Regulation of autophagy by cytoplasmic p53

Nature Cell Biology

Volumn 10, Issue 6, 2008, Pages 676-687

  Tasdemir, Ezgi ^a,b,c   Maiuri, M Chiara ^a,b,d   Galluzzi, Lorenzo ^a,b,c   Vitale, Ilio ^a,b,c   Djavaheri Mergny, Mojgan ^a   D'Amelio, Marcello ^e   Criollo, Alfredo ^a,b,c   Morselli, Eugenia ^a,b,c   Zhu, Changlian ^f   Harper, Francis ^g   Nannmark, Ulf ^f   Samara, Chrysanthi ^h   Pinton, Paolo ⁱ   Vicencio, José Miguel ^a,b,c   Carnuccio, Rosa ^d   Moll, Ute M ^j   Madeo, Frank ^k   Paterlini Brechot, Patrizia ^a   Rizzuto, Rosario ⁱ   Szabadkai, Gyorgy ^a,l   Pierron, Gérard ^g   Blomgren, Klas ^f   Tavernarakis, Nektarios ^h   Codogno, Patrice ^a   Cecconi, Francesco ^e   Kroemer, Guido ^a,b,c   more..

^a INSERM   (France)

^b INSTITUT GUSTAVE ROUSSY   (France)

^c UNIVERSITÉ PARIS SACLAY   (France)

^d UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^e UNIVERSITY OF ROME TOR VERGATA   (Italy)

^f UNIVERSITY OF GOTHENBURG   (Sweden)

^g CNRS   (France)

^h INSTITUTE OF MOLECULAR BIOLOGY AND BIOTECHNOLOGY   (Greece)

ⁱ UNIVERSITY OF FERRARA   (Italy)

^j STONY BROOK UNIVERSITY   (United States)

^k UNIVERSITY OF GRAZ   (Austria)

^l UNIVERSITY COLLEGE LONDON   (United Kingdom)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; PROTEIN P53; RAPAMYCIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; AUTOPHAGY; CANCER CELL CULTURE; CELL CYCLE REGULATION; CELL NUCLEUS; CELL STRESS; ENDOPLASMIC RETICULUM; FOOD DEPRIVATION; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FUNCTION; TUMOR SUPPRESSOR GENE;

ANIMALS; ANOXIA; AUTOPHAGY; CELL LINE, TUMOR; CYTOPLASM; ENDOPLASMIC RETICULUM; GENE EXPRESSION REGULATION; GENES, P53; HUMANS; LYSOSOMES; MICE; MICE, TRANSGENIC; MODELS, BIOLOGICAL; PROTEASOME ENDOPEPTIDASE COMPLEX; TUMOR SUPPRESSOR PROTEIN P53;

EID: 44649141966     PISSN: 14657392     EISSN: None     Source Type: Journal    
DOI: 10.1038/ncb1730     Document Type: Article

References (50)

1. Levine, B. & Kroemer, G. Autophagy in the pathogenesis of disease. Cell 132, 27-42 (2008).
2. Levine, B. & Yuan, J. Autophagy in cell death: An innocent convict? J. Clin. Invest. 115, 2679-2688 (2005).
3. Degenhardt, K. et al. Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis. Cancer Cell 10, 51-64 (2006).
4. Qu, X. et al. Autophagy gene-dependent clearance of apoptotic cells during embryonic development. Cell 128, 931-946 (2007).
5. Matthew, R., Karantza-Wadsworth, V. & White, E. Role of autophagy in cancer. Nature Rev. Cancer 7, 961-967 (2007).
6. Kroemer, G. & Jaattela, M. Lysosomes and autophagy in cell death control. Nature Rev. Cancer 5, 886-897 (2005).
7. Boya, P. et al. Inhibition of macroautophagy triggers apoptosis. Mol. Cell Biol. 25, 1025-1040 (2005).
8. Maiuri, C., Zalckvar, E., Kimchi, A. & Kroemer, G. Self-eating and self-killing: Cross-talk between autophagy and apoptosis. Nature Rev. Mol. Cell Biol. 8, 741-752 (2007).
9. Vousden, K. H. & Lane, D. P. p53 in health and disease. Nature Rev. Mol. Cell Biol. 8, 275-283 (2007).
10. Feng, Z., Zhang, H., Levine, A. J. & Jin. S. The coordinate regulation of the p53 and mTOR pathways in cells. Proc. Natl Acad. Sci. USA 102, 8204-8209 (2005).
11. Martins, C. P., Brown-Swigart, L. & Evan, G. I. Modeling the therapeutic efficacy of p53 restoration in tumors. Cell 127, 1323-1334 (2006).
12. Xue, W. et al. Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas. Nature 445, 656-660 (2007).
13. Amaravadi, R. K. et al. Autophagy inhibition enhances therapy-induced apoptosis in a Myc-induced model of lymphoma. J. Clin. Invest. 117, 326-336 (2007).
14. Crighton, D. et al. DRAM, a p53-induced modulator of autophagy, is critical for apoptosis. Cell 126, 121-134 (2006).
15. Bunz, F. et al. Disruption of p53 in human cancer cells alters the responses to therapeutic agents. J. Clin. Invest. 104, 263-269 (1999).
16. Komarov, P. G. et al. A chemical inhibitor of p53 that protects mice from the side effects of cancer therapy. Science 285, 1733-1737 (1999).
17. Klionsky, D. J. & al., e. Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy 4, 151-175 (2008).
18. Mizushima, N., Yamamoto, A., Matsui, M., Yoshimori, T. & Ohsumi, Y. In vivo analysis of autophagy in response to nutrient starvation using transgenic mice expressing a fluorescent autophagosome marker. Mol. Biol. Cell 15, 1101-1111 (2004).
19. Criollo, A. et al. Regulation of autophagy by the inositol trisphosphate receptor. Cell Death Differ. 14, 1029-1039 (2007).
20. Liang, X. H. et al. Induction of autophagy and inhibition of tumorigenesis by beclin 1. Nature 402, 672-676 (1999).
21. Mizushima, N. & Yoshimori, T. How to Interpret LC3 Immunoblotting. Autophagy 3 (2007).
22. Meley, D. et al. AMP-activated protein kinase and the regulation of autophagic proteolysis. J. Biol. Chem. 281, 34870-34879 (2006).
23. Faivre, S., Kroemer, G. & Raymond, E. Current development of mTOR inhibitors as anticancer agents. Nature Rev. Drug Discov. 5, 671-688 (2006).
24. Lum, J. J., DeBerardinis, R. J. & Thompson, C. B. Autophagy in metazoans: Cell survival in the land of plenty. Natue Rev. Mol. Cell Biol. 6, 439-448 (2005).
25. Talos, F., Petrenko, O., Mena, P. & Moll, U. M. Mitochondrially targeted p53 has tumor suppressor activities in vivo. Cancer Res. 65, 9971-9981 (2005).
26. Baker, S. J. et al. Chromosome 17 deletions and p53 gene mutations in colorectal carcinomas. Science 244, 217-221 (1989).
27. Tomita, Y. et al. WT p53, but not tumor-derived mutants, bind to Bc12 via the DNA binding domain and induce mitochondrial permeabilization. J. Biol. Chem. 281, 8600-8606 (2006).
28. -/- mouse embryo fibroblasts. Oncogene 13, 739-748 (1996).
29. Ogata, M. et al. Autophagy is activated for cell survival after endoplasmic reticulum stress. Mol. Cell Biol. 26, 9220-9231 (2006).
30. Qu, L. et al. Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta. Genes Dev. 18, 261-277 (2004).
31. Pluquet, O., Qu, L. K., Baltzis, D. & Koromilas, A. E. Endoplasmic reticulum stress accelerates p53 degradation by the cooperative actions of Hdm2 and glycogen synthase kinase 3β. Mol. Cell Biol. 25 9392-9405 (2005).
32. Yorimitsu, T., Nair, U., Yang, Z. & Klionsky, D. J. Endoplasmic reticulum stress triggers autophagy. J. Biol. Chem. 281, 30299-30304 (2006).
33. Vassilev, L. T. et al. In vivo activation of the p53 pathway by small-molecule antagonists of MDM2. Science 303, 844-848 (2004).
34. Issaeva, N. et al. Small molecule RITA binds to p53, blocks p53-HDM-2 interaction and activates p53 function in tumors. Nature Med. 10, 1321-1328 (2004).
35. Kubbutat, M. H., Jones, S. N. & Vousden, K. H. Regulation of p53 stability by Mdm2. Nature 387, 299-303 (1997).
36. Mihara, M. et al. p53 has a direct apoptogenic role at the mitochondria. Mol. Cell 11, 577-590 (2003).
37. Chipuk, J. E., Maurer, U., Green, D. R. & Schuler, M. Pharmacologic activation of p53 elicits Bax-dependent apoptosis in the absence of transcription. Cancer Cell 4, 371-381 (2003).
38. Chipuk, J. E. et al. Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis. Science 303, 1010-1014 (2004).
39. Pattingre, S. et al. Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy. Cell 122, 927-939 (2005).
40. Leu, J. I., Dumont, P., Hafey, M., Murphy, M. E. & George, D. L. Mitochondrial p53 activates Bak and causes disruption of a Bak-Mcll complex. Nature Cell Biol. 6, 443-450 (2004).
41. Maiuri, M. C. et al. Functional and physical interaction between Bcl-X(L) and a BH3-like domain in Beclin-1. EMBO J. 26, 2527-2539 (2007).
42. Feng, Z. et al. The regulation of AMPK β1, TSC2, and PTEN expression by p53: Stress, cell and tissue specificity, and the role of these gene products in modulating the IGF-1-AKT-mTOR pathways. Cancer Res. 67, 3043-3053 (2007).
43. Fabbro, M. & Henderson, B. R. Regulation at tumor suppressors by nuclear-cytoplasmic shuttling. Exp. Cell Res. 282, 59-69 (2003).
44. Toledo, F. & Wahl, G. M. Regulating the p53 pathway: in vitro hypotheses, in vivo veritas. Nature Rev. Cancer 6, 909-923 (2006).
45. Lim, Y. P. et al. The p53 knowledgebase: An integrated information resource for p53 research. Oncogene 26, 1517-1521 (2007).
46. Jones, R. G. et al. AMP-activated protein kinase induces a p53-dependent metabolic checkpoint. Mol. Cell 18, 283-293 (2005).
47. Rubinsztein, D. C., Gestwicki, J. E., Murphy, L. O. & Klionsky, D. J. Potential therapeutic applications of autophagy. Nature Rev. Drug Discov. 6, 304-312. (2007).
48. Hanahan, D. & Weinberg, R. A. The hallmarks of cancer. Cell 100 57-70 (2000).
49. Brahimi-Horn, M. C., Chiche, J. & Pouyssegur, J. Hypoxia signalling controls metabolic demand. Curr. Opin. Cell Biol. 19, 223-229 (2007).
50. Kabeya, Y. et al. LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing. EMBO J. 19, 5720-5728 (2000).