Microtubule disruption inhibits autophagosome-lysosome fusion: Implications for studying the roles of aggresomes in polyglutamine diseases

International Journal of Biochemistry and Cell Biology

Volumn 36, Issue 10, 2004, Pages 1910-1919

  Webb, Julie L ^a   Ravikumar, Brinda ^a   Rubinsztein, David C ^a  

^a ADDENBROOKE S HOSPITAL   (United Kingdom)

Author keywords

Aggresomes; Alpha synuclein; Autophagy; Huntington's disease; Nocodazole; Polyglutamine diseases

Indexed keywords

ALANINE; GLUTAMINE; HUNTINGTIN; NOCODAZOLE DERIVATIVE; POLYGLUTAMINE;

ANIMAL CELL; ARTICLE; AUTOPHAGY; CELL DISRUPTION; CELL INCLUSION; CELL PROTECTION; CELL STRAIN; CONTROLLED STUDY; DRUG INHIBITION; EXON; HUNTINGTON CHOREA; MICROTUBULE ASSEMBLY; NONHUMAN; PARKINSON DISEASE; PHAGOSOME; PROTEIN AGGREGATION; PROTEIN DEGRADATION; PROTEIN EXPRESSION; RAT;

EID: 2942566227     PISSN: 13572725     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biocel.2004.01.027     Document Type: Article

References (31)

1. Ambrose C.M., Duyao M.P., Barnes G., Bates G.P., Lin C.S., Srinidhi J., et al. Structure and expression of the Huntington's disease gene: evidence against simple inactivation due to an expanded CAG repeat. Somatosensory & Motor Research. 20:1994;27-38
2. Aplin A., Jasionowski T., Tuttle D.L., Lenk S.E., Dunn W.A. Jr. Cytoskeletal elements are required for the formation and maturation of autophagic vacuoles. Journal of Cellular Physiology. 152:1992;458-466
3. Brais B., Bouchard J.P., Xie Y.G., Rochefort D.L., Chretien N., Tome F.M., et al. Short GCG expansions in the PABP2 gene cause oculopharyngeal muscular dystrophy. Nature Genetics. 18:1998;164-167
4. Garcia-Mata R., Bebock Z., Sorscher E.J., Sztul E.S. Characterization and dynamics of aggresome formation by a cytosolic GFP-chimera. Journal of Cell Biology. 146:1999;1239-1254
5. Gusella J.F., McNeil S., Persichetti F., Srinidhi J., Nevelletto A., Bird E., et al. Huntington's disease. Cold Spring Harbor Symposia. 61:1996;615-626
6. Hazeki N., Tukamoto T., Goto J., Kanazawa I. Formic acid dissolves aggregates of an N-terminal Huntingtin fragment containing an expanded polyglutamine tract: applying to quantification of protein components of the aggregates. Biochemical and Biophysical Research Communications. 277:2000;386-393
7. Ho L., Carmichael J., Swartz J.E., Wyttenbach A., Rankin J., Rubinsztein D.C. The molecular biology of Huntington's disease. Psychological Medicine. 31:2001;3-14
8. Hoyvik H., Gordon P.B., Seglen P.O. Use of a hydrolysable probe, [14C]lactose, to distinguish between pre-lysosomal and lysosomal steps in the autophagic pathway. Experimental Cell Research. 166:1986;1-14
9. Johnston J.A., Ward C.L., Kopito R.R. Aggresomes: a cellular response to misfolded proteins. Journal of Cell Biology. 143:1998;1883-1898
10. Kabeya Y., Mizushima N., Ueno T., Yamoto A., Kirisako T., Noda T., et al. LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing. The EMBO Journal. 19:2000;5720-5728
11. Kahle P.J., Haass C., Kretzschmar H.A., Neumann M. Structure/function of alpha-synuclein in health and disease: rational development of animal models for Parkinson's and related diseases. Journal of Neurochemistry. 82:2002;449-457
12. Klionsky D.J., Oshumi Y. Vacuolar import of proteins and organelles from the cytoplasm. Annual Review of Cell and Developmental Biology. 15:1999;1-32
13. Kopito R.R. Aggresomes. Trends in Cell Biology. 10:2000;524-530
14. Kovacs A.L., Reith A., Seglen P.O. Accumulation of autophagosomes after inhibition of hepatocytic protein degradation by vinblastine, leupeptin or a lysosomotropic amine. Experimental Cell Research. 137:1982;191-201
15. Lin C., Tallaksen-Greene S., Chien W., Cearley J.A., Jackson W.S., Crouse A.B., et al. Neurological abnormalities in a knock-in mouse model of Huntington's disease. Human Molecular Genetics. 10:2001;137-144
16. Mizushima N., Ohsumi Y., Yoshimori T. Autophagosome formation in Mammalian cells. Cell Structure and Function. 27:2002;421-429
17. Muchowski P.J., Ning K., D'Souza-Schorey C., Fields S. Requirement of an intact microtubule cytoskeleton for aggregation and inclusion body formation by a mutant huntingtin fragment. Proceedings of the National Academy of Sciences of the United States of America. 99:2002;727-732
18. Narain J., Wyttenbach A., Rankin J., Furlong R.A., Rubinsztein D.C. A molecular investigation of true dominance in Huntington's disease. Journal of Medical Genetics. 36:1999;739-746
19. Peters M.F., Nucifora F.C. Jr., Kushi J., Seaman H.C., Cooper J.K., Herring W.J., et al. Nuclear targeting of mutant Huntingtin increases toxicity. Molecular and Cellular Neurosciences. 14:1999;121-128
20. Rankin J., Wyttenbach A., Rubinsztein D.C. Intracellular green fluorescent protein-polyalanine aggregates are associated with cell death. Biochemistry Journal. 348:2000;15-19
21. Ravikumar B., Stewart A., Kita H., Kato K., Duden R., Rubinsztein D.C. Raised intracellular glucose concentrations reduce aggregation and cell death caused by mutant huntingtin exon 1 by decreasing mTOR phosphorylation and inducing autophagy. Human Molecular Genetics. 12:2003;985-994
22. Ravikumar B., Duden R., Rubinsztein D.C. Aggregate-prone proteins with polyglutamine and polyalanine expansions are degraded by autophagy. Human Molecular Genetics. 11:2002;1107-1117
23. Rennel E., Gerwins P. How to make tetracycline-regulated transgene expression go on and off. Analytical Biochemistry. 309:2002;79-84
24. Sánchez I., Mahlke C., Yuan J. Pivotal role of oligomerization in expanded polyglutamine neurodegenerative disorders. Nature. 42:2003;373-379
25. Sathasivam K., Amaechi I., Mangiarini L., Bates G. Identification of an HD patient with a (CAG)180 repeat expansion and the propagation of highly expanded CAG repeats in lambda phage. Human Genetics. 99:1997;692-695
26. Taylor J.P., Tanaka F., Robitschek J., Sandoval C.M., Taye A., Markovic-Plese S., et al. Aggresomes protect cells by enhancing the degradation of toxic polyglutamine-containing protein. Human Molecular Genetics. 12:2003;749-757
27. Vasquez R.J., Hoewll B., Yvon A.M., Wadsworth P., Cassimeris L. Nanomolar concentrations of nocodazole alter microtubule dynamic instability in vivo and in vitro. Molecular Biology of the Cell. 8:1997;973-985
28. Waelter S., Boeddrich A., Lurz R., Scherzinger E., Lueder G., Lehrach H., et al. Accumulation of mutant huntingtin fragments in aggresome-like inclusion bodies as a result of insufficient protein degradation. Molecular Biology of the Cell. 12:2001;1393-1407
29. Webb J.L., Ravikumar B., Atkins J., Skepper J.N., Rubinsztein D.C. α-Synuclein is degraded by both autophagy and the proteasome. Journal of Biological Chemistry. 278:2003;25009-25013
30. Wyttenbach A., Swartz J., Kita H., Thykjaer T., Carmichael J., Bradley J., et al. Polyglutamine expansions cause decreased CRE-mediated transcription and early gene expression changes prior to cell death in an inducible cell model of Huntington's disease. Human Molecular Genetics. 10:2001;1829-1845
31. Yamamoto A., Tagawa Y., Yoshimori T., Moriyama Y., Masaki R., Tashiro Y. Bafilomycin A1 prevents maturation of autophagic vacuoles by inhibiting fusion between autophagosomes and lysosomes in rat hepatoma cell line, H-4-II-E cells. Cell Structure and Function. 23:1998;33-42