A subdomain of the endoplasmic reticulum forms a cradle for autophagosome formation

Nature Cell Biology

Volumn 11, Issue 12, 2009, Pages 1433-1437

  Hayashi Nishino, Mitsuko ^a,b   Fujita, Naonobu ^c   Noda, Takeshi ^c   Yamaguchi, Akihito ^a   Yoshimori, Tamotsu ^c   Yamamoto, Akitsugu ^b  

^a OSAKA UNIVERSITY   (Japan)

^b NAGAHAMA INSTITUTE OF BIO SCIENCE AND TECHNOLOGY   (Japan)

^c OSAKA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ATG4B PROTEIN, HUMAN; CARRIER PROTEIN; CYSTEINE PROTEINASE; ZFYVE1 PROTEIN, HUMAN;

ANIMAL; ARTICLE; AUTOPHAGY; CELL LINE; ENDOPLASMIC RETICULUM; GENETICS; HUMAN; IMMUNOELECTRON MICROSCOPY; METABOLISM; MOUSE; PHAGOSOME; TRANSMISSION ELECTRON MICROSCOPY; ULTRASTRUCTURE;

ANIMALS; AUTOPHAGY; CARRIER PROTEINS; CELL LINE; CYSTEINE ENDOPEPTIDASES; ENDOPLASMIC RETICULUM; HUMANS; MICE; MICROSCOPY, ELECTRON, TRANSMISSION; MICROSCOPY, IMMUNOELECTRON; PHAGOSOMES;

EID: 71649087199     PISSN: 14657392     EISSN: 14764679     Source Type: Journal    
DOI: 10.1038/ncb1991     Document Type: Article

References (22)

1. Mizushima, N. Autophagy: process and function. Genes Dev. 21, 2861-2873 (2007). (Pubitemid 350133435)
2. Suzuki, K. & Ohsumi, Y. Molecular machinery of autophagosome formation in yeast, Saccharomyces cerevisiae. FEBS Lett. 581, 2156-2161 (2007). (Pubitemid 46709906)
3. Yoshimori, T. & Noda, T. Toward unraveling membrane biogenesis in mammalian autophagy. Curr. Opin. Cell Biol. 20, 401-407 (2008).
4. Juhasz, G. & Neufeld, T. P. Autophagy: a forty-year search for a missing membrane source. PLoS Biol. 4, e36 (2006).
5. Dunn, W.A. Jr Autophagy and related mechanisms of lysosome-mediated protein degradation. Trends Cell Biol. 4, 139-143 (1994). (Pubitemid 24107709)
6. Furuno, K. et al. Immunocytochemical study of the surrounding envelope of autophagic vacuoles in cultured rat hepatocytes. Exp. Cell Res. 189, 261-268 (1990).
7. Yamamoto, A., Masaki, R., Fukui, Y. & Tashiro, Y. Absence of cytochrome P-450 and presence of autolysosomal membrane antigens on the isolation membranes and autophagosomal membranes in rat hepatocytes. J. Histochem. Cytochem. 38, 1571-1581 (1990). (Pubitemid 20346967)
8. Yamamoto, A., Masaki, R. & Tashiro, Y. Characterization of the isolation membranes and the limiting membranes of autophagosomes in rat hepatocytes by lectin cytochemistry. J. Histochem. Cytochem. 38, 573-580 (1990). (Pubitemid 20106508)
9. Kovacs, A. L., Palfia, Z., Rez, G., Vellai, T. & Kovacs, J. Sequestration revisited: integrating traditional electron microscopy, de novo assembly and new results. Autophagy 3, 655-662 (2007). (Pubitemid 350064220)
10. Axe, E. L. et al. Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum. J. Cell Biol. 182, 685-701 (2008).
11. Walker, S., Chandra, P., Manifava, M., Axe, E. & Ktistakis, N. T. Making autophagosomes: localized synthesis of phosphatidylinositol 3-phosphate holds the clue. Autophagy 4, 1093-1096 (2008).
12. Fujita, N. et al. An Atg4B mutant hampers the lipidation of LC3 paralogues and causes defects in autophagosome closure. Mol. Biol. Cell 19, 4651-4659 (2008).
13. Fengsrud, M. et al. Ultrastructural and immunocytochemical characterization of autophagic vacuoles in isolated hepatocytes: effects of vinblastine and asparagine on vacuole distributions. Exp. Cell Res. 221, 504-519 (1995).
14. Mizushima, N. et al. Dissection of autophagosome formation using Apg5-deficient mouse embryonic stem cells. J. Cell Biol. 152, 657-668 (2001).
15. Mizushima, N. et al. Mouse Apg16L, a novel WD repeat protein, targets to the autophagic isolation membrane with the Apg12-Apg5 conjugate. J. Cell Sci. 116, 1679-1688 (2003). (Pubitemid 36582155)
16. Saitoh, T. et al. Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL 1β production. Nature 456, 264-268 (2008).
17. McIntosh, R., Nicastro, D. & Mastronarde, D. New views of cells in 3D: an introduction to electron tomography. Trends Cell Biol. 15, 43-51 (2005). (Pubitemid 40094680)
18. Bannykh, S. I., Rowe, T. & Balch, W. E. The organization of endoplasmic reticulum export complexes. J. Cell Biol. 135, 19-35 (1996). (Pubitemid 26337734)
19. Saitoh, T. et al. TWEAK induces NF kappaB2 p100 processing and long lasting NF kappaB activation. J. Biol. Chem. 278, 36005-36012 (2003). (Pubitemid 37139919)
20. Mastronarde, D. N. Dual-axis tomography: an approach with alignment methods that preserve resolution. J. Struct. Biol. 120, 343-352 (1997). (Pubitemid 28137307)
21. Kremer, J. R., Mastronarde, D. N. & McIntosh, J. R. Computer visualization of three-dimensional image data using IMOD. J. Struct. Biol. 116, 71-76 (1996). (Pubitemid 26093126)
22. Wakana, Y. et al. Bap31 is an itinerant protein that moves between the peripheral endoplasmic reticulum (ER) and a juxtanuclear compartment related to ER associated Degradation. Mol. Biol. Cell 19, 1825-1836 (2008).