Autophagy-related proteins (p62, NBR1 and LC3) in intranuclear inclusions in neurodegenerative diseases

Neuroscience Letters

Volumn 522, Issue 2, 2012, Pages 134-138

  Mori, Fumiaki ^a   Tanji, Kunikazu ^a   Odagiri, Saori ^a   Toyoshima, Yasuko ^b   Yoshida, Mari ^c   Kakita, Akiyoshi ^b   Takahashi, Hitoshi ^b   Wakabayashi, Koichi ^a  

^a HIROSAKI UNIVERSITY   (Japan)

^b NIIGATA UNIVERSITY   (Japan)

^c AICHI MEDICAL UNIVERSITY   (Japan)

Author keywords

Autophagy; Intranuclear inclusions; LC3; NBR1; P62; Ubiquitin

Indexed keywords

LC3 PROTEIN; NBR1 PROTEIN; PEPTIDES AND PROTEINS; PROTEIN P62; UBIQUITIN; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; AUTOPHAGY; AUTOPSY; BRAIN; CELL NUCLEUS INCLUSION BODY; CONTROLLED STUDY; DEGENERATIVE DISEASE; DENTATORUBROPALLIDOLUYSIAN ATROPHY; HUMAN; IMMUNOHISTOCHEMISTRY; INTRANUCLEAR INCLUSION BODY DISEASE; MACHADO JOSEPH DISEASE; MORPHOMETRICS; PRIORITY JOURNAL;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ADULT; AGED; AGED, 80 AND OVER; AUTOPHAGY; BRAIN; CASE-CONTROL STUDIES; HUMANS; IMMUNOHISTOCHEMISTRY; INTRANUCLEAR INCLUSION BODIES; MICROTUBULE-ASSOCIATED PROTEINS; MIDDLE AGED; NEURODEGENERATIVE DISEASES; NEURONS; PROTEINS;

EID: 84863858429     PISSN: 03043940     EISSN: 18727972     Source Type: Journal    
DOI: 10.1016/j.neulet.2012.06.026     Document Type: Article

References (24)

1. Arai T., Nonaka T., Hasegawa M., Akiyama H., Yoshida M., Hashizume Y., Tsuchiya K., Oda T., Ikeda K. Neuronal and glial inclusions in frontotemporal dementia with or without motor neuron disease are immunopositive for p62. Neuroscience Letters 2003, 342:41-44.
2. Bjørkøy G., Lamark T., Brech A., Outzen H., Perander M., Øvervatn A., Stenmark H., Johansen T. p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death. Journal of Cell Biology 2005, 171:603-614.
3. Campbell I.G., Nicolai H.M., Foulkes W.D., Senger G., Stamp G.W., Allan G., Boyer C., Jones K., Bast R.C., Solomon E. A novel gene encoding a B-box protein within the BRCA1 region at 17q21.1. Human Molecular Genetics 1994, 3:589-594.
4. Chambers J.A., Solomon E. Isolation of the murine Nbr1 gene adjacent to the murine Brca1 gene. Genomics 1996, 38:305-313.
5. Crews L., Spencer B., Desplats P., Patrick C., Paulino A., Rockenstein E., Hansen L., Adame A., Galasko D., Masliah E. Selective molecular alterations in the autophagy pathway in patients with Lewy body disease and in models of alpha-synucleinopathy. PLoS ONE 2010, 5:e9313.
6. Higashi S., Moore D.J., Minegishi M., Kasanuki K., Fujishiro H., Kabuta T., Togo T., Katsuse O., Uchikado H., Furukawa Y., Hino H., Kosaka K., Sato K., Arai H., Wada K., Iseki E. Localization of MAP1-LC3 in vulnerable neurons and Lewy bodies in brains of patients with dementia with Lewy bodies. Journal of Neuropathology and Experimental Neurology 2011, 70:264-280.
7. Itakura E., Mizushima N. p62 Targeting to the autophagosome formation site requires self-oligomerization but not LC3 binding. Journal of Cell Biology 2011, 192:17-27.
8. Johansen T., Lamark T. Selective autophagy mediated by autophagic adapter proteins. Autophagy 2011, 7:279-296.
9. Kabeya Y., Mizushima N., Ueno T., Yamamoto A., Kirisako T., Noda T., Kominami E., Ohsumi Y., Yoshimori T. LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing. EMBO Journal 2000, 19:5720-5728.
10. Kirkin V., Lamark T., Sou Y.S., Bjorkoy G., Nunn J.L., Bruun J.A., Shvets E., McEwan D.G., Clausen T.H., Wild P., Bilusic I., Theurillat J.P., Overvatn A., Ishii T., Elazar Z., Komatsu M., Dikic I., Johansen T. A role for NBR1 in autophagosomal degradation of ubiquitinated substrates. Molecular Cell 2009, 33:505-516.
11. Kuusisto E., Kauppinen T., Alafuzoff I. Use of p62/SQSTM1 antibodies for neuropathological diagnosis. Neuropathology and Applied Neurobiology 2008, 34:169-180.
12. Kuusisto E., Salminen A., Alafuzoff I. Ubiquitin-binding protein p62 is present in neuronal and glial inclusions in human tauopathies and synucleinopathies. Neuroreport 2001, 12:2085-2090.
13. Mori F., Tanji K., Kakita A., Takahashi H., Wakabayashi K. Enhancement of native and phosphorylated TDP-43 immunoreactivity by proteinase K treatment following autoclave heating. Neuropathology 2011, 31:401-404.
14. Mori F., Tanji K., Kon T., Odagiri S., Hattori M., Hoshikawa Y., Kono C., Yasui K., Yokoi S., Hasegawa Y., Yoshida M., Wakabayashi K K. FUS immunoreactivity of neuronal and glial intranuclear inclusions in intranuclear inclusion body disease. Neuropathology and Applied Neurobiology 2012, 38:322-328.
15. Mori F., Tanji K., Toyoshima Y., Yoshida M., Kakita A., Takahashi H., Wakabayashi K. Optineurin immunoreactivity in neuronal nuclear inclusions of polyglutamine diseases (Huntington's, DRPLA SCA2, SCA3) and intranuclear inclusion body disease. Acta Neuropathologica 2012, 123:747-749.
16. Nakano T., Nakaso K., Nakashima K., Ohama E. Expression of ubiquitin-binding protein p62 in ubiquitin-immunoreactive intraneuronal inclusions in amyotrophic lateral sclerosis with dementia: analysis of five autopsy cases with broad clinicopathological spectrum. Acta Neuropathologica 2004, 107:359-364.
17. Odagiri S., Tanji K., Mori F., Kakita A., Takahashi H., Kamitani T., Wakabayashi K. Immunohistochemical analysis of Marinesco bodies, using antibodies against proteins implicated in the ubiquitin-proteasome system, autophagy and aggresome formation. Neuropathology 2012, 32:261-266.
18. S. Odagiri, K. Tanji, F. Mori, A. Kakita, H. Takahashi, K. Wakabayashi, Autophagic adapter protein, NBR1, is localized in Lewy bodies and glial cytoplasmic inclusions in α-synucleinopathy, Acta Neuropathologica, in press. doi:10.1007/s00401-012-0975-7.
19. Seibenhener M.L., Babu J.R., Geetha T., Wong H.C., Krishna N.R., Wooten M.W. Sequestosome 1/p62 is a polyubiquitin chain binding protein involved in ubiquitin proteasome degradation. Molecular and Cellular Biology 2004, 24:8055-8068.
20. Svenning S., Lamark T., Krause K., Johansen T. Plant NBR1 is a selective autophagy substrate and a functional hybrid of the mammalian autophagic adapters NBR1 and p62/SQSTM1. Autophagy 2011, 7:993-1010.
21. Takahashi T., Katada S., Onodera O. Polyglutamine diseases: Where does toxicity come from What is toxicity? Where are we going?. Journal of Molecular Cell Biology 2010, 2:180-191.
22. Tanji K., Mori F., Kakita A., Takahashi H., Wakabayashi K. Alteration of autophagosomal proteins (LC3, GABARAP and GATE-16) in Lewy body disease. Neurobiology of Disease 2011, 43:690-697.
23. Waters S., Marchbank K., Solomon E., Whitehouse C., Gautel M. Interactions with LC3 and polyubiquitin chains link nbr1 to autophagic protein turnover. FEBS Letters 2009, 583:1846-1852.
24. Weidberg H., Shvets E., Shpilka T., Shimron F., Shinder V., Elazar Z. LC3 and GATE-16/GABARAP subfamilies are both essential yet act differently in autophagosome biogenesis. EMBO Journal 2010, 29:1792-1802.