-
1
-
-
67649467294
-
Dynamics and diversity in autophagy mechanisms: Lessons from yeast
-
Nakatogawa, H., Suzuki, K., Kamada, Y. & Ohsumi, Y. Dynamics and diversity in autophagy mechanisms: lessons from yeast. Nature Rev. Mol. Cell Biol. 10, 458-467 (2009).
-
(2009)
Nature Rev. Mol. Cell Biol.
, vol.10
, pp. 458-467
-
-
Nakatogawa, H.1
Suzuki, K.2
Kamada, Y.3
Ohsumi, Y.4
-
2
-
-
77956404377
-
Eaten alive: A history of macroautophagy
-
Yang, Z. & Klionsky, D. J. Eaten alive: a history of macroautophagy. Nature Cell Biol. 12, 814-822 (2010).
-
(2010)
Nature Cell Biol.
, vol.12
, pp. 814-822
-
-
Yang, Z.1
Klionsky, D.J.2
-
3
-
-
77957198526
-
An Atg9 containing compartment that functions in the early steps of autophagosome biogenesis
-
Mari, M. et al. An Atg9 containing compartment that functions in the early steps of autophagosome biogenesis. J. Cell Biol. 190, 1005-1022 (2010).
-
(2010)
J. Cell Biol.
, vol.190
, pp. 1005-1022
-
-
Mari, M.1
-
4
-
-
50249084987
-
Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3 phosphate and dynamically connected to the endoplasmic reticulum
-
Axe, E. L. et al. Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3 phosphate and dynamically connected to the endoplasmic reticulum. J. Cell Biol. 182, 685-701 (2008).
-
(2008)
J. Cell Biol.
, vol.182
, pp. 685-701
-
-
Axe, E.L.1
-
5
-
-
77952495224
-
Mitochondria supply membranes for autophagosome biogenesis during starvation
-
Hailey, D. W. et al. Mitochondria supply membranes for autophagosome biogenesis during starvation. Cell 141, 656-667 (2010).
-
(2010)
Cell
, vol.141
, pp. 656-667
-
-
Hailey, D.W.1
-
6
-
-
77955131007
-
Plasma membrane contributes to the formation of preautophagosomal structures
-
Ravikumar, B., Moreau, K., Jahreiss, L., Puri, C. & Rubinsztein, D. C. Plasma membrane contributes to the formation of preautophagosomal structures. Nature Cell Biol. 12, 747-757 (2010).
-
(2010)
Nature Cell Biol.
, vol.12
, pp. 747-757
-
-
Ravikumar, B.1
Moreau, K.2
Jahreiss, L.3
Puri, C.4
Rubinsztein, D.C.5
-
7
-
-
77953724901
-
A comprehensive glossary of autophagy related molecules and processes
-
Klionsky, D. J. et al. A comprehensive glossary of autophagy related molecules and processes. Autophagy 6, 438-448 (2010).
-
(2010)
Autophagy
, vol.6
, pp. 438-448
-
-
Klionsky, D.J.1
-
8
-
-
61949429767
-
Pexophagy in Pichia pastoris
-
Oku, M. & Sakai, Y. Pexophagy in Pichia pastoris. Methods Enzymol. 451, 217-228 (2008).
-
(2008)
Methods Enzymol.
, vol.451
, pp. 217-228
-
-
Oku, M.1
Sakai, Y.2
-
10
-
-
34249934085
-
Selective degradation of mitochondria by mitophagy
-
Kim, I., Rodriguez Enriquez, S. & Lemasters, J. J. Selective degradation of mitochondria by mitophagy. Arch. Biochem. Biophys. 462, 245-253 (2007).
-
(2007)
Arch. Biochem. Biophys.
, vol.462
, pp. 245-253
-
-
Kim, I.1
Rodriguez Enriquez, S.2
Lemasters, J.J.3
-
11
-
-
34447099450
-
Atg8, a ubiquitin like protein required for autophagosome formation, mediates membrane tethering and hemifusion
-
Nakatogawa, H., Ichimura, Y. & Ohsumi, Y. Atg8, a ubiquitin like protein required for autophagosome formation, mediates membrane tethering and hemifusion. Cell 130, 165-178 (2007).
-
(2007)
Cell
, vol.130
, pp. 165-178
-
-
Nakatogawa, H.1
Ichimura, Y.2
Ohsumi, Y.3
-
12
-
-
77950484269
-
Atg8 family interacting motif crucial for selective autophagy
-
Noda, N. N., Ohsumi, Y. & Inagaki, F. Atg8 family interacting motif crucial for selective autophagy. FEBS Lett. 584, 1379-1385 (2010).
-
(2010)
FEBS Lett.
, vol.584
, pp. 1379-1385
-
-
Noda, N.N.1
Ohsumi, Y.2
Inagaki, F.3
-
13
-
-
0036479052
-
Mitochondrial disappearance from cells: A clue to the role of autophagy in programmed cell death and disease
-
Tolkovsky, A. M., Xue, L., Fletcher, G. C. & Borutaite, V. Mitochondrial disappearance from cells: a clue to the role of autophagy in programmed cell death and disease Biochimie 84, 233-240 (2002).
-
(2002)
Biochimie
, vol.84
, pp. 233-240
-
-
Tolkovsky, A.M.1
Xue, L.2
Fletcher, G.C.3
Borutaite, V.4
-
15
-
-
38549110110
-
Fission and selective fusion govern mitochondrial segregation and elimination by autophagy
-
Twig, G. et al. Fission and selective fusion govern mitochondrial segregation and elimination by autophagy. EMBO J. 27, 433-446 (2008).
-
(2008)
EMBO J.
, vol.27
, pp. 433-446
-
-
Twig, G.1
-
16
-
-
78649413837
-
Mitochondrial fusion and fission in cell life and death
-
Westermann, D. Mitochondrial fusion and fission in cell life and death. Nature Rev. Mol. Cell Biol. 11, 872-884 (2010).
-
(2010)
Nature Rev. Mol. Cell Biol.
, vol.11
, pp. 872-884
-
-
Westermann, D.1
-
17
-
-
34247172582
-
Aup1p a yeast mitochondrial protein phosphatase homolog, is required for efficient stationary phase mitophagy and cell survival
-
Tal, R., Winter, G., Ecker, N., Klionsky, D. J. & Abeliovich, H. Aup1p, a yeast mitochondrial protein phosphatase homolog, is required for efficient stationary phase mitophagy and cell survival. J. Biol. Chem. 282, 5617-5624 (2007).
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 5617-5624
-
-
Tal, R.1
Winter, G.2
Ecker, N.3
Klionsky, D.J.4
Abeliovich, H.5
-
18
-
-
4644273585
-
Uth1p is involved in the autophagic degradation of mitochondria
-
Kissova, I., Deffieu, M., Manon, S. & Camougrand, N. Uth1p is involved in the autophagic degradation of mitochondria. J. Biol. Chem. 279, 39068-39074 (2004).
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 39068-39074
-
-
Kissova, I.1
Deffieu, M.2
Manon, S.3
Camougrand, N.4
-
19
-
-
37649017266
-
NIX is required for programmed mitochondrial clearance during reticulocyte maturation
-
Schweers, R. L. et al. NIX is required for programmed mitochondrial clearance during reticulocyte maturation. Proc. Natl Acad. Sci. USA 104, 19500-19505 (2007).
-
(2007)
Proc. Natl Acad. Sci. USA
, vol.104
, pp. 19500-19505
-
-
Schweers, R.L.1
-
20
-
-
51649124519
-
Ulk1 plays a critical role in the autophagic clearance of mitochondria and ribosomes during reticulocyte maturation
-
Kundu, M. et al. Ulk1 plays a critical role in the autophagic clearance of mitochondria and ribosomes during reticulocyte maturation. Blood 11 2, 1493-1502 (2008).
-
(2008)
Blood
, vol.11
, Issue.2
, pp. 1493-1502
-
-
Kundu, M.1
-
21
-
-
67650246357
-
Mitochondria anchored receptor Atg32 mediates degradation of mitochondria via selective autophagy
-
Okamoto, K., Kondo Okamoto, N. & Ohsumi, Y. Mitochondria anchored receptor Atg32 mediates degradation of mitochondria via selective autophagy. Dev. Cell 17, 87-97 (2009).
-
(2009)
Dev. Cell
, vol.17
, pp. 87-97
-
-
Okamoto, K.1
Kondo Okamoto, N.2
Ohsumi, Y.3
-
22
-
-
77953515698
-
A genomic screen for yeast mutants defective in mitophagy
-
Kanki, T., Wang, K. & Klionsky, D. J. A genomic screen for yeast mutants defective in mitophagy. Autophagy 6, 278-280 (2010).
-
(2010)
Autophagy
, vol.6
, pp. 278-280
-
-
Kanki, T.1
Wang, K.2
Klionsky, D.J.3
-
23
-
-
67650264633
-
Atg32 is a mitochondrial protein that confers selectivity during mitophagy
-
Kanki, T., Wang, K., Cao, Y., Baba, M. & Klionsky, D. J. Atg32 is a mitochondrial protein that confers selectivity during mitophagy. Dev. Cell 17, 98-109 (2009).
-
(2009)
Dev. Cell
, vol.17
, pp. 98-109
-
-
Kanki, T.1
Wang, K.2
Cao, Y.3
Baba, M.4
Klionsky, D.J.5
-
24
-
-
76249127368
-
Loss of autophagy in erythroid cells leads to defective removal of mitochondria and severe anemia in vivo
-
Mortensen, M. et al. Loss of autophagy in erythroid cells leads to defective removal of mitochondria and severe anemia in vivo. Proc. Natl Acad. Sci. USA 107, 832-837 (2010).
-
(2010)
Proc. Natl Acad. Sci. USA
, vol.107
, pp. 832-837
-
-
Mortensen, M.1
-
25
-
-
67650230871
-
Mitochondrial clearance is regulated by Atg7 dependent and independent mechanisms during reticulocyte maturation
-
Zhang, J. et al. Mitochondrial clearance is regulated by Atg7 dependent and independent mechanisms during reticulocyte maturation. Blood 11 4, 157-164 (2009).
-
(2009)
Blood
, vol.11
, Issue.4
, pp. 157-164
-
-
Zhang, J.1
-
26
-
-
0038156122
-
The proapoptotic factor Nix is coexpressed with Bcl xL during terminal erythroid differentiation
-
Aerbajinai, W., Giattina, M., Lee, Y. T., Raffeld, M. & Miller, J. L. The proapoptotic factor Nix is coexpressed with Bcl xL during terminal erythroid differentiation. Blood 102, 712-717 (2003).
-
(2003)
Blood
, vol.102
, pp. 712-717
-
-
Aerbajinai, W.1
Giattina, M.2
Lee, Y.T.3
Raffeld, M.4
Miller, J.L.5
-
27
-
-
47049100413
-
Essential role for Nix in autophagic maturation of erythroid cells
-
Sandoval, H. et al. Essential role for Nix in autophagic maturation of erythroid cells. Nature 454, 232-235 (2008).
-
(2008)
Nature
, vol.454
, pp. 232-235
-
-
Sandoval, H.1
-
28
-
-
27944470616
-
Phylogenomics of life or death switches in multicellular animals: Bcl 2 BH3 only, and BNip families of apoptotic regulators
-
Aouacheria, A., Brunet, F. & Gouy, M. Phylogenomics of life or death switches in multicellular animals: Bcl 2, BH3 only, and BNip families of apoptotic regulators. Mol. Biol. Evol. 22, 2395-2416 (2005).
-
(2005)
Mol. Biol. Evol.
, vol.22
, pp. 2395-2416
-
-
Aouacheria, A.1
Brunet, F.2
Gouy, M.3
-
29
-
-
67650219052
-
Nix directly binds to GABARAP: A possible crosstalk between apoptosis and autophagy
-
Schwarten, M. et al. Nix directly binds to GABARAP: a possible crosstalk between apoptosis and autophagy. Autophagy 5, 690-698 (2009).
-
(2009)
Autophagy
, vol.5
, pp. 690-698
-
-
Schwarten, M.1
-
30
-
-
74049153002
-
Nix is a selective autophagy receptor for mitochondrial clearance
-
Novak, I. et al. Nix is a selective autophagy receptor for mitochondrial clearance. EMBO Rep. 11, 45-51 (2010).
-
(2010)
EMBO Rep.
, vol.11
, pp. 45-51
-
-
Novak, I.1
-
31
-
-
2442668926
-
Hereditary earlyonset Parkinson's disease caused by mutations in PINK1
-
Valente, E. M. et al. Hereditary earlyonset Parkinson's disease caused by mutations in PINK1. Science 304, 1158-1160 (2004).
-
(2004)
Science
, vol.304
, pp. 1158-1160
-
-
Valente, E.M.1
-
32
-
-
0032499264
-
Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism
-
DOI 10.1038/33416
-
Kitada, T. et al. Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism. Nature 392, 605-608 (1998). (Pubitemid 28207717)
-
(1998)
Nature
, vol.392
, Issue.6676
, pp. 605-608
-
-
Kitada, T.1
Asakawa, S.2
Hattori, N.3
Matsumine, H.4
Yamamura, Y.5
Minoshima, S.6
Yokochi, M.7
Mizuno, Y.8
Shimizu, N.9
-
33
-
-
0037386532
-
Mitochondrial pathology and apoptotic muscle degeneration in Drosophila parkin mutants
-
Greene, J. C. et al. Mitochondrial pathology and apoptotic muscle degeneration in Drosophila parkin mutants. Proc. Natl Acad. Sci. USA 100, 4078-4083 (2003).
-
(2003)
Proc. Natl Acad. Sci. USA
, vol.100
, pp. 4078-4083
-
-
Greene, J.C.1
-
34
-
-
33745602748
-
Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin
-
Park, J. et al. Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin. Nature 441, 1157-1161 (2006).
-
(2006)
Nature
, vol.441
, pp. 1157-1161
-
-
Park, J.1
-
35
-
-
33745589773
-
Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin
-
Clark, I. E. et al. Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin. Nature 441, 1162-1166 (2006).
-
(2006)
Nature
, vol.441
, pp. 1162-1166
-
-
Clark, I.E.1
-
36
-
-
39449088321
-
The PINK1/Parkin pathway regulates mitochondrial morphology
-
Poole, A. C. et al. The PINK1/Parkin pathway regulates mitochondrial morphology. Proc. Natl Acad. Sci. USA 105, 1638-1643 (2008).
-
(2008)
Proc. Natl Acad. Sci. USA
, vol.105
, pp. 1638-1643
-
-
Poole, A.C.1
-
37
-
-
44349195101
-
Pink1 regulates mitochondrial dynamics through interaction with the fission/fusion machinery
-
Yang, Y. et al. Pink1 regulates mitochondrial dynamics through interaction with the fission/fusion machinery. Proc. Natl Acad. Sci. USA 105, 7070-7075 (2008).
-
(2008)
Proc. Natl Acad. Sci. USA
, vol.105
, pp. 7070-7075
-
-
Yang, Y.1
-
38
-
-
55749090654
-
The Parkinson's disease genes pink1 and parkin promote mitochondrial fission and/or inhibit fusion in Drosophila
-
Deng, H., Dodson, M. W., Huang, H. & Guo, M. The Parkinson's disease genes pink1 and parkin promote mitochondrial fission and/or inhibit fusion in Drosophila. Proc. Natl Acad. Sci. USA 105, 14503-14508 (2008).
-
(2008)
Proc. Natl Acad. Sci. USA
, vol.105
, pp. 14503-14508
-
-
Deng, H.1
Dodson, M.W.2
Huang, H.3
Guo, M.4
-
39
-
-
77955398958
-
Parkin overexpression selects against a deleterious mtDNA mutation in heteroplasmic cybrid cells
-
Suen, D. F., Narendra, D. P., Tanaka, A., Manfredi, G. & Youle, R. J. Parkin overexpression selects against a deleterious mtDNA mutation in heteroplasmic cybrid cells. Proc. Natl Acad. Sci. USA 107, 11835-11840 (2010).
-
(2010)
Proc. Natl Acad. Sci. USA
, vol.107
, pp. 11835-11840
-
-
Suen, D.F.1
Narendra, D.P.2
Tanaka, A.3
Manfredi, G.4
Youle, R.J.5
-
40
-
-
58149314211
-
Parkin is recruited selectively to impaired mitochondria and promotes their autophagy
-
Narendra, D., Tanaka, A., Suen, D. F. & Youle, R. J. Parkin is recruited selectively to impaired mitochondria and promotes their autophagy. J. Cell Biol. 183, 795-803 (2008).
-
(2008)
J. Cell Biol.
, vol.183
, pp. 795-803
-
-
Narendra, D.1
Tanaka, A.2
Suen, D.F.3
Youle, R.J.4
-
41
-
-
75749156257
-
PINK1 is selectively stabilized on impaired mitochondria to activate Parkin
-
Narendra, D. P. et al. PINK1 is selectively stabilized on impaired mitochondria to activate Parkin. PLoS Biol. 8, e1000298 (2010).
-
(2010)
PLoS Biol.
, vol.8
-
-
Narendra, D.P.1
-
42
-
-
75949098487
-
PINK1 dependent recruitment of Parkin to mitochondria in mitophagy
-
Vives Bauza, C. et al. PINK1 dependent recruitment of Parkin to mitochondria in mitophagy. Proc. Natl Acad. Sci. USA 107, 378-383 (2010).
-
(2010)
Proc. Natl Acad. Sci. USA
, vol.107
, pp. 378-383
-
-
Vives Bauza, C.1
-
43
-
-
75949130828
-
PINK1/Parkin mediated mitophagy is dependent on VDAC1 and p62/SQSTM1
-
Geisler, S. et al. PINK1/Parkin mediated mitophagy is dependent on VDAC1 and p62/SQSTM1. Nature Cell Biol. 12, 119-131 (2010).
-
(2010)
Nature Cell Biol.
, vol.12
, pp. 119-131
-
-
Geisler, S.1
-
44
-
-
77951181836
-
PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy
-
Matsuda, N. et al. PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy. J. Cell Biol. 189, 211-221 (2010).
-
(2010)
J. Cell Biol.
, vol.189
, pp. 211-221
-
-
Matsuda, N.1
-
45
-
-
56049091236
-
PINK1 controls mitochondrial localization of Parkin through direct phosphorylation
-
Kim, Y. et al. PINK1 controls mitochondrial localization of Parkin through direct phosphorylation. BBRC 377, 975-980 (2008).
-
(2008)
BBRC
, vol.377
, pp. 975-980
-
-
Kim, Y.1
-
46
-
-
77950371695
-
PINK1 is recruited to mitochondria with parkin and associates with LC3 in mitophagy
-
Kawajiri, S. et al. PINK1 is recruited to mitochondria with parkin and associates with LC3 in mitophagy. FEBS Lett. 584, 1073-1079 (2010).
-
(2010)
FEBS Lett.
, vol.584
, pp. 1073-1079
-
-
Kawajiri, S.1
-
47
-
-
33746080412
-
Mitochondrial pathology and muscle and dopaminergic neuron degeneration caused by inactivation of Drosophila Pink1 is rescued by Parkin
-
Yang, Y. et al. Mitochondrial pathology and muscle and dopaminergic neuron degeneration caused by inactivation of Drosophila Pink1 is rescued by Parkin. Proc. Natl Acad. Sci. USA 103, 10793-10798 (2006).
-
(2006)
Proc. Natl Acad. Sci. USA
, vol.103
, pp. 10793-10798
-
-
Yang, Y.1
-
48
-
-
77956252454
-
Nix is critical to two distinct phases of mitophagy, reactive oxygen species mediated autophagy induction and Parkin-ubiquitin-p62 mediated mitochondrial priming
-
Ding, W. X. et al. Nix is critical to two distinct phases of mitophagy, reactive oxygen species mediated autophagy induction and Parkin-ubiquitin-p62 mediated mitochondrial priming. J. Biol. Chem. 285, 27879-27890 (2010).
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 27879-27890
-
-
Ding, W.X.1
-
49
-
-
45249112594
-
Characterization of PINK1 processing, stability, and subcellular localization
-
Lin, W. & Kang, U. J. Characterization of PINK1 processing, stability, and subcellular localization. J. Neurochem. 106, 464-474 (2008).
-
(2008)
J. Neurochem.
, vol.106
, pp. 464-474
-
-
Lin, W.1
Kang, U.J.2
-
50
-
-
58149397651
-
Rhomboid 7 and HtrA2/Omi act in a common pathway with the Parkinson's disease factors Pink1 and Parkin
-
Whitworth, A. J. et al. Rhomboid 7 and HtrA2/Omi act in a common pathway with the Parkinson's disease factors Pink1 and Parkin. Dis. Model Mech. 1, 168-174 (2008).
-
(2008)
Dis. Model Mech.
, vol.1
, pp. 168-174
-
-
Whitworth, A.J.1
-
51
-
-
67349239050
-
Parkin stabilizes PINK1 through direct interaction
-
Shiba, K. et al. Parkin stabilizes PINK1 through direct interaction. Biochem. Biophys. Res. Commun. 383, 331-335 (2009).
-
(2009)
Biochem. Biophys. Res. Commun.
, vol.383
, pp. 331-335
-
-
Shiba, K.1
-
52
-
-
62749138404
-
Molecular interaction between Parkin and Pink1 in mammalian neuronal cells
-
Um, J. W., Stichel Gunkel, C., Lübbert, H., Lee, G. & Chung, K. C. Molecular interaction between Parkin and Pink1 in mammalian neuronal cells. Mol. Cell Neurosci. 40, 421-432 (2009).
-
(2009)
Mol. Cell Neurosci.
, vol.40
, pp. 421-432
-
-
Um, J.W.1
Stichel Gunkel, C.2
Lübbert, H.3
Lee, G.4
Chung, K.C.5
-
53
-
-
77949478474
-
Phosphorylation of parkin by Parkinson disease linked kinase PINK1 activates parkin E3 ligase function and NF κb signaling
-
Sha, D., Chin, L. S. & Li, L. Phosphorylation of parkin by Parkinson disease linked kinase PINK1 activates parkin E3 ligase function and NF κB signaling. Hum. Mol. Genet. 19, 352-363 (2010).
-
(2010)
Hum. Mol. Genet.
, vol.19
, pp. 352-363
-
-
Sha, D.1
Chin, L.S.2
Li, L.3
-
54
-
-
77952326081
-
Disease causing mutations in Parkin impair mitochondrial ubiquitination, aggregation, and HDAC6 dependent mitophagy
-
Lee, J. Y., Nagano, Y., Taylor, J. P., Lim, K. L. & Yao, T. P. Disease causing mutations in Parkin impair mitochondrial ubiquitination, aggregation, and HDAC6 dependent mitophagy. J. Cell Biol. 189, 671-679 (2010).
-
(2010)
J. Cell Biol.
, vol.189
, pp. 671-679
-
-
Lee, J.Y.1
Nagano, Y.2
Taylor, J.P.3
Lim, K.L.4
Yao, T.P.5
-
55
-
-
77954695260
-
P62/SQSTM1 cooperates with Parkin for perinuclear clustering of depolarized mitochondria
-
Okatsu, K. et al. p62/SQSTM1 cooperates with Parkin for perinuclear clustering of depolarized mitochondria. Genes Cells 15, 887-900 (2010).
-
(2010)
Genes Cells
, vol.15
, pp. 887-900
-
-
Okatsu, K.1
-
56
-
-
78649300971
-
P62/SQSTM1 is required for Parkin induced mitochondrial clustering but not mitophagy; VDAC1 is dispensible for both
-
Narendra, D., Kane, L., Hauser, D., Fearnley, I. & Youle, R. p62/SQSTM1 is required for Parkin induced mitochondrial clustering but not mitophagy; VDAC1 is dispensible for both. Autophagy 6, 1090-1106 (2010).
-
(2010)
Autophagy
, vol.6
, pp. 1090-1106
-
-
Narendra, D.1
Kane, L.2
Hauser, D.3
Fearnley, I.4
Youle, R.5
-
57
-
-
34548259958
-
P62/SQSTM1 binds directly to Atg8/ LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy
-
Pankiv, S. et al. p62/SQSTM1 binds directly to Atg8/ LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy. J. Biol. Chem. 282, 24131-24145 (2007).
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 24131-24145
-
-
Pankiv, S.1
-
58
-
-
77953424577
-
The role of parkin in familial and sporadic Parkinson's disease
-
Dawson, T. M. & Dawson, V. L. The role of parkin in familial and sporadic Parkinson's disease. Mov. Disord. 25 (Suppl. 1), S32-S39 (2010).
-
(2010)
Mov. Disord.
, vol.25
, Issue.SUPPL. 1
-
-
Dawson, T.M.1
Dawson, V.L.2
-
59
-
-
77950384477
-
Drosophila parkin requires PINK1 for mitochondrial translocation and ubiquitinates mitofusin
-
Ziviani, E., Tao, R. N. & Whitworth, A. J. Drosophila parkin requires PINK1 for mitochondrial translocation and ubiquitinates mitofusin. Proc. Natl Acad. Sci. USA 107, 5018-5023 (2010).
-
(2010)
Proc. Natl Acad. Sci. USA
, vol.107
, pp. 5018-5023
-
-
Ziviani, E.1
Tao, R.N.2
Whitworth, A.J.3
-
60
-
-
77955844260
-
The mitochondrial fusion promoting factor mitofusin is a substrate of the PINK1/parkin pathway
-
Poole, A. C., Thomas, R. E., Yu, S., Vincow, E. S. & Pallanck, L. The mitochondrial fusion promoting factor mitofusin is a substrate of the PINK1/parkin pathway. PLoS ONE 5, e10054 (2010).
-
(2010)
PLoS ONE
, vol.5
-
-
Poole, A.C.1
Thomas, R.E.2
Yu, S.3
Vincow, E.S.4
Pallanck, L.5
-
61
-
-
78649463381
-
Mitofusin 1 and mitofusin 2 are ubiquitinated in a PINK1/parkin dependent manner upon induction of mitophagy
-
Gegg, M. E. et al. Mitofusin 1 and mitofusin 2 are ubiquitinated in a PINK1/parkin dependent manner upon induction of mitophagy. Hum. Mol. Genet. 19, 4861-4870 (2010).
-
(2010)
Hum. Mol. Genet.
, vol.19
, pp. 4861-4870
-
-
Gegg, M.E.1
-
62
-
-
78650729600
-
Proteasome and p97 mediate mitophagy and degradation of mitofusins induced by Parkin
-
in the press; doi:10.1083/ jcb.201007013
-
Tanaka, A. et al. Proteasome and p97 mediate mitophagy and degradation of mitofusins induced by Parkin. J. Cell Biol. (in the press; doi:10.1083/ jcb.201007013).
-
J. Cell Biol.
-
-
Tanaka, A.1
-
63
-
-
77957673363
-
The PINK1/Parkin mediated mitophagy is compromised by PD associated mutations
-
Geisler, S. et al. The PINK1/Parkin mediated mitophagy is compromised by PD associated mutations. Autophagy 6, 871-878 (2010).
-
(2010)
Autophagy
, vol.6
, pp. 871-878
-
-
Geisler, S.1
-
64
-
-
0038732456
-
Parkin, a gene implicated in autosomal recessive juvenile parkinsonism, is a candidate tumor suppressor gene on chromosome 6q25 q27
-
Cesari, R. et al. Parkin, a gene implicated in autosomal recessive juvenile parkinsonism, is a candidate tumor suppressor gene on chromosome 6q25 q27. Proc. Natl Acad. Sci. USA 100, 5956-5961 (2003).
-
(2003)
Proc. Natl Acad. Sci. USA
, vol.100
, pp. 5956-5961
-
-
Cesari, R.1
-
65
-
-
77956990244
-
PARK2 deletions occur frequently in sporadic colorectal cancer and accelerate adenoma development in Apc mutant mice
-
Poulogiannis, G. et al. PARK2 deletions occur frequently in sporadic colorectal cancer and accelerate adenoma development in Apc mutant mice. Proc. Natl Acad. Sci. USA 107, 15145-15150 (2010).
-
(2010)
Proc. Natl Acad. Sci. USA
, vol.107
, pp. 15145-15150
-
-
Poulogiannis, G.1
-
66
-
-
33644610520
-
The genetics of Parkinson disease: Implications for neurological care
-
Klein, C. & Schlossmacher, M. G. The genetics of Parkinson disease: implications for neurological care. Nature Clin. Pract. Neurol. 2, 136-146 (2006).
-
(2006)
Nature Clin. Pract. Neurol.
, vol.2
, pp. 136-146
-
-
Klein, C.1
Schlossmacher, M.G.2
-
67
-
-
37049004489
-
Mitochondria in the aetiology and pathogenesis of Parkinson's disease
-
Schapira, A. H. Mitochondria in the aetiology and pathogenesis of Parkinson's disease. Lancet Neurol. 7, 97-109 (2008).
-
(2008)
Lancet Neurol.
, vol.7
, pp. 97-109
-
-
Schapira, A.H.1
-
68
-
-
33646351299
-
Mitochondrial DNA deletions are abundant and cause functional impairment in aged human substantia nigra neurons
-
Kraytsberg, Y. et al. Mitochondrial DNA deletions are abundant and cause functional impairment in aged human substantia nigra neurons. Nature Genet. 38, 518-520 (2006).
-
(2006)
Nature Genet.
, vol.38
, pp. 518-520
-
-
Kraytsberg, Y.1
-
69
-
-
33646375711
-
High levels of mitochondrial DNA deletions in substantia nigra neurons in aging and Parkinson disease
-
Bender, A. et al. High levels of mitochondrial DNA deletions in substantia nigra neurons in aging and Parkinson disease. Nature Genet. 38, 515-517 (2006).
-
(2006)
Nature Genet.
, vol.38
, pp. 515-517
-
-
Bender, A.1
-
70
-
-
4544273256
-
Parkinsonism, premature menopause, and mitochondrial DNA polymerase γ mutations: Clinical and molecular genetic study
-
Luoma, P. et al. Parkinsonism, premature menopause, and mitochondrial DNA polymerase γ mutations: clinical and molecular genetic study. Lancet 364, 875-882 (2004).
-
(2004)
Lancet
, vol.364
, pp. 875-882
-
-
Luoma, P.1
-
71
-
-
38749102795
-
Nature of mitochondrial DNA deletions in substantia nigra neurons
-
Reeve, A. K. et al. Nature of mitochondrial DNA deletions in substantia nigra neurons. Am. J. Hum. Genet. 82, 228-235 (2008).
-
(2008)
Am. J. Hum. Genet.
, vol.82
, pp. 228-235
-
-
Reeve, A.K.1
-
72
-
-
34447249263
-
Familial parkinsonism and ophthalmoplegia from a mutation in the mitochondrial DNA helicase twinkle
-
Baloh, R. H., Salavaggione, E., Milbrandt, J. & Pestronk, A. Familial parkinsonism and ophthalmoplegia from a mutation in the mitochondrial DNA helicase twinkle. Arch. Neurol. 64, 998-1000 (2007).
-
(2007)
Arch. Neurol.
, vol.64
, pp. 998-1000
-
-
Baloh, R.H.1
Salavaggione, E.2
Milbrandt, J.3
Pestronk, A.4
|