-
1
-
-
22044442015
-
Autophagosomes: Biogenesis from scratch?
-
Reggiori, F. and Klionsky, D. J. (2005) Autophagosomes: biogenesis from scratch? Curr. Opin. Cell Biol. 17, 415-422.
-
(2005)
Curr. Opin. Cell Biol
, vol.17
, pp. 415-422
-
-
Reggiori, F.1
Klionsky, D.J.2
-
2
-
-
27644484061
-
Autophagy: Molecular machinery for self-eating
-
Yorimitsu, T. and Klionsky, D. J. (2005) Autophagy: molecular machinery for self-eating. Cell Death. Differ. 12, 1542-1552.
-
(2005)
Cell Death. Differ
, vol.12
, pp. 1542-1552
-
-
Yorimitsu, T.1
Klionsky, D.J.2
-
3
-
-
33745192802
-
Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice
-
Hara, T., Nakamura, K., Matsui, M., et al. (2006) Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice. Nature 441, 885-889.
-
(2006)
Nature
, vol.441
, pp. 885-889
-
-
Hara, T.1
Nakamura, K.2
Matsui, M.3
-
4
-
-
33646800306
-
Loss of autophagy in the central nervous system causes neurodegeneration in mice
-
Komatsu, M., Waguri, S., Chiba,T., et al. (2006) Loss of autophagy in the central nervous system causes neurodegeneration in mice. Nature 441, 880-884.
-
(2006)
Nature
, vol.441
, pp. 880-884
-
-
Komatsu, M.1
Waguri, S.2
Chiba, T.3
-
5
-
-
0017697151
-
Induction of autophagy by aminoacid deprivation in perfused rat liver
-
Mortimore, G. E. and Schworer, C. M. (1977) Induction of autophagy by aminoacid deprivation in perfused rat liver. Nature 270, 174-176.
-
(1977)
Nature
, vol.270
, pp. 174-176
-
-
Mortimore, G.E.1
Schworer, C.M.2
-
6
-
-
0030957959
-
Autophagic proteolysis: Control and specificity
-
Blommaart, E. F., Luiken, J. J., and Meijer, A. J. (1997) Autophagic proteolysis: control and specificity. Histochem. J. 29, 365-385.
-
(1997)
Histochem. J
, vol.29
, pp. 365-385
-
-
Blommaart, E.F.1
Luiken, J.J.2
Meijer, A.J.3
-
7
-
-
0014083718
-
Influence of glucagon, an inducer of cellular autophagy, on some physical properties of rat liver lysosomes
-
Deter, R. L. and De Duve, C. (1967) Influence of glucagon, an inducer of cellular autophagy, on some physical properties of rat liver lysosomes. J. Cell Biol. 33, 437-449.
-
(1967)
J. Cell Biol
, vol.33
, pp. 437-449
-
-
Deter, R.L.1
De Duve, C.2
-
8
-
-
0034329612
-
Amino-acid-dependent signal transduction
-
van Sluijters, D. A., Dubbelhuis, P. F., Blommaart, E. F., and Meijer, A. J. (2000) Amino-acid-dependent signal transduction. Biochem. J. 351, 545-550.
-
(2000)
Biochem. J
, vol.351
, pp. 545-550
-
-
van Sluijters, D.A.1
Dubbelhuis, P.F.2
Blommaart, E.F.3
Meijer, A.J.4
-
9
-
-
0038269032
-
Amino acids interfere with the ERK1/2-dependent control of macroautophagy by controlling the activation of Raf-1 in human colon cancer HT-29 cells
-
Pattingre, S., Bauvy, C., and Codogno, P. (2003) Amino acids interfere with the ERK1/2-dependent control of macroautophagy by controlling the activation of Raf-1 in human colon cancer HT-29 cells. J. Biol. Chem. 278, 16667-16674.
-
(2003)
J. Biol. Chem
, vol.278
, pp. 16667-16674
-
-
Pattingre, S.1
Bauvy, C.2
Codogno, P.3
-
10
-
-
33744783122
-
The hepatocyte integrin system and cell volume sensing
-
Häussinger, D., Reinehr, R., and Schliess, F. (2006) The hepatocyte integrin system and cell volume sensing. Acta Physiol (Oxf) 187, 249-255.
-
(2006)
Acta Physiol (Oxf)
, vol.187
, pp. 249-255
-
-
Häussinger, D.1
Reinehr, R.2
Schliess, F.3
-
11
-
-
0037312507
-
Tor signalling in bugs, brain and brawn
-
Jacinto, E. and Hall, M. N. (2003) Tor signalling in bugs, brain and brawn. Nat. Rev. Mol. Cell Biol. 4, 117-126.
-
(2003)
Nat. Rev. Mol. Cell Biol
, vol.4
, pp. 117-126
-
-
Jacinto, E.1
Hall, M.N.2
-
12
-
-
33645990907
-
Regulation of protein synthesis by insulin
-
Proud, C. G. (2006) Regulation of protein synthesis by insulin. Biochem. Soc. Trans. 34, 213-216.
-
(2006)
Biochem. Soc. Trans
, vol.34
, pp. 213-216
-
-
Proud, C.G.1
-
13
-
-
33645997012
-
Bridging the GAP between insulin signaling and GLUT4 translocation
-
Watson, R. T. and Pessin, J. E. (2006) Bridging the GAP between insulin signaling and GLUT4 translocation. Trends Biochem. Sci. 31, 215-222.
-
(2006)
Trends Biochem. Sci
, vol.31
, pp. 215-222
-
-
Watson, R.T.1
Pessin, J.E.2
-
14
-
-
11244297916
-
Dysregulation of the TSCmTOR pathway in human disease
-
Inoki, K., Corradetti, M. N., and Guan, K. L. (2005) Dysregulation of the TSCmTOR pathway in human disease. Nat. Genet. 37, 19-24.
-
(2005)
Nat. Genet
, vol.37
, pp. 19-24
-
-
Inoki, K.1
Corradetti, M.N.2
Guan, K.L.3
-
15
-
-
33646548305
-
The amino acid sensitive TOR pathway from yeast to mammals
-
Dann, S. G. and Thomas, G. (2006) The amino acid sensitive TOR pathway from yeast to mammals. FEBS Lett. 580, 2821-2829.
-
(2006)
FEBS Lett
, vol.580
, pp. 2821-2829
-
-
Dann, S.G.1
Thomas, G.2
-
16
-
-
0027296748
-
Inhibition of hepatocytic autophagy by okadaic acid and other protein phosphatase inhibitors
-
Holen, I., Gordon, P. B., and Seglen, P. O. (1993) Inhibition of hepatocytic autophagy by okadaic acid and other protein phosphatase inhibitors. Eur. J. Biochem. 215, 113-122.
-
(1993)
Eur. J. Biochem
, vol.215
, pp. 113-122
-
-
Holen, I.1
Gordon, P.B.2
Seglen, P.O.3
-
17
-
-
0028234322
-
Cell swelling and the control of autophagic proteolysis in hepatocytes: Involvement of phosphorylation of ribosomal protein S6?
-
Luiken, J. J., Blommaart, E. F., Boon, L., van Woerkom, G. M., and Meijer, A. J. (1994) Cell swelling and the control of autophagic proteolysis in hepatocytes: involvement of phosphorylation of ribosomal protein S6? Biochem. Soc. Trans. 22, 508-511.
-
(1994)
Biochem. Soc. Trans
, vol.22
, pp. 508-511
-
-
Luiken, J.J.1
Blommaart, E.F.2
Boon, L.3
van Woerkom, G.M.4
Meijer, A.J.5
-
18
-
-
0028899789
-
Phosphorylation of ribosomal protein S6 is inhibitory for autophagy in isolated rat hepatocytes
-
Blommaart, E. F., Luiken, J. J., Blommaart, P. J., van Woerkom, G. M., and Meijer, A. J. (1995) Phosphorylation of ribosomal protein S6 is inhibitory for autophagy in isolated rat hepatocytes. J. Biol. Chem. 270, 2320-2326.
-
(1995)
J. Biol. Chem
, vol.270
, pp. 2320-2326
-
-
Blommaart, E.F.1
Luiken, J.J.2
Blommaart, P.J.3
van Woerkom, G.M.4
Meijer, A.J.5
-
19
-
-
8344242220
-
Autophagy in health and disease: A double-edged sword
-
Shintani, T. and Klionsky, D. J. (2004) Autophagy in health and disease: a double-edged sword. Science 306, 990-995.
-
(2004)
Science
, vol.306
, pp. 990-995
-
-
Shintani, T.1
Klionsky, D.J.2
-
20
-
-
0032512636
-
Tor, a phosphatidylinositol kinase homologue, controls autophagy in yeast
-
Noda, T. and Ohsumi, Y. (1998) Tor, a phosphatidylinositol kinase homologue, controls autophagy in yeast. J. Biol. Chem. 273, 3963-3966.
-
(1998)
J. Biol. Chem
, vol.273
, pp. 3963-3966
-
-
Noda, T.1
Ohsumi, Y.2
-
21
-
-
32944460806
-
In yeast, loss of Hogl leads to osmosensitivity of autophagy
-
Prick, T., Thumm, M., Kohrer, K., Häussinger, D., and vom Dahl, S. (2006) In yeast, loss of Hogl leads to osmosensitivity of autophagy. Biochem. J. 394, 153-161.
-
(2006)
Biochem. J
, vol.394
, pp. 153-161
-
-
Prick, T.1
Thumm, M.2
Kohrer, K.3
Häussinger, D.4
vom Dahl, S.5
-
22
-
-
11144219992
-
Glucagon represses signaling through the mammalian target of rapamycin in rat liver by activating AMP-activated protein kinase
-
Kimball, S. R., Siegfried, B. A., and Jefferson, L. S. (2004) Glucagon represses signaling through the mammalian target of rapamycin in rat liver by activating AMP-activated protein kinase. J. Biol. Chem. 279, 54103-54109.
-
(2004)
J. Biol. Chem
, vol.279
, pp. 54103-54109
-
-
Kimball, S.R.1
Siegfried, B.A.2
Jefferson, L.S.3
-
23
-
-
5644285347
-
In rat hepatocytes glucagon increases mammalian target of rapamycin phosphorylation on serine 2448 but antagonizes the phosphorylation of its downstream targets induced by insulin and amino acids
-
Mothe-Satney, I., Gautier, N., Hinault, C., Lawrence, J. C., Jr., and van Obberghen, E. (2004) In rat hepatocytes glucagon increases mammalian target of rapamycin phosphorylation on serine 2448 but antagonizes the phosphorylation of its downstream targets induced by insulin and amino acids. J. Biol. Chem. 279, 42628-42637.
-
(2004)
J. Biol. Chem
, vol.279
, pp. 42628-42637
-
-
Mothe-Satney, I.1
Gautier, N.2
Hinault, C.3
Lawrence Jr., J.C.4
van Obberghen, E.5
-
24
-
-
8044257699
-
The phosphatidylinositol 3-kinase inhibitors wortmannin and LY294002 inhibit autophagy in isolated rat hepatocytes
-
Blommaart, E. F., Krause, U., Schellens, J. P., Vreeling-Sindelarova, H., and Meijer, A. J. (1997) The phosphatidylinositol 3-kinase inhibitors wortmannin and LY294002 inhibit autophagy in isolated rat hepatocytes. Eur. J. Biochem. 243, 240-246.
-
(1997)
Eur. J. Biochem
, vol.243
, pp. 240-246
-
-
Blommaart, E.F.1
Krause, U.2
Schellens, J.P.3
Vreeling-Sindelarova, H.4
Meijer, A.J.5
-
25
-
-
0042326762
-
Muscarinic receptormediated activation of p70 S6 kinase 1 (S6K1) in 1321N1 astrocytoma cells: Permissive role of phosphoinositide 3-kinase
-
Tang, X., Wang, L., Proud, C. G., and Downes, C. P. (2003) Muscarinic receptormediated activation of p70 S6 kinase 1 (S6K1) in 1321N1 astrocytoma cells: permissive role of phosphoinositide 3-kinase. Biochem. J. 374, 137-143.
-
(2003)
Biochem. J
, vol.374
, pp. 137-143
-
-
Tang, X.1
Wang, L.2
Proud, C.G.3
Downes, C.P.4
-
26
-
-
26444575415
-
Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase
-
Nobukuni, T., Joaquin, M., Roccio, M., et al. (2005) Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase. Proc. Natl. Acad. Sci. USA 102, 14238-14243.
-
(2005)
Proc. Natl. Acad. Sci. USA
, vol.102
, pp. 14238-14243
-
-
Nobukuni, T.1
Joaquin, M.2
Roccio, M.3
-
27
-
-
25444457577
-
hVps34 is a nutrient-regulated lipid kinase required for activation of p70 S6 kinase
-
Byfield, M. P., Murray, J. T., and Backer, J. M. (2005) hVps34 is a nutrient-regulated lipid kinase required for activation of p70 S6 kinase. J. Biol. Chem. 280, 33076-33082.
-
(2005)
J. Biol. Chem
, vol.280
, pp. 33076-33082
-
-
Byfield, M.P.1
Murray, J.T.2
Backer, J.M.3
-
28
-
-
0033978633
-
Distinct classes of phosphatidylinositol 3'-kinases are involved in signaling pathways that control macroautophagy in HT-29 cells. 7
-
Petiot, A., Ogier-Denis, E., Blommaart, E. F., Meijer, A. J., and Codogno, P. (2000) Distinct classes of phosphatidylinositol 3'-kinases are involved in signaling pathways that control macroautophagy in HT-29 cells. 7. Biol. Chem. 275, 992-998.
-
(2000)
Biol. Chem
, vol.275
, pp. 992-998
-
-
Petiot, A.1
Ogier-Denis, E.2
Blommaart, E.F.3
Meijer, A.J.4
Codogno, P.5
-
29
-
-
0035929650
-
The tumor suppressor PTEN positively regulates macroautophagy by inhibiting the phosphatidylinositol 3kinase/protein kinase B pathway
-
Arico, S., Petiot, A., Bauvy, C., et al. (2001) The tumor suppressor PTEN positively regulates macroautophagy by inhibiting the phosphatidylinositol 3kinase/protein kinase B pathway. J. Biol. Chem. 276, 35243-35246.
-
(2001)
J. Biol. Chem
, vol.276
, pp. 35243-35246
-
-
Arico, S.1
Petiot, A.2
Bauvy, C.3
-
30
-
-
0005677775
-
3-Methyladenine: Specific inhibitor of autophagic/lysosomal protein degradation in isolated rat hepatocytes
-
Seglen, P. O. and Gordon, P. B. (1982) 3-Methyladenine: specific inhibitor of autophagic/lysosomal protein degradation in isolated rat hepatocytes. Proc. Natl. Acad. Sci. USA 79, 1889-1892.
-
(1982)
Proc. Natl. Acad. Sci. USA
, vol.79
, pp. 1889-1892
-
-
Seglen, P.O.1
Gordon, P.B.2
-
31
-
-
0000906170
-
Induction of autophagy and inhibition of tumorigenesis by beclin 1
-
Liang, X. H., Jackson, S., Seaman, M., et al. (1999) Induction of autophagy and inhibition of tumorigenesis by beclin 1. Nature 402, 672-676.
-
(1999)
Nature
, vol.402
, pp. 672-676
-
-
Liang, X.H.1
Jackson, S.2
Seaman, M.3
-
32
-
-
0035032723
-
Beclinphosphatidylinositol 3-kinase complex functions at the trans-Golgi network
-
Kihara, A., Kabeya, Y., Ohsumi, Y., and Yoshimori, T. (2001) Beclinphosphatidylinositol 3-kinase complex functions at the trans-Golgi network. EMBO Rep. 2, 330-335.
-
(2001)
EMBO Rep
, vol.2
, pp. 330-335
-
-
Kihara, A.1
Kabeya, Y.2
Ohsumi, Y.3
Yoshimori, T.4
-
33
-
-
39049194057
-
The Evolutionarily Conserved Domain of Beclin 1 is Required for Vps34 Binding, Autophagy and Tumor Suppressor Function
-
Furuya, N., Yu, J., Byfield, M., Pattingre, S., and Levine, B. (2005) The Evolutionarily Conserved Domain of Beclin 1 is Required for Vps34 Binding, Autophagy and Tumor Suppressor Function. Autophagy 1, 46-52.
-
(2005)
Autophagy
, vol.1
, pp. 46-52
-
-
Furuya, N.1
Yu, J.2
Byfield, M.3
Pattingre, S.4
Levine, B.5
-
34
-
-
25144457455
-
Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy
-
Pattingre, S., Tassa, A., Qu, X., et al. (2005) Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy. Cell 122, 927-939.
-
(2005)
Cell
, vol.122
, pp. 927-939
-
-
Pattingre, S.1
Tassa, A.2
Qu, X.3
-
35
-
-
0347986620
-
Class III phosphoinositide 3-kinase-Beclinl complex mediates the amino acid-dependent regulation of autophagy in C2C12 myotubes
-
Tassa, A., Roux, M. P., Attaix, D., and Bechet, D. M. (2003) Class III phosphoinositide 3-kinase-Beclinl complex mediates the amino acid-dependent regulation of autophagy in C2C12 myotubes. Biochem. J. 376, 577-586.
-
(2003)
Biochem. J
, vol.376
, pp. 577-586
-
-
Tassa, A.1
Roux, M.P.2
Attaix, D.3
Bechet, D.M.4
-
36
-
-
0034703021
-
Leucine limitation induces autophagy and activation of lysosome-dependent proteolysis in C2C12 myotubes through a mammalian target of rapamycin- independent signaling pathway
-
Mordier, S., Deval, C., Bechet, D., Tassa, A., and Ferrara, M. (2000) Leucine limitation induces autophagy and activation of lysosome-dependent proteolysis in C2C12 myotubes through a mammalian target of rapamycin- independent signaling pathway. J. Biol. Chem. 275, 29900-29906.
-
(2000)
J. Biol. Chem
, vol.275
, pp. 29900-29906
-
-
Mordier, S.1
Deval, C.2
Bechet, D.3
Tassa, A.4
Ferrara, M.5
-
37
-
-
1542289063
-
Amino acids and insulin control autophagic proteolysis through different signaling pathways in relation to mTOR in isolated rat hepatocytes
-
Kanazawa, T., Taneike, I., Akaishi, R., et al. (2004) Amino acids and insulin control autophagic proteolysis through different signaling pathways in relation to mTOR in isolated rat hepatocytes. J. Biol. Chem. 279, 8452-8459.
-
(2004)
J. Biol. Chem
, vol.279
, pp. 8452-8459
-
-
Kanazawa, T.1
Taneike, I.2
Akaishi, R.3
-
38
-
-
33744803992
-
Cell hydration and mTOR-dependent signalling
-
Schliess, F., Richter, L., vom Dahl, S., and Häussinger, D. (2006) Cell hydration and mTOR-dependent signalling. Acta Physiol (Oxf). 187, 223-229.
-
(2006)
Acta Physiol (Oxf)
, vol.187
, pp. 223-229
-
-
Schliess, F.1
Richter, L.2
vom Dahl, S.3
Häussinger, D.4
-
39
-
-
10044219517
-
Amino acids and leucine allow insulin activation of the PKB/mTOR pathway in normal adipocytes treated with wortmannin and in adipocytes from db/db mice
-
Hinault, C., Mothe-Satney, I., Gautier, N., Lawrence, J. C., Jr., and van Obberghen, E. (2004) Amino acids and leucine allow insulin activation of the PKB/mTOR pathway in normal adipocytes treated with wortmannin and in adipocytes from db/db mice. FASEB J. 18, 1894-1896.
-
(2004)
FASEB J
, vol.18
, pp. 1894-1896
-
-
Hinault, C.1
Mothe-Satney, I.2
Gautier, N.3
Lawrence Jr., J.C.4
van Obberghen, E.5
-
40
-
-
14344254476
-
Inhibition of wortmannin activities by amino compounds
-
Isosaki M. (2004) Inhibition of wortmannin activities by amino compounds. Biochem. Biophys. Res. Commun. 324, 1406-1412.
-
(2004)
Biochem. Biophys. Res. Commun
, vol.324
, pp. 1406-1412
-
-
Isosaki, M.1
-
41
-
-
0034683568
-
Tor-mediated induction of autophagy via an Apg1 protein kinase complex
-
Kamada, Y., Funakoshi, T., Shintani, T., Nagano, K., Ohsumi, M., and Ohsumi, Y. (2000) Tor-mediated induction of autophagy via an Apg1 protein kinase complex. J. Cell Biol. 150, 1507-1513.
-
(2000)
J. Cell Biol
, vol.150
, pp. 1507-1513
-
-
Kamada, Y.1
Funakoshi, T.2
Shintani, T.3
Nagano, K.4
Ohsumi, M.5
Ohsumi, Y.6
-
42
-
-
18244394277
-
Atg17 functions in cooperation with Atg1 and Atg13 in yeast autophagy
-
Kabeya, Y., Kamada, Y., Baba, M., Takikawa, H., Sasaki, M., and Ohsumi, Y. (2005) Atg17 functions in cooperation with Atg1 and Atg13 in yeast autophagy. Mol. Biol. Cell 16, 2544-2553.
-
(2005)
Mol. Biol. Cell
, vol.16
, pp. 2544-2553
-
-
Kabeya, Y.1
Kamada, Y.2
Baba, M.3
Takikawa, H.4
Sasaki, M.5
Ohsumi, Y.6
-
43
-
-
0035798097
-
Mammalian TOR: A homeostatic ATP sensor
-
Dennis, P. B., Jaeschke, A., Saitoh, M., Fowler, B., Kozma, S. C., and Thomas, G. (2001) Mammalian TOR: a homeostatic ATP sensor. Science 294, 1102-1105.
-
(2001)
Science
, vol.294
, pp. 1102-1105
-
-
Dennis, P.B.1
Jaeschke, A.2
Saitoh, M.3
Fowler, B.4
Kozma, S.C.5
Thomas, G.6
-
44
-
-
0347627140
-
Amino acid signalling and the integration of metabolism
-
Meijer, A. J. and Dubbelhuis, P. F. (2004) Amino acid signalling and the integration of metabolism. Biochem. Biophys. Res. Commun. 313, 397-403.
-
(2004)
Biochem. Biophys. Res. Commun
, vol.313
, pp. 397-403
-
-
Meijer, A.J.1
Dubbelhuis, P.F.2
-
45
-
-
20844451123
-
AMP-activated protein kinase: Ancient energy gauge provides clues to modern understanding of metabolism
-
Kahn, B. B., Alquier, T., Carling, D., and Hardie, D. G. (2005) AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism. Cell Metab. 1, 15-25.
-
(2005)
Cell Metab
, vol.1
, pp. 15-25
-
-
Kahn, B.B.1
Alquier, T.2
Carling, D.3
Hardie, D.G.4
-
46
-
-
3042818799
-
Regulation of the TSC pathway by LKB1 : Evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome
-
Corradetti, M. N., Inoki, K., Bardeesy, N., DePinho, R. A., and Guan, K. L. (2004) Regulation of the TSC pathway by LKB1 : evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome. Genes Dev. 18, 1533-1538.
-
(2004)
Genes Dev
, vol.18
, pp. 1533-1538
-
-
Corradetti, M.N.1
Inoki, K.2
Bardeesy, N.3
DePinho, R.A.4
Guan, K.L.5
-
47
-
-
1942469564
-
Thr2446 is a novel mammalian target of rapamycin (mTOR) phosphorylation site regulated by nutrient status
-
Cheng, S. W., Fryer, L. G., Carling, D., and Shepherd, P. R. (2004) Thr2446 is a novel mammalian target of rapamycin (mTOR) phosphorylation site regulated by nutrient status. J. Biol. Chem. 279, 15719-15722.
-
(2004)
J. Biol. Chem
, vol.279
, pp. 15719-15722
-
-
Cheng, S.W.1
Fryer, L.G.2
Carling, D.3
Shepherd, P.R.4
-
48
-
-
0034898851
-
Antagonistic controls of autophagy and glycogen accumulation by Snf1p, the yeast homolog of AMP-activated protein kinase, and the cyclin-dependent kinase Pho85p
-
Wang, Z., Wilson, W. A., Fujino, M. A., and Roach, P. J. (2001) Antagonistic controls of autophagy and glycogen accumulation by Snf1p, the yeast homolog of AMP-activated protein kinase, and the cyclin-dependent kinase Pho85p. Mol. Cell Biol. 21, 5742-5752.
-
(2001)
Mol. Cell Biol
, vol.21
, pp. 5742-5752
-
-
Wang, Z.1
Wilson, W.A.2
Fujino, M.A.3
Roach, P.J.4
-
49
-
-
0032508564
-
Inhibition of hepatocytic autophagy by adenosine, aminoimidazole-4-carboxamide riboside, and N6-mercaptopurine riboside. Evidence for involvement of amp-activated protein kinase
-
Samari, H. R. and Seglen, P. O. (1998) Inhibition of hepatocytic autophagy by adenosine, aminoimidazole-4-carboxamide riboside, and N6-mercaptopurine riboside. Evidence for involvement of amp-activated protein kinase. J. Biol. Chem. 273, 23758-23763.
-
(1998)
J. Biol. Chem
, vol.273
, pp. 23758-23763
-
-
Samari, H.R.1
Seglen, P.O.2
-
50
-
-
27644575235
-
Macroautophagy versus mitochondrial autophagy: A question of fate?
-
Kundu M. and Thompson C. B. (2005) Macroautophagy versus mitochondrial autophagy: a question of fate? Cell Death. Differ. 12., 1484-1489.
-
(2005)
Cell Death. Differ
, vol.12
, pp. 1484-1489
-
-
Kundu, M.1
Thompson, C.B.2
-
51
-
-
33644606491
-
Tracker dyes to probe mitochondrial autophagy (mitophagy) in rat hepatocytes
-
Rodriguez-Enriquez S., Kim I., Currin R. T., and Lemasters J. J. (2006) Tracker dyes to probe mitochondrial autophagy (mitophagy) in rat hepatocytes. Autophagy 2, 39-46.
-
(2006)
Autophagy
, vol.2
, pp. 39-46
-
-
Rodriguez-Enriquez, S.1
Kim, I.2
Currin, R.T.3
Lemasters, J.J.4
-
52
-
-
33746710976
-
Oligomycin A induces autophagy in the IPLB-LdFB insect cell line
-
Tettamanti, G., Malagoli, D., Marchesini, E., Congiu, T., de E. M., and Ottaviani, E. (2006) Oligomycin A induces autophagy in the IPLB-LdFB insect cell line. Cell Tissue Res. 326, 179-186.
-
(2006)
Cell Tissue Res
, vol.326
, pp. 179-186
-
-
Tettamanti, G.1
Malagoli, D.2
Marchesini, E.3
Congiu, T.4
de, E.M.5
Ottaviani, E.6
-
53
-
-
20444363122
-
The coordinate regulation of the p53 and mTOR pathways in cells
-
Feng, Z., Zhang, H., Levine, A. J., and Jin, S. (2005) The coordinate regulation of the p53 and mTOR pathways in cells. Proc. Natl. Acad. Sci. USA 102, 8204-8209.
-
(2005)
Proc. Natl. Acad. Sci. USA
, vol.102
, pp. 8204-8209
-
-
Feng, Z.1
Zhang, H.2
Levine, A.J.3
Jin, S.4
-
54
-
-
32044435126
-
Coordination and communication between the p53 and IGF-1-AKT-TOR signal transduction pathways
-
Levine, A. J., Feng, Z., Mak, T. W., You, H., and Jin, S. (2006) Coordination and communication between the p53 and IGF-1-AKT-TOR signal transduction pathways. Genes Dev. 20, 267-275.
-
(2006)
Genes Dev
, vol.20
, pp. 267-275
-
-
Levine, A.J.1
Feng, Z.2
Mak, T.W.3
You, H.4
Jin, S.5
-
55
-
-
33645531089
-
Elongation factor-2 kinase regulates autophagy in human glioblastoma cells
-
Wu, H., Yang, J. M., Jin, S., Zhang, H., and Hait, W. N. (2006) Elongation factor-2 kinase regulates autophagy in human glioblastoma cells. Cancer Res. 66, 3015-3023.
-
(2006)
Cancer Res
, vol.66
, pp. 3015-3023
-
-
Wu, H.1
Yang, J.M.2
Jin, S.3
Zhang, H.4
Hait, W.N.5
-
56
-
-
1642328617
-
Stimulation of the AMP-activated protein kinase leads to activation of eukaryotic elongation factor 2 kinase and to its phosphorylation at a novel site, serine 398
-
Browne, G. J., Finn, S. G., and Proud, C. G. (2004) Stimulation of the AMP-activated protein kinase leads to activation of eukaryotic elongation factor 2 kinase and to its phosphorylation at a novel site, serine 398. J. Biol. Chem. 279, 12220-12231.
-
(2004)
J. Biol. Chem
, vol.279
, pp. 12220-12231
-
-
Browne, G.J.1
Finn, S.G.2
Proud, C.G.3
-
57
-
-
33845924783
-
AMP-activated protein kinase and the regulation of autophagic proteolysis
-
Meley, D., Bauvy, C., Houben-Weerts, J. H., et al. (2006) AMP-activated protein kinase and the regulation of autophagic proteolysis. J. Biol. Chem. 281, 34870-34879.
-
(2006)
J. Biol. Chem
, vol.281
, pp. 34870-34879
-
-
Meley, D.1
Bauvy, C.2
Houben-Weerts, J.H.3
-
58
-
-
0035578226
-
Exogenous amino acids regulate trophectoderm differentiation in the mouse blastocyst through an mTORdependent pathway
-
Martin, P. M. and Sutherland, A. E. (2001) Exogenous amino acids regulate trophectoderm differentiation in the mouse blastocyst through an mTORdependent pathway. Dev. Biol. 240, 182-193.
-
(2001)
Dev. Biol
, vol.240
, pp. 182-193
-
-
Martin, P.M.1
Sutherland, A.E.2
-
59
-
-
0037662713
-
Regulation of targets of mTOR (mammalian target of rapamycin) signalling by intracellular amino acid availability
-
Beugnet, A., Tee, A. R., Taylor, P. M., and Proud, C. G. (2003) Regulation of targets of mTOR (mammalian target of rapamycin) signalling by intracellular amino acid availability. Biochem. J. 372, 555-566.
-
(2003)
Biochem. J
, vol.372
, pp. 555-566
-
-
Beugnet, A.1
Tee, A.R.2
Taylor, P.M.3
Proud, C.G.4
-
60
-
-
0034073638
-
-
Lynch, C. J., Fox, H. L., Vary, T. C., Jefferson, L. S., and Kimbal,l S. R. (2000) Regulation of amino acid-sensitive TOR signaling by leucine analogues in adipocytes. J. Cell Biochem. 77, 234-251.
-
Lynch, C. J., Fox, H. L., Vary, T. C., Jefferson, L. S., and Kimbal,l S. R. (2000) Regulation of amino acid-sensitive TOR signaling by leucine analogues in adipocytes. J. Cell Biochem. 77, 234-251.
-
-
-
-
61
-
-
0032971333
-
Structural requirement of leucine for activation of p70 S6 kinase
-
Shigemitsu, K., Tsujishita, Y., Miyaké, H., et al. (1999) Structural requirement of leucine for activation of p70 S6 kinase. FEBS Lett. 447, 303-306.
-
(1999)
FEBS Lett
, vol.447
, pp. 303-306
-
-
Shigemitsu, K.1
Tsujishita, Y.2
Miyaké, H.3
-
62
-
-
21244480367
-
The tuberous sclerosis protein TSC2 is not required for the regulation of the mammalian target of rapamycin by amino acids and certain cellular stresses
-
Smith, E. M., Finn, S. G., Tee, A. R., Browne, G. J., and Proud, C. G. (2005) The tuberous sclerosis protein TSC2 is not required for the regulation of the mammalian target of rapamycin by amino acids and certain cellular stresses. J. Biol. Chem. 280, 18717-18727.
-
(2005)
J. Biol. Chem
, vol.280
, pp. 18717-18727
-
-
Smith, E.M.1
Finn, S.G.2
Tee, A.R.3
Browne, G.J.4
Proud, C.G.5
-
63
-
-
32244435285
-
Regulation of the small GTPase Rheb by amino acids
-
Roccio, M., Bos, J. L., and Zwartkruis, F. J. (2006) Regulation of the small GTPase Rheb by amino acids. Oncogene 25, 657-664.
-
(2006)
Oncogene
, vol.25
, pp. 657-664
-
-
Roccio, M.1
Bos, J.L.2
Zwartkruis, F.J.3
-
64
-
-
33644886769
-
Nutrients suppress phosphatidylinositol 3-kinase/Akt signaling via raptor-dependent mTOR-mediated insulin receptor substrate 1 phosphorylation
-
Tzatsos, A. and Kandror, K. V. (2006) Nutrients suppress phosphatidylinositol 3-kinase/Akt signaling via raptor-dependent mTOR-mediated insulin receptor substrate 1 phosphorylation. Mol. Cell Biol. 26, 63-76.
-
(2006)
Mol. Cell Biol
, vol.26
, pp. 63-76
-
-
Tzatsos, A.1
Kandror, K.V.2
-
65
-
-
21244456553
-
Rheb binding to mammalian target of rapamycin (mTOR) is regulated by amino acid sufficiency
-
Long, X., Ortiz-Vega, S., Lin, Y., and Avruch, J. (2005) Rheb binding to mammalian target of rapamycin (mTOR) is regulated by amino acid sufficiency. J. Biol. Chem. 280, 23433-23436.
-
(2005)
J. Biol. Chem
, vol.280
, pp. 23433-23436
-
-
Long, X.1
Ortiz-Vega, S.2
Lin, Y.3
Avruch, J.4
-
66
-
-
0141615891
-
Potential role of leucine metabolism in the leucine-signaling pathway involving mTOR
-
Lynch, C. J., Halle, B., Fujii, H., et al. (2003) Potential role of leucine metabolism in the leucine-signaling pathway involving mTOR. Am. J. Physiol. Endocrinol. Metab. 285, E854-E863.
-
(2003)
Am. J. Physiol. Endocrinol. Metab
, vol.285
-
-
Lynch, C.J.1
Halle, B.2
Fujii, H.3
-
67
-
-
0035145602
-
Metabolie regulation by leucine of translation initiation through the mTORsignaling pathway by pancreatic beta-cells
-
Xu, G., Kwon, G., Cruz, W. S., Marshall, C. A., and McDaniel, M. L. (2001) Metabolie regulation by leucine of translation initiation through the mTORsignaling pathway by pancreatic beta-cells. Diabetes 50, 353-360.
-
(2001)
Diabetes
, vol.50
, pp. 353-360
-
-
Xu, G.1
Kwon, G.2
Cruz, W.S.3
Marshall, C.A.4
McDaniel, M.L.5
-
68
-
-
0014421614
-
Adenine nucleotide translocation of mitochondria. 1. Specificity and control
-
Pfaff, E. and Klingenberg, M. (1968) Adenine nucleotide translocation of mitochondria. 1. Specificity and control. Eur. J. Biochem. 6, 66-79.
-
(1968)
Eur. J. Biochem
, vol.6
, pp. 66-79
-
-
Pfaff, E.1
Klingenberg, M.2
-
69
-
-
0037012552
-
How does the mitochondrial ADP/ATP carrier distinguish transportable ATP and ADP from untransportable AMP and GTP?Dynamic modeling of the recognition/translocation process in the major substrate binding region
-
Goto, S., Chuman, H., Majima, E., and Terada, H. (2002) How does the mitochondrial ADP/ATP carrier distinguish transportable ATP and ADP from untransportable AMP and GTP?Dynamic modeling of the recognition/translocation process in the major substrate binding region. Biochim. Biophys. Acta 1589, 203-218.
-
(2002)
Biochim. Biophys. Acta
, vol.1589
, pp. 203-218
-
-
Goto, S.1
Chuman, H.2
Majima, E.3
Terada, H.4
-
70
-
-
0033403353
-
A novel human nucleoside diphosphate (NDP) kinase, Nm23-H6, localizes in mitochondria and affects cytokinesis
-
Tsuiki, H., Nitta, M., Furuya, A., et al. (1999) A novel human nucleoside diphosphate (NDP) kinase, Nm23-H6, localizes in mitochondria and affects cytokinesis. J. Cell Biochem. 76, 254-269.
-
(1999)
J. Cell Biochem
, vol.76
, pp. 254-269
-
-
Tsuiki, H.1
Nitta, M.2
Furuya, A.3
-
71
-
-
30344465756
-
Functional coupling between nucleoside diphosphate kinase of the outer mitochondrial compartment and oxidative phosphorylation
-
Lipskaya, T. Y. and Voinova, V. V. (2005) Functional coupling between nucleoside diphosphate kinase of the outer mitochondrial compartment and oxidative phosphorylation. Biochemistry (Mose.) 70, 1354-1362.
-
(2005)
Biochemistry (Mose.)
, vol.70
, pp. 1354-1362
-
-
Lipskaya, T.Y.1
Voinova, V.V.2
-
72
-
-
0025191311
-
-
Board, M., Humm, S., and Newsholme, E. A. (1990) Maximum activities of key enzymes of glycolysis, glutaminolysis, pentose phosphatepathway and tricarboxylic acid cycle in normal, neoplastic and suppressed cells. Biochem. J. 265, 503-509.
-
Board, M., Humm, S., and Newsholme, E. A. (1990) Maximum activities of key enzymes of glycolysis, glutaminolysis, pentose phosphatepathway and tricarboxylic acid cycle in normal, neoplastic and suppressed cells. Biochem. J. 265, 503-509.
-
-
-
-
73
-
-
34247186472
-
Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4
-
Scherz-Shouval, R., Shvets, E., Fass, E., et al. (2007) Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4. EMBO J. 26, 1749-1760.
-
(2007)
EMBO J
, vol.26
, pp. 1749-1760
-
-
Scherz-Shouval, R.1
Shvets, E.2
Fass, E.3
-
74
-
-
33750071414
-
NF-{Kappa}B activation represses tumor necrosis factor-{alpha}-induced autophagy
-
Djavaheri-Mergny, M., Amelotti, M., Mathieu, J., et al. (2006) NF-{Kappa}B activation represses tumor necrosis factor-{alpha}-induced autophagy. J. Biol. Chem. 281, 30373-30382.
-
(2006)
J. Biol. Chem
, vol.281
, pp. 30373-30382
-
-
Djavaheri-Mergny, M.1
Amelotti, M.2
Mathieu, J.3
-
75
-
-
0031791670
-
Intracellular diadenosine polyphosphates: A novel second messenger in stimulus-secretion coupling
-
Martin, F., Pintor, J., Rovira, J. M., Ripoll, C., Miras-Portugal, M. T., and Soria, B. (1998) Intracellular diadenosine polyphosphates: a novel second messenger in stimulus-secretion coupling. FASEB J. 12, 1499-1506.
-
(1998)
FASEB J
, vol.12
, pp. 1499-1506
-
-
Martin, F.1
Pintor, J.2
Rovira, J.M.3
Ripoll, C.4
Miras-Portugal, M.T.5
Soria, B.6
-
76
-
-
0037007014
-
FKBP12-rapamycinassociated protein associates with mitochondria and senses osmotic stress via mitochondrial dysfunction
-
Desai, B. N., Myers, B. R., and Schreiber, S. L. (2002) FKBP12-rapamycinassociated protein associates with mitochondria and senses osmotic stress via mitochondrial dysfunction. Proc. Natl. Acad. Sci. USA 99, 4319-4324.
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 4319-4324
-
-
Desai, B.N.1
Myers, B.R.2
Schreiber, S.L.3
-
77
-
-
33748752151
-
The mammalian target of rapamycin (mTOR) pathway regulates mitochondrial oxygen consumption and oxidative capacity
-
Schieke, S. M., Phillips, D., McCoy ,J. P., Jr., et al. (2006) The mammalian target of rapamycin (mTOR) pathway regulates mitochondrial oxygen consumption and oxidative capacity. J. Biol. Chem. 281, 27643-27652.
-
(2006)
J. Biol. Chem
, vol.281
, pp. 27643-27652
-
-
Schieke, S.M.1
Phillips, D.2
McCoy Jr., J.P.3
-
78
-
-
0027979626
-
Activation of rat liver AMP-activated protein kinase by kinase kinase in a purified, reconstituted system. Effects of AMP and AMP analogues
-
Weekes, J., Hawley, S. A., Cortón, J., Shugar, D., and Hardie, D. G. (1994) Activation of rat liver AMP-activated protein kinase by kinase kinase in a purified, reconstituted system. Effects of AMP and AMP analogues. Eur. J. Biochem. 219, 751-757.
-
(1994)
Eur. J. Biochem
, vol.219
, pp. 751-757
-
-
Weekes, J.1
Hawley, S.A.2
Cortón, J.3
Shugar, D.4
Hardie, D.G.5
-
79
-
-
0033635215
-
Uncharged tRNA activates GCN2 by displacing the protein kinase moiety from a bipartite tRNA-binding domain
-
Dong, J., Qiu, H., Garcia-Barrio, M., Anderson, J., and Hinnebusch, A. G. (2000) Uncharged tRNA activates GCN2 by displacing the protein kinase moiety from a bipartite tRNA-binding domain. Mol. Cell 6, 269-279.
-
(2000)
Mol. Cell
, vol.6
, pp. 269-279
-
-
Dong, J.1
Qiu, H.2
Garcia-Barrio, M.3
Anderson, J.4
Hinnebusch, A.G.5
-
80
-
-
0034973590
-
Transcriptional profiling shows that Gcn4p is a master regulator of gene expression during amino acid starvation in yeast
-
Natarajan, K., Meyer, M. R., Jackson, B. M., et al. (2001) Transcriptional profiling shows that Gcn4p is a master regulator of gene expression during amino acid starvation in yeast. Mol. Cell Biol. 21, 4347-4368.
-
(2001)
Mol. Cell Biol
, vol.21
, pp. 4347-4368
-
-
Natarajan, K.1
Meyer, M.R.2
Jackson, B.M.3
-
81
-
-
0037382865
-
Translations control by TOR and TAP42 through dephosphorylation of eIF2alpha kinase GCN2
-
Cherkasova, V. A. and Hinnebusch, A. G. (2003) Translations control by TOR and TAP42 through dephosphorylation of eIF2alpha kinase GCN2. Genes Dev. 17, 859-872.
-
(2003)
Genes Dev
, vol.17
, pp. 859-872
-
-
Cherkasova, V.A.1
Hinnebusch, A.G.2
-
82
-
-
0037039442
-
Regulation of starvation- and virus-induced autophagy by the eIF2alpha kinase signaling pathway
-
Talloczy, Z., Jiang, W., Virgin, H. W., et al. (2002) Regulation of starvation- and virus-induced autophagy by the eIF2alpha kinase signaling pathway. Proc. Natl. Acad. Sci. USA 99, 190-195.
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 190-195
-
-
Talloczy, Z.1
Jiang, W.2
Virgin, H.W.3
-
83
-
-
0035976615
-
Phosphatidic acid-mediated mitogenic activation of mTOR signaling
-
Fang, Y., Vilella-Bach, M., Bachmann, R., Flanigan, A., and Chen, J. (2001) Phosphatidic acid-mediated mitogenic activation of mTOR signaling. Science 294, 1942-1945.
-
(2001)
Science
, vol.294
, pp. 1942-1945
-
-
Fang, Y.1
Vilella-Bach, M.2
Bachmann, R.3
Flanigan, A.4
Chen, J.5
-
84
-
-
33645241260
-
The role of phospholipase D and phosphatidic acid in the mechanical activation of mTOR signaling in skeletal muscle
-
Hornberger, T. A., Chu, W. K., Mak, Y. W., Hsiung, J. W., Huang, S. A., and Chien, S. (2006) The role of phospholipase D and phosphatidic acid in the mechanical activation of mTOR signaling in skeletal muscle. Proc. Natl. Acad. Sci USA 103, 4741-4746.
-
(2006)
Proc. Natl. Acad. Sci USA
, vol.103
, pp. 4741-4746
-
-
Hornberger, T.A.1
Chu, W.K.2
Mak, Y.W.3
Hsiung, J.W.4
Huang, S.A.5
Chien, S.6
-
85
-
-
4544220704
-
Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity
-
Um, S. H., Frigerio, F., Watanabe, M., et al. (2004) Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity. Nature 431, 200-205.
-
(2004)
Nature
, vol.431
, pp. 200-205
-
-
Um, S.H.1
Frigerio, F.2
Watanabe, M.3
-
86
-
-
14244256097
-
Increased activation of the mammalian target of rapamycin pathway in liver and skeletal muscle of obese rats: Possible involvement in obesity-linked insulin resistance
-
Khamzina, L., Veilleux, A., Bergeron, S., and Marette, A. (2005) Increased activation of the mammalian target of rapamycin pathway in liver and skeletal muscle of obese rats: possible involvement in obesity-linked insulin resistance. Endocrinology 146, 1473-1481.
-
(2005)
Endocrinology
, vol.146
, pp. 1473-1481
-
-
Khamzina, L.1
Veilleux, A.2
Bergeron, S.3
Marette, A.4
-
87
-
-
33744505375
-
Nutrient overload, insulin resistance, and ribosomal protein S6 kinase 1, S6K1
-
Um, S. H., D'Alessio, D., and Thomas, G. (2006) Nutrient overload, insulin resistance, and ribosomal protein S6 kinase 1, S6K1. Cell Metab 3, 393-402.
-
(2006)
Cell Metab
, vol.3
, pp. 393-402
-
-
Um, S.H.1
D'Alessio, D.2
Thomas, G.3
-
88
-
-
6344226632
-
Amino acid metabolism in the Zucker diabetic fatty rat: Effects of insulin resistance and of type 2 diabetes
-
Wijekoon, E. P., Skinner, C., Brosnan, M. E., and Brosnan, J. T. (2004) Amino acid metabolism in the Zucker diabetic fatty rat: effects of insulin resistance and of type 2 diabetes. Can. J. Physiol Pharmacol. 82, 506-514.
-
(2004)
Can. J. Physiol Pharmacol
, vol.82
, pp. 506-514
-
-
Wijekoon, E.P.1
Skinner, C.2
Brosnan, M.E.3
Brosnan, J.T.4
-
89
-
-
33747619854
-
Insulin resistance accelerates muscle protein degradation: Activation of the ubiquitin-proteasome pathway by defects in muscle cell signaling
-
Wang, X., Hu, Z., Hu, J., Du, J., and Mitch, W. E. (2006) Insulin resistance accelerates muscle protein degradation: activation of the ubiquitin-proteasome pathway by defects in muscle cell signaling. Endocrinology 147, 4160-4168.
-
(2006)
Endocrinology
, vol.147
, pp. 4160-4168
-
-
Wang, X.1
Hu, Z.2
Hu, J.3
Du, J.4
Mitch, W.E.5
-
90
-
-
27644582647
-
Autophagy and p70S6 Kinase
-
Klionsky, D. J., Meijer, A. J., Codogno, P., Neufeld, T. P., and Scott, R. C. (2005) Autophagy and p70S6 Kinase. Autophagy 1, 59-61.
-
(2005)
Autophagy
, vol.1
, pp. 59-61
-
-
Klionsky, D.J.1
Meijer, A.J.2
Codogno, P.3
Neufeld, T.P.4
Scott, R.C.5
-
91
-
-
4344563878
-
Role and regulation of starvation-induced autophagy in the Drosophila fat body
-
Scott, R. C., Schuldiner, O., and Neufeld, T. P. (2004) Role and regulation of starvation-induced autophagy in the Drosophila fat body. Dev. Cell. 7, 167-178.
-
(2004)
Dev. Cell
, vol.7
, pp. 167-178
-
-
Scott, R.C.1
Schuldiner, O.2
Neufeld, T.P.3
-
92
-
-
2642586352
-
Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease
-
Ravikumar, B., Vacher, C., Berger, Z., et al. (2004) Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease. Nat. Genet. 36, 585-595.
-
(2004)
Nat. Genet
, vol.36
, pp. 585-595
-
-
Ravikumar, B.1
Vacher, C.2
Berger, Z.3
-
93
-
-
33644540193
-
Autophagy-mediated clearance of huntingtin aggregates triggered by the insulin-signaling pathway
-
Yamamoto, A., Cremona, M. L., and Rothman, J. E. (2006) Autophagy-mediated clearance of huntingtin aggregates triggered by the insulin-signaling pathway. J. Cell Biol. 172, 719-731.
-
(2006)
J. Cell Biol
, vol.172
, pp. 719-731
-
-
Yamamoto, A.1
Cremona, M.L.2
Rothman, J.E.3
-
94
-
-
4344595626
-
Regulation and role of autophagy in mammalian cells
-
Meijer, A. J. and Codogno, P. (2004) Regulation and role of autophagy in mammalian cells. Int. J. Biochem. Cell Biol. 36, 2445-2462.
-
(2004)
Int. J. Biochem. Cell Biol
, vol.36
, pp. 2445-2462
-
-
Meijer, A.J.1
Codogno, P.2
-
95
-
-
2442485884
-
Ceramide-mediated macroautophagy involves inhibition of protein kinase B and up-regulation of beclin 1
-
Scarlatti, F., Bauvy, C., Ventruti, A., et al. (2004) Ceramide-mediated macroautophagy involves inhibition of protein kinase B and up-regulation of beclin 1. J. Biol. Chem. 279, 18384-18391.
-
(2004)
J. Biol. Chem
, vol.279
, pp. 18384-18391
-
-
Scarlatti, F.1
Bauvy, C.2
Ventruti, A.3
-
96
-
-
14644417747
-
Ceramide down-regulates System A amino acid transport and protein synthesis in rat skeletal muscle cells
-
Hyde, R., Hajduch, E., Powell, D. J., Taylor, P. M., and Hundal, H. S. (2005) Ceramide down-regulates System A amino acid transport and protein synthesis in rat skeletal muscle cells. FASEB J. 19, 461-463.
-
(2005)
FASEB J
, vol.19
, pp. 461-463
-
-
Hyde, R.1
Hajduch, E.2
Powell, D.J.3
Taylor, P.M.4
Hundal, H.S.5
-
97
-
-
0032588907
-
Involvement of p38MAPK in the regulation of proteolysis by liver cell hydration
-
Häussinger, D., Schliess, F., Dombrowski, F., and vom Dahl, S. (1999) Involvement of p38MAPK in the regulation of proteolysis by liver cell hydration. Gastroenterology 116, 921-935.
-
(1999)
Gastroenterology
, vol.116
, pp. 921-935
-
-
Häussinger, D.1
Schliess, F.2
Dombrowski, F.3
vom Dahl, S.4
-
98
-
-
0038711645
-
Involvement of integrins in osmosensing and signaling toward autophagic proteolysis in rat liver
-
vom Dahl, S., Schliess, F., Reissmann, R., et al. (2003) Involvement of integrins in osmosensing and signaling toward autophagic proteolysis in rat liver. J. Biol. Chem. 278, 27088-27095.
-
(2003)
J. Biol. Chem
, vol.278
, pp. 27088-27095
-
-
vom Dahl, S.1
Schliess, F.2
Reissmann, R.3
-
99
-
-
2442674271
-
Involvement of integrins and Src in insulin signaling toward autophagic proteolysis in rat liver
-
Schliess, F., Reissmann, R., Reinehr, R., vom Dahl, S., and Häussinger, D. (2004) Involvement of integrins and Src in insulin signaling toward autophagic proteolysis in rat liver. J. Biol. Chem. 279, 21294-21301.
-
(2004)
J. Biol. Chem
, vol.279
, pp. 21294-21301
-
-
Schliess, F.1
Reissmann, R.2
Reinehr, R.3
vom Dahl, S.4
Häussinger, D.5
-
100
-
-
33644670987
-
Insulin-stimulated glucose uptake does not require p38 mitogen-activated protein kinase in adipose tissue or skeletal muscle
-
Turban, S., Beardmore, V. A., Carr, J. M., et al. (2005) Insulin-stimulated glucose uptake does not require p38 mitogen-activated protein kinase in adipose tissue or skeletal muscle. Diabetes 54, 3161-3168.
-
(2005)
Diabetes
, vol.54
, pp. 3161-3168
-
-
Turban, S.1
Beardmore, V.A.2
Carr, J.M.3
-
101
-
-
0030338042
-
Autophagy
-
Mortimore, G. E., Miotto, G., Venerando, R., and Kadowaki, M. (1996) Autophagy. Subcell. Biochem. 27, 93-135.
-
(1996)
Subcell. Biochem
, vol.27
, pp. 93-135
-
-
Mortimore, G.E.1
Miotto, G.2
Venerando, R.3
Kadowaki, M.4
-
102
-
-
0027163450
-
Cell swelling and the sensitivity of autophagic proteolysis to inhibition by amino acids in isolated rat hepatocytes
-
Meijer, A. J., Gustafson, L. A., Luiken, J. J., et al. (1993) Cell swelling and the sensitivity of autophagic proteolysis to inhibition by amino acids in isolated rat hepatocytes. Eur. J. Biochem. 215, 449-454.
-
(1993)
Eur. J. Biochem
, vol.215
, pp. 449-454
-
-
Meijer, A.J.1
Gustafson, L.A.2
Luiken, J.J.3
-
103
-
-
27644466759
-
Autophagy and signaling: Their role in cell survival and cell death
-
Codogno, P. and Meijer, A. J. (2005) Autophagy and signaling: their role in cell survival and cell death. Cell Death. Differ. 12, 1509-1518.
-
(2005)
Cell Death. Differ
, vol.12
, pp. 1509-1518
-
-
Codogno, P.1
Meijer, A.J.2
-
104
-
-
1842583789
-
Development by self-digestion: Molecular mechanisms and biological functions of autophagy
-
Levine, B. and Klionsky, D. J. (2004) Development by self-digestion: molecular mechanisms and biological functions of autophagy. Dev. Cell 6, 463-477.
-
(2004)
Dev. Cell
, vol.6
, pp. 463-477
-
-
Levine, B.1
Klionsky, D.J.2
-
105
-
-
25444440875
-
The role of autophagy in cancer development and response to therapy
-
Kondo, Y., Kanzawa, T., Sawaya, R., and Kondo, S. (2005) The role of autophagy in cancer development and response to therapy. Nat. Rev. Cancer 5, 726-734.
-
(2005)
Nat. Rev. Cancer
, vol.5
, pp. 726-734
-
-
Kondo, Y.1
Kanzawa, T.2
Sawaya, R.3
Kondo, S.4
-
106
-
-
23644443068
-
The significance of autophagy in cancer
-
Ng, G. and Huang, J. (2005) The significance of autophagy in cancer. Mol. Carcinog. 43, 183-187.
-
(2005)
Mol. Carcinog
, vol.43
, pp. 183-187
-
-
Ng, G.1
Huang, J.2
-
107
-
-
33646271855
-
A matter of life or death (or both): Understanding autophagy in cancer
-
Hait, W. N., Jin, S., and Yang, J. M. (2006) A matter of life or death (or both): understanding autophagy in cancer. Clin. Cancer Res. 12, 1961-1965.
-
(2006)
Clin. Cancer Res
, vol.12
, pp. 1961-1965
-
-
Hait, W.N.1
Jin, S.2
Yang, J.M.3
-
108
-
-
33645520907
-
Autophagy signaling and the cogwheels of cancer
-
Botti, J., Djavaheri-Mergny, M., Pilatte, Y., and Codogno, P. (2006) Autophagy signaling and the cogwheels of cancer. Autophagy 2, 67-73.
-
(2006)
Autophagy
, vol.2
, pp. 67-73
-
-
Botti, J.1
Djavaheri-Mergny, M.2
Pilatte, Y.3
Codogno, P.4
-
109
-
-
33745026738
-
Autophagy and aging: The importance of maintaining "clean" cells
-
Cuervo, A. M., Bergamini, E., Brunk, U. T., Droge, W., French, M., and Terman, A. (2005) Autophagy and aging: the importance of maintaining "clean" cells. Autophagy 1, 131-140.
-
(2005)
Autophagy
, vol.1
, pp. 131-140
-
-
Cuervo, A.M.1
Bergamini, E.2
Brunk, U.T.3
Droge, W.4
French, M.5
Terman, A.6
-
110
-
-
0037470501
-
The endocrine regulation of aging by insulin-like signals
-
Tatar, M., Bartke, A., and Antebi, A. (2003) The endocrine regulation of aging by insulin-like signals. Science 299, 1346-1351.
-
(2003)
Science
, vol.299
, pp. 1346-1351
-
-
Tatar, M.1
Bartke, A.2
Antebi, A.3
-
111
-
-
14844293962
-
The role of insulin and IGF-1 signaling in longevity
-
Katie, M. and Kahn, C. R. (2005) The role of insulin and IGF-1 signaling in longevity. Cell Mol. Life Sci. 62, 320-343.
-
(2005)
Cell Mol. Life Sci
, vol.62
, pp. 320-343
-
-
Katie, M.1
Kahn, C.R.2
-
112
-
-
0042691506
-
Autophagy genes are essential for dauer development and life-span extension in C. elegans
-
Melendez, A., Talloczy, Z., Seaman, M., Eskelinen, E. L., Hall, D. H., and Levine, B. (2003) Autophagy genes are essential for dauer development and life-span extension in C. elegans. Science 301, 1387-1391.
-
(2003)
Science
, vol.301
, pp. 1387-1391
-
-
Melendez, A.1
Talloczy, Z.2
Seaman, M.3
Eskelinen, E.L.4
Hall, D.H.5
Levine, B.6
-
113
-
-
24944481544
-
Suppression of aging in mice by the hormone Klotho
-
Kurosu, H., Yamamoto, M., Clark, J. D., et al. (2005) Suppression of aging in mice by the hormone Klotho. Science 309, 1829-1833.
-
(2005)
Science
, vol.309
, pp. 1829-1833
-
-
Kurosu, H.1
Yamamoto, M.2
Clark, J.D.3
-
114
-
-
33748316536
-
SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells
-
Haigis, M. C., Mostoslavsky, R., Haigis, K. M., et al. (2006) SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells. Cell 126, 941-954.
-
(2006)
Cell
, vol.126
, pp. 941-954
-
-
Haigis, M.C.1
Mostoslavsky, R.2
Haigis, K.M.3
-
115
-
-
12344305124
-
Mitochondrial dysfunction and type 2 diabetes
-
Lowell, B. B. and Shulman, G. I. (2005) Mitochondrial dysfunction and type 2 diabetes. Science 307, 384-387.
-
(2005)
Science
, vol.307
, pp. 384-387
-
-
Lowell, B.B.1
Shulman, G.I.2
|