-
1
-
-
0000906170
-
Induction of autophagy and inhibition of tumorigenesis by beclin 1
-
Liang, X. H. et al. Induction of autophagy and inhibition of tumorigenesis by beclin 1. Nature 402, 672-676 (1999).
-
(1999)
Nature
, vol.402
, pp. 672-676
-
-
Liang, X.H.1
-
2
-
-
0001488499
-
Protection against fatal Sindbis virus encephalitis by beclin, a novel Bcl-2-interacting protein
-
Liang, X. H. et al. Protection against fatal Sindbis virus encephalitis by beclin, a novel Bcl-2-interacting protein. J. Virol. 72, 8586-8596 (1998).
-
(1998)
J. Virol
, vol.72
, pp. 8586-8596
-
-
Liang, X.H.1
-
3
-
-
0345166111
-
Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor
-
Yue, Z., Jin, S., Yang, C., Levine, A. J. & Heintz, N. Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor. Proc. Natl Acad. Sci. USA 100, 15077-15082 (2003).
-
(2003)
Proc. Natl Acad. Sci. USA
, vol.100
, pp. 15077-15082
-
-
Yue, Z.1
Jin, S.2
Yang, C.3
Levine, A.J.4
Heintz, N.5
-
4
-
-
9144240441
-
Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene
-
Qu, X. et al. Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene. J. Clin. Invest. 112, 1809-1820 (2003).
-
(2003)
J. Clin. Invest
, vol.112
, pp. 1809-1820
-
-
Qu, X.1
-
5
-
-
0346998038
-
Defective autophagy leads to cancer
-
Edinger, A. L. & Thompson, C. B. Defective autophagy leads to cancer. Cancer Cell 4, 422 (2003).
-
(2003)
Cancer Cell
, vol.4
, pp. 422
-
-
Edinger, A.L.1
Thompson, C.B.2
-
6
-
-
0037194894
-
A novel protein complex linking the δ2 glutamate receptor and autophagy: Implications for neurodegeneration in lurcher mice
-
Yue, Z. et al. A novel protein complex linking the δ2 glutamate receptor and autophagy: Implications for neurodegeneration in lurcher mice. Neuron 35, 921-933 (2002).
-
(2002)
Neuron
, vol.35
, pp. 921-933
-
-
Yue, Z.1
-
7
-
-
33744916798
-
Regulation of intracellular accumulation of mutant Huntingtin by Beclin 1
-
Shibata, M. et al. Regulation of intracellular accumulation of mutant Huntingtin by Beclin 1. J. Biol. Chem. 281, 14474-14485 (2006).
-
(2006)
J. Biol. Chem
, vol.281
, pp. 14474-14485
-
-
Shibata, M.1
-
8
-
-
34447302577
-
Autophagy in Niemann-Pick C disease is dependent upon Beclin-1 and responsive to lipid trafficking defects
-
Pacheco, C. D., Kunkel, R. & Lieberman, A. P. Autophagy in Niemann-Pick C disease is dependent upon Beclin-1 and responsive to lipid trafficking defects. Hum. Mol. Genet. 16, 1495-1503 (2007).
-
(2007)
Hum. Mol. Genet
, vol.16
, pp. 1495-1503
-
-
Pacheco, C.D.1
Kunkel, R.2
Lieberman, A.P.3
-
9
-
-
0035032723
-
Beclin-phosphatidylinositol 3-kinase complex functions at the trans-Golgi network
-
330-335
-
Kihara, A., Kabeya, Y., Ohsumi, Y. & Yoshimori, T. Beclin-phosphatidylinositol 3-kinase complex functions at the trans-Golgi network. EMBO Rep. 2, 330-335 (2001).
-
(2001)
EMBO Rep
, vol.2
-
-
Kihara, A.1
Kabeya, Y.2
Ohsumi, Y.3
Yoshimori, T.4
-
10
-
-
0035809160
-
Two distinct Vps34 phosphatidylinositol 3-kinase complexes function in autophagy and carboxypeptidase Y sorting in Saccharomyces cerevisiae
-
Kihara, A., Noda, T., Ishihara, N. & Ohsumi, Y. Two distinct Vps34 phosphatidylinositol 3-kinase complexes function in autophagy and carboxypeptidase Y sorting in Saccharomyces cerevisiae. J. Cell Biol. 152, 519-530 (2001).
-
(2001)
J. Cell Biol
, vol.152
, pp. 519-530
-
-
Kihara, A.1
Noda, T.2
Ishihara, N.3
Ohsumi, Y.4
-
11
-
-
32244442749
-
Functional specificity of the mammalian Beclin-Vps34 PI 3-kinase complex in macroautophagy versus endocytosis and lysosomal enzyme trafficking
-
Zeng, X., Overmeyer, J. H. & Maltese, W. A. Functional specificity of the mammalian Beclin-Vps34 PI 3-kinase complex in macroautophagy versus endocytosis and lysosomal enzyme trafficking. J. Cell Sci. 119 259-270 (2006).
-
(2006)
J. Cell Sci
, vol.119
, pp. 259-270
-
-
Zeng, X.1
Overmeyer, J.H.2
Maltese, W.A.3
-
12
-
-
0028964232
-
Vesicle-mediated protein transport: Regulatory interactions between the Vps15 protein kinase and the Vps34 PtdIns 3-kinase essential for protein sorting to the vacuole in yeast
-
Stack, J. H., DeWald, D. B., Takegawa, K. & Emr, S. D. Vesicle-mediated protein transport: Regulatory interactions between the Vps15 protein kinase and the Vps34 PtdIns 3-kinase essential for protein sorting to the vacuole in yeast. J. Cell Biol. 129, 321-334 (1995).
-
(1995)
J. Cell Biol
, vol.129
, pp. 321-334
-
-
Stack, J.H.1
DeWald, D.B.2
Takegawa, K.3
Emr, S.D.4
-
13
-
-
33745751085
-
Autophagic and tumour suppressor activity of a novel Beclin1-binding protein UVRAG
-
Liang, C. et al. Autophagic and tumour suppressor activity of a novel Beclin1-binding protein UVRAG. Nature Cell Biol. 8, 688-699 (2006).
-
(2006)
Nature Cell Biol
, vol.8
, pp. 688-699
-
-
Liang, C.1
-
14
-
-
34347344990
-
Ambra1 regulates autophagy and development of the nervous system
-
Fimia, G. M. et al. Ambra1 regulates autophagy and development of the nervous system. Nature 447, 1121-1125 (2007).
-
(2007)
Nature
, vol.447
, pp. 1121-1125
-
-
Fimia, G.M.1
-
15
-
-
34848899280
-
Bif-1 interacts with Beclin 1 through UVRAG and regulates autophagy and tumorigenesis
-
Takahashi, Y. et al. Bif-1 interacts with Beclin 1 through UVRAG and regulates autophagy and tumorigenesis. Nature Cell Biol. 9 1142-1151 (2007).
-
(2007)
Nature Cell Biol
, vol.9
, pp. 1142-1151
-
-
Takahashi, Y.1
-
16
-
-
0034329418
-
LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing
-
Kabeya, Y. et al. LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing. EMBO J. 19, 5720-5728 (2000).
-
(2000)
EMBO J
, vol.19
, pp. 5720-5728
-
-
Kabeya, Y.1
-
17
-
-
0034707036
-
A ubiquitin-like system mediates protein lipidation
-
Ichimura, Y. et al. A ubiquitin-like system mediates protein lipidation. Nature 408, 488-492 (2000).
-
(2000)
Nature
, vol.408
, pp. 488-492
-
-
Ichimura, Y.1
-
18
-
-
3242888703
-
LC3, GABARAP and GATE16 localize to autophagosomal membrane depending on form-II formation
-
Kabeya, Y. et al. LC3, GABARAP and GATE16 localize to autophagosomal membrane depending on form-II formation. J. Cell Sci. 117, 2805-2812 (2004).
-
(2004)
J. Cell Sci
, vol.117
, pp. 2805-2812
-
-
Kabeya, Y.1
-
19
-
-
33748154216
-
Induction of autophagy in axonal dystrophy and degeneration
-
Wang, Q. J. et al. Induction of autophagy in axonal dystrophy and degeneration. J. Neurosci. 26, 8057-8068 (2006).
-
(2006)
J. Neurosci
, vol.26
, pp. 8057-8068
-
-
Wang, Q.J.1
-
20
-
-
33947372556
-
Regulation of neuronal autophagy in axon: Implication of autophagy in axonal function and dysfunction/degeneration
-
Yue, Z. Regulation of neuronal autophagy in axon: Implication of autophagy in axonal function and dysfunction/degeneration. Autophagy 3, 139-141 (2007).
-
(2007)
Autophagy
, vol.3
, pp. 139-141
-
-
Yue, Z.1
-
21
-
-
36849089101
-
Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice
-
Komatsu, M. et al. Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice. Cell 131 1149-1163 (2007).
-
(2007)
Cell
, vol.131
, pp. 1149-1163
-
-
Komatsu, M.1
-
22
-
-
33745192802
-
Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice
-
Hara, T. et al. Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice. Nature 441, 885-889 (2006).
-
(2006)
Nature
, vol.441
, pp. 885-889
-
-
Hara, T.1
-
23
-
-
33646800306
-
Loss of autophagy in the central nervous system causes neurodegeneration in mice
-
Komatsu, M. et al. Loss of autophagy in the central nervous system causes neurodegeneration in mice. Nature 441, 880-884 (2006).
-
(2006)
Nature
, vol.441
, pp. 880-884
-
-
Komatsu, M.1
-
24
-
-
59849113021
-
hVps15 but not calcium/calmodulin is required for the activity and regulation of hVps34 in mammalian cells
-
Yan, Y., Flinn, R. J., Wu, H., Schnur, R. S. & Backer, J. M. hVps15 but not calcium/calmodulin is required for the activity and regulation of hVps34 in mammalian cells. Biochem. J. 417, 747-755 (2009).
-
(2009)
Biochem. J
, vol.417
, pp. 747-755
-
-
Yan, Y.1
Flinn, R.J.2
Wu, H.3
Schnur, R.S.4
Backer, J.M.5
-
25
-
-
49949098271
-
BAC-mediated transgenic expression of fluorescent autophagic protein Beclin 1 reveals a role for Beclin 1 in lymphocyte development
-
Arsov, I. et al. BAC-mediated transgenic expression of fluorescent autophagic protein Beclin 1 reveals a role for Beclin 1 in lymphocyte development. Cell Death Differ. 15, 1385-1395 (2008).
-
(2008)
Cell Death Differ
, vol.15
, pp. 1385-1395
-
-
Arsov, I.1
-
26
-
-
34548259958
-
p62/SQSTM1 binds directly to Atg8/LC3 to facilitatedegradation of ubiquitinated protein aggregates by autophagy
-
Pankiv, S. et al. p62/SQSTM1 binds directly to Atg8/LC3 to facilitatedegradation of ubiquitinated protein aggregates by autophagy. J. Biol. Chem. 282, 24131-24145 (2007).
-
(2007)
J. Biol. Chem
, vol.282
, pp. 24131-24145
-
-
Pankiv, S.1
-
27
-
-
0032510559
-
A lipid associated with the antiphospholipid syndrome regulates endosome structure and function
-
Kobayashi, T. et al. A lipid associated with the antiphospholipid syndrome regulates endosome structure and function. Nature 392 193-197 (1998).
-
(1998)
Nature
, vol.392
, pp. 193-197
-
-
Kobayashi, T.1
-
28
-
-
0036902646
-
Receptor downregulation and multivesicular-body sorting
-
Katzmann, D. J., Odorizzi, G. & Emr, S. D. Receptor downregulation and multivesicular-body sorting. Nature Rev. Mol. Cell Biol. 3, 893-905 (2002).
-
(2002)
Nature Rev. Mol. Cell Biol
, vol.3
, pp. 893-905
-
-
Katzmann, D.J.1
Odorizzi, G.2
Emr, S.D.3
-
29
-
-
0037138361
-
The phosphatidylinositol 3-phosphate-binding FYVE finger
-
Stenmark, H., Aasland, R. & Driscoll, P. C. The phosphatidylinositol 3-phosphate-binding FYVE finger. FEBS Lett. 513, 77-84 (2002).
-
(2002)
FEBS Lett
, vol.513
, pp. 77-84
-
-
Stenmark, H.1
Aasland, R.2
Driscoll, P.C.3
-
30
-
-
0036911371
-
Highly efficient modification of bacterial artificial chromosomes (BACs) using novel shuttle vectors containing the R6Kgamma origin of replication
-
Gong, S., Yang, X. W., Li, C. & Heintz, N. Highly efficient modification of bacterial artificial chromosomes (BACs) using novel shuttle vectors containing the R6Kgamma origin of replication. Genome Res. 12 1992-1998 (2002).
-
(2002)
Genome Res
, vol.12
, pp. 1992-1998
-
-
Gong, S.1
Yang, X.W.2
Li, C.3
Heintz, N.4
-
31
-
-
34447503808
-
Mechanism of two classes of cancer mutations in the phosphoinositide 3-kinase catalytic subunit
-
Miled, N. et al. Mechanism of two classes of cancer mutations in the phosphoinositide 3-kinase catalytic subunit. Science 317 239-242 (2007).
-
(2007)
Science
, vol.317
, pp. 239-242
-
-
Miled, N.1
-
32
-
-
0021361182
-
Protein degradation in 3T3 cells and tumorigenic transformed 3T3 cells
-
Gronostajski, R. M. & Pardee, A. B. Protein degradation in 3T3 cells and tumorigenic transformed 3T3 cells. J. Cell Physiol. 119, 127-132 (1984).
-
(1984)
J. Cell Physiol
, vol.119
, pp. 127-132
-
-
Gronostajski, R.M.1
Pardee, A.B.2
-
33
-
-
35448938087
-
Essential role for autophagy protein Atg7 in the maintenance of axonal homeostasis and the prevention of axonal degeneration
-
Komatsu, M. et al. Essential role for autophagy protein Atg7 in the maintenance of axonal homeostasis and the prevention of axonal degeneration. Proc. Natl Acad. Sci. USA 104, 14489-14494 (2007).
-
(2007)
Proc. Natl Acad. Sci. USA
, vol.104
, pp. 14489-14494
-
-
Komatsu, M.1
|