrophy
-
Papp, M. I., Kahn, J. E. & Lantos, P. L. Glial cytoplasmic inclusions in the CNS of patients with multiple system atrophy. J. Neurol. Sci. 94, 79-100 (1989).
-
(1989)
J. Neurol. Sci.
, vol.94
, pp. 79-100
-
-
Papp, M.I.1
Kahn, J.E.2
Lantos, P.L.3
-
104
-
-
0032546895
-
α-Synuclein immunoreactivity in glial cytoplasmic inclusions in multiple system atrophy
-
Wakabayashi, K., Yoshimoto, M., Tsuji, S. & Takahashi, H. α-Synuclein immunoreactivity in glial cytoplasmic inclusions in multiple system atrophy. Neurosci. Lett. 249, 180-182 (1998).
-
(1998)
Neurosci. Lett.
, vol.249
, pp. 180-182
-
-
Wakabayashi, K.1
Yoshimoto, M.2
Tsuji, S.3
Takahashi, H.4
-
105
-
-
0032584686
-
Filamentous α-synuclein inclusions link multiple system atrophy with Parkinson's disease and dementia with Lewy bodies
-
Spillantini, M. G. et al. Filamentous α-synuclein inclusions link multiple system atrophy with Parkinson's disease and dementia with Lewy bodies. Neurosci. Lett. 251, 205-208 (1998).
-
(1998)
Neurosci. Lett.
, vol.251
, pp. 205-208
-
-
Spillantini, M.G.1
-
106
-
-
0031713491
-
Glial cytoplasmic inclusions in white matter oligodendrocytes of multiple system atrophy brains contain insoluble α-synuclein
-
Tu, P. H. et al. Glial cytoplasmic inclusions in white matter oligodendrocytes of multiple system atrophy brains contain insoluble α-synuclein. Ann. Neurol. 44, 415-422 (1998).
-
(1998)
Ann. Neurol.
, vol.44
, pp. 415-422
-
-
Tu, P.H.1
-
107
-
-
67249139655
-
SNCA variants are associated with increased risk for multiple system atrophy
-
Scholz, S. W. et al. SNCA variants are associated with increased risk for multiple system atrophy. Ann. Neurol. 65, 610-614 (2009).
-
(2009)
Ann. Neurol.
, vol.65
, pp. 610-614
-
-
Scholz, S.W.1
-
108
-
-
70349578343
-
Genetic variants of the α-synuclein gene SNCA are associated with multiple system atrophy
-
Al-Chalabi, A. et al. Genetic variants of the α-synuclein gene SNCA are associated with multiple system atrophy. PLoS ONE 22. e7114 (2009).
-
(2009)
PLoS ONE
, vol.22
-
-
Al-Chalabi, A.1
-
109
-
-
0034077041
-
Mice lacking α-synuclein display functional deficits in the nigrostriatal dopamine system
-
Abeliovich A. et al. Mice lacking α-synuclein display functional deficits in the nigrostriatal dopamine system. Neuron 25, 239-252 (2000).
-
(2000)
Neuron
, vol.25
, pp. 239-252
-
-
Abeliovich, A.1
-
110
-
-
0035789203
-
Deletion of the α-synuclein locus in a subpopulation of C57BL/6J inbred mice
-
Specht, C. G. & Schoepfer, R. Deletion of the α-synuclein locus in a subpopulation of C57BL/6J inbred mice. BMC Neurosci. 2, 11 (2001).
-
(2001)
BMC Neurosci
, vol.2
, pp. 11
-
-
Specht, C.G.1
Schoepfer, R.2
-
111
-
-
78650431984
-
αβγ-Synuclein triple knockout mice reveal age-dependent neuronal dysfunction
-
Greten-Harrison, B. et al. αβγ-Synuclein triple knockout mice reveal age-dependent neuronal dysfunction. Proc. Natl Acad. Sci. USA 107, 19573-19578 (2010).
-
(2010)
Proc. Natl Acad. Sci. USA
, vol.107
, pp. 19573-19578
-
-
Greten-Harrison, B.1
-
112
-
-
77957877526
-
α-Synuclein suppression by targeted small interfering RNA in the primate substantia nigra
-
McCormack, A. L. et al. α-Synuclein suppression by targeted small interfering RNA in the primate substantia nigra. PLoS ONE 5. e12122 (2010).
-
(2010)
PLoS ONE
, vol.5
-
-
McCormack, A.L.1
-
113
-
-
79960069979
-
α-Syn suppression reverses synaptic and memory defects in a mouse model of dementia with Lewy bodies
-
Lim, V. et al. α-Syn suppression reverses synaptic and memory defects in a mouse model of dementia with Lewy bodies. J. Neurosci. 31, 10076-10087 (2011).
-
(2011)
J. Neurosci.
, vol.31
, pp. 10076-10087
-
-
Lim, V.1
-
114
-
-
0034681471
-
Dopaminergic loss and inclusion body formation in α-synuclein mice: Implications for neurodegenerative disorders
-
Masliah, E. et al. Dopaminergic loss and inclusion body formation in α-synuclein mice: implications for neurodegenerative disorders. Science 287, 1265-1269 (2000).
-
(2000)
Science
, vol.287
, pp. 1265-1269
-
-
Masliah, E.1
-
115
-
-
0037118259
-
Neuronal α-synucleinopathy with severe movement disorder in mice expressing A53T human α-synuclein
-
Giasson, B. I. et al. Neuronal α-synucleinopathy with severe movement disorder in mice expressing A53T human α-synuclein. Neuron 34, 521-533 (2002).
-
(2002)
Neuron
, vol.34
, pp. 521-533
-
-
Giasson, B.I.1
-
116
-
-
80053421282
-
E46K human α-synuclein transgenic mice develop Lewy-like and tau pathology associated with age-dependent, detrimental motor impairment
-
Emmer, K. L., Waxman, E. A., Covey, J. P. & Giasson, B. I. E46K human α-synuclein transgenic mice develop Lewy-like and tau pathology associated with age-dependent, detrimental motor impairment. J. Biol. Chem. 286, 35104-35118 (2011).
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 35104-35118
-
-
Emmer, K.L.1
Waxman, E.A.2
Covey, J.P.3
Giasson, B.I.4
-
117
-
-
79956317900
-
Enhanced phosphatase activity attenuates α-synucleinopathy in a mouse model
-
Lee, K. W. et al. Enhanced phosphatase activity attenuates α-synucleinopathy in a mouse model. J. Neurosci. 31, 6963-6971 (2012).
-
(2012)
J. Neurosci.
, vol.31
, pp. 6963-6971
-
-
Lee, K.W.1
-
118
-
-
33646097224
-
Pathological changes in dopaminergic nerve cells of the substantia nigra and olfactory bulb in mice transgenic for truncated human α-synuclein(1- 120): Implications for Lewy body disorders
-
Tofaris, G. K. et al. Pathological changes in dopaminergic nerve cells of the substantia nigra and olfactory bulb in mice transgenic for truncated human α-synuclein(1-120): implications for Lewy body disorders. J. Neurosci. 26, 3942-3950 (2006).
-
(2006)
J. Neurosci.
, vol.26
, pp. 3942-3950
-
-
Tofaris, G.K.1
-
119
-
-
77954379317
-
SNARE protein redistribution and synaptic failure in a transgenic mouse model of Parkinson's disease
-
Garcia-Reitböck, P. et al. SNARE protein redistribution and synaptic failure in a transgenic mouse model of Parkinson's disease. Brain 133, 2032-2044 (2010).
-
(2010)
Brain
, vol.133
, pp. 2032-2044
-
-
Garcia-Reitböck, P.1
-
120
-
-
0033681149
-
Chronic systemic pesticide exposure reproduces features of Parkinson's disease
-
Betarbet, R. et al. Chronic systemic pesticide exposure reproduces features of Parkinson's disease. Nat. Neurosci. 3, 1301-1306 (2000).
-
(2000)
Nat. Neurosci.
, vol.3
, pp. 1301-1306
-
-
Betarbet, R.1
-
121
-
-
77649284470
-
Progression of Parkinson's disease pathology is reproduced by intragastric administration of rotenone in mice
-
Pan-Montojo, F. et al. Progression of Parkinson's disease pathology is reproduced by intragastric administration of rotenone in mice. PLoS ONE 5. e8762 (2010).
-
(2010)
PLoS ONE
, vol.5
-
-
Pan-Montojo, F.1
-
122
-
-
0036550101
-
Parkinson-like neurodegeneration induced by targeted overexpression of α-synuclein in the nigrostriatal system
-
Kirik, D. et al. Parkinson-like neurodegeneration induced by targeted overexpression of α-synuclein in the nigrostriatal system. J. Neurosci. 22, 2780-2791 (2002).
-
(2002)
J. Neurosci.
, vol.22
, pp. 2780-2791
-
-
Kirik, D.1
-
123
-
-
0036679197
-
α-Synucleinopathy and selective dopaminergic neuron loss in a rat lentiviral-based model of Parkinson's disease
-
Lo Bianco, C., Ridet, J. L., Schneider, B. L., Deglon, N. & Aebischer, P. α-Synucleinopathy and selective dopaminergic neuron loss in a rat lentiviral-based model of Parkinson's disease. Proc. Natl Acad. Sci. USA 99, 10813-10818 (2002).
-
(2002)
Proc. Natl Acad. Sci. USA
, vol.99
, pp. 10813-10818
-
-
Lo Bianco, C.1
Ridet, J.L.2
Schneider, B.L.3
Deglon, N.4
Aebischer, P.5
-
124
-
-
84862672217
-
Aggregation of α-synuclein promotes progressive in vivo neurotoxicity in adult rat dopaminergic neurons
-
Taschenberger, G. et al. Aggregation of α-synuclein promotes progressive in vivo neurotoxicity in adult rat dopaminergic neurons. Acta Neuropathol. 123, 671-683 (2012).
-
(2012)
Acta Neuropathol.
, vol.123
, pp. 671-683
-
-
Taschenberger, G.1
-
125
-
-
84867787595
-
Systematic mutagenesis of α-synuclein reveals distinct sequence requirements for physiological and pathological activities
-
Burré, J., Sharma, M. & Südhof, T. C. Systematic mutagenesis of α-synuclein reveals distinct sequence requirements for physiological and pathological activities. J. Neurosci. 32, 15227-15242 (2012).
-
(2012)
J. Neurosci.
, vol.32
, pp. 15227-15242
-
-
Burré, J.1
Sharma, M.2
Südhof, T.C.3
-
126
-
-
0034704752
-
A Drosophila model of Parkinson's disease
-
Feany, M. B. & Bender, W. W. A Drosophila model of Parkinson's disease. Nature 404, 394-398 (2000).
-
(2000)
Nature
, vol.404
, pp. 394-398
-
-
Feany, M.B.1
Bender, W.W.2
-
127
-
-
0036468432
-
Chaperone suppression of α-synuclein toxicity in a Drosophila model for Parkinson's disease
-
Auluck, P. K., Chan, H. Y., Trojanowski, J. Q., Lee, V. M. & Bonini, N. M. Chaperone suppression of α-synuclein toxicity in a Drosophila model for Parkinson's disease. Science 295, 865-868 (2002).
-
(2002)
Science
, vol.295
, pp. 865-868
-
-
Auluck, P.K.1
Chan, H.Y.2
Trojanowski, J.Q.3
Lee, V.M.4
Bonini, N.M.5
-
128
-
-
33947505619
-
Aggregated α-synuclein mediates dopaminergic neurotoxicity in vivo
-
Periquet, M., Fulga, T., Myllykangas, L., Schlossmacher, M. G. & Feany, M. B. Aggregated α-synuclein mediates dopaminergic neurotoxicity in vivo. J. Neurosci. 27, 3338-3346 (2007).
-
(2007)
J. Neurosci.
, vol.27
, pp. 3338-3346
-
-
Periquet, M.1
Fulga, T.2
Myllykangas, L.3
Schlossmacher, M.G.4
Feany, M.B.5
-
129
-
-
0037971209
-
Dopaminergic neuronal loss and motor deficits in Caenorhabditis elegans overexpressing human α-synuclein
-
Lakso, M. et al. Dopaminergic neuronal loss and motor deficits in Caenorhabditis elegans overexpressing human α-synuclein. J. Neurochem. 86, 165-172 (2003).
-
(2003)
J. Neurochem.
, vol.86
, pp. 165-172
-
-
Lakso, M.1
-
130
-
-
52949083619
-
A systematic RNAi screen reveals involvement of endocytic pathway in neuronal dysfunction in α-synuclein transgenic C. elegans
-
Kuwahara, T. et al. A systematic RNAi screen reveals involvement of endocytic pathway in neuronal dysfunction in α-synuclein transgenic C. elegans. Hum. Mol. Genet. 17, 2997-3009 (2007).
-
(2007)
Hum. Mol. Genet.
, vol.17
, pp. 2997-3009
-
-
Kuwahara, T.1
-
131
-
-
33646570598
-
Small molecule inhibitors of α-synuclein filament assembly
-
Masuda, M. et al. Small molecule inhibitors of α-synuclein filament assembly. Biochemistry 45, 6085-6094 (2006).
-
(2006)
Biochemistry
, vol.45
, pp. 6085-6094
-
-
Masuda, M.1
-
132
-
-
80053613574
-
Exogenous α-synuclein fibrils induce Lewy body pathology leading to synaptic dysfunction and neuron death
-
Volpicelli-Daley, L. A. et al. Exogenous α-synuclein fibrils induce Lewy body pathology leading to synaptic dysfunction and neuron death. Neuron 72, 57-71 (2011).
-
(2011)
Neuron
, vol.72
, pp. 57-71
-
-
Volpicelli-Daley, L.A.1
-
133
-
-
69149089854
-
Inclusion formation and neuronal cell death through neuron-to-neuron transmission of α-synuclein
-
Desplats, P. et al. Inclusion formation and neuronal cell death through neuron-to-neuron transmission of α-synuclein. Proc. Natl Acad. Sci. USA 106, 13010-13015 (2009).
-
(2009)
Proc. Natl Acad. Sci. USA
, vol.106
, pp. 13010-13015
-
-
Desplats, P.1
-
134
-
-
79551519276
-
α-Synuclein propagates from mouse brain to grafted dopaminergic neurons and seeds aggregation in cultured human cells
-
Hansen, C. et al. α-Synuclein propagates from mouse brain to grafted dopaminergic neurons and seeds aggregation in cultured human cells. J. Clin. Invest. 121, 715-725 (2011).
-
(2011)
J. Clin. Invest.
, vol.121
, pp. 715-725
-
-
Hansen, C.1
-
135
-
-
79960285197
-
Transfer of host-derived α-synuclein to grafted dopaminergic neurons in rat
-
Kordower, J. H. et al. Transfer of host-derived α-synuclein to grafted dopaminergic neurons in rat. Neurobiol. Dis. 43, 552-557 (2011).
-
(2011)
Neurobiol. Dis.
, vol.43
, pp. 552-557
-
-
Kordower, J.H.1
-
136
-
-
84863433677
-
Prion-like acceleration of a synucleinopathy in a transgenic mouse model
-
Mougenot, A. L. et al. Prion-like acceleration of a synucleinopathy in a transgenic mouse model. Neurobiol. Aging 33, 2225-2228 (2012).
-
(2012)
Neurobiol. Aging
, vol.33
, pp. 2225-2228
-
-
Mougenot, A.L.1
-
137
-
-
84862609075
-
Intracerebral inoculation of pathological α-synuclein initiates a rapidly progressive neurodegenerative α-synucleinopathy in mice
-
Luk, K. C. et al. Intracerebral inoculation of pathological α-synuclein initiates a rapidly progressive neurodegenerative α-synucleinopathy in mice. J. Exp. Med. 209, 975-986 (2012).
-
(2012)
J. Exp. Med.
, vol.209
, pp. 975-986
-
-
Luk, K.C.1
-
138
-
-
20444413356
-
Effects of α-synuclein immunization in a mouse model of Parkinson's disease
-
Masliah, E. et al. Effects of α-synuclein immunization in a mouse model of Parkinson's disease. Neuron 46, 857-868 (2005).
-
(2005)
Neuron
, vol.46
, pp. 857-868
-
-
Masliah, E.1
-
139
-
-
79955757052
-
Passive immunization reduces behavioural and neuropathological deficits in an alpha-synuclein transgenic model of Lewy body disease
-
Masliah, E. et al. Passive immunization reduces behavioural and neuropathological deficits in an alpha-synuclein transgenic model of Lewy body disease. PLoS ONE 6. e19338 (2011).
-
(2011)
PLoS ONE
, vol.6
-
-
Masliah, E.1
-
140
-
-
80052419902
-
Parkinson's disease induced pluripotent stem cells with triplication of the α-synuclein locus
-
Devine, M. J. et al. Parkinson's disease induced pluripotent stem cells with triplication of the α-synuclein locus. Nat. Commun. 2, 440 (2011).
-
(2011)
Nat. Commun.
, vol.2
, pp. 440
-
-
Devine, M.J.1
-
141
-
-
79960833952
-
Generation of isogenic pluripotent stem cells differing exclusively at two early onset Parkinson point mutations
-
Soldner, F. et al. Generation of isogenic pluripotent stem cells differing exclusively at two early onset Parkinson point mutations. Cell 146, 318-331 (2011).
-
(2011)
Cell
, vol.146
, pp. 318-331
-
-
Soldner, F.1
-
142
-
-
84937088414
-
Phase and electron microscopic observations of Lewy bodies and melanin granules in the substantia nigra and locus coeruleus in Parkinson's disease
-
Duffy, P. E. & Tennyson, V. M. Phase and electron microscopic observations of Lewy bodies and melanin granules in the substantia nigra and locus coeruleus in Parkinson's disease. J. Neuropathol. Exp. Neurol. 24, 398-414 (1965).
-
(1965)
J. Neuropathol. Exp. Neurol.
, vol.24
, pp. 398-414
-
-
Duffy, P.E.1
Tennyson, V.M.2
-
145
-
-
0001205583
-
Die Encephalitis Lethargica [German]
-
Von Economo, C. Die Encephalitis lethargica [German]. Wien. klin. Wochenschr. 30, 581-585 (1917).
-
(1917)
Wien. Klin. Wochenschr.
, vol.30
, pp. 581-585
-
-
Von Economo, C.1
-
146
-
-
84871923490
-
Zur Lehre Der Erkrankung Des Striären Systems [German]
-
Vogt, C. & Vogt, O. Zur Lehre der Erkrankung des striären Systems [German]. J. Psychol. Neurol. 26, 43-57 (1920).
-
(1920)
J. Psychol. Neurol.
, vol.26
, pp. 43-57
-
-
Vogt, C.1
Vogt, O.2
-
147
-
-
0002385655
-
Postural hypotension: A report of three cases
-
Bradbury, S. & Eggleston, C. Postural hypotension: a report of three cases. Am. Heart J. 1, 75-86 (1925).
-
(1925)
Am. Heart J.
, vol.1
, pp. 75-86
-
-
Bradbury, S.1
Eggleston, C.2
-
148
-
-
34250928307
-
Verteilung Von Noradrenalin Und Dopamin (3-Hydroxytyramin) Im Gehirn Des Menschen Und Ihr Verhalten Bei Erkrankungen Des Extrapyramidalen Systems [German]
-
Ehringer, H. & Hornykiewicz, O. Verteilung von Noradrenalin und Dopamin (3-Hydroxytyramin) im Gehirn des Menschen und ihr Verhalten bei Erkrankungen des extrapyramidalen Systems [German]. Klin. Wochenschr. 38, 1236-1239 (1960).
-
(1960)
Klin. Wochenschr.
, vol.38
, pp. 1236-1239
-
-
Ehringer, H.1
Hornykiewicz, O.2
-
149
-
-
73049129373
-
Der L-Dioxyphenylalanineffekt Bei Der Parkinson-Akinese [German]
-
Birkmayer, W. & Hornykiewicz, O. Der l-Dioxyphenylalanineffekt bei der Parkinson-Akinese [German]. Wien. klin. Wochenschr. 73, 787-788 (1961).
-
(1961)
Wien. Klin. Wochenschr.
, vol.73
, pp. 787-788
-
-
Birkmayer, W.1
Hornykiewicz, O.2
-
150
-
-
0014208039
-
Aromatic amino acids and modification of parkinsonism
-
Cotzias, G. C., Van Woert, M. H. & Schiffer, L. M. Aromatic amino acids and modification of parkinsonism. N. Engl. J. Med. 276, 374-379 (1967).
-
(1967)
N. Engl. J. Med.
, vol.276
, pp. 374-379
-
-
Cotzias, G.C.1
Van Woert, M.H.2
Schiffer, L.M.3
-
151
-
-
0014082977
-
Parkinsonism: Onset progression and mortality
-
Hoehn, M. M. & Yahr, M. D. Parkinsonism: onset, progression and mortality. Neurology 17, 427-442 (1967).
-
(1967)
Neurology
, vol.17
, pp. 427-442
-
-
Hoehn, M.M.1
Yahr, M.D.2
-
152
-
-
0014672357
-
L-dopa in postencephalitic parkinsonism
-
Calne, D. B., Stern, G. M., Laurence, D. R., Sharkey, J. & Armitage, P. l-DOPA in postencephalitic parkinsonism. Lancet 1, 744-747 (1969).
-
(1969)
Lancet
, vol.1
, pp. 744-747
-
-
Calne, D.B.1
Stern, G.M.2
Laurence, D.R.3
Sharkey, J.4
Armitage, P.5
-
153
-
-
0004059246
-
-
Duckworth, London
-
Sacks, O. Awakenings (Duckworth, London, 1973).
-
(1973)
Awakenings
-
-
Sacks, O.1
-
154
-
-
0016708285
-
Olfactory function in Parkinson's disease
-
Ansari, K. A. & Johnson, A. J. Olfactory function in Parkinson's disease. J. Chronic Dis. 28, 493-497 (1975).
-
(1975)
J. Chronic Dis.
, vol.28
, pp. 493-497
-
-
Ansari, K.A.1
Johnson, A.J.2
-
155
-
-
0017104485
-
Presenile dementia with alzheimer- pick-and lewy-body changes
-
Kosaka, K., Oyanagi, S., Matsushita, M. & Hori, A. Presenile dementia with Alzheimer-, Pick-and Lewy-body changes. Acta Neuropathol. 36, 221-233 (1976).
-
(1976)
Acta Neuropathol.
, vol.36
, pp. 221-233
-
-
Kosaka, K.1
Oyanagi, S.2
Matsushita, M.3
Hori, A.4
-
156
-
-
0020680904
-
Chronic parkinsonism in humans due to a product of meperidine-analog synthesis
-
Langston, J. W., Ballard, P., Tetrud, J. & Irwin, I. Chronic parkinsonism in humans due to a product of meperidine-analog synthesis. Science 219, 979-980 (1983).
-
(1983)
Science
, vol.219
, pp. 979-980
-
-
Langston, J.W.1
Ballard, P.2
Tetrud, J.3
Irwin, I.4
-
157
-
-
0021161884
-
Esophageal Lewy bodies associated with ganglion cell loss in achalasia: Similarity to Parkinson's disease
-
Qualman, S., Haupt, H. M., Yang, P. & Hamilton, S. D. Esophageal Lewy bodies associated with ganglion cell loss in achalasia: similarity to Parkinson's disease. Gastroenterology 87, 848-856 (1984).
-
(1984)
Gastroenterology
, vol.87
, pp. 848-856
-
-
Qualman, S.1
Haupt, H.M.2
Yang, P.3
Hamilton, S.D.4
-
158
-
-
0022982498
-
Chronic behavioural disorders of human REM sleep: A new category of parasomnia
-
Schenck, C. H., Bundle, S. R., Ettinger. M. G. & Mahowald, M. W. Chronic behavioural disorders of human REM sleep: a new category of parasomnia. Sleep 9, 293-308 (1986).
-
(1986)
Sleep
, vol.9
, pp. 293-308
-
-
Schenck, C.H.1
Bundle, S.R.2
Ettinger, M.G.3
Mahowald, M.W.4
-
159
-
-
0023578840
-
Combined (thalamotomy and Stimulation) stereotactic surgery of the VIM thalamic nucleus for bilateral Parkinson disease
-
Benabid, A. L., Pollak, P., Louveau, A., Henry, S. & de Rougemont, J. Combined (thalamotomy and stimulation) stereotactic surgery of the VIM thalamic nucleus for bilateral Parkinson disease. Appl. Neurophysiol. 50, 344-346 (1987).
-
(1987)
Appl. Neurophysiol.
, vol.50
, pp. 344-346
-
-
Benabid, A.L.1
Pollak, P.2
Louveau, A.3
Henry, S.4
De Rougemont, J.5
-
160
-
-
0006164301
-
Consensus guidelines for the clinical and pathological diagnosis of dementia with Lewy bodies (DLB)
-
McKeith, I. G. et al. Consensus guidelines for the clinical and pathological diagnosis of dementia with Lewy bodies (DLB). Neurology 47, 1113-1124 (1996).
-
(1996)
Neurology
, vol.47
, pp. 1113-1124
-
-
McKeith, I.G.1
-
161
-
-
77955759020
-
Association of the human leucocyte antigen region with susceptibility to Parkinson's disease
-
Saiki, M. et al. Association of the human leucocyte antigen region with susceptibility to Parkinson's disease. J. Neurol. Neurosurg. Psychiatry 81, 890-891 (2010).
-
(2010)
J. Neurol. Neurosurg. Psychiatry
, vol.81
, pp. 890-891
-
-
Saiki, M.1
-
162
-
-
33846419768
-
Stanley Fahn Lecture 2005. The staging procedure for the inclusion body pathology associated with sporadic Parkinson's disease reconsidered
-
Braak, H. et al. Stanley Fahn Lecture 2005. The staging procedure for the inclusion body pathology associated with sporadic Parkinson's disease reconsidered. Mov. Disord. 21, 2042-2051 (2006).
-
(2006)
Mov. Disord.
, vol.21
, pp. 2042-2051
-
-
Braak, H.1
|