-
1
-
-
34547121206
-
Hypoxia in cancer: Significance and impact on clinical outcome
-
Vaupel P, Mayer A. Hypoxia in cancer: Significance and impact on clinical outcome. Cancer Metastasis Rev 2007; 26: 225-239.
-
(2007)
Cancer Metastasis Rev
, vol.26
, pp. 225-239
-
-
Vaupel, P.1
Mayer, A.2
-
2
-
-
0034798178
-
Hypoxic heterogeneity in human tumors: EF5 binding, vasculature, necrosis, and proliferation
-
Evans SM, Hahn SM, Magarelli DP, Koch CJ. Hypoxic heterogeneity in human tumors: EF5 binding, vasculature, necrosis, and proliferation. Am J Clin Oncol 2001; 24: 467-472.
-
(2001)
Am J Clin Oncol
, vol.24
, pp. 467-472
-
-
Evans, S.M.1
Hahn, S.M.2
Magarelli, D.P.3
Koch, C.J.4
-
3
-
-
0037480606
-
Hypoxic cervical cancers with low apoptotic index are highly aggressive
-
Hockel M, Schlenger K, Hockel S, Vaupel P. Hypoxic cervical cancers with low apoptotic index are highly aggressive. Cancer Res 1999; 59 4525-4528.
-
(1999)
Cancer Res
, vol.59
, pp. 4525-4528
-
-
Hockel, M.1
Schlenger, K.2
Hockel, S.3
Vaupel, P.4
-
4
-
-
33846924500
-
Loss of Mcl-1 protein and inhibition of electron transport chain together induce anoxic cell death
-
Brunelle JK, Shroff EH, Perlman H, Strasser A, Moraes CT, Flavell RA et al. Loss of Mcl-1 protein and inhibition of electron transport chain together induce anoxic cell death. Mol Cell Biol 2007; 27 1222-1235.
-
(2007)
Mol Cell Biol
, vol.27
, pp. 1222-1235
-
-
Brunelle, J.K.1
Shroff, E.H.2
Perlman, H.3
Strasser, A.4
Moraes, C.T.5
Flavell, R.A.6
-
5
-
-
17144416875
-
Anoxia is necessary for tumor cell toxicity caused by a low-oxygen environment
-
Papandreou I, Krishna C, Kaper F, Cai D, Giaccia AJ, Denko NC. Anoxia is necessary for tumor cell toxicity caused by a low-oxygen environment. Cancer Res 2005; 65: 3171-3178.
-
(2005)
Cancer Res
, vol.65
, pp. 3171-3178
-
-
Papandreou, I.1
Krishna, C.2
Kaper, F.3
Cai, D.4
Giaccia, A.J.5
Denko, N.C.6
-
6
-
-
0036082689
-
Anoxia-induced apoptosis occurs through a mitochondria-dependent pathway in lung epithelial cells
-
Santore MT, McClintock DS, Lee VY, Budinger GR, Chandel NS. Anoxia-induced apoptosis occurs through a mitochondria-dependent pathway in lung epithelial cells. Am J Physiol Lung Cell Mol Physiol 2002; 282: L727-L734.
-
(2002)
Am J Physiol Lung Cell Mol Physiol
, vol.282
-
-
Santore, M.T.1
McClintock, D.S.2
Lee, V.Y.3
Budinger, G.R.4
Chandel, N.S.5
-
7
-
-
34548235820
-
BNIP3 is an RB/E2F target gene required for hypoxia-induced autophagy
-
Tracy K, Dibling BC, Spike BT, Knabb JR, Schumacker P, Macleod KF. BNIP3 is an RB/E2F target gene required for hypoxia-induced autophagy. Mol Cell Biol 2007; 27: 6229-6242.
-
(2007)
Mol Cell Biol
, vol.27
, pp. 6229-6242
-
-
Tracy, K.1
Dibling, B.C.2
Spike, B.T.3
Knabb, J.R.4
Schumacker, P.5
Macleod, K.F.6
-
8
-
-
0033942613
-
BNIP3 and genetic control of necrosis-like cell death through the mitochondrial permeability transition pore
-
Vande Velde C, Cizeau J, Dubik D, Alimonti J, Brown T, Israels S et al. BNIP3 and genetic control of necrosis-like cell death through the mitochondrial permeability transition pore. Mol Cell Biol 2000; 20: 5454-5468.
-
(2000)
Mol Cell Biol
, vol.20
, pp. 5454-5468
-
-
Vande Velde, C.1
Cizeau, J.2
Dubik, D.3
Alimonti, J.4
Brown, T.5
Israels, S.6
-
9
-
-
3042562282
-
Pivotal role of the cell death factor BNIP3 in ceramide-induced autophagic cell death in malignant glioma cells
-
Daido S, Kanzawa T, Yamamoto A, Takeuchi H, Kondo Y, Kondo S. Pivotal role of the cell death factor BNIP3 in ceramide-induced autophagic cell death in malignant glioma cells. Cancer Res 2004; 64: 4286-4293.
-
(2004)
Cancer Res
, vol.64
, pp. 4286-4293
-
-
Daido, S.1
Kanzawa, T.2
Yamamoto, A.3
Takeuchi, H.4
Kondo, Y.5
Kondo, S.6
-
10
-
-
13944256602
-
Arsenic trioxide induces autophagic cell death in malignant glioma cells by upregulation of mitochondrial cell death protein BNIP3
-
Kanzawa T, Zhang L, Xiao L, Germano IM, Kondo Y, Kondo S. Arsenic trioxide induces autophagic cell death in malignant glioma cells by upregulation of mitochondrial cell death protein BNIP3. Oncogene 2005; 24: 980-991.
-
(2005)
Oncogene
, vol.24
, pp. 980-991
-
-
Kanzawa, T.1
Zhang, L.2
Xiao, L.3
Germano, I.M.4
Kondo, Y.5
Kondo, S.6
-
11
-
-
33845511362
-
Response to myocardial ischemia/reperfusion injury involves Bnip3 and autophagy
-
Hamacher-Brady A, Brady NR, Logue SE, Sayen MR, Jinno M, Kirshenbaum LA et al. Response to myocardial ischemia/reperfusion injury involves Bnip3 and autophagy. Cell Death Differ 2007; 14: 146-157.
-
(2007)
Cell Death Differ
, vol.14
, pp. 146-157
-
-
Hamacher-Brady, A.1
Brady, N.R.2
Logue, S.E.3
Sayen, M.R.4
Jinno, M.5
Kirshenbaum, L.A.6
-
12
-
-
34648828532
-
AMP-activated/SNF1 protein kinases: Conserved guardians of cellular energy
-
Hardie DG. AMP-activated/SNF1 protein kinases: Conserved guardians of cellular energy. Nat Rev Mol Cell Biol 2007; 8: 774-785.
-
(2007)
Nat Rev Mol Cell Biol
, vol.8
, pp. 774-785
-
-
Hardie, D.G.1
-
13
-
-
0344081177
-
Minireview: The AMP-activTted protein kinase cascade: the key sensor of cellular energy status
-
Hardie DG. Minireview: The AMP-activTted protein kinase cascade: the key sensor of cellular energy status. Endocrinology 2003; 144: 5179-5183.
-
(2003)
Endocrinology
, vol.144
, pp. 5179-5183
-
-
Hardie, D.G.1
-
14
-
-
27744588780
-
Tuberous sclerosis: A GAP at the crossroads of multiple signaling pathways
-
Kwiatkowski DJ, Manning BD. Tuberous sclerosis: A GAP at the crossroads of multiple signaling pathways. Hum Mol Genet 2005; 14 (Spec No. 2) R251-R258.
-
(2005)
Hum Mol Genet
, vol.14
, Issue.SPEC 2
-
-
Kwiatkowski, D.J.1
Manning, B.D.2
-
15
-
-
33745840203
-
5′-AMP-activated protein kinase (AMPK) is induced by low-oxygen and glucose deprivation conditions found in solid-tumor microenvironments
-
Laderoute KR, Amin K, Calaoagan JM, Knapp M, Le T, Orduna J et al. 5′-AMP-activated protein kinase (AMPK) is induced by low-oxygen and glucose deprivation conditions found in solid-tumor microenvironments. Mol Cell Biol 2006; 26: 5336-5347.
-
(2006)
Mol Cell Biol
, vol.26
, pp. 5336-5347
-
-
Laderoute, K.R.1
Amin, K.2
Calaoagan, J.M.3
Knapp, M.4
Le, T.5
Orduna, J.6
-
16
-
-
32444433450
-
Hypoxia-induced energy stress regulates mRNA translation and cell growth
-
Liu L, Cash TP, Jones RG, Keith B, Thompson CB, Simon MC. Hypoxia-induced energy stress regulates mRNA translation and cell growth. Mol Cell 2006; 21: 521-531.
-
(2006)
Mol Cell
, vol.21
, pp. 521-531
-
-
Liu, L.1
Cash, T.P.2
Jones, R.G.3
Keith, B.4
Thompson, C.B.5
Simon, M.C.6
-
17
-
-
34147168105
-
Distinct roles of autophagy in the heart during ischemia and reperfusion: Roles of AMP-activated protein kinase and Beclin 1 in mediating autophagy
-
Matsui Y, Takagi H, Qu X, Abdellatif M, Sakoda H, Asano T et al. Distinct roles of autophagy in the heart during ischemia and reperfusion: Roles of AMP-activated protein kinase and Beclin 1 in mediating autophagy. Circ Res 2007; 100: 914-922.
-
(2007)
Circ Res
, vol.100
, pp. 914-922
-
-
Matsui, Y.1
Takagi, H.2
Qu, X.3
Abdellatif, M.4
Sakoda, H.5
Asano, T.6
-
18
-
-
33845924783
-
AMP-activated protein kinase and the regulation of autophagic proteolysis
-
Meley D, Bauvy C, Houben-Weerts JH, Dubbelhuis PF, Helmond MT, Codogno P et al. AMP-activated protein kinase and the regulation of autophagic proteolysis. J Biol Chem 2006; 281: 34870-34879.
-
(2006)
J Biol Chem
, vol.281
, pp. 34870-34879
-
-
Meley, D.1
Bauvy, C.2
Houben-Weerts, J.H.3
Dubbelhuis, P.F.4
Helmond, M.T.5
Codogno, P.6
-
20
-
-
35448981935
-
Autophagy: From phenomenology to molecular understanding in less than a decade
-
Klionsky DJ. Autophagy: From phenomenology to molecular understanding in less than a decade. Nat Rev Mol Cell Biol 2007; 8: 931-937.
-
(2007)
Nat Rev Mol Cell Biol
, vol.8
, pp. 931-937
-
-
Klionsky, D.J.1
-
21
-
-
0032563798
-
A protein conjugation system essential for autophagy
-
Mizushima N, Noda T, Yoshimori T, Tanaka Y, Ishii T, George MD et al A protein conjugation system essential for autophagy. Nature 1998; 395: 395-398.
-
(1998)
Nature
, vol.395
, pp. 395-398
-
-
Mizushima, N.1
Noda, T.2
Yoshimori, T.3
Tanaka, Y.4
Ishii, T.5
George, M.D.6
-
22
-
-
33947250696
-
The energy sensing LKB1-AMPK pathway regulates p27(kip1) phosphorylation mediating the decision to enter autophagy or apoptosis
-
Liang J, Shao SH, Xu ZX, Hennessy B, Ding Z, Larrea M et al. The energy sensing LKB1-AMPK pathway regulates p27(kip1) phosphorylation mediating the decision to enter autophagy or apoptosis. Nat Cell Biol 2007; 9: 218-224.
-
(2007)
Nat Cell Biol
, vol.9
, pp. 218-224
-
-
Liang, J.1
Shao, S.H.2
Xu, Z.X.3
Hennessy, B.4
Ding, Z.5
Larrea, M.6
-
23
-
-
0345166111
-
Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor
-
Yue Z, Jin S, Yang C, Levine AJ, Heintz N. Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor. Proc Natl Acad Sci USA 2003; 100: 15077-15082.
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 15077-15082
-
-
Yue, Z.1
Jin, S.2
Yang, C.3
Levine, A.J.4
Heintz, N.5
-
24
-
-
0000906170
-
Induction of autophagy and inhibition of tumorigenesis by beclin 1
-
Liang XH, Jackson S, Seaman M, Brown K, Kempkes B, Hibshoosh H et al Induction of autophagy and inhibition of tumorigenesis by beclin 1. Nature 1999; 402: 672-676.
-
(1999)
Nature
, vol.402
, pp. 672-676
-
-
Liang, X.H.1
Jackson, S.2
Seaman, M.3
Brown, K.4
Kempkes, B.5
Hibshoosh, H.6
-
25
-
-
12944303650
-
Growth factor regulation of autophagy and cell survival in the absence of apoptasis
-
Lum JJ, Bauer DE, Kong M, Harris MH, Li C, Lindsten T et al. Growth factor regulation of autophagy and cell survival in the absence of apoptasis. Cell 2005; 120: 237-248.
-
(2005)
Cell
, vol.120
, pp. 237-248
-
-
Lum, J.J.1
Bauer, D.E.2
Kong, M.3
Harris, M.H.4
Li, C.5
Lindsten, T.6
-
26
-
-
33745713171
-
Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis
-
Degenhardt K, Mathew R, Beaudoin B, Bray K, Anderson D, Chen G et al Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis. Cancer Cell 2006; 10: 51-64.
-
(2006)
Cancer Cell
, vol.10
, pp. 51-64
-
-
Degenhardt, K.1
Mathew, R.2
Beaudoin, B.3
Bray, K.4
Anderson, D.5
Chen, G.6
-
27
-
-
34347404887
-
Autophagy mitigates metabolic stress and genome damage in mammary tumorgenesis
-
Karantza-Wadsworth V, Patel S, Kravchuk O, Chen G, Mathew R, Jin S et al. Autophagy mitigates metabolic stress and genome damage in mammary tumorgenesis. Genes Dev 2007; 21: 1621-1635.
-
(2007)
Genes Dev
, vol.21
, pp. 1621-1635
-
-
Karantza-Wadsworth, V.1
Patel, S.2
Kravchuk, O.3
Chen, G.4
Mathew, R.5
Jin, S.6
-
28
-
-
34249863298
-
Autophagy suppresses tumor progression by limiting chromosomal instability
-
Mathew R, Kongara S, Beaudoin B, Karp CM, Bray K, Dogenhardt K et al Autophagy suppresses tumor progression by limiting chromosomal instability. Genes Dev 2007; 21: 1367-1381.
-
(2007)
Genes Dev
, vol.21
, pp. 1367-1381
-
-
Mathew, R.1
Kongara, S.2
Beaudoin, B.3
Karp, C.M.4
Bray, K.5
Dogenhardt, K.6
-
29
-
-
10344262564
-
Role of Bcl-2 family proteins in a non-apoptotic programmed cell death dependent on autophagy genes
-
Shimizu S, Kanaseki T, Mizushima N, Mizuta T, Arakawa-Koboyashi S, Thompson CB et al. Role of Bcl-2 family proteins in a non-apoptotic programmed cell death dependent on autophagy genes. Nat Cell Biol 2004; 6: 1221-1228.
-
(2004)
Nat Cell Biol
, vol.6
, pp. 1221-1228
-
-
Shimizu, S.1
Kanaseki, T.2
Mizushima, N.3
Mizuta, T.4
Arakawa-Koboyashi, S.5
Thompson, C.B.6
-
30
-
-
2642553881
-
Regulation of an ATG7-beclin 1 program of autophagic cell death by caspase-8
-
Yu L, Alva A, Su H, Dutt P, Freundt E, Welsh S et al. Regulation of an ATG7-beclin 1 program of autophagic cell death by caspase-8. Science 2004; 304: 1500-1502.
-
(2004)
Science
, vol.304
, pp. 1500-1502
-
-
Yu, L.1
Alva, A.2
Su, H.3
Dutt, P.4
Freundt, E.5
Welsh, S.6
-
31
-
-
34248583762
-
Methods for monitoring autophagy from yeast to human
-
Klionsky DJ, Cuervo AM, Seglen PO. Methods for monitoring autophagy from yeast to human. Autophagy 2007; 3: 181-206.
-
(2007)
Autophagy
, vol.3
, pp. 181-206
-
-
Klionsky, D.J.1
Cuervo, A.M.2
Seglen, P.O.3
-
32
-
-
0035027828
-
Transcription factor HIF-1 is a necessary mediator of the Pasteur effect in mammalian cells
-
Seagroves TN, Ryan HE, Lu H, Wouters BG, Knapp M, Thibault P et al Transcription factor HIF-1 is a necessary mediator of the Pasteur effect in mammalian cells. Mol Cell Biol 2001; 21: 3436-3444.
-
(2001)
Mol Cell Biol
, vol.21
, pp. 3436-3444
-
-
Seagroves, T.N.1
Ryan, H.E.2
Lu, H.3
Wouters, B.G.4
Knapp, M.5
Thibault, P.6
-
33
-
-
38949119423
-
Hypoxis induces autophagic cell death in apoptosis-compotent cells through a mechanism involving BNIP3
-
Azad MB, Chen Y, Hanson ES, Cizeau J, McMillan-Ward E, Israels SJ et al. Hypoxis induces autophagic cell death in apoptosis-compotent cells through a mechanism involving BNIP3. Autophagy 2008; 4 195-204.
-
(2008)
Autophagy
, vol.4
, pp. 195-204
-
-
Azad, M.B.1
Chen, Y.2
Hanson, E.S.3
Cizeau, J.4
McMillan-Ward, E.5
Israels, S.J.6
-
34
-
-
43649104579
-
Mitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxia
-
Zhang H, Bosch-Marce M, Shimoda LA, Tan YS, Baek JH, Wesley JB et al Mitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxia. J Biol Chem 2008; 283: 10892-10903.
-
(2008)
J Biol Chem
, vol.283
, pp. 10892-10903
-
-
Zhang, H.1
Bosch-Marce, M.2
Shimoda, L.A.3
Tan, Y.S.4
Baek, J.H.5
Wesley, J.B.6
-
35
-
-
33846094145
-
Selective silencing of the hypoxia-inducible factor 1 target gene BNIP3 by histone deacetylation and methylation in colorectal cancer
-
Bacon AL, Fox S, Turley H, Harris AL. Selective silencing of the hypoxia-inducible factor 1 target gene BNIP3 by histone deacetylation and methylation in colorectal cancer. Oncogene 2007; 26: 132-141.
-
(2007)
Oncogene
, vol.26
, pp. 132-141
-
-
Bacon, A.L.1
Fox, S.2
Turley, H.3
Harris, A.L.4
-
36
-
-
19944433480
-
Aberrant methylation and silencing of the BNIP3 gene in colorectal and gastric cancer
-
Murai M, Toyota M, Suzuki H, Satoh A, Sasaki Y, Akino K et al. Aberrant methylation and silencing of the BNIP3 gene in colorectal and gastric cancer. Clin Cancer Res 2005; 11: 1021-1027.
-
(2005)
Clin Cancer Res
, vol.11
, pp. 1021-1027
-
-
Murai, M.1
Toyota, M.2
Suzuki, H.3
Satoh, A.4
Sasaki, Y.5
Akino, K.6
-
37
-
-
33644622570
-
HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption
-
Papandreou I, Caims RA, Fontana L, Lim AL, Denko NC. HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption. Cell Metab 2006; 3: 187-197.
-
(2006)
Cell Metab
, vol.3
, pp. 187-197
-
-
Papandreou, I.1
Caims, R.A.2
Fontana, L.3
Lim, A.L.4
Denko, N.C.5
-
38
-
-
33947386684
-
Endoplasmic reticulum stress: A new pathway to induce autophagy
-
Yorimitsu T, Klionsky DJ. Endoplasmic reticulum stress: A new pathway to induce autophagy. Autophagy 2007; 3: 160-162.
-
(2007)
Autophagy
, vol.3
, pp. 160-162
-
-
Yorimitsu, T.1
Klionsky, D.J.2
-
39
-
-
4344660747
-
XBP1 is essential for survival under hypoxic conditions and is required for tumor growth
-
Romero-Ramirez L, Cao H, Nelson D, Hammond E, Lee AH, Yoshida H et al XBP1 is essential for survival under hypoxic conditions and is required for tumor growth. Cancer Res 2004; 64: 5943-5947.
-
(2004)
Cancer Res
, vol.64
, pp. 5943-5947
-
-
Romero-Ramirez, L.1
Cao, H.2
Nelson, D.3
Hammond, E.4
Lee, A.H.5
Yoshida, H.6
-
40
-
-
33646204392
-
Generation of cell lines with tetracycline-regulated autophagy and a role for autophagy in controlling cell size
-
Hosokawa N, Hara Y, Mizushima N. Generation of cell lines with tetracycline-regulated autophagy and a role for autophagy in controlling cell size. FEBS Lett 2006; 580: 2623-2629.
-
(2006)
FEBS Lett
, vol.580
, pp. 2623-2629
-
-
Hosokawa, N.1
Hara, Y.2
Mizushima, N.3
-
41
-
-
0035863399
-
A novel response of cancer cells to radiation involves autophagy and formation of acidic vesicles
-
Paglin S, Hollister T, Delohery T, Hackett N, McMahill M, Sphicas E et al. A novel response of cancer cells to radiation involves autophagy and formation of acidic vesicles. Cancer Res 2001; 61 439-444.
-
(2001)
Cancer Res
, vol.61
, pp. 439-444
-
-
Paglin, S.1
Hollister, T.2
Delohery, T.3
Hackett, N.4
McMahill, M.5
Sphicas, E.6
-
42
-
-
0034099224
-
Apg5p functions in the sequestration step in the cytoplasm-to-vacuole targeting and macroautophagy pathways
-
George MD, Baba M, Scott SV, Mizushima N, Garrison BS, Ohsumi Y et al Apg5p functions in the sequestration step in the cytoplasm-to-vacuole targeting and macroautophagy pathways. Mol Biol Cell 2000; 11: 969-982.
-
(2000)
Mol Biol Cell
, vol.11
, pp. 969-982
-
-
George, M.D.1
Baba, M.2
Scott, S.V.3
Mizushima, N.4
Garrison, B.S.5
Ohsumi, Y.6
-
43
-
-
8144228566
-
Why do cancers have high aerobic glycolysis?
-
Gatenby RA, Gillies RJ. Why do cancers have high aerobic glycolysis? Nat Rev Cancer 2004; 4: 891-899.
-
(2004)
Nat Rev Cancer
, vol.4
, pp. 891-899
-
-
Gatenby, R.A.1
Gillies, R.J.2
-
44
-
-
0036210708
-
The response of c-jun/AP-1 to chronic hypoxia is hypoxia-inducible factor 1 alpha dependent
-
Laderoute KR, Calaoagan JM, Gustafson-Brown C, Knapp AM, Li GC, Mendonca HL et al. The response of c-jun/AP-1 to chronic hypoxia is hypoxia-inducible factor 1 alpha dependent. Mol Cell Biol 2002; 22: 2515-2523.
-
(2002)
Mol Cell Biol
, vol.22
, pp. 2515-2523
-
-
Laderoute, K.R.1
Calaoagan, J.M.2
Gustafson-Brown, C.3
Knapp, A.M.4
Li, G.C.5
Mendonca, H.L.6
|