Loss of autophagy in the central nervous system causes neurodegeneration in mice

Nature

Volumn 441, Issue 7095, 2006, Pages 880-884

  Komatsu, Masaaki ^a,b   Waguri, Satoshi ^c,d   Chiba, Tomoki ^a   Murata, Shigeo ^a   Iwata, Jun Ichi ^a,b   Tanida, Isei ^b   Ueno, Takashi ^b   Koike, Masato ^c   Uchiyama, Yasuo ^c   Kominami, Eiki ^b   Tanaka, Keiji ^a  

^a TOKYO METROPOLITAN INSTITUTE OF MEDICAL SCIENCE   (Japan)

^b JUNTENDO UNIVERSITY   (Japan)

^c OSAKA UNIVERSITY   (Japan)

^d FUKUSHIMA MEDICAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BIODIVERSITY; BIOMEDICAL ENGINEERING; CELLS; DEGRADATION; DISEASES; PROTEINS;

AUTOPHAGY; HOMEOSTASIS; NEURODEGENERATIVE DISORDERS; UBIQUITIN-PROTEASOME SYSTEMS;

NEUROLOGY;

AGING; BEHAVIORAL RESPONSE; DEGRADATION; HOMEOSTASIS; NERVOUS SYSTEM; NERVOUS SYSTEM DISORDER; PATHOGENICITY; PROTEIN; RODENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOPHAGY; AUTOPHAGY RELATED 7 GENE; CELL INCLUSION; CELL SURVIVAL; CENTRAL NERVOUS SYSTEM; CEREBELLUM; CONTROLLED STUDY; GENE; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; MOTOR COORDINATION; MOTOR DYSFUNCTION; MOUSE; NERVE CELL; NERVE DEGENERATION; NONHUMAN; PRIORITY JOURNAL; REFLEX DISORDER; TRANSGENIC MOUSE; UBIQUITINATION;

ANIMALS; AUTOPHAGY; CELL DEATH; CENTRAL NERVOUS SYSTEM; CEREBELLUM; CEREBRAL CORTEX; INCLUSION BODIES; INTERMEDIATE FILAMENT PROTEINS; MICE; MICE, TRANSGENIC; MICROTUBULE-ASSOCIATED PROTEINS; NERVE TISSUE PROTEINS; NEURODEGENERATIVE DISEASES; NEURONS; PROTEASOME ENDOPEPTIDASE COMPLEX; SURVIVAL RATE; UBIQUITIN;

EID: 33646800306     PISSN: 00280836     EISSN: 14764679     Source Type: Journal    
DOI: 10.1038/nature04723     Document Type: Article

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