p62/SQSTM1-Dependent Autophagy of Lewy Body-Like α-Synuclein Inclusions

PLoS ONE

Volumn 7, Issue 12, 2012, Pages

  Watanabe, Yoshihisa ^a   Tatebe, Harutsugu ^a   Taguchi, Katsutoshi ^a   Endo, Yasuhisa ^b   Tokuda, Takahiko ^a   Mizuno, Toshiki ^a   Nakagawa, Masanori ^a   Tanaka, Masaki ^a  

^a KYOTO PREFECTURAL UNIVERSITY OF MEDICINE   (Japan)

^b KYOTO INSTITUTE OF TECHNOLOGY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTOR PROTEIN; ALPHA SYNUCLEIN; AUTOPHAGY PROTEIN 5; BAFILOMYCIN A1; PROTEASOME; PROTEIN P62; SMALL INTERFERING RNA; SQSTM1 PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; AUTOPHAGOSOME; AUTOPHAGY; CELL CULTURE; CELL INCLUSION; CELL STRAIN HEK293; CONTROLLED STUDY; DEGRADATION; ENZYME INHIBITION; GENE SILENCING; HUMAN; HUMAN CELL; IN VITRO STUDY; LEWY BODY LIKE ALPHA SYNUCLEIN INCLUSION; LYSOSOME; MITOCHONDRION; PARKINSON DISEASE; PHOSPHORYLATION; UBIQUITINATION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ALPHA-SYNUCLEIN; AMYLOID; AUTOPHAGY; HEK293 CELLS; HUMANS; LEWY BODIES; LYSOSOMES; MITOCHONDRIA; MITOCHONDRIAL DEGRADATION; PHAGOSOMES; PHOSPHORYLATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEOLYSIS; UBIQUITINATION;

EID: 84871742997     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0052868     Document Type: Article

References (37)

1. Galvin JE, Lee VMY, Trojanowski JQ, (2001) Synucleinopathies: Clinical and Pathological Implications. Arch Neurol 58: 186-190.
2. Vila M, Przedborski S, (2004) Genetic clues to the pathogenesis of Parkinson's disease. Nature Med 10: S58-S62.
3. Shults CW, (2006) Lewy bodies. Proc Natl Acad Sci USA 103: 1661-1668.
4. Bisaglia M, Mammi S, Bubacco L, (2009) Structural insights on physiological functions and pathological effects of alpha-synuclein. FASEB J 23: 329-340.
5. Goldberg AL, (2003) Protein degradation and protection against misfolded or damaged proteins. Nature 426: 895-899.
6. Ebrahimi-Fakhari D, Cantuti-Castelvetri I, Fan Z, Rockenstein E, Masliah E, et al. (2011) Distinct roles in vivo for the ubiquitin-proteasome system and the autophagy-lysosomal pathway in the degradation of alpha-synuclein. J Neurosci 31: 14508-14520.
7. Pan T, Kondo S, Le W, Jankovic J, (2008) The role of autophagy-lysosome pathway in neurodegeneration associated with Parkinson's disease. Brain 131: 1969-1978.
8. Webb JL, (2003) α-Synuclein Is Degraded by Both Autophagy and the Proteasome. J Biol Chem 278: 25009-25013.
9. Vogiatzi T, Xilouri M, Vekrellis K, Stefanis L, (2008) Wild type alpha-synuclein is degraded by chaperone-mediated autophagy and macroautophagy in neuronal cells. J Biol Chem 283: 23542-23556.
10. Cuervo AM, (2004) Impaired Degradation of Mutant α-Synuclein by Chaperone-Mediated Autophagy. Science 305: 1292-1295.
11. Narendra D, Tanaka A, Suen DF, Youle RJ, (2008) Parkin is recruited selectively to impaired mitochondria and promotes their autophagy. J Cell Biol 183: 795-803.
12. Vives-Bauza C, Zhou C, Huang Y, Cui M, de Vries RLA, et al. (2009) PINK1-dependent recruitment of Parkin to mitochondria in mitophagy. Proc Natl Acad Sci USA 107: 378-383.
13. Waxman EA, Giasson BI, (2010) A novel, high-efficiency cellular model of fibrillar α-synuclein inclusions and the examination of mutations that inhibit amyloid formation. J Neurochem 113: 374-388.
14. Conway KA, Harper JD, Lansbury PT, (1998) Accelerated in vitro fibril formation by a mutant α-synuclein linked to early-onset Parkinson disease. Nature Med 11: 1318-1320.
15. Luk KC, Song C, O'Brien P, Stieber A, Branch JR, et al. (2009) Exogenous α-synuclein fibrils seed the formation of Lewy body-like intracellular inclusions in cultured cells. Proc Natl Acad Sci USA: 20051-20056.
16. Nonaka T, Watanabe ST, Iwatsubo T, Hasegawa M, (2010) Seeded Aggregation and Toxicity of α-Synuclein and Tau: Cellular Models of Neurodegenerative Diseases. J Biol Chem 285: 34885-34898.
17. Kuusisto E, Salminen A, Alafuzoff I, (2001) Ubiquitin-binding protein p62 is present in neuronal and glial inclusions in human tauopathies and synucleinopathies. Neuroreport 12: 2085-2090.
18. Lee HJ, (2004) Clearance of α-Synuclein Oligomeric Intermediates via the Lysosomal Degradation Pathway. J Neurosci 24: 1888-1896.
19. Shvets E, Elazar Z, (2008) Autophagy-independent incorporation of GFP-LC3 into protein aggregates is dependent on its interaction with p62/SQSTM1. Autophagy 4: 1054-1056.
20. Knævelsrud H, Simonsen A, (2010) Fighting disease by selective autophagy of aggregate-prone proteins. FEBS Lett 584: 2635-2645.
21. Komatsu M, Ichimura Y, (2010) Physiological significance of selective degradation of p62 by autophagy. FEBS Lett 584: 1374-1378.
22. Kim PK, Hailey DW, Mullen RT, Lippincott-Schwartz J, (2008) Ubiquitin signals autophagic degradation of cytosolic proteins and peroxisomes. Proc Natl Acad Sci U S A 105: 20567-20574.
23. Matsuda N, Sato S, Shiba K, Okatsu K, Saisho K, et al. (2010) PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy. J Cell Biol 189: 211-221.
24. Matsui H, Ito H, Taniguchi Y, Takeda S, Takahashi R, (2010) Ammonium chloride and tunicamycin are novel toxins for dopaminergic neurons and induce Parkinson's disease-like phenotypes in medaka fish. J Neurochem 115: 1150-1160.
25. Crews L, Spencer B, Desplats P, Patrick C, Paulino A, et al. (2010) Selective molecular alterations in the autophagy pathway in patients with Lewy body disease and in models of alpha-synucleinopathy. PLoS One 5: e9313.
26. Olanow CW, McNaught K, (2011) Parkinson's disease, proteins, and prions: milestones. Mov Disord 26: 1056-1071.
27. Nezis IP, Simonsen A, Sagona AP, Finley K, Gaumer S, et al. (2008) Ref(2)P, the Drosophila melanogaster homologue of mammalian p62, is required for the formation of protein aggregates in adult brain. J Cell Biol 180: 1065-1071.
28. Yao TP, (2010) The role of ubiquitin in autophagy-dependent protein aggregate processing. Genes Cancer 1: 779-786.
29. Bennett MC, Bishop JF, Leng Y, Chock PB, Chase TN, et al. (1999) Degradation of alpha-synuclein by proteasome. J Biol Chem 274: 33855-33858.
30. Youle RJ, Narendra DP, (2011) Mechanisms of mitophagy. Nat Rev Mol Cell Biol 12: 9-14.
31. Winslow AR, Chen CW, Corrochano S, Acevedo-Arozena A, Gordon DE, et al. (2010) alpha-Synuclein impairs macroautophagy: implications for Parkinson's disease. J Cell Biol 190: 1023-1037.
32. Choubey V, Safiulina D, Vaarmann A, Cagalinec M, Wareski P, et al. (2011) Mutant A53T alpha-synuclein induces neuronal death by increasing mitochondrial autophagy. J Biol Chem 286: 10814-10824.
33. Tanji K, Mori F, Kakita A, Takahashi H, Wakabayashi K, (2011) Alteration of autophagosomal proteins (LC3, GABARAP and GATE-16) in Lewy body disease. Neurobiol Dis 43: 690-697.
34. Lipinski MM, Zheng B, Lu T, Yan Z, Py BF, et al. (2010) Genome-wide analysis reveals mechanisms modulating autophagy in normal brain aging and in Alzheimer's disease. Proc Natl Acad Sci U S A 107: 14164-14169.
35. Watanabe Y, Tanaka M, (2011) p62/SQSTM1 in autophagic clearance of a non-ubiquitylated substrate. J Cell Sci 124: 2692-2701.
36. Tatebe H, Watanabe Y, Kasai T, Mizuno T, Nakagawa M, et al. (2010) Extracellular neurosin degrades α-synuclein in cultured cells. Neurosci Res 67: 341-346.
37. Yamaguchi T, Watanabe Y, Tanaka M, Nakagawa M, Yamaguchi N, (2008) cAMP-dependent regulation of spinesin/TMPRSS5 gene expression in astrocytes. J Neurosci Res 86: 610-617.