Inhibition of mTOR by rapamycin abolishes cognitive deficits and reduces amyloid-β levels in a mouse model of alzheimer's disease

PLoS ONE

Volumn 5, Issue 4, 2010, Pages

  Spilman, Patricia ^e   Podlutskaya, Natalia ^a   Hart, Matthew J ^a   Debnath, Jayanta ^d   Gorostiza, Olivia ^e   Bredesen, Dale ^e   Richardson, Arlan ^a,b,c   Strong, Randy ^a,b,c   Galvan, Veronica ^a  

^a UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^b Mays Cancer Center at UT Health San Antonio   (United States)

^c SOUTH TEXAS VETERANS HEALTH CARE SYSTEM   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e BUCK INSTITUTE FOR RESEARCH ON AGING   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN[1-42]; MAMMALIAN TARGET OF RAPAMYCIN; RAPAMYCIN; AMYLOID BETA PROTEIN; IMMUNOSUPPRESSIVE AGENT; MTOR PROTEIN, MOUSE; TARGET OF RAPAMYCIN KINASE;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOPHAGY; COGNITIVE DEFECT; CONTROLLED STUDY; ENZYME INHIBITION; LEARNING; LIFESPAN; MOUSE; NONHUMAN; SPATIAL MEMORY; TRANSGENIC MOUSE; AGING; ANIMAL; DISEASE MODEL; DRUG ANTAGONISM; DRUG EFFECT; SIGNAL TRANSDUCTION;

MUS; MUS MUSCULUS;

AGING; ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; ANIMALS; AUTOPHAGY; COGNITION DISORDERS; DISEASE MODELS, ANIMAL; IMMUNOSUPPRESSIVE AGENTS; MICE; SIGNAL TRANSDUCTION; SIROLIMUS; TOR SERINE-THREONINE KINASES;

EID: 77956305343     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0009979     Document Type: Article

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